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At least 1,315 records · Page 73

WE-E-17A-05: Complementary Prognostic Value of CT and 18F-FDG PET Non-Small Cell Lung Cancer Tumor Heterogeneity Features Quantified Through Texture Analysis

Purpose: Previous studies have shown that CT or 18F-FDG PET intratumor heterogeneity features computed using texture analysis may have prognostic value in Non-Small Cell Lung Cancer (NSCLC), but have been mostly investigated separately. The purpose of this study was to evaluate the potential added value with respect to prognosis regarding the combination of non-enhanced CT and 18F-FDG PET heterogeneity textural features on primary NSCLC tumors. Methods: One hundred patients with non-metastatic NSCLC (stage I–III), treated with surgery and/or (chemo)radiotherapy, that underwent staging 18F-FDG PET/CT images, were retrospectively included. Morphological tumor volumes were semi-automatically delineated on non-enhanced CT using 3D SlicerTM. Metabolically active tumor volumes (MATV) were automatically delineated on PET using the Fuzzy Locally Adaptive Bayesian (FLAB) method. Intratumoral tissue density and FDG uptake heterogeneities were quantified using texture parameters calculated from co-occurrence, difference, and run-length matrices. In addition to these textural features, first order histogram-derived metrics were computed on the whole morphological CT tumor volume, as well as on sub-volumes corresponding to fine, medium or coarse textures determined through various levels of LoG-filtering. Association with survival regarding all extracted features was assessed using Cox regression for both univariate and multivariate analysis. Results: Several PET and CT heterogeneity features were prognostic factors of overall survival in the univariate analysis. CT histogram-derived kurtosis and uniformity, as well as Low Grey-level High Run Emphasis (LGHRE), and PET local entropy were independent prognostic factors. Combined with stage and MATV, they led to a powerful prognostic model (p<0.0001), with median survival of 49 vs. 12.6 months and a hazard ratio of 3.5. Conclusion: Intratumoral heterogeneity quantified through textural features extracted from both CT and FDG PET images have complementary and independent prognostic value in NSCLC.

60 APPLIED LIFE SCIENCES↗

MCG+08-22-082: A DOUBLE CORE AND BOXY APPEARANCE DWARF LENTICULAR GALAXY SUSPECTED TO BE A MERGER REMNANT

We present a study on the dwarf lenticular galaxy MCG+08-22-082 (U141), located in the Ursa Major cluster, blue-centered, double-cored, and having a boxy appearance. Using publicly available data from the Sloan Digital Sky Survey (SDSS), we perform an analysis of the structural and stellar population properties of the galaxy and the cores. We find that the light profile of U141 follows an exponential law. U141 has a brightness of M{sub r}=−16.01 mag, and an effective radius of R{sub e}=1.7 kpc. The boxiness parameter a{sub 4}/a is mostly between 0 and −0.05 in the inner parts, reaching an extreme of about −0.1. Double cores are seen at the center of U141; each of these cores has a stellar mass of ∼10{sup 6} M{sub ☉} and the separation between them is ∼300 pc. Optical spectroscopy of these cores shows prominent emission in Hα, suggesting ongoing star-forming activities. We interpret these morphological properties and speculate that U141 is a merger remnant of two disk galaxies. Thus, we might have discovered an intermediate stage of merging, providing possible evidence of double cores in the center of the galaxy.

79 ASTRONOMY AND ASTROPHYSICS↗

The comparative evaluation of ERTS-1 imagery for resource inventory in land use planning

The author has identified the following significant results. Multidiscipline team interpretation and mapping of resources for Crook County is complete on 1:250,000 scale enlargements of ERTS imagery and 1:120,000 hi-flight photography. Maps of geology, soils, vegetation-land use and land resources units were interpreted to show limitations, suitabilities, and geologic hazards for land use planning. Mapping of lineaments and structures from ERTS imagery has shown a number of features not previously mapped in Oregon. A multistage timber inventory of Ochoco National Forest was made, using ERTS images as the first stage. Inventory of forest clear-cutting practices was successfully demonstrated with color composites. Soil tonal differences in fallow fields correspond with major soil boundaries in loess-mantled terrain. A digital classification system used for discriminating natural vegetation and geologic material classes was successful in separating most major classes around Newberry Caldera, Mt. Washington, and Big Summit Prairie.

Schrumpf, B. J.↗

An investigation of the side force that is sometimes observed in rocket start-up

The occurrence of a large but momentary side force during the start-up of rocket motors employing convergent-divergent nozzles has been noted occasionally. Asymmetric flow separation within the divergent section of the nozzle is proposed as the principal source of this lateral force. A method for estimating this force and its concomitant lateral impulse is outlined, and results obtained by applying the method to Scout vehicle first-, second-, and third-stage rocket motor start-ups are presented and compared with similar estimates that other researchers obtained by a different method.

Bowyer, J. M., Jr.↗

Second Generation RLV Space Vehicle Concept

NASA has a long history of conducting development programs and projects in a consistent fashion. Systems Engineering within those programs and projects has also followed a given method outlined by such documents as the NASA Systems Engineering Handbook. The relatively new NASA Space Launch Initiative (SLI) is taking a new approach to developing a space vehicle, with innovative management methods as well as new Systems Engineering processes. With the program less than a year into its life cycle, the efficacy of these new processes has yet to be proven or disproven. At $776M for phase 1, SLI represents a major portion of the NASA focus; however, the new processes being incorporated are not reflected in the training provided by NASA to its engineers. The NASA Academy of Program and Project Leadership (APPL) offers core classes in program and project management and systems engineering to NASA employees with the purpose of creating a "knowledge community where ideas, skills, and experiences are exchanged to increase each other's capacity for strong leadership". The SLI program is, in one sense, a combination of a conceptual design program and a technology program. The program as a whole doesn't map into the generic systems engineering project cycle as currently, and for some time, taught. For example, the NASA APPL Systems Engineering training course teaches that the "first step in developing an architecture is to define the external boundaries of the system", which will require definition of the interfaces with other systems and the next step will be to "define all the components that make up the next lower level of the system hierarchy" where fundamental requirements are allocated to each component. Whereas, the SLI technology risk reduction approach develops architecture subsystem technologies prior to developing architectures. The higher level architecture requirements are not allowed to fully develop and undergo decomposition and allocation down to the subsystems before the subsystems must develop allocated requirements based on the highest level of requirements. In the vernacular of the project cycles prior to the mid 1990's, the architecture definition portion of the program appears to be at a generic Phase A stage, while the subsystems are operating at Phase B. Even the management structure of the SLI program is innovative in its approach to Systems Engineering and is not reflected in the APPL training modules. The SLI program has established a Systems Engineering office as an office separate from the architecture development or the subsystem technology development, while that office does have representatives within these other offices. The distributed resources of the Systems Engineering Office are co-located with the respective Project Offices. This template is intended to provide systems engineering as an integrated function at the Program Level. the program management of SLI and the MAT agree that "program/project managers and the systems engineering team must work closely together towards the single objective of delivering quality products that meet the customer needs". This paper will explore the differences between the methods being taught by NASA, which represent decades of ideas, and those currently in practice in SLI. Time will tell if the innovation employed by SLI will prove to be the model of the future. For now, it is suggested that the training of the present exercise the flexibility of recognizing the new processes employed by a major new NASA program.

Bailey, Michelle↗

Advanced Lithium-Ion Cell Development for NASA's Constellation Missions

The Energy Storage Project of NASA s Exploration Technology Development Program is developing advanced lithium-ion batteries to meet the requirements for specific Constellation missions. NASA GRC, in conjunction with JPL and JSC, is leading efforts to develop High Energy and Ultra High Energy cells for three primary Constellation customers: Altair, Extravehicular Activities (EVA), and Lunar Surface Systems. The objective of the High Energy cell development is to enable a battery system that can operationally deliver approximately 150 Wh/kg for 2000 cycles. The Ultra High Energy cell development will enable a battery system that can operationally deliver 220 Wh/kg for 200 cycles. To accomplish these goals, cathode, electrolyte, separator, and safety components are being developed for High Energy Cells. The Ultra High Energy cell development adds lithium alloy anodes to the component development portfolio to enable much higher cell-level specific energy. The Ultra High Energy cell development is targeted for the ascent stage of Altair, which is the Lunar Lander, and for power for the Portable Life support System of the EVA Lunar spacesuit. For these missions, mass is highly critical, but only a limited number of cycles are required. The High Energy cell development is primarily targeted for Mobility Systems (rovers) for Lunar Surface Systems, however, due to the high risk nature of the Ultra High Energy cell development, the High Energy cell will also serve as a backup technology for Altair and EVA. This paper will discuss mission requirements and the goals of the material, component, and cell development efforts in further detail.

Reid, Concha M.↗

ISS Contingency Attitude Control Recovery Method for Loss of Automatic Thruster Control

In this paper, the attitude control issues associated with International Space Station (ISS) loss of automatic thruster control capability are discussed and methods for attitude control recovery are presented. This scenario was experienced recently during Shuttle mission STS-117 and ISS Stage 13A in June 2007 when the Russian GN&C computers, which command the ISS thrusters, failed. Without automatic propulsive attitude control, the ISS would not be able to regain attitude control after the Orbiter undocked. The core issues associated with recovering long-term attitude control using CMGs are described as well as the systems engineering analysis to identify recovery options. It is shown that the recovery method can be separated into a procedure for rate damping to a safe harbor gravity gradient stable orientation and a capability to maneuver the vehicle to the necessary initial conditions for long term attitude hold. A manual control option using Soyuz and Progress vehicle thrusters is investigated for rate damping and maneuvers. The issues with implementing such an option are presented and the key issue of closed-loop stability is addressed. A new non-propulsive alternative to thruster control, Zero Propellant Maneuver (ZPM) attitude control method is introduced and its rate damping and maneuver performance evaluated. It is shown that ZPM can meet the tight attitude and rate error tolerances needed for long term attitude control. A combination of manual thruster rate damping to a safe harbor attitude followed by a ZPM to Stage long term attitude control orientation was selected by the Anomaly Resolution Team as the alternate attitude control method for such a contingency.

Bedrossian, Nazareth↗

Effect of microalgae cell composition and size on responsiveness to ultrasonic harvesting

Ultrasonic harvesting could reduce the energy consumption and costs associated with separating microalgae from growth media. The responsiveness of microalgae cells to an ultrasonic standing wave depends on the cell radius and acoustic contrast factor (ACF). The ACF can vary as cell composition (e.g. lipid, protein, carbohydrate content) varies depending on the algae strain, cultivation conditions, and growth stage. Here, two independent experimental methods were used to characterize the ACF of three algae ;strains—Nannochloropsis salina, Chlamydomonas reinhardtii, and Tetraselmis chuii—as a function of dynamic cellular composition over 9- to 14-day growth periods. For N. salina, lipid content increased from 25 ± 1% to 33 ± 1% ash-free dry weight (AFDW) and ACF decreased by 46% (from 0.041 ± 0.002 to 0.022 ± 0.002) between growth days 3 and 10. For C. reinhardtii, lipid content increased from 26 ± 1% to 40 ± 1% AFDW and ACF decreased by 33% (from 0.051 ± 0.013 to 0.034 ± 0.006) between growth days 3 and 9. For T. chuii, lipid content and ACF remained stable (~ 10% AFDW and ~ 0.3) over the growth period. ACF decreased as lipid content increased because lipids have a negative ACF in the growth media; however, cell size had a greater impact on cell responsiveness because the ratio of the acoustic radiation force to the drag force is proportional to cell radius squared.

09 BIOMASS FUELS↗

Formaldehyde and co-exposure with benzene induce compensation of bone marrow and hematopoietic stem/progenitor cells in BALB/c mice during post-exposure period

Formaldehyde (FA) is a human leukemogen. Since there is a latency period between initial FA exposure and the development of leukemia, the subsequent impact of FA on hematopoietic stem or progenitor cells (HSCs/HPCs) in post-exposure stage is crucial for a deep understanding of FA-induced hematotoxicity. BALB/c mice were exposed to 3 mg/m{sup 3} FA for 2 weeks, mimicking occupational exposure, and were monitored for another 7 days post-exposure. Meanwhile, we included benzene (BZ) as a positive control, separately and together with FA because co-exposure occurs frequently. After 7-day recovery, colonies of progenitors for CFU-GM and BFU-E, and nucleated bone marrow cells in FA-exposed mice were comparable to controls, although they were significantly reduced during exposure. Levels of reactive oxygen species (ROS) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in CFU-GM and BFU-E from FA-exposed mice were higher than controls, although the increase in 8-OHdG was not significant. Granulocyte-macrophage colony stimulating factor (GM-CSF) level in the FA group was lower than controls, but the expression level for the receptor was not upregulated. It suggests that HSCs/HPCs in FA-exposed mice respond to a small amount of GM-CSF and proliferate rapidly, which may cause a possible risk of expansion of abnormal stem/progenitor cell clones. FA co-exposure with BZ was more potent for promoting CFU-GM formation and inducing ROS in BFU-E and 8-OHdG in CFU-GM during the post-exposure period. The compensation of myeloid progenitors with elevated ROS and 8-OHdG may lead to a risk of transforming normal HSCs/HPCs to leukemic stem/progenitor cells. Thus, co-exposure may pose a greater leukemia risk. - Highlights: • Nucleated bone marrow cell count recovered after 7 days post-FA and/or BZ exposure. • CFU-GM showed an increase in colonies and 8-OHdG after 7 days post-FA + BZ exposure. • Levels of ROS in CFU-GM and BFU-E were increased by FA or FA + BZ during recovery. • Levels of GM-CSF and EPOR were suppressed after 7 days post-FA or FA + BZ exposure. • Co-exposure was more potent for some endpoints and may pose a greater leukemia risk.

60 APPLIED LIFE SCIENCES↗

Temperature distributions and gradients in laser-heated plasmas relevant to magnetized liner inertial fusion

We present two-dimensional temperature measurements of magnetized and unmagnetized plasma experiments performed at Z relevant to the preheat stage in magnetized liner inertial fusion. The deuterium gas fill was doped with a trace amount of argon for spectroscopy purposes, and time-integrated spatially resolved spectra and narrow-band images were collected in both experiments. The spectrum and image data were included in two separate multiobjective analysis methods to extract the electron temperature spatial distribution T e ( r , z ) . The results indicate that the magnetic field increases T e , the axial extent of the laser heating, and the magnitude of the radial temperature gradients. Comparisons with simulations reveal that the simulations overpredict the extent of the laser heating and underpredict the temperature. Temperature gradient scale lengths extracted from the measurements also permit an assessment of the importance of nonlocal heat transport.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Modification of Structural, Chemical and Process Properties of Rare Metal Minerals under Treatment by High-Voltage Nanosecond Pulses

The authors have studied the mechanism of controlled modification of composition, structure, chemistry, physicochemical and process properties of columbite, tantalite, zircon and feldspar at the meso-, micro- and nanoscales after nonthermal treatment by high-voltage nanosecond electromagnetic pulses. The studies used methods: X-ray photoelectron spectroscopy, scanning electron and atomic force microscopy, potentiometric titration, electromigration chromatography, Kelvin probe force microscopy, microhardness metering and assessment of hydrophobic behavior and flotation activity of the minerals. It is found that changes in the chemical state of atoms on the surface of minerals are mainly connected with the sequential transformation of stages in the process of formation and modification of a functional cover of mineral surface, with variation in a ratio of different type hydroxyl groups on the surface of columbite, zircon and feldspar, which conditions contrast physicochemical properties of rare metal minerals and improves selectivity of their separation by flotation.

77 NANOSCIENCE AND NANOTECHNOLOGY↗

Noise comparison of two 1.2-pressure-ratio fans with 15 and 42 rotor blades

Two 1.829-m-(6-ft-) diameter fans suitable for a quiet engine for future short-takeoff-and-landing (STOL) aircraft were compared. Both fans were designed for a 1.2 pressure ratio with similar weight flows, thrusts, and tip speeds. The first fan, designated QF-9, had 15 rotor blades and 11 stator blades. The rotor was highly loaded and the tip solidity was less than 1. The QF-9 rotor blades had an adjustable pitch feature which can be used for thrust reversal. The second fan, designated QF-6, operated at a moderate loading with a rotor tip solidity greater than 1. Fan QF-6 had 42 rotor blades and 50 stator blades. The low number of rotor blades for QF-9 reduced the frequency of the blade-passage tone below the range of maximum annoyance. In addition to this difference, the QF-9 fan had a somewhat smaller rotor-stator separation than the QF-6 fan. In terms of sound pressure level and sound power level, QF-9 was the noisier fan, with the power level results for QF-9 being about 1 db above those for QF-6 at equivalent operating points as determined by similar stage pressure ratios. At the same equivalent operating points, the maximum perceived noise along a 152.5-m (500-ft) sideline for QF-9 was about 2.5 PNdb below that for QF-6, which indicated that QF-9 was less objectionable to human hearing.

Woodward, R. P.↗

NASA to launch second business communications satellite

The two stage Delta 3910 launch vehicle was chosen to place the second small business satellite (SBS-B) into a transfer orbit with an apogee of 36,619 kilometers and a perigee of 167 km, at an inclination of 27.7 degrees to Earth's equator. The firing and separation sequence and the inertial guidance system are described as well as the payload assist module. Facilities and services for tracking and control by NASA, COMSAT, Intelsat, and SBS are outlined and prelaunch operations are summarized.

Source record↗

Behavior of centrosomes during fertilization and cell division in mouse oocytes and in sea urchin eggs

The behavior of centrosomes during the stages of fertilization and cell division in mouse oocytes and in sea urchin eggs was monitored in an immunofluorescence microscope, using autoimmune centrosomal antiserum derived from a patient with scleroderma to label the centrosomal material. These observations showed that centrosomes reproduce during the interphase and aggregate and separate during cell mitosis. Results supported the hypothesis of Mazia (1984), who proposed that centrosomes are 'flexible bodies'. It was also found that, while the sea urchin centrosomes are paternally inherited as was initially proposed by Bovery (1904), the mouse centrosomes are of maternal origin.

Schatten, Heide↗

Numerical simulation of stability and stability control of high speed compressible rotating couette flow

The nonlinear temporal evolution of disturbances in compressible flow between infinitely long, concentric cylinders is investigated through direct numerical simulations of the full, three-dimensional Navier-Stokes and energy equations. Counter-rotating cylinders separated by wide gaps are considered with supersonic velocities of the inner cylinder. Initially, the primary disturbance grows exponentially in accordance with linear stability theory. As the disturbances evolve, higher harmonics and subharmonics are generated in a cascading order eventually reaching a saturation state. Subsequent highly nonlinear stages of the evolution are governed by the interaction of the disturbance modes, particularly the axial subharmonics. Nonlinear evolution of the disturbance field is characterized by the formation of high-shear layers extending from the inner cylinder towards the center of the gap in the form of jets similar to the ejection events in transitional and turbulent wall-bounded shear flows.

Biringen, Sedat↗

NASA Ares I Launch Vehicle Roll and Reaction Control Systems Lessons Learned

On April 15, 2010 President Barak Obama made the official announcement that the Constellation Program, which included the Ares I launch vehicle, would be canceled. NASA s Ares I launch vehicle was being designed to launch the Orion Crew Exploration Vehicle, returning humans to the moon, Mars, and beyond. It consisted of a First Stage (FS) five segment solid rocket booster and a liquid J-2X Upper Stage (US) engine. Roll control for the FS was planned to be handled by a dedicated Roll Control System (RoCS), located on the connecting interstage. Induced yaw or pitch moments experienced during FS ascent would have been handled by vectoring of the booster nozzle. After FS booster separation, the US Reaction Control System (ReCS) would have provided the US Element with three degrees of freedom control as needed. The lessons learned documented in this paper will be focused on the technical designs and producibility of both systems along with the partnership between NASA and Boeing, who was on contract to build the Ares I US Element, which included the FS RoCS and US ReCS. In regards to partnership, focus will be placed on integration along with technical work accomplished by Boeing with special emphasis on each task order. In summary, this paper attempts to capture key lessons learned that should be helpful in the development of future launch vehicle RCS designs.

Butt, Adam↗

Best Practices from the Design and Development of the Ares I Launch Vehicle Roll and Reaction Control Systems

On April 15, 2010 President Barak Obama made the official announcement that the Constellation Program, which included the Ares I launch vehicle, would be canceled. NASA s Ares I launch vehicle was being designed to launch the Orion Crew Exploration Vehicle, returning humans to the moon, Mars, and beyond. It consisted of a First Stage (FS) five segment solid rocket booster and a liquid J-2X Upper Stage (US) engine. Roll control for the FS was planned to be handled by a dedicated Roll Control System (RoCS), located on the connecting interstage. Induced yaw or pitch moments experienced during FS ascent would have been handled by vectoring of the booster nozzle. After FS booster separation, the US Reaction Control System (ReCS) would have provided the US Element with three degrees of freedom control as needed. The best practices documented in this paper will be focused on the technical designs and producibility of both systems along with the partnership between NASA and Boeing, who was on contract to build the Ares I US Element, which included the FS RoCS and US ReCS. In regards to partnership, focus will be placed on integration along with technical work accomplished by Boeing. This will include detailed emphasis on task orders developed between NASA and Boeing that were used to direct specific work that needed to be accomplished. In summary, this paper attempts to capture key best practices that should be helpful in the development of future launch vehicle and spacecraft RCS designs.

Butt, Adam↗

Flight Environment HEPA Filter Testing for Lunar Dust Removal Capability

Lunar dust is an abrasive regolith that can cause critical damage to hardware and crew. Its morphology and chemical makeup differs from typical earth dust due to space weathering effects. Current space missions require extensive air filtration of lunar dust to ensure mission success; as such filtration testing is paramount in verifying the dust-removal capabilities of the system. Previous testing at NASA GRC consisted of two stages: testing a flat high efficiency particulate air (HEPA) media sheet at various pressure ranges (Stage 1) and testing a pleated HEPA filter at different humidity and dust levels (Stage 2). This testing was done to buy-down risk when testing the flight-qualification HEPA filter for the proposed Stage 3 test. Stage 3 testing used a flight-ready HEPA filter to measure its performance characteristics to verify programmatic requirements. This included measuring lunar dust loading versus pressure drop performance and establishing a maximum capacity based on the allowable pressure drop, determining the HEPA filter efficiency utilizing two separate methodologies, and assessing if the lunar dust caused the HEPA filter to experience any damage. Additionally, dust removal from the HEPA filter was performed using a vacuum to ascertain if the filter life can be prolonged. These test results will aid the program in verifying programmatic requirements and ensuring risk buydown before this HEPA filter takes flight.

HEPA↗