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At least 1,333 records · Page 74

Measurement of the ratio of branching fractions and difference in CP asymmetries of the decays $B^+$ → $J/ψπ^+$ and $B^+$ → $J/ψK^+$

The ratio of branching fractions and the difference in $CP$ asymmetries of the decays $B^+$ → $J/ψπ^+$ and $B^+$ → $J/ψK^+$ are measured using a data sample of $pp$ collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 3 fb -1 at centre-of-mass energies of 7 and 8 TeV. The results are B ( B + &#x2192;<!-- → --> J / &#x03C8;<!-- ψ --> &#x03C0;<!-- π --> + ) B ( B + &#x2192;<!-- → --> J / &#x03C8;<!-- ψ --> K + ) = ( 3.83 &#x00B1;<!-- ± --> 0.03 &#x00B1;<!-- ± --> 0.03 ) &#x00D7;<!-- × --> 10 &#x2212;<!-- - --> 2 , A C P ( B + &#x2192;<!-- → --> J / &#x03C8;<!-- ψ --> &#x03C0;<!-- π --> + ) &#x2212;<!-- - --> A C P ( B + &#x2192;<!-- → --> J / &#x03C8;<!-- ψ --> K + ) = ( 1.82 &#x00B1;<!-- ± --> 0.86 &#x00B1;<!-- ± --> 0.14 ) &#x00D7;<!-- × --> 10 &#x2212;<!-- - --> 2 , where the first uncertainties are statistical and the second are systematic. Combining this result with a recent LHCb measurement of $A^{CP}$ ($B^+$ → $J/ ψK^+$) provides the most precise estimate to date of $CP$ violation in the decay $B^+$ → $J/ψπ^+$, A C P ( B + &#x2192;<!-- → --> J / &#x03C8;<!-- ψ --> &#x03C0;<!-- π --> + ) = ( 1.91 &#x00B1;<!-- ± --> 0.89 &#x00B1;<!-- ± --> 0.16 ) &#x00D7;<!-- × --> 1 0 &#x2212;<!-- - --> 2 .

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Energy dependence and fluctuations of anisotropic flow in Pb-Pb collisions at $ \sqrt{s_{\mathrm{NN}}}=5.02 $ and 2.76 TeV

Here, measurements of anisotropic flow coefficients with two- and multi-particle cumulants for inclusive charged particles in Pb-Pb collisions at $ \sqrt{s_{\mathrm{NN}}}=5.02 $ and 2.76 TeV are reported in the pseudorapidity range |η| < 0.8 and transverse momentum 0.2 < p T < 50 GeV/c. The full data sample collected by the ALICE detector in 2015 (2010), corresponding to an integrated luminosity of 12.7 (2.0) μb –1 in the centrality range 0-80%, is analysed.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for high-mass $Wγ$ and $Zγ$ resonances using hadronic $W/Z$ boson decays from 139 fb –1 of $pp$ collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector

A search for high-mass charged and neutral bosons decaying to $Wγ$ and $Zγ$ final states is presented in this paper. The analysis uses a data sample of $\sqrt{s}$ = 13 TeV proton-proton collisions with an integrated luminosity of 139 fb –1 collected by the ATLAS detector during LHC Run 2 operation. The sensitivity of the search is determined using models of the production and decay of spin-1 charged bosons and spin-0/2 neutral bosons. The range of resonance masses explored extends from 1.0 TeV to 6.8 TeV. At these high resonance masses, it is beneficial to target the hadronic decays of the $W$ and $Z$ bosons because of their large branching fractions. The decay products of the high-momentum $W/Z$ bosons are strongly collimated and boosted-boson tagging techniques are employed to improve the sensitivity. No evidence of a signal above the Standard Model backgrounds is observed, and upper limits on the production cross-sections of these bosons times their branching fractions to $Wγ$ and $Zγ$ are derived for various boson production models.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Measurement of the Υ(1S), Υ(2S), and Υ(3S) differential cross sections in pp collisions at $\sqrt{s}=13.6$ TeV

The production cross sections of the Υ(1S), Υ(2S), and Υ(3S) mesons are measured in proton-proton collisions at $\sqrt{s}=13.6$ TeV, using a data sample collected in 2022 by the CMS experiment and corresponding to an integrated luminosity of 37.4 fb −1 . The measurement is performed in the μ + μ − decay channels, differentially as a function of transverse momentum in the 20–200 GeV range, in the |y| < 0.6 and 0.6 < |y| < 1.2 rapidity intervals.

Hadron-Hadron Scattering↗

Finite elements for Matérn-type random fields: Uncertainty in computational mechanics and design optimization

This work highlights an approach for incorporating realistic uncertainties into scientific computing workflows based on finite elements, focusing on prevalent applications in computational mechanics and design optimization. We leverage Matérn-type Gaussian random fields (GRFs) generated using the SPDE method to model aleatoric uncertainties, including environmental influences, variating material properties, and geometric ambiguities. Our focus lies on delivering practical GRF realizations that accurately capture imperfections and variations and understanding how they impact the predictions of computational models as well as the shape and topology of optimized designs. Here we describe a numerical algorithm based on solving a generalized SPDE to sample GRFs on arbitrary meshed domains. The algorithm leverages established techniques and integrates seamlessly with the open-source finite element library MFEM and associated scientific computing workflows, like those found in industrial and national laboratory settings. Our solver scales efficiently for large-scale problems and supports various domain types, including surfaces and embedded manifolds. We showcase its versatility through biomechanics and topology optimization applications, emphasizing the potential to influence these domains. The flexibility and efficiency of SPDE-based GRF generation empowers us to run large-scale optimization problems on 2D and 3D domains, including finding optimized designs on embedded surfaces, and to generate design features and topologies beyond the reach of conventional techniques. Moreover, these capabilities allow us to model and quantify geometric uncertainties on reconstructed submanifolds, such as the interpolated surfaces of cerebral aneurysms provided by postprocessing CT scans. In addition to offering benefits in these specific domains, the proposed techniques transcend specific applications and generalize to arbitrary forward and backward problems in uncertainty quantification involving finite elements.

97 MATHEMATICS AND COMPUTING↗

Dynamics of deuterium retention and desorption from plasma-facing materials in fusion reactor-relevant conditions

Hydrogen isotopes retention and desorption during and after discharges in fusion devices are still not well understood due to the complex device conditions and limitations of in-situ diagnostics and measurements. Here, we simulated well-diagnosed recent experiments at the DIII-D facility to benchmark our ITMC-DYN integrated package of modeling deuterium diffusion, retention, and desorption during and after D discharge irradiation. Modeling results were compared with detail experimental data of D desorption fluxes for various irradiation conditions. We predicted the temporal evolution of free and trapped D distribution in tungsten (W) plasma-facing material (PFM). Effects of key parameters namely diffusion coefficient, recombination rate, trapping energies against different defect types, were examined in these simulations. Existing experimental data of these parameters in literature varies significantly which makes it harder to identify key mechanisms and physics responsible for hydrogen isotope retention and desorption. The purpose of this work is to accurately simulate recent well-diagnosed reactor experiments given the uncertainties in such parameters and identify mechanisms responsible for the retention and desorption. We implemented the best identified diffusion, recombination, and trapping parameters in ITMC-DYN package that integrate both various collisional and thermal processes. We predicted, for example, that sample cooling between discharges in DIII-D operations can significantly affect the spatial distribution of trapped D in W under reactor irradiation conditions. Correct prediction of desorption spectra from samples irradiated during 10 DIII-D discharges showed that up to 35% of D can be retained in high binding energy defects such as vacancy clusters or voids.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Observation of B$^0_s$ mesons and measurement of the B$^0_s$/B$^+$ yield ratio in PbPb collisions at $\sqrt{s_\mathrm{NN}}$ = 5.02 TeV

The B$^0_s$ and B$^+$ production yields are measured in PbPb collisions at a center-of-mass energy per nucleon pair of 5.02 TeV. The data sample, collected with the CMS detector at the LHC, corresponds to an integrated luminosity of 1.7 nb$^{-1}$. The mesons are reconstructed in the exclusive decay channels B$^0_s$$\to$ J/$\psi(\mu^+\mu^-)\phi($K$^+$K$^-)$ and B$^+$$\to$ J/$\psi(\mu^+\mu^-)$K$^+$. The B$^0_s$ meson is observed with a statistical significance in excess of five standard deviations for the first time in nucleus-nucleus collisions. The measurements are performed as functions of the transverse momentum of the B mesons and of the PbPb collision centrality. The ratio of production yields of B$^0_s$ and B$^+$ is measured and compared to theoretical models that include quark recombination effects.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Potential Chemical Impacts of Subsurface CO 2 : An Integrated Experimental and Numerical Assessment for a Case Study of the Ogallala Aquifer

Leakage from geologic CO 2 sequestration (GCS) reservoirs to overlying underground sources of drinking water (USDW) is a tangible risk. This study is an integrated assessment that combines column experiments and reactive transport simulations of sediments sampled from the Ogallala aquifer above an active commercial-scale GCS site (the Farnsworth Unit in northern Texas). Experimental and simulation results suggest that carbonate mineral (calcite and dolomite) dissolution is the most significant reaction following CO 2 intrusion, and is also the dominant source of trace metal release. Cation exchange is another key mechanism controlling trace metal release by cation interference. Most of the trace metals, including Ba, Sr, As, Pb, and Zn, show a short-term release and quickly drop to the baseline values, suggesting low risk to the overlying USDW quality. Other trace metals, such as Mn and U, exhibit a tangible increase of their concentrations in the beginning, and drop to a higher level compared to the baseline, which may become a potential concern of long-term USDW quality change with CO2introduction. This study provides a comprehensive example of combining laboratory experiments and simulations for assessment of CO 2 -sediment interactions with combined release mechanisms in shallow groundwater aquifers. Data presented here provides useful insights for quantitative risk assessment and effective public education regarding CO 2 geological sequestration, and trace metal reactive transport studies in shallow groundwater aquifers.

54 ENVIRONMENTAL SCIENCES↗

Development and flight-testing of modular autonomous cultivation systems for biological plastics upcycling aboard the ISS

Cultivation of microorganisms in space has enormous potential to enable in-situ resource utilization (ISRU) Here, we develop an autonomous payload with fully programmable serial passaging and sample preservation, termed the Modular Open Biological Platform (MOBP), and flight-test the MOBP aboard the International Space Station (ISS) by conducting enzymatic and microbial plastics upcycling experiments. The MOBP is a compact, modular bioreactor system that allows for sustained microbial growth via automated media transfers, such as those for sample collection and storage for terrestrial analyses, and precise data monitoring from integrated sensors. The MOBP was flight-tested with two experiments designed to evaluate biological upcycling of the plastic poly(ethylene terephthalate) (PET). The bioproduct βKA can be polymerized into a nylon-6,6 analog with improved properties for use in the production of a variety of materials. We posit the MOBP will aid in democratizing the execution of synthetic biology in spaceflight towards enabling ISRU.

09 BIOMASS FUELS↗

Geometric integrator for simulations in the canonical ensemble

We introduce a geometric integrator for molecular dynamics simulations of physical systems in the canonical ensemble that preserves the invariant distribution in equations arising from the density dynamics algorithm, with any possible type of thermostat. Our integrator thus constitutes a unified framework that allows the study and comparison of different thermostats and of their influence on the equilibrium and non-equilibrium (thermo-)dynamic properties of a system. To show the validity and the generality of the integrator, we implement it with a second-order, time-reversible method and apply it to the simulation of a Lennard-Jones system with three different thermostats, obtaining good conservation of the geometrical properties and recovering the expected thermodynamic results. Moreover, to show the advantage of our geometric integrator over a non-geometric one, we compare the results with those obtained by using the non-geometric Gear integrator, which is frequently used to perform simulations in the canonical ensemble. The non-geometric integrator induces a drift in the invariant quantity, while our integrator has no such drift, thus ensuring that the system is effectively sampling the correct ensemble.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Online charge measurement for petawatt laser-driven ion acceleration

Laser-driven ion beams have gained considerable attention for their potential use in multidisciplinary research and technology. Preclinical studies into their radiobiological effectiveness have established the prospect of using laser-driven ion beams for radiotherapy. In particular, research into the beneficial effects of ultrahigh instantaneous dose rates is enabled by the high ion bunch charge and uniquely short bunch lengths present for laser-driven ion beams. Such studies require reliable, online dosimetry methods to monitor the bunch charge for every laser shot to ensure that the prescribed dose is accurately applied to the biological sample. In this paper, we present the first successful use of an Integrating Current Transformer (ICT) for laser-driven ion accelerators. This is a noninvasive diagnostic to measure the charge of the accelerated ion bunch. It enables online estimates of the applied dose in radiobiological experiments and facilitates ion beam tuning, in particular, optimization of the laser ion source, and alignment of the proton transport beamline. We present the ICT implementation and the correlation with other diagnostics, such as radiochromic films, a Thomson parabola spectrometer, and a scintillator.

47 OTHER INSTRUMENTATION↗

Galaxy Zoo: kinematics of strongly and weakly barred galaxies

ABSTRACT We study the bar pattern speeds and corotation radii of 225 barred galaxies, using integral field unit data from MaNGA and the Tremaine–Weinberg method. Our sample, which is divided between strongly and weakly barred galaxies identified via Galaxy Zoo, is the largest that this method has been applied to. We find lower pattern speeds for strongly barred galaxies than for weakly barred galaxies. As simulations show that the pattern speed decreases as the bar exchanges angular momentum with its host, these results suggest that strong bars are more evolved than weak bars. Interestingly, the corotation radius is not different between weakly and strongly barred galaxies, despite being proportional to bar length. We also find that the corotation radius is significantly different between quenching and star-forming galaxies. Additionally, we find that strongly barred galaxies have significantly lower values for $\mathcal {R}$, the ratio between the corotation radius and the bar radius, than weakly barred galaxies, despite a big overlap in both distributions. This ratio classifies bars into ultrafast bars ($\mathcal {R} \lt $ 1.0; 11 per cent of our sample), fast bars (1.0 $\lt \mathcal {R} \lt $ 1.4; 27 per cent), and slow bars ($\mathcal {R} \gt $ 1.4; 62 per cent). Simulations show that $\mathcal {R}$ is correlated with the bar formation mechanism, so our results suggest that strong bars are more likely to be formed by different mechanisms than weak bars. Finally, we find a lower fraction of ultrafast bars than most other studies, which decreases the recently claimed tension with Lambda cold dark matter. However, the median value of $\mathcal {R}$ is still lower than what is predicted by simulations.

79 ASTRONOMY AND ASTROPHYSICS↗

Moonshot Objectives: Catalyze New Scientific Breakthroughs—Proteogenomics

Breaking down the silos between disciplines to accelerate the pace of cancer research is a key paradigm for the Cancer Moonshot. Molecular analyses of cancer biology have tended to segregate between a focus on nucleic acids – DNA, RNA and their modifications – and a focus on proteins and protein function. Proteogenomics represents a fusion of those two fields, leveraging the strengths of each to provide a more integrated vision of the flow of information from DNA to RNA to protein and eventually function. Proteogenomic studies have been incorporated into multiple activities associated with the cancer moonshot, demonstrating substantial added value. Innovative study designs integrating genomic, transcriptomic and proteomic data, particularly those that use clinically relevant samples and engage clinical trials, are poised to provide new insights regarding cancer risk, progression, and response to therapy,

proteogenomics, proteomics, cancer moonshot, mass ↗

Measurement of B$_\mathrm{c}$(2S)$^+$ and B$_\mathrm{c}^*$(2S)$^+$ cross section ratios in proton-proton collisions at $\sqrt{s} =$ 13 TeV

The ratios of the Bc(2S)+ to Bc+, Bc*(2S)+ to Bc+, and Bc*(2S)+ to Bc(2S)+ production cross sections are measured in proton-proton collisions at s=13 TeV, using a data sample collected by the CMS experiment at the LHC, corresponding to an integrated luminosity of 143 fb-1. The three measurements are made in the Bc+ meson phase space region defined by the transverse momentum pT>15 GeV and absolute rapidity |y|<2.4, with the excited Bc(*)(2S)+ states reconstructed through the Bc(*)+π+π−, followed by the Bc+→J/ψπ+ and J/ψ→μ+μ− decays. The Bc(2S)+ to Bc+, Bc*(2S)+ to Bc+, and Bc*(2S)+ to Bc(2S)+ cross section ratios, including the unknown Bc(*)(2S)+→Bc(*)+π+π− branching fractions, are (3.47±0.63(stat)±0.33(syst))%, (4.69±0.71(stat)±0.56(syst))%, and 1.35±0.32(stat)±0.09(syst), respectively. None of these ratios shows a significant dependence on the pT or |y| of the Bc+ meson. The normalized dipion invariant mass distributions from the decays Bc(*)(2S)+→Bc(*)+π+π− are also reported.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy

Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to higher energy demands. Despite significant advances in elucidating sarcomeric structure–function relationships, there is still much to be learned about the mechanisms that link altered cardiac energetics to HCM phenotypes. Here, we test the hypothesis that changes in cardiac energetics represent a common pathophysiologic pathway in HCM. Methods: We performed a comprehensive multiomics profile of the molecular (transcripts, metabolites, and complex lipids), ultrastructural, and functional components of HCM energetics using myocardial samples from 27 HCM patients and 13 normal controls (donor hearts). Results: Integrated omics analysis revealed alterations in a wide array of biochemical pathways with major dysregulation in fatty acid metabolism, reduction of acylcarnitines, and accumulation of free fatty acids. HCM hearts showed evidence of global energetic decompensation manifested by a decrease in high energy phosphate metabolites (ATP, ADP, and phosphocreatine) and a reduction in mitochondrial genes involved in creatine kinase and ATP synthesis. Accompanying these metabolic derangements, electron microscopy showed an increased fraction of severely damaged mitochondria with reduced cristae density, coinciding with reduced citrate synthase activity and mitochondrial oxidative respiration. These mitochondrial abnormalities were associated with elevated reactive oxygen species and reduced antioxidant defenses. However, despite significant mitochondrial injury, HCM hearts failed to upregulate mitophagic clearance. Conclusions: Overall, our findings suggest that perturbed metabolic signaling and mitochondrial dysfunction are common pathogenic mechanisms in patients with HCM. These results highlight potential new drug targets for attenuation of the clinical disease through improving metabolic function and reducing mitochondrial injury.

60 APPLIED LIFE SCIENCES↗

Single-distance nano-holotomography with coded apertures

High-resolution phase-contrast 3D imaging using nano-holotomography typically requires collecting multiple tomograms at varying sample-to-detector distances, usually 3 to 4. This multi-distance approach limits temporal resolution, making it impractical for operando studies. Moreover, shifting the sample complicates reconstruction, requiring precise alignment, registration, and interpolation to correct for shift-dependent magnification on the detector. In response, we propose and validate through simulations a novel, to the best of our knowledge, single-distance approach that leverages coded apertures to structure beam illumination while the sample rotates. Finally, this approach relies on a joint reconstruction scheme, which integrates phase retrieval with 3D tomography, ensuring data consistency and achieving artifact-free reconstructions from a single distance, unlocking dynamic experiments.

Nikitin, Viktor [Argonne National Laboratory (ANL)↗

A Handheld Medical Diagnostic Device for Harsh Environments

Medical diagnostic capabilities for extreme environments, are currently limited in nature to single marker type assays. We propose to develop a handheld device for medical diagnostics in extreme environments that provide sensitive and specific detection of biomarkers with an emphasis initially on radiation exposure. Such a device will have multiple uses, and will be easily adaptable to many applications. For example, first responders, the battlefield, in low resource settings in developing countries facing emerging disease outbreaks, and during long-duration space flights. To this end, we will develop highly adaptable microfluidic devices (cards) for profiling different biomarkers with an emphasis on those related to radiation exposure. We will leverage the previous centrifugal separator work from LLNL and Sandia National Laboratory. The radiation exposure biomarker work at LLNL will provide a biological platform for demonstrating the utility of the device. We will develop a fluidic system using a pump-less mechanical method (centrifugal) to move, control, order and layer fluids in the platform. This decreases complexity, while enabling simultaneous cell separation and plasma generation for two uses: the first is differential blood cell counts and the second is biomarker assay panels. This work will be accomplished in three Aims: Aim 1) Test multiplex microfluidic cards and integrated reader. Aim 2) Demonstrate system capabilities to take and process blood samples for multi-endpoint analysis. Aim 3) Test multiplex detection based on measuring differential blood cell counts, while measuring plasma protein biomarkers. The proposed work addresses the mission research challenge of chemical and biological countermeasure in that our work aims to provide new research capabilities to respond to man-made or natural outbreaks of pandemic diseases in particular in low resource and triage environments.

60 APPLIED LIFE SCIENCES↗

Long-slit Spectroscopy of Edge-on Low Surface Brightness Galaxies

We present long-slit optical spectra of 12 edge-on low surface brightness galaxies (LSBGs) positioned along their major axes. After performing reddening corrections for the emission-line fluxes measured from the extracted integrated spectra, we measured the gas-phase metallicities of our LSBG sample using both the [N ii]/H α and the R {sub 23} diagnostics. Both sets of oxygen abundances show good agreement with each other, giving a median value of 12 + log(O/H) = 8.26 dex. In the luminosity–metallicity plot, our LSBG sample is consistent with the behavior of normal galaxies. In the mass–metallicity diagram, our LSBG sample has lower metallicities for lower stellar mass, similar to normal galaxies. The stellar masses estimated from z -band luminosities are comparable to those of prominent spirals. In a plot of the gas mass fraction versus metallicity, our LSBG sample generally agrees with other samples in the high gas mass fraction space. Additionally, we have studied stellar populations of three LSBGs, which have relatively reliable spectral continua and high signal-to-noise ratios, and qualitatively conclude that they have a potential dearth of stars with ages <1 Gyr instead of being dominated by stellar populations with ages >1 Gyr. Regarding the chemical evolution of our sample, the LSBG data appear to allow for up to 30% metal loss, but we cannot completely rule out the closed-box model. Additionally, we find evidence that our galaxies retain up to about three times as much of their metals compared with dwarfs, consistent with metal retention being related to galaxy mass. In conclusion, our data support the view that LSBGs are probably just normal disk galaxies continuously extending to the low end of surface brightness.

79 ASTRONOMY AND ASTROPHYSICS↗