Cellular effects of microgravity
Experiments are recounted that test the effects of microgravity on cells, from the 60's up to the present. Results of these experiments are briefly discussed.
Morrison, Dennis R.↗
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Results for “microgravity”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Protein crystal growth in a microgravity environment
Protein crystal growth is a major experimental problem and is the bottleneck in widespread applications of protein crystallography. Research efforts now being pursued and sponsored by NASA are making fundamental contributions to the understanding of the science of protein crystal growth. Microgravity environments offer the possibility of performing new types of experiments that may produce a better understanding of protein crystal growth processes and may permit growth environments that are more favorable for obtaining high quality protein crystals. A series of protein crystal growth experiments using the space shuttle was initiated. The first phase of these experiments was focused on the development of micro-methods for protein crystal growth by vapor diffusion techniques, using a space version of the hanging drop method. The preliminary space experiments were used to evolve prototype hardware that will form the basis for a more advanced system that can be used to evaluate effects of gravity on protein crystal growth.
Bugg, Charles E.↗
Microgravity science at Langley Research Center
Although space research is still in an embryonic state, a combination of Earth based and space flight experiments are being coupled to yield a better understanding of the complex interaction of heat and fluid flow on the dynamics of crystal growth. Continued efforts on the ground as well as additional flight opportunities are needed to continue the drive to fully understand the advantages, both scientifically and economically, of microgravity crystal growth.
Fripp, Archibald L.↗
Electromagnetic, heat and fluid flow phenomena in levitated metal droplets both under earthbound and microgravity conditions
The purpose is to develop an improved understanding of the electromagnetic, heat, and fluid flow phenomena in electromagnetically levitated metal droplets, both under earthbound and microgravity conditions. The main motivation for doing this work, together with the past accomplishments, and the plans for future research are discussed.
Szekely, Julian↗
The lambda point experiment in microgravity
The motivation and potential for performing very high resolution measurements of the heat capacity singularity at the lambda point of helium in microgravity conditions was briefly discussed. It is clear that tests extending deep into the asymptotic region can be performed, where the theoretical predictions take on their simplest form. This advantageous situation should lead to a major improvement in the understanding of the range of applicability of current theoretical ideas in this field. The lambda transition holds out the prospect of giving the maximum advance of any system, and with the application of cryogenic techniques, the potential of this system can be realized. The technology for the initial experiments is already developed, and results could be obtained in 1990.
Lipa, J. A.↗
Particle cloud mixing in microgravity
Quasi-steady flame propagation through clouds of combustible particles requires quasi-steady transport properties and quasi-steady particle number density. Microgravity conditions may be employed to help achieve the conditions of quiescent, uniform clouds needed for such combustion studies. Joint experimental and theoretical NASA-UCSD studies were concerned with the use of acoustic, electrostatic, and other methods of dispersion of fuel particulates. Results of these studies are presented for particle clouds in long cylindrical tubes.
Ross, H.↗
Techniques for studying the effects of microgravity on model particle/cell systems
To study the direct effects of a low gravity environment on skeletal and cardiac muscle cells, experiments were initiated to determine whether skeletal and/or cardiac muscule cells would grow within the lumen of XM-80 hollow fibers (i.d. = 0.5 mm). Cells were prepared from skeletal or cardiac muscle tissue of 12 day embryos and were cultured for up to 7 days in the hollow fiber environment. Light microscopy revealed that cells proliferated to confluency over this period of time and fusion was apparent in the skeletal muscle cells. Once it was verified that cells would grow to confluency, additional XM-80 fibers containing cells were placed in a Clinostat in the horizontal position at 100 rpm. Fibers were stretched by a built-in spring mechanism to hold the fiber tightly at the center of rotation. Under these conditions, the gravity vector approaches zero and the cells are in an environment that simulates microgravity. Examination of skeletal muscle cells by electron microscopy revealed that myoblast fusion and myofibril accumulation were extensive. Although data obtained thus far are preliminary, they suggest that myofibril organization in chicken skeletal muscle cultures is somewhat more poorly defined in Clinostat rotated cultures than in controls that were not subjected to Clinostat conditions.
Young, Ronald B.↗
Facilities for microgravity combustion research
The microgravity test facilities at NASA Lewis Research Center are discussed. Low gravity combustion test apparatus and experiments are examined including the study of solid surface combustion and droplet combustion. Plans for the Space Station capability and the Modular Combustion Facility are described.
Sacksteder, K. R.↗
Changes in size and compliance of the calf after 30 days of simulated microgravity
The hypothesis that reducing muscle compartment by a long-term exposure to microgravity would cause increased leg venous compliance was tested in eight men who were assessed for vascular compliance and for serial circumferences of the calf before and after 30 days of continuous 6-deg head-down bed rest. It was found that head-down bed rest caused decreases in the calculated calf volume and the calf-muscle compartment, as well as increases in calf compliance. The percent increases in calf compliance correlated significantly with decreases in calf muscle compartment.
Convertino, Victor A.↗
A facility for precise temperature control applications in microgravity
The general design, main components, and operation of the isothermal dendritic growth apparatus (IDGA) designed for microgravity experimentation are described. The four major subsystems of the IDGA are a temperature controlled thermostatic bath capable of milli-kelvin stability, a photographic data collection system, a crystal growth chamber, and a growth detection system to initiate data collection. Some of the specific experiments that could utilize the capabilities of the IDGA are dendritic growth in alloys, monotectic systems, life science experiments, and technological applications.
Glicksman, M. E.↗
Time-dependent dynamical behavior of surface tension on rotating fluids under microgravity environment
Time dependent evolutions of the profile of free surface (bubble shapes) for a cylindrical container partially filled with a Newtonian fluid of constant density, rotating about its axis of symmetry, have been studied. Numerical computations of the dynamics of bubble shapes have been carried out with the following situations: (1) linear functions of spin-up and spin-down in low and microgravity environments, (2) step functions of spin-up and spin-down in a low gravity environment, and (3) sinusoidal function oscillation of gravity environment in high and low rotating cylinder speeds.
Hung, R. J.↗
Microgravity particle research on the Space Station - The gas-grain simulation facility
In the gravitational field on earth, the large settling rate of micron-sized particles and the effects of gravity-induced convection prohibit many interesting studies of phenomena such as coagulation, collisions, and mutual interactions of droplets, dust grains and other particles. Examples of exobiology experiments involving these phenomena are the simulation of organic aerosol formation in Titan's atmosphere, studies of the role of comets in prebiotic chemical evolution, and simulations of carbon grain interactions in various astrophysical environments. The Gas-Grain Simulation Facility (GGSF) is a proposed earth-orbital laboratory that will allow present ground-based experimental programs which study processes involving small particles and weak interactions to be extended to a new domain. Physics issues that scientists wishing to propose GGSF experiments must consider are reviewed in this paper. Specifically, coagulation, motion in gases and vacua, and wall deposition of particles in a microgravity environment are discussed.
Fogleman, G.↗
A study of the effects of prolonged simulated microgravity on the musculature of the lower extremities in man - An introduction
The experimental approach and the protocol are described for a study designed to investigate the effect of prolonged microgravity (simulated by a continuous exposure of subjects to 30-d-long 6-deg headdown tilt) on the musculature of the lower extremities in humans. The objectives of this study are as follows: (1) to determine changes in the functional characteristics of knee joint flexor and extensor muscle group; (2) to examine changes in the histochemical, biochemical, electron microscopic, and computed tomographic characteristics of skeletal muscle; (3) to determine if functional characteristics of skeletal muscle would be normalized four weeks after the bedrest; and (4) to compare these results to those of spaceflight. Percutaneous muscle biopsy, computed tomography, anthropometry, and in vivo muscle strength measurements are to be used to assess mechanical, structural, and metabolic characteristics of skeletal muscle.
Buchanan, Paul↗
Changes in volume, muscle compartment, and compliance of the lower extremities in man following 30 days of exposure to simulated microgravity
To investigate the relationship between leg compliance and a reduction in the size of the leg muscle compartment due to long-duration exposure to microgravity, eight men were exposed for 30 d of continuous 6-deg headdown tilt, and changes in vascular compliance (vol pct/mm Hg x 100) of the calf and serial circumferences of the thigh and the calf were measured before, during, and after the tilt. It was found that the tilt exposure led to calculated leg volume decreases of 9.9 percent in the calf and of 4.5 in the thigh. Leg compliance was found to increase from 3.9 to about 4.9. Calf compliance measured before and after bedrest was found to be inversely related to calf-muscle compartment cross-sectional area (CSA).
Convertino, Victor A.↗
Characteristics and preliminary observations of the influence of electromyostimulation on the size and function of human skeletal muscle during 30 days of simulated microgravity
The effect of transcutaneous electromyostimulation (EMS) on the development of atrophy and the loss of strength in lower limb musculature in humans exposed to microgravity was determined in three subjects who received EMS twice daily in a 3-d on/1-d off cycle on their dominant leg during 30 days of bedrest. The output waveform from the stimulator was sequenced to the knee extensors, knee flexors, ankle extensors, and ankle flexors, and caused three isometric contractions of each muscle group per minute. It was found that, in the dominant leg, EMS acted to attenuate the changes caused by bedrest, such as reductions in the leg volume, muscle compartment size, cross-sectional area of slow- and fast-twitch fibers, strength, and aerobic enzyme activities, and an increase in leg compliance.
Duvoisin, Marc R.↗
New results concerning the use of kinematically redundant manipulators in microgravity environments
This paper is concerned with the development of control strategies for kinematically redundant manipulators to be used in Space Station laboratories. These robots must be able to conduct experiments and manufacturing processes without disturbing the microgravity environment, and thus their dynamic base reactions/motions must be nearly eliminated. Redundant degrees of freedom permit the inverse kinematics problem to be solved in conjuction with the minimization of a cost function defined as a weighted sum of the base reactions. It is shown that the weights in the cost function should be used as an additional set of parameters in the minimization problem. The actual performance of the local optimal trajectory approach is demonstrated to be not as good as was previously reported.
Quinn, R. D.↗
Concepts for microgravity experiments utilizing gloveboxes
The need for glovebox facilities on spacecraft in which microgravity materials processing experiments are performed is discussed. At present such facilities are being designed, and some of their capabilities are briefly described. A list of experiment concepts which would require or benefit from such facilities is presented.
Kroes, Roger L.↗
Free swimming organisms: Microgravity as an investigative tool
On earth, micro-organisms are in the grip of gravitational and viscous forces. These forces, in combination with sensory stimuli, determine the average orientation of the organisms' swimming trajectories relative to the fluid environment. Microgravity provides the opportunity to study the rules which govern the summation or orienting influences and to develop quantitative physical measurements of sensory responses, e.g. the measurement of phototactic orientation tendency in torque units. Also, by reducing or eliminating density anisotropy-driven buoyant convection, it will be possible to study illumination, temperature gradient and concentration gradient-mediated collective dynamics.
Kessler, John O.↗