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At least 1,333 records · Page 74

Toll-like Receptor Ligands Enhance Vaccine Efficacy against a Virulent Newcastle Disease Virus Challenge in Chickens

To enhance the efficacy of the current Newcastle disease vaccine, we have selected potential adjuvants that target well-characterized pattern recognition receptors: the toll-like receptors (TLRs). Imiquimod is a small-molecule activator of TLR7, which is a sensor of dsDNA. ODN-1826 is a mimetic of CpG DNA and ligates TLR21 (a chicken homologue of TLR9 in mammals). The activation of TLRs leads to antiviral responses, including the induction of type I interferons (IFNs). In this study, birds were vaccinated intranasally with a live LaSota strain with or without imiquimod or ODN-1826 (50 µg/bird). Two weeks after vaccination, the birds were challenged with a virulent Newcastle disease virus (chicken/CA/212676/2002). Both adjuvants (imiquimod or ODN-1826) induced higher and more uniform antibody titers among vaccinated birds compared with the live vaccine-alone group. In addition, adjuvanted vaccines demonstrated greater protective efficacy in terms of the reduction in virus-shedding titer and the number of birds shedding the challenge virus at 2 and 4 days post-challenge. A differential expression of antiviral and immune-related genes was observed among groups from tissues (Harderian gland, trachea, cecal tonsil, and spleen) collected 1 and 3 days after treatment. These results demonstrate the potential of TLR-targeted adjuvants as mucosal vaccine enhancers and warrant a further characterization of immune correlates and optimization for efficacy.

59 BASIC BIOLOGICAL SCIENCES↗

The longitudinal movement of stratospheric ozone waves as determined by satellite

The Nimbus III Infrared Interferometer Spectrometer sensor provides several thousand total ozone data points over the entire globe each day. A time-longitudinal distribution of total ozone for 60 deg S is shown. A selection of this latitude makes it possible to compare the data with radiance values computed by Fritz (1970). Hemispheric differences in longitudinal progression during June 1969 are discussed together with group- and phase-velocities of ozone 'waves.'

Reiter, E. R.↗

Mission analysis to define satellite orbits for earth radiation budget measurements

Information is presented concerning the number of satellites, the orbit altitude, and the inclinations which will provide the spatial and temporal earth coverage required for accurate radiation measurements on regional, zonal, and global scales. Measurement considerations are discussed and an analysis is conducted regarding the selection of suitable orbit parameters. Attention is also given to the results of a simulation model study for the determination of the radiation which can be measured by satellite sensors in different orbits.

Harrison, E. F.↗

F-8C adaptive flight control laws

Three candidate digital adaptive control laws were designed for NASA's F-8C digital flyby wire aircraft. Each design used the same control laws but adjusted the gains with a different adaptative algorithm. The three adaptive concepts were: high-gain limit cycle, Liapunov-stable model tracking, and maximum likelihood estimation. Sensors were restricted to conventional inertial instruments (rate gyros and accelerometers) without use of air-data measurements. Performance, growth potential, and computer requirements were used as criteria for selecting the most promising of these candidates for further refinement. The maximum likelihood concept was selected primarily because it offers the greatest potential for identifying several aircraft parameters and hence for improved control performance in future aircraft application. In terms of identification and gain adjustment accuracy, the MLE design is slightly superior to the other two, but this has no significant effects on the control performance achievable with the F-8C aircraft. The maximum likelihood design is recommended for flight test, and several refinements to that design are proposed.

Hartmann, G. L.↗

Photoelectric detection system

A photoelectric beam system for the detection of the arrival of an object at a discrete station wherein artificial light, natural light, or no light may be present is described. A signal generator turns on and off a signal light at a selected frequency. When the object in question arrives on station, ambient light is blocked by the object, and the light from the signal light is reflected onto a photoelectric sensor which has a delayed electrical output but is of the frequency of the signal light. Outputs from both the signal source and the photoelectric sensor are fed to inputs of an exclusively OR detector which provides as an output the difference between them. The difference signal is a small width pulse occurring at the frequency of the signal source. By filter means, this signal is distinguished from those responsive to sunlight, darkness, or 120 Hz artificial light. In this fashion, the presence of an object is positively established.

Currie, J. R.↗

Munsell color analysis of Landsat color-ratio-composite images of limonitic areas in southwest New Mexico

The causes of color variations in the green areas on Landsat 4/5-4/6-6/7 (red-blue-green) color-ratio-composite (CRC) images, defined as limonitic areas, were investigated by analyzing the CRC images of the Lordsburg, New Mexico area. The red-blue-green additive color system was mathematically transformed into the cylindrical Munsell color coordinates (hue, saturation, and value), and selected areas were digitally analyzed for color variation. The obtained precise color characteristics were then correlated with properties of surface material. The amount of limonite (L) visible to the sensor was found to be the primary cause of the observed color differences. The visible L is, is turn, affected by the amount of L on the material's surface and by within-pixel mixing of limonitic and nonlimonitic materials. The secondary cause of variation was vegetation density, which shifted CRC hues towards yellow-green, decreased saturation, and increased value.

Kruse, F. A.↗

Fiber optic control system integration

A total fiber optic, integrated propulsion/flight control system concept for advanced fighter aircraft is presented. Fiber optic technology pertaining to this system is identified and evaluated for application readiness. A fiber optic sensor vendor survey was completed, and the results are reported. The advantages of centralized/direct architecture are reviewed, and the concept of the protocol branch is explained. Preliminary protocol branch selections are made based on the F-18/F404 application. Concepts for new optical tools are described. Development plans for the optical technology and the described system are included.

Poppel, G. L.↗

Procedures for minimizing the effects of high solar activity on satellite tracking and ephemeris generation

We are currently experiencing a period of high solar radiation combined with wide short-term fluctuations in the radiation. The short-term fluctuations, especially when combined with highly energetic solar flares, can adversely affect the mission of U.S. Space Command's Space Surveillance Center (SSC) which catalogs and tracks the satellites in orbit around the Earth. Rapidly increasing levels of solar electromagnetic and/or particle radiation (solar wind) causes atmospheric warming, which, in turn, causes the upper-most portions of the atmosphere to expand outward, into the regime of low altitude satellites. The increased drag on satellites from this expansion can cause large, unmodeled, in-track displacements, thus undermining the SSC's ability to track and predict satellite position. On 13 March 1989, high solar radiation levels, combined with a high-energy solar flare, caused an exceptional amount of short-term atmospheric warming. The SSC temporarily lost track of over 1300 low altitude satellites--nearly half of the low altitude satellite population. Observational data on satellites that became lost during the days following the 13 March 'solar event' was analyzed and compared with the satellites' last element set prior to the event (referred to as a geomagnetic storm because of the large increase in magnetic flux in the upper atmosphere). The analysis led to a set of procedures for reducing the impact of future geomagnetic storms. These procedures adjust selected software limit parameters in the differential correction of element sets and in the observation association process and must be manually initiated at the onset of a geomagnetic storm. Sensor tasking procedures must be adjusted to ensure that a minimum of four observations per day are received for low altitude satellites. These procedures have been implemented and, thus far, appear to be successful in minimizing the effect of subsequent geomagnetic storms on satellite tracking and ephemeris computation.

Bredvik, Gordon D.↗

Potential Commercial Applications from Combustion and Fire Research in Space

The near-zero (microgravity) environment of orbiting spacecraft minimizes buoyant flows, greatly simplifying combustion processes and isolating important phenomena ordinarily concealed by the overwhelming gravity-driven forces and flows. Fundamental combustion understanding - the focus to date of the NASA microgravity-combustion program - has greatly benefited from analyses and experiments conducted in the microgravity environment. Because of the economic and commercial importance of combustion in practice, there is strong motivation to seek wider applications for the microgravity-combustion findings. This paper reviews selected technology developments to illustrate some emerging applications. Topics cover improved fire-safety technology in spacecraft and terrestrial systems, innovative combustor designs for aerospace and ground propulsion, applied sensors and controls for combustion processes, and self-sustaining synthesis techniques for advanced materials.

Friedman, Robert↗

Overview of Microgravity Combustion Research at NASA Lewis Research Center and its Potential Commercial Impact

The near-zero (microgravity) environment of orbiting spacecraft minimizes buoyant flows, greatly simplifying combustion processes and isolating important phenomena ordinarily concealed by the overwhelming gravity-driven forces and flows. Fundamental combustion understanding has greatly benefited from analyses and experiments conducted in the microgravity environment. Because of the economic and commercial importance of combustion in practice, there is strong motivation to seek wider applications for the microgravity-combustion findings. This paper reviews selected technology developments to illustrate some emerging applications. Topics cover improved fire-safety technology in spacecraft and terrestrial systems, innovative combustor designs for aerospace and ground propulsion, applied sensors and controls for combustion processes, and self-sustaining synthesis techniques for advanced materials.

Lyons, Valerie↗

Materials Science Research Hardware for Application on the International Space Station: an Overview of Typical Hardware Requirements and Features

NASA's Marshall Space Flight Center (MSFC) is the lead center for Materials Science Microgravity Research. The Materials Science Research Facility (MSRF) is a key development effort underway at MSFC. The MSRF will be the primary facility for microgravity materials science research on board the International Space Station (ISS) and will implement the NASA Materials Science Microgravity Research Program. It will operate in the U.S. Laboratory Module and support U. S. Microgravity Materials Science Investigations. This facility is being designed to maintain the momentum of the U.S. role in microgravity materials science and support NASA's Human Exploration and Development of Space (HEDS) Enterprise goals and objectives for Materials Science. The MSRF as currently envisioned will consist of three Materials Science Research Racks (MSRR), which will be deployed to the International Space Station (ISS) in phases, Each rack is being designed to accommodate various Experiment Modules, which comprise processing facilities for peer selected Materials Science experiments. Phased deployment will enable early opportunities for the U.S. and International Partners, and support the timely incorporation of technology updates to the Experiment Modules and sensor devices.

Schaefer, D. A.↗

Incident Energy Focused Design and Validation for the Floating Potential Probe

Utilizing the spacecraft shadowing and incident energy analysis capabilities of the NASA Glenn Research Center Power and Propulsion Office's SPACE System Power Analysis for Capability Evaluation) computer code, this paper documents the analyses for various International Space Station (ISS) Floating Potential Probe (EPP) preliminary design options. These options include various solar panel orientations and configurations as well as deployment locations on the ISS. The incident energy for the final selected option is characterized. A good correlation between the predicted data and on-orbit operational telemetry is demonstrated. Minor deviations are postulated to be induced by degradation or sensor drift.

Fincannon, James↗

Near-Real Time Cloud Retrievals from Operational and Research Meteorological Satellites

A set of cloud retrieval algorithms developed for CERES and applied to MODIS data have been adapted to analyze other satellite imager data in near-real time. The cloud products, including single-layer cloud amount, top and base height, optical depth, phase, effective particle size, and liquid and ice water paths, are being retrieved from GOES- 10/11/12, MTSAT-1R, FY-2C, and Meteosat imager data as well as from MODIS. A comprehensive system to normalize the calibrations to MODIS has been implemented to maximize consistency in the products across platforms. Estimates of surface and top-of-atmosphere broadband radiative fluxes are also provided. Multilayered cloud properties are retrieved from GOES-12, Meteosat, and MODIS data. Native pixel resolution analyses are performed over selected domains, while reduced sampling is used for full-disk retrievals. Tools have been developed for matching the pixel-level results with instrumented surface sites and active sensor satellites. The calibrations, methods, examples of the products, and comparisons with the ICESat GLAS lidar are discussed. These products are currently being used for aircraft icing diagnoses, numerical weather modeling assimilation, and atmospheric radiation research and have potential for use in many other applications.

Minnis, Patrick↗

Test Beam Analysis of Silicon Microstrip Module with Transverse Momentum Discrimination for CMS HL-LHC

The front end chip of the 2S modules (CBC) is capable of reconstructing short track segments correlating the hits of the two closely spaced silicon microstrip sensors constituting a module. These track segments can be used at the level 1 trigger to reconstruct complete tracks with a transverse momentum above 2 GeV/c keeping the trigger selection discrimination very efficient. A prototype mini-module was produced with the latest CBC version and tested before and after irradiation at the Fermilab Test Beam Facility (FTBF) during 3 test-beam campaigns.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Fluid level and conductivity sensor for high temperature applications

A fluid level and conductivity sensor having a sensing probe with four electrodes disposed therein particularly suited for high temperature applications. A distal end of the second and third electrodes are positioned a distance from the sensing end that is greater than distal ends of the first and fourth electrodes. The sensor includes an electronics system having a signal relay system for receiving signals from each of the electrodes and switching between different measurement modes by determining a resistance between selected pairs of electrodes based on instructions from the microcontroller. The measurement modes include a conductivity measurement mode in which a resistance between the first and fourth electrodes is determined, and a fluid level measurement mode in which a resistance between the first and third electrodes is determined and compared to a resistance between the second and third electrodes.

Holland, Justin M.↗

Optical Multi-Gas Monitor Technology Demonstration on the International Space Station

There are a variety of both portable and fixed gas monitors onboard the International Space Station (ISS). Devices range from rack-mounted mass spectrometers to hand-held electrochemical sensors. An optical Multi-Gas Monitor has been developed as an ISS Technology Demonstration to evaluate long-term continuous measurement of 4 gases. Based on tunable diode laser spectroscopy, this technology offers unprecedented selectivity, concentration range, precision, and calibration stability. The monitor utilizes the combination of high performance laser absorption spectroscopy with a rugged optical path length enhancement cell that is nearly impossible to misalign. The enhancement cell serves simultaneously as the measurement sampling cell for multiple laser channels operating within a common measurement volume. Four laser diode based detection channels allow quantitative determination of ISS cabin concentrations of water vapor (humidity), carbon dioxide, ammonia and oxygen. Each channel utilizes a separate vertical cavity surface emitting laser (VCSEL) at a different wavelength. In addition to measuring major air constituents in their relevant ranges, the multiple gas monitor provides real time quantitative gaseous ammonia measurements between 5 and 20,000 parts-per-million (ppm). A small ventilation fan draws air with no pumps or valves into the enclosure in which analysis occurs. Power draw is only about 3 W from USB sources when installed in Nanoracks or when connected to 28V source from any EXPRESS rack interface. Internal battery power can run the sensor for over 20 hours during portable operation. The sensor is controlled digitally with an FPGA/microcontroller architecture that stores data internally while displaying running average measurements on an LCD screen and interfacing with the rack or laptop via USB. Design, construction and certification of the Multi-Gas Monitor were a joint effort between Vista Photonics, Nanoracks and NASA-Johnson Space Center (JSC). Vista Photonics developed the core technology and built the sensor. Nanoracks designed, constructed the enclosure, interfaces, and battery power management circuitry, integrated all subsystems into the enclosure, and then managed the certification tests, documentation and manifesting. The unit was calibrated in the JSC Toxicology Laboratory. The Multi-Gas Monitor is manifested to fly as a technology demonstration to the ISS in November 2013 and will operate for at least 6 months with data sent to the ground for evaluation. The primary goal is to demonstrate long term interference free operation in the real spacecraft environment.

Pilgrim, Jeffrey S.↗

End-point control of a two-link manipulator with a very flexible forearm - Issues and experiments

For mechanical manipulators, a logical sensor location is at the manipulator end-point where tasks are performed. Unfortunately, when bending flexibility exists between an end-point sensor and a joint actuator, stability and performance are achieved only through sophisticated control design. Some of the issues involved in utilizing end-point sensing for two-link flexible manipulators are addressed. A modeling technique that properly represents the foreshortening of a flexible link undergoing deflections is presented. In order to realize fully the advantages of the assumed-modes modeling method, mode shapes are selected that allow a low-order model to be used effectively for simulation and control purposes. A nonlinear controller, incorporating state feedback and a constant-gain extended Kalman filter driven by end-point measurements, is designed and compared to a conventional proportional-plus-derivative controller that uses collocated sensors. Results from implementing these controllers on the experimental Stanford multilink flexible manipulator are given.

Oakley, Celia M.↗

Advanced Layered Composite Polylaminate Electroactive Actuator and Sensor

The present invention relates to the mounting of pre-stressed electroactive material in such a manner that large displacement actuators or sensors result. The invention comprises mounting the pre-stressed electroactive material to a support layer. This combination of a pre-stressed electroactive material and support layer may in turn be attached to a mounting surface. The pre-stressed electroactive material may be a ferroelectric, pyroelectric, piezoelectric, or magnetostrictive material. The size, stiffness, mass, and material of the support layer is selected to result in the electroactive device having dynamic response properties, environmental capability characteristics, and the required resilience optimized for a given application. The capacity to connect the support layer to a surface expands the arenas in which the prestressed electroactive device may be used. Application for which the invention may be used include actuators, sensors, or as a component in a pumps, switches, relays, pressure transducers and acoustic devices.

Fox, Robert L.↗