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At least 1,315 records · Page 73

Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950–2003

The scientific community faces important discussions on the validity of the linear no-threshold (LNT) model for radiation-associated cardiovascular diseases at low and moderate doses. In the present study, mortalities from cerebrovascular diseases (CeVD) and heart diseases from the latest data on atomic bomb survivors were analyzed. The analysis was performed with several radio-biologically motivated linear and nonlinear dose–response models. For each detrimental health outcome one set of models was identified that all fitted the data about equally well. This set was used for multi-model inference (MMI), a statistical method of superposing different models to allow risk estimates to be based on several plausible dose–response models rather than just relying on a single model of choice. MMI provides a more accurate determination of the dose response and a more comprehensive characterization of uncertainties. It was found that for CeVD, the dose–response curve from MMI is located below the linear no-threshold model at low and medium doses (0–1.4 Gy). At higher doses MMI predicts a higher risk compared to the LNT model. A sublinear dose–response was also found for heart diseases (0–3 Gy). The analyses provide no conclusive answer to the question whether there is a radiation risk below 0.75 Gy for CeVD and 2.6 Gy for heart diseases. MMI suggests that the dose–response curves for CeVD and heart diseases in the Lifespan Study are sublinear at low and moderate doses. This has relevance for radiotherapy treatment planning and for international radiation protection practices in general.

60 APPLIED LIFE SCIENCES↗

Quantifying the local influence at a tall tower site in nocturnal conditions

The influence of the local terrestrial environment on nocturnal atmospheric CO 2 measurements at a 329-m television transmitter tower (and a component of a CO 2 monitoring network) was estimated in this paper with a tracer release experiment and a subsequent simulation of the releases. This was done to characterize the vertical transport of emissions from the surface to the uppermost tower level and how it is affected by atmospheric stability. The tracer release experiment was conducted over two nights in May of 2009 near the Department of Energy’s Savannah River Site (SRS) in South Carolina. Tracer was released on two contrasting nights—slightly stable and moderately stable—from several upwind surface locations. Measurements at the 329-m level on both nights indicate that tracer was able to mix vertically within a relatively short (~24 km) distance, implying that nocturnal stable conditions do not necessarily prevent vertical dispersion in the boundary layer and that CO 2 measurements at the tower are at least partly influenced by nearby emissions. A simulation of the tracer release is used to calculate the tower footprint on the two nights to estimate the degree to which the local domain affects the tower readings. The effect of the nocturnal boundary layer on the area sampled by the tower can be seen clearly, as the footprints were affected by changes in stability. Finally, the contribution of local sources to the measurements at the tower was minimal, however, suggesting that nocturnal concentrations at upper levels are contributed mostly by regional sources.

54 ENVIRONMENTAL SCIENCES↗

Assessing the impact of climate change on rainfall-triggered landslides: a case study in California

Landslides are widespread natural hazards which take a heavy toll on lives, property, and infrastructure each year. In January 2023 and 2024, widespread landslides occurred in California as a result of extreme winter precipitation. Estimating the regional evolution of landslide hazard in a changing climate is essential for adaptation planning and risk mitigation efforts. The complex effects of climate change on landslide hazard, however, are poorly understood. Here, we use climate and landslide observations to develop a novel data-driven approach for landslide susceptibility assessment under historical and future climate conditions. We apply this framework to investigate the evolution of landslide susceptibility in California and its impacts on the roadway system based on downscaled climate projections under moderate and high greenhouse gas emission scenarios. On average, the results indicate an increase in landslide susceptibility through 2100 in regions where historical susceptibility is moderate to very high. Although the spatio-temporal variations in landslide susceptibility are sensitive to climate model uncertainties in predicting extreme rainfall, the direst impacts are largely circumvented in lower emission scenarios.

Climate Change↗

Finetuned Cancellations and Improbable Theories

It is argued that the x–y cancellation model (XYCM) is a good proxy for discussions of finetuned cancellations in physical theories. XYCM is then analyzed from a statistical perspective, where it is argued that a finetuned point in the parameter space is not abnormal, with any such point being just as probable as any other point. However, landing inside a standardly defined finetuned region (i.e., the full parameter space of finetuned points) has a much lower probability than landing outside the region, and that probability is invariant under assumed ranges of parameters. This proposition requires asserting also that the finetuned target region is a priori established. Furthermore, it is surmised that highly finetuned theories are generally expected to be highly improbable. An actionable implication of this moderate naturalness position is that the search for a non-finetuned explanation to supplant an apparently finetuned theory is likely to be a valid pursuit, but not guaranteed to be. A statistical characterization of this moderate position is presented, as well as those of the extreme pro-naturalness and anti-naturalness positions.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Role of Ti Content on the Occurrence of the 3309-cm{sup –1} Peak in FTIR Absorption Spectra of Ruby Samples

The study is based on the determination of trace elements in ruby samples, Ti in particular, using laser ablation inductively coupled plasma mass spectrometry (LA–ICP–MS). The samples were then divided into three groups: high (≥ 200 ppma), moderate (100–200 ppma), and low (≤ 50 ppma) Ti content. In addition, X-ray absorption spectroscopy (XAS) was employed to confirm that the Ti oxidation state was Ti{sup 4+}. The heat experiment conditions were set at 800, 1200, and 1650°C to investigate the transformation of the –OH vibration in the FTIR spectra of ruby samples. The FTIR spectra showed that samples containing a low Ti concentration did not show the 3309-cm{sup –1} absorption peak either before or after heating at any of the designed temperatures. An obvious 3309-cm{sup –1} peak appeared only in samples with a moderate to high Ti content after heating at ≥ 1200°C. The results also suggest that, in addition of Ti{sup 4+}, the occurrence of the 3309-cm{sup –1} peak in the FTIR spectra is strongly affected by the charge compensation of –OH in Al sites, i.e., the structural –OH; thus, the structural –Ti–OH stretching in the ruby samples. Hence, for gemological identification, the 3309-cm{sup –1} peak can be applied to indicate whether a ruby has undergone heat treatment if those samples contain enough Ti ions in their structure, i.e., Ti ≥ 100 ppma. This condition is usually found in ruby samples from major deposits such as Mong Hsu and Mogok, Myanmar; Luc Yen, Vietnam; and Montopuez, Mozambique.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Physicochemical, Microstructural and Thermal Characterization of Chitosan from Blue Crab Shell Waste and Its Bioactivity Characteristics

The aim of the present study was to characterize the chitosan synthesized from blue crab (Callinectes sapidus, Rathbun, 1986) shell waste and to investigate its physicochemical and microstructural analyses as well as its antioxidant and antibacterial potentials. Microstructural and elemental characterization of the synthesized and commercial chitosan powders were performed using fourier transform infra-red spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy. Thermal analysis were done using thermogravimetric analysis. Antioxidant and antimicrobial analysis were done using by DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging assay and agar well diffusion assay, respectively. The yield of the synthesized chitosan was calculated as 7.47% with moisture and ash contents of 0.151 ± 0.0025% and 0.19 ± 0.01%, respectively. Synthesized chitosan demonstrated the values of degree of deacetylation (71%), water (620.029 ± 52.59%) and fat (437.93 ± 15.92%) binding capacities, solubility (94.15 ± 2.84%), viscosity (463.25 ± 13.10 cPs) and whiteness (90.23 ± 0.27%). Antioxidant activity of synthesized chitosan was found to be moderate (55.30 ± 5.05%) when compared to ascorbic acid standard (87.61 ± 1.34). Chitosan obtained from blue crab shell also showed moderate antibacterial activity against Staphylococcus aureus and Escherichia coli. The findings of the study indicated that blue crab shell waste might be a potentially effective biopolymer source for commercial applications especially in food industry.

36 MATERIALS SCIENCE↗

Can Direct Oral Anticoagulants Be Used for Stroke Prevention Among Patients with Valvular Atrial Fibrillation?

Purpose of Review: To review the clinical evidence underlying the efficacy and safety of the use of direct oral anticoagulants (DOACs) for the treatment of patients with valvular atrial fibrillation (AF). Recent Findings: The recent focused update to the 2014 AHA/ACC/HRS Atrial Fibrillation Guidelines defines valvular AF as AF in the setting of moderate-to-severe mitral stenosis (MS) and/or in the presence of a mechanical heart valve. Landmark clinical trials of DOACs in patients with AF systematically excluded these patient populations. However, there are trial data in both animals and humans regarding the use of DOACs in patients with MS and in those with mechanical heart valves. Summary: Based on sub-analyses and meta-analyses of clinical trial data in patients with AF, the use of DOACs in valvular AF is not recommended. Patients with moderate-to-severe MS or a mechanical heart valve and AF should be anticoagulated with dose-adjusted warfarin. DOACs are reasonable alternatives to warfarin in patients with AF and other types of valvular disease, including mild MS and bioprosthetic valves.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Variation in Biomass Yield and Cell Wall Composition in Switchgrass Natural Variants Under Two Nitrogen Regimes

Switchgrass (Panicum virgatum) is a promising lignocellulosic biofuel crop for which biomass and processing quality are important. Inherent plant variability across genotypes and environments challenges uniformity and product quality. In this study, the impact of nitrogen (N) application on switchgrass yield and quality was examined under field conditions using a highly diverse switchgrass panel over a 4-year period at Knoxville, TN. Overall, biomass production was correlated between low (0 kg of added N/ha) and moderate (135 kg of added N/ha) nitrogen treatments, suggesting that the N impact is largely uniform across the genotypes. Nonetheless, high biomass genotypes were identified with high nitrogen-use efficiency ; biomass was congruent or even higher (up to 9-fold) in the low N treatment. Genotypes were also identified with up to 94% nitrogen-remobilization efficiency. Furthermore, nitrogen application appeared to impact lignin content in whole tillers but was neutral to lignin monomer syringyl-to-guaiacyl (S/G) ratio. The same panel grown under natural conditions in Watkinsville, GA, produced significantly more biomass than the Tennessee panel in the first 3 years, but biomass was similar across both sites and treatments in year 4. Top performing genotypes overlapped between sites by 20-37%. There were low correlations in lignin content in whole tillers across the two field sites, but moderate correlations were observed for S/G ratios. The high yielding genotypes from the low N plot identified in this study can be used in breeding programs and management strategies in switchgrass to evade adverse environmental and economic effects.

09 BIOMASS FUELS↗

Complete revascularization determined by myocardial perfusion imaging could improve the outcomes of patients with stable coronary artery disease, compared with incomplete revascularization and no revascularization

Objectives: To compare the outcomes among patients treated by complete coronary revascularization (CCR) or incomplete coronary revascularization (ICR) and no coronary revascularization (NCR) by myocardial perfusion imaging (MPI), as well as to evaluate the impact of severity of ischemia on patients with coronary artery disease (CAD) by different therapy strategies. Background: Using myocardial ischemia severity determined by MPI guiding treatment strategies for CAD patients still lacks strong clinical evidences. Methods: Consecutive patients (N = 286) underwent clinical stress-rest SPECT MPI and were retrospectively followed-up. For assessment of outcome of treatment, all patients were classified into three groups (CCR, ICR, and NCR), and further divided into two subgroups as mild ischemia (< 10% ischemic myocardium) and moderate-severe ischemia (≥ 10% ischemic myocardium). All-cause death was defined as the primary endpoint, and the composite of deaths, nonfatal myocardial infarction, and repeat revascularization (MACE) as the secondary endpoint. Results: Two-hundred eighty-six patients were followed-up for 46 ± 21 months. Thirty deaths and 65 MACEs were recorded. Patients treated by revascularization had significantly lower MACE (P < .001) but not mortality (P = .158) than patients treated by NCR. Outcomes of CCR related to mortality rate were greater than ICR and NCR (death: P = .019, MACE: P < .001). In patients with moderate-severe ischemia, CCR showed improved outcomes than ICR and NCR (death: P = .034; and MACE: P < .001). In patients with mild ischemia, the outcomes of CCR, ICR, and NCR had no significant difference (P > .05). Multivariate regression Cox analysis revealed that summed difference score [death: HR 1.09 (1.03, 1.15), P = .004] was an independent risk factor and CCR was an independent negative predictor [death: HR 0.31 (0.12, 0.81), P = .017; MACE: HR 0.30 (0.16, 0.57), P < .001]. Conclusions: Outcomes of patients treated by CCR were most likely more promising in comparison with treatment of ICR and NCR, especially when patients had over 10% ischemic myocardium.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

A Bayesian modeling framework for crash severity effects of active traffic management systems

Transportation agencies utilize Active traffic management (ATM) systems to dynamically manage recurrent and non-recurrent congestion based on real-time conditions. While these systems have been shown to have some safety benefits, their impact on injury severity outcomes is currently uncertain. In this paper, we used full Bayesian mixed logit models to quantify the impact that ATM deployment had on crash severities. The estimation results revealed lower severities with ATM deployment. Marginal effects for ATM deployments that featured hard shoulder running (HSR) revealed lower likelihoods for severe and moderate injury crashes of 15.9 % and for minor injury crashes of 10.1 %. The likelihood of severe and moderate injury crashes and minor injury crashes reduced by 12.4 % and 8.33 % with ATM without HSR. The models were observed to be temporally transferable and had forecast error of 0.301 and 0.304 for the two models, revealing better performance with validation data. These results have implications for improving freeway crash risk at critical locations.

97 MATHEMATICS AND COMPUTING↗

Statistical uncertainty of eddy covariance CO 2 fluxes inferred using a residual bootstrap approach

High-frequency eddy-covariance measurements of net ecosystem CO 2 exchange (NEE) with the atmosphere are valuable resources for model parameterization, calibration, and validation. However, uncertainties in measured data, i.e., data gaps and inherent random errors, create problems for researchers attempting to quantify uncertainties in model projections of terrestrial ecosystem carbon cycling. Here, we demonstrate that a model-data fusion method (residual bootstrap) produces defensible annual NEE sums, through mimicking the behavior of random errors, filling missing values, and simulating gap-filling biases. This study estimated annual NEE sums for 53 site-years based on nine eddy-covariance tower sites in the USA, and found that our annual estimates were, in most cases, comparable in magnitude with those obtained from AmeriFlux gap-filled data. Additionally, compared to the AmeriFlux standardized gap-filling, our approach provides better NEE estimates for moderate to longer, and more frequent, data gaps. Annual accumulated uncertainties in NEE at the 95% confidence level were ±30gCm -2 year -1 for evergreen needleleaf forests; ±60gCm -2 year -1 for deciduous broadleaf forests; and ±80gCm -2 year -1 for croplands. The residual bootstrap performed worst when gap length was greater than one month or data exclusion greater than 90% during the growing season, common to other gap-filling techniques. However, this study produced robust results for most site years when monthly data coverage during the growing season is not extremely low. We therefore suggest that the inclusion of NEE uncertainty estimates and better estimation for moderate to longer, and more frequent, data gaps as provided by the residual bootstrap approach can be beneficial for ecosystem model evaluation.

54 ENVIRONMENTAL SCIENCES↗

Parameterized representation of macroscopic cross section for PWR reactor

Here we describe, by means of Chebyshev polynomials, a parameterized representation of the homogenized macroscopic cross section for PWR fuel element as a function of soluble boron concentration, moderator temperature, fuel temperature, moderator density and U-235(92) enrichment. The cross-section data analyzed are fission, scattering, total, transport, absorption and capture. The parameterization enables a quick and easy determination of problem-dependent cross-sections to be used in few group calculations. The methodology presented in this paper will allow generation of group cross-section data from stored polynomials to perform PWR core calculations without the need to generate them based on computer code calculations using standard steps. The results obtained by the proposed methodology when compared with results from the SCALE code calculations show very good agreement.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

DRACS thermal performance evaluation for FHR

Direct Reactor Auxiliary Cooling System (DRACS) is a passive decay heat removal system proposed for the Fluoride-salt-cooled High-temperature Reactor (FHR) that combines coated particle fuel and a graphite moderator with a liquid fluoride salt as the coolant. The DRACS features three coupled natural circulation/convection loops, relying completely on buoyancy as the driving force. These loops are coupled through two heat exchangers, namely, the DRACS Heat Exchanger and the Natural Draft Heat Exchanger. In addition, a fluidic diode is employed to minimize the parasitic flow into the DRACS primary loop and correspondingly the heat loss to the DRACS during normal operation of the reactor, and to keep the DRACS ready for activation, if needed, during accidents. To help with the design and thermal performance evaluation of the DRACS, a computer code using MATLAB has been developed. This code is based on a one-dimensional formulation and its principle is to solve the energy balance and integral momentum equations. By discretizing the DRACS system in the axial direction, a bulk mean temperature is assumed for each mesh cell. The temperatures of all the cells, as well as the mass flow rates in the DRACS loops, are predicted by solving the governing equations that are obtained by integrating the energy conservation equation over each cell and integrating the momentum conservation equation over each of the DRACS loops. In addition, an intermediate heat transfer loop equipped with a pump has also been modeled in the code. This enables the study of flow reversal phenomenon in the DRACS primary loop, associated with the pump trip process. Experimental data from a High-Temperature DRACS Test Facility (HTDF) are not available yet to benchmark the code. A preliminary code validation is performed by using natural circulation experimental data available in the literature, which are as closely relevant as possible. The code is subsequently applied to the HTDF that is under construction at the Ohio State University.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Implementation and testing of the on-the-fly thermal scattering Monte Carlo sampling method for graphite and light water in MCNP6

Here, a proper treatment of thermal neutron scattering requires accounting for chemical binding through a scattering law S(α,β,T). Monte Carlo codes sample the secondary neutron energy and angle after a thermal scattering event from probability tables generated from S(α,β,T) tables at discrete temperatures, requiring a large amount of data for multiscale and multiphysics problems with detailed temperature gradients. We have previously developed a method to handle this temperature dependence on-the-fly during the Monte Carlo random walk using polynomial expansions in 1/T to directly sample the secondary energy and angle. In this paper, the on-the-fly method is implemented into MCNP6 and tested in both graphite-moderated and light water-moderated systems. The on-the-fly method is compared with the thermal ACE libraries that come standard with MCNP6, yielding good agreement with integral reactor quantities like k-eigenvalue and differential quantities like single-scatter secondary energy and angle distributions. The simulation runtimes are comparable between the two methods (on the order of 5–15% difference for the problems tested) and the on-the-fly fit coefficients only require 5–15 MB of total data storage.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Implementation of the direct S ( α , β ) method in the KENO Monte Carlo code

The Monte Carlo code KENO contains thermal scattering data for a wide variety of thermal moderators. These data are processed from Evaluated Nuclear Data Files (ENDF) by AMPX and stored as double differential probability distribution functions. The method examined in this study uses S(α,β) probability distribution functions derived from the ENDF data files directly instead of being converted to double differential cross sections. This allows the size of the cross section data on the disk to be reduced substantially amount. KENO has also been updated to allow interpolation in temperature on these data so that problems can be run at any temperature. Results are shown for several simplified problems for a variety of moderators. In addition, benchmark models based on the KRITZ reactor in Sweden were run, and the results are compared with the previous versions of KENO without the direct S(α,β) method. Results from the direct S(α,β) method compare favorably with the original results obtained using the double differential cross sections. Finally, sampling the data increases the run-time of the Monte Carlo calculation, but memory usage is decreased substantially.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Sensitivity/uncertainty analyses comparing LR-0 reactor experiments containing FLiBe salt with models for molten-salt-cooled and molten-salt-fueled reactors

Here, critical experiments using an insertion zone with FLiBe salt performed at the LR-0 reactor at Research Centre Rež (RC Rež) have been compared to application models for solid-fueled, fluoride-salt-cooled high-temperature reactor (FHR) and liquid-fueled molten salt reactor (MSR) concepts using sensitivity and uncertainty (S/U) analysis techniques. These experiments support FHR and MSR advanced reactor concepts by informing on neutron spectral effects and nuclear data uncertainties related to fluoride salts. The FLiBe salt in the LR-0 experiments is from the Oak Ridge National Laboratory Molten Salt Reactor Experiment and is enriched to greater than 99.99% 7 Li. This work is part of a broader collaboration between the United States and the Czech Republic on MSR and FHR technology. Results from the S/U analyses for FHR and MSR models indicated the most significant potential source of eigenvalue bias due to nuclear data within the FLiBe salt is radiative capture in 7 Li. Other smaller but potentially significant contributions come from 19 F, 6 Li, and other 7 Li reactions. Similarity comparisons of the RC Rež LR-0 experiments and FHR and MSR application models indicate that the LR-0 FLiBe experiments could be useful as candidate benchmarks for low-enriched uranium–fueled application models. However, sensitivity differences observed included both spectral effects, due to the LR-0 reactor being moderated by water instead of graphite and fluoride salt, and sensitivity magnitude effects driven by the amount of FLiBe inserted and its location. New experiments with refined designs to increase the volume and importance of salt in the system could provide improved data. Results also demonstrate that salt systems using thorium and/or 233 U fuel will require additional experiments with relevant driver fuels. Increased contributions from the graphite moderator and 19 F and covariance between reactions such as 233 U fission and 233 U radiative capture indicate higher uncertainty contributions from the salt and significant differences in contributions from the fuel species due to underlying uncertainties in their nuclear data.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Thermal scattering law of C 2 H 4 n : Integrating experimental data with DFT calculations

Improvements in determination of the thermal scattering law of moderator materials (measuring, calculating and validating) are important for accurate prediction of neutron thermalization in nuclear systems. In this paper a methodology for producing thermal scattering libraries from the experimental data for polyethylene C 2 H 4 n is discussed. Double differential scattering cross section (DDSCS) experiments were performed at the Spallation Neutron Source of Oak Ridge National Laboratory (SNS ORNL). New scattering kernel evaluations, based on phonon spectrum for C 2 H 4 n , are created using the NJOY2016 code. Two different methods were used: direct and indirect geometry neutron scattering at ARCS and SEQUOIA, and VISION instruments, respectively, where the phonon spectrum was derived from the dynamical structure factor S(Q, ω ) obtained from the measured DDSCS. In order to compare and validate the newly created library, the experimental setup was simulated using MCNP6.1. Compared with the current ENDF/B-VII.1, the resulting RPI C 2 H 4 n libraries improved both double differential scattering and total scattering cross sections. A set of criticality benchmarks containing C 2 H 4 n from HEU-MET-THERM resulted in an overall improved calculation of K eff , although the libraries should be tested against benchmarks more sensitive to C 2 H 4 n . The DFT + oClimax method is used and is shown to be most comprehensive method for analysis of moderator materials. Finally, the importance of DFT + oClimax method lies in the fact that it can be validated against all data measured at VISION, ARCS and SEQUOIA, and experimental total scattering cross section measurements.

74 ATOMIC AND MOLECULAR PHYSICS↗

Serpent transient analyses of GIACINT geometrical change experiments

This paper simulates seven transient experiments with geometrical movements performed at the GIACINT facility of Belarus. These experiments include three slow control rods insertion in more than 25 s, one fast control rod insertion in less than 1 s, and three water moderator draining transients. In the fast control rod insertion experiment, the control rods are first pushed by a mechanical spring and then let fall by gravity in the assembly. In this experiment, the control rods speed varies because of the initial spring force, the gravitational acceleration, and the water buoyancy force. In all other transient experiments, the geometry change occurs with a constant speed. The Serpent computer program was utilized to simulate these transient experiments with geometrical changes by performing two separate computations. One time-independent computation is performed in criticality mode and the other time-dependent computation is performed in dynamic-source mode. The first computation writes the neutron population and delayed neutron precursors for starting the transient simulation. The second computation divides the transient time into several time bins, reads the two files from the first computation, and updates them at the end of each time bin. The Serpent simulation results obtained for this set of experiments are in good agreement with the time dependent experimental measurements. In addition, Serpent and MCNP simulations results show an excellent agreement for the water moderator transient

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗