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At least 1,315 records · Page 73

NASA microgravity materials science program

The current NASA microgravity materials science flight research program is reviewed focusing on crystal growth experiments, solidification fundamentals, and thermophysical property measurements of materials. It is noted that most of the hardware which is utilized in joint international cooperation is flown on the International Microgravity Laboratory series of Spacelab missions. The Microgravity Science and Applications Program establishes a framework for the cooperative utilization of the SSF.

Sokolowski, Robert S.↗

Microgravity sciences application visiting scientist program

Contract NAS8-38785, Microgravity Experimental and Theoretical Research, is a project involving a large number of individual research programs related to: determination of the structure of human serum albumin and other biomedically important proteins; analysis of thermodynamic properties of various proteins and models of protein nucleation; development of experimental techniques for the growth of protein crystals in space; study of the physics of electrical double layers in the mechanics of liquid interfaces; computational analysis of vapor crystal growth processes in microgravity; analysis of the influence of magnetic fields in damping residual flows in directional solidification processes; crystal growth and characterization of II-VI semiconductor alloys; and production of thin films for nonlinear optics. It is not intended that the programs will be necessarily limited to this set at any one time. The visiting scientists accomplishing these programs shall serve on-site at MSFC to take advantage of existing laboratory facilities and the daily opportunities for technical communications with various senior scientists.

Source record↗

Status Report on the Penn State RBCC Test Program

The status of the RBCC ejector mode research program at Penn State is reviewed. Recent hardware modifications and measurement system improvements are discussed, including the motivation for these changes. Results from a series of tests with a single thruster configuration at a chamber pressure of 200 psia and with an area ratio 3.3 nozzle are presented. These results indicate that the primary (rocket exhaust) and secondary (entrained air) flow streams mix much more rapidly than a previous test series with an area ratio of 6.0 nozzle. Finally, the plans for a test series with a twin thruster configuration are discussed.

Cramer, J.↗

ERA Advanced Core Compressor Technology Program

As part of the NASA Integrated Systems Research Program, Environmentally Responsible Aviation Project, NASA GRC and GE Aviation have partnered to investigate the technology barriers associated with improved fuel economy of large gas turbine engines. Crucial to improving fuel economy is the increase in Pressure Ratio (PR) of the core compressor. General Electric is in the process of defining new advanced technology engine concepts and related engine architectures for both commercial and military subsonic and supersonic flight applications. These new concepts and architectures offer the potential of providing substantial improvements in mission fuel burn, emissions, and noise levels relative to SOTA engines and support the needs and goals of future Air force, Navy, and NASA aircraft systems. A key aspect of many of these new engine concepts is an ultra high pressure ratio core compressor. Current SOTA engines such as the GENx utilize a 23:1 class pressure ratio core compressor to achieve an overall pressure ratio in the 50:1 class. Future engines with overall pressure ratios in the 70– 80:1 class will need core compressors with pressure ratios in the 30:1 class. These single spool, ultra high pressure ratio compressors will have inherent challenges. The goal of this work is to provide a dedicated component test vehicle to study the very challenging compressor front stage performance and operability issues that arise in these aggressive machines. With a view to providing highly detailed aerodynamic data that will provide, subject to the rights restrictions for test data afforded under NASA Contract NNC10BA06B/NNC10TA64T, an industry standard data set for CFD validation.

Axial Compressors↗

Plant Modernization Pathway: FY 2019 External Review Summary Report

This report describes an external review conducted by the Light Water Reactor Sustainability Program Plant Modernization Pathway (referred to as Pathway) to solicit feedback on the topics and results of the ongoing Instrumentation and Control (I&C) research program. This review was held in conjunction with the Nuclear Energy Institute (NEI) Digital I&C Working Group meeting that was held at Idaho National Laboratory on October 16–17, 2018. Members of the Nuclear Regulatory Commission (NRC) staff working on digital I&C issues through their Integrated Action Plan also attended. The NEI and NRC agreed that the meeting participants would serve as an external review panel for the purpose of obtaining expert input on the value and timing of the research projects. Five major research areas were presented, along with demonstrations of new technologies in the Human Systems Simulation Laboratory and the Computer-Assisted Virtual Environment. Following the presentations, the external review was conducted by referring to a set of summary slides of the five research areas, and allowing each participant to enter ratings and comments on a survey form as each area was addressed. Fourteen forms were returned. These feedback forms were analyzed by the Pathway who compiled and responded to the data and comments, which are documented in this report. The participants also had opportunity to provide comments on the LWRS Program as a whole and to suggest additional research topics of value. The feedback provided by the external review participants is taken to be a strong endorsement of the types of projects being conducted by the Pathway, the value they hold for the operating nuclear plants, and the general timing of need. The feedback aligns well with the priorities, levels of efforts allocated for the research projects, and project schedules of the current Pathway research program. The feedback also provides realistic observations on the practicality of some aspects of implementing these technologies. The Pathway will consider all of the feedback and address the recommended research topics that have been identified by the external review participants. Pathway research plans will be adjusted as warranted.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Optimizing Sample Collection and Accessibility through the Biospecimen and Tissue Sharing Collection (BTSC) Program

The Space Radiation Element (SRE) of the Human Research Program (HRP) is dedicated to establishing a robust biospecimen and tissue sharing collection (BTSC) program that enhances sample collection, tracking, access, distribution, and usability, with the goal of maximizing scientific return. By leveraging biospecimens and tissues from previous experiments, HRP effectively achieves its scientific objectives in characterizing and mitigating the human health impacts of spaceflight while optimizing resource utilization. To further improve the usability and accessibility of the current biospecimen archive, the project aims to expand upon NASA's existing resources and institutional knowledge, ensuring ongoing modernization. To facilitate seamless navigation of the program's workflow, an educational series on the BTSC program is provided to Principal Investigators (PIs). This comprehensive series equips PIs with crucial information on submitting their inventory via the BTSC Metadata Intake Form, ultimately leading to the public availability of their data on NASA's Life Science Portal (NLSP). Covering various aspects such as metadata submission instructions and backend processes for transferring metadata to the Laboratory Information Management System (LIMS), the series incorporates guidance from NASA's Biological Institutional Scientific Collection (NBISC) and Ames Life Sciences Data Archive (ALSDA). The BTSC program represents a significant stride towards enhancing the usability and accessibility of biospecimens for space research. By enabling NASA to deepen its understanding of the health implications of long-term spaceflight, this initiative plays a pivotal role in ensuring the safety and well-being of astronauts.

Shelita Renee Augustus↗

SU-E-J-110: Dosimetric Analysis of Respiratory Motion Based On Four-Dimensional Dose Accumulation in Liver Stereotactic Body Radiotherapy

Purpose: Respiratory motion in thoracic and abdominal region could lead to significant underdosing of target and increased dose to healthy tissues. The aim of this study is to evaluate the dosimetric effect of respiratory motion in conventional 3D dose by comparing 4D deformable dose in liver stereotactic body radiotherapy (SBRT). Methods: Five patients who had previously treated liver SBRT were included in this study. Four-dimensional computed tomography (4DCT) images with 10 phases for all patients were acquired on multi-slice CT scanner (Siemens, Somatom definition). Conventional 3D planning was performed using the average intensity projection (AIP) images. 4D dose accumulation was calculated by summation of dose distribution for all phase images of 4DCT using deformable image registration (DIR) . The target volume and normal organs dose were evaluated with the 4D dose and compared with those from 3D dose. And also, Index of achievement (IOA) which assesses the consistency between planned dose and prescription dose was used to compare target dose distribution between 3D and 4D dose. Results: Although the 3D dose calculation considered the moving target coverage, significant differences of various dosimetric parameters between 4D and 3D dose were observed in normal organs and PTV. The conventional 3D dose overestimated dose to PTV, however, there was no significant difference for GTV. The average difference of IOA which become ‘1’ in an ideal case was 3.2% in PTV. The average difference of liver and duodenum was 5% and 16% respectively. Conclusion: 4D dose accumulation which can provide dosimetric effect of respiratory motion has a possibility to predict the more accurate delivered dose to target and normal organs and improve treatment accuracy. This work was supported by the Radiation Technology R&D program (No. 2013M2A2A7043498) and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning (MSIP) of Korea.

60 APPLIED LIFE SCIENCES↗

SU-E-T-589: Optimization of Patient Head Angle Position to Spare Hippocampus During the Brain Radiation Therapy

Purpose: Hippocampus is one of the important organs which controls emotions, behaviors, movements the memorizing and learning ability. In the conventional head & neck therapy position, it is difficult to perform the hippocampal-sparing brain radiation therapy. The purpose of this study is to investigate optimal head angle which can save the hippocampal-sparing and organ at risk (OAR) in conformal radiation therapy (CRT), Intensity modulation radiation therapy (IMRT) and helical tomotherapy (HT). Methods: Three types of radiation treatment plans, CRT, IMRT and Tomotherapy plans, were performed for 10 brain tumor patients. The image fusion between CT and MRI data were used in the contour due to the limited delineation of the target and OAR in the CT scan. The optimal condition plan was determined by comparing the dosimetric performance of the each plan with the use of various parameters which include three different techniques (CRT, IMRT, HT) and 4 angle (0, 15, 30, 40 degree). The each treatment plans of three different techniques were compared with the following parameters: conformity index (CI), homogeneity index (HI), target coverage, dose in the OARs, monitor units (MU), beam on time and the normal tissue complication probability (NTCP). Results: HI, CI and target coverage was most excellent in head angle 30 degree among all angle. When compared by modality, target coverage and CI showed good results in IMRT and TOMO than compared to the CRT. HI at the head angle 0 degrees is 1.137±0.17 (CRT), 1.085±0.09 (IMRT) and 1.077±0.06 (HT). HI at the head angle 30 degrees is 1.056±0.08 (CRT), 1.020±0.05 (IMRT) and 1.022±0.07 (HT). Conclusion: The results of our study show that when head angle tilted at 30 degree, target coverage, HI, CI were improved, and the dose delivered to OAR was reduced compared with conventional supine position in brain radiation therapy. This work was supported by the Radiation Technology R&D program (No. 2013M2A2A7043498) and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

TU-CD-304-09: Feasibility Study for Thermoplastic Mask Set Up Monitoring Using Force Sensing Resistor (FSR) Sensor

Purpose: To improve the setup accuracy of thermoplastic mask, we developed a new monitoring method based on force sensing technology and evaluated its feasibility. Methods: The thermoplastic mask setup monitoring system consists of a force sensing resistor sensor unit, a signal transport device, a control PC and an in-house software. The system is designed to monitor pressure variation between the mask and patient in real time. It also provides a warning to the user when there is a possibility of movement. A preliminary study was performed to evaluate the reliability of the sensor unit and developed monitoring system with a head phantom. Then, a simulation study with volunteers was conducted to evaluate the feasibility of the monitoring system. Note that the sensor unit can have multiple end-sensors and every end-sensor was confirmed to be within 2% reliability in pressure reading through a screening test. Results: To evaluate the reproducibility of the proposed monitoring system in practice, we simulated a mask setup with the head phantom. FRS sensors were attached on the face of the head phantom and pressure was monitored. For 3 repeated mask setups on the phantom, the variation of the pressure was less than 3% (only 1% larger than 2% potential uncertainty confirmed in the screening test). In the volunteer study, we intended to verify that the system could detect patient movements within the mask. Thus, volunteers were asked to turn their head or lift their chin. The system was able to detect movements effectively, confirming the clinical feasibility of the monitoring system developed. Conclusion: Through the proposed setup monitoring method, it is possible to monitor patient motion inside a mask in real time, which has never been possible with most commonly used systems using non-radiographic technology such as infrared camera system and surface imaging system. This work was supported by the Radiation Technology R&D program (No. 2013M2A2A7043498) and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning.

60 APPLIED LIFE SCIENCES↗

Chemical Control of Charge Trapping and Charge Transfer Processes at the Organic-Inorganic Interface within Quantum Dot-Organic Complexes

Within the research program funded through the Early Career Research Award we designed complexes of colloidal semiconductor quantum dots (QDs) and organic molecules in which the interfacial chemistry controls the electronic structure and dynamics of the excitonic state of the QD. The program included two main projects; (1) investigation of the mechanisms by which organic surfactants control the quantum confinement of excitonic charge carriers; and (2) development of models for electron transfer between QDs and adsorbed molecules as a function of interfacial chemistry. This project was extremely successful in that our achievements in those two areas addressed the great majority of questions we outlined in the original proposal and answered questions I did not think to ask in that original proposal. Our work led to the discovery of “exciton delocalizing ligands”, which change the electronic structure of colloidal semiconductor nanocrystals by altering, with small synthetic modifications to their surfaces, their most defining characteristic – the quantum confinement of their excited states. It also led to detailed, quantitative descriptions of how the surface chemistry of a QD dictates, thermodynamically and kinetically, the probability of exchange of electrons between the QD and a small molecule. We used two of the three major techniques in the proposal (transient photoluminescence and transient absorption). Electrogenerated chemiluminescence was also proposed, but was too technically difficult with these systems to be useful. Instead, NMR spectroscopy emerged as a major analytical tool in our studies. With the fundamental advancements we made with this project, we believe that we can design QDs to be the next great class of visible-light photocatalysts.

14 SOLAR ENERGY↗

Scientist-Stakeholder Relationships Drive Carbon Data Product Transfer Effectiveness within NASA Program

Carbon cycle science is at the heart of research on global climate change and its long-term impacts, as it examines the exchange of carbon between the atmosphere, oceans, land, and the impact of fossil fuel emissions on this cycling. Given the urgency of the climate challenge, NASA’s Carbon Monitoring System (CMS) requires all funded investigators to identify and work with stakeholder organizations at project inception to accelerate the transfer of the products developed by funded research into decision making systems. In this study, we contribute to the literature through the implementation of a quantitative analysis of 908 unique survey responses from funded investigators to explore the maturity of the scientist-stakeholder engagement. The paper employs multiple correspondence analysis to provide evidence to support policy options to increase stakeholder integration into research programs. Despite limitations of the dataset used, we demonstrated that multiple funding rounds, long-standing relationships between the stakeholder and scientist, and the scientific productivity of the PI, including the ability to produce datasets and research papers on these datasets, all contribute to carbon products moving from research to operational use. The maturity of relationships between scientists and stakeholders was shown to result improved stakeholder engagement. The use of carbon products should be identified in every stage of the program, and that capacity building is needed to support both existing and newly identified stakeholders better understand and use CMS products. As Federal, State, and local policy on climate adaptation and mitigation matures, the need for information on carbon will expand. Building of stakeholder-scientist relationships in CMS results in an effective generation and use of datasets to support this need and prototype ways that improved information needed for decision making can be created.

Monitoring↗

Scientist-Stakeholder Relationships Drive Carbon Data Product Transfer Effectiveness within NASA Program

Carbon cycle science is at the heart of research on global climate change and its long-term impacts, as it examines the exchange of carbon between the atmosphere, oceans, land, and the impact of fossil fuel emissions on this cycling. Given the urgency of the climate challenge, NASA's Carbon Monitoring System (CMS) requires all funded investigators to identify and work with stakeholder organizations at project inception to accelerate the transfer of the products developed by funded research into decision making systems. In this study, we contribute to the literature through the implementation of a quantitative analysis of 908 unique survey responses from funded investigators to explore the maturity of the scientist-stakeholder engagement. The paper employs multiple correspondence analysis to provide evidence to support policy options to increase stakeholder integration into research programs. Despite limitations of the dataset used, we demonstrated that multiple funding rounds, long-standing relationships between the stakeholder and scientist, and the scientific productivity of the Principal Investigator, including the ability to produce datasets and research papers on these datasets, all contribute to carbon products moving from research to operational use. The maturity of relationships between scientists and stakeholders was shown to result improved stakeholder engagement. The use of carbon products should be identified in every stage of the program, and that capacity building is needed to support both existing and newly identified stakeholders better understand and use CMS products. As federal, state, and local policy on climate adaptation and mitigation matures, the need for information on carbon will expand. Building of stakeholder-scientist relationships in CMS results in an effective generation and use of datasets to support this need and prototype ways that improved information needed for decision making can be created.

Molly E Brown↗

2013 Space Radiation Standing Review Panel Status Review for: The Risk of Acute and Late Central Nervous System Effects from Radiation Exposure, The Risk of Acute Radiation Syndromes Due to Solar Particle Events (SPEs), The Risk Of Degenerative Tissue Or Other Health Effects From Radiation Exposure, and The Risk of Radiation Carcinogenesis

The Space Radiation Standing Review Panel (from here on referred to as the SRP) was impressed with the strong research program presented by the scientists and staff associated with NASA's Space Radiation Program Element and National Space Biomedical Research Institute (NSBRI). The presentations given on-site and the reports of ongoing research that were provided in advance indicated the potential Risk of Acute and Late Central Nervous System Effects from Radiation Exposure (CNS) and were extensively discussed by the SRP. This new data leads the SRP to recommend that a higher priority should be placed on research designed to identify and understand these risks at the mechanistic level. To support this effort the SRP feels that a shift of emphasis from Acute Radiation Syndromes (ARS) and carcinogenesis to CNS-related endpoints is justified at this point. However, these research efforts need to focus on mechanisms, should follow pace with advances in the field of CNS in general and should consider the specific comments and suggestions made by the SRP as outlined below. The SRP further recommends that the Space Radiation Program Element continue with its efforts to fill the vacant positions (Element Scientist, CNS Risk Discipline Lead) as soon as possible. The SRP also strongly recommends that NASA should continue the NASA Space Radiation Summer School. In addition to these broad recommendations, there are specific comments/recommendations noted for each risk, described in detail below.

Source record↗

Lunar Human Research Requirements (LHRR)

Biomedical research will be conducted during transit and on the surface of the Moon to prepare for extended stays on the Moon and to prepare for the exploration of Mars. The objective of the Human Research Program (HRP) is to preserve the health and enhance performance of astronaut explorers. Specific objectives of the HRP include developing the knowledge, capabilities, and necessary countermeasures and technologies in support of human space exploration; focusing on mitigating the highest risks to crew health and performance; and defining and improving human spaceflight medical, environmental, behavioral, and human factors standards. This document contains a detailed description of the resource accommodations, interfaces, and environments to be provided by the Constellation Program (CxP) to support the HRP research in transit and on the lunar surface. Covered, specifically, are the requirements for mass and volume transport; crew availability; ground operations, baseline data collection, and payload processing; power, and data. Volumes and mass are given for transport of conditioned samples only. They do not account for the engineering solution that the Constellation Program will implement (refrigerator/freezer volume/mass). This document does not account for requirements on the Orion vehicle for transportation to and from the International Space Station (ISS). The ISS Program has supplied requirements for this mission.

Denkins, Pamela↗

Graduate engineering research participation in aeronautics

The Aeronautics Graduate Research Program commenced in 1971, with the primary goal of engaging students who qualified for regular admission to the Graduate School of Engineering at Old Dominion University in a graduate engineering research and study program in collaboration with NASA Langley Research Center, Hampton, Virginia. The format and purposes of this program are discussed. Student selection and program statistics are summarized. Abstracts are presented in the folowing areas: aircraft design, aerodynamics, lift/drag characteristics; avionics; fluid mechanics; solid mechanics; instrumentation and measurement techniques; thermophysical properties experiments; large space structures; earth orbital dynamics; and environmental engineering.

Roberts, A. S., Jr.↗

Research opportunities in human behavior and performances

The NASA research program in the biological and medical aspects of space flight includes investigations of human behavior and performance. The research focuses on psychological and psychophysiological responses to operational and environmental stresses and demands of spaceflight, and encompasses problems in perception, cognition, motivation, psychological stability, small group dynamics, and performance. The primary objective is to acquire the knowledge and methodology to aid in achieving high productivity and essential psychological support of space and ground crews in the Space Shuttle and space station programs. The Life Sciences Research Office (LSRO) of the Federation of American Societies for Experimental Biology reviewed its program in psychology and identified its research for future program planning to be in line with NASA's goals.

Christensen, J. M.↗

2015 Advanced Environmental Health/Advanced Food Technology Standing Review Panel

The 2015 Advanced Environmental Health/Advanced Food Technology (AEH/AFT) Standing Review Panel (from here on referred to as the SRP) met for a site visit in Houston, TX on December 14 - 15, 2015. The SRP met with representatives from the Space Human Factors and Habitability (SHFH) Element and members of the Human Research Program (HRP) to review the updated research plans for the Risk of Adverse Health Effects Due to Host-Microorganism Interactions (MicroHost Risk) and the Risk of Performance Decrement and Crew Illness due to an Inadequate Food System (Food Risk). During the meeting, the SRP also met with the vehicle engineers to discuss possible food storage options. The SRP would like to commend Dr. Oubre and Dr. Douglas for their detailed presentations, as well the frank, refreshing, and comprehensive engineering presentation. This gave much needed perspective to the food storage issues and reassured the committee about NASA's approach to the problem. In terms of critiques, the SRP remains unconvinced about the rationale for probiotic use other than for specific applications supported by the literature. It is not clear what gap or problem is being addressed by the use of probiotics, and the rationale for their use needs to be clearly rooted in the available literature. The SRP thinks that if low-Earth orbit is associated with immune system impairment, then there may additional risks linked with the use of probiotics. It is not clear to the SRP how NASA will determine if probiotics are having their intended beneficial effect. A similar concern is raised as to what gaps or problems are being addressed by "functional foods". Mixed infections, rather than single species infections, which can augment severity of disease, also represent a significant concern. Overall, the SRP considers this to be a strong program that is well-organized, well-coordinated and generates valuable data.

Steinberg, Susan↗

Performance seeking control program overview

The Performance Seeking Control (PSC) program evolved from a series of integrated propulsion-flight control research programs flown at NASA Dryden Flight Research Center (DFRC) on an F-15. The first of these was the Digital Electronic Engine Control (DEEC) program and provided digital engine controls suitable for integration. The DEEC and digital electronic flight control system of the NASA F-15 were ideally suited for integrated controls research. The Advanced Engine Control System (ADECS) program proved that integrated engine and aircraft control could improve overall system performance. The objective of the PSC program was to advance the technology for a fully integrated propulsion flight control system. Whereas ADECS provided single variable control for an average engine, PSC controlled multiple propulsion system variables while adapting to the measured engine performance. PSC was developed as a model-based, adaptive control algorithm and included four optimization modes: minimum fuel flow at constant thrust, minimum turbine temperature at constant thrust, maximum thrust, and minimum thrust. Subsonic and supersonic flight testing were conducted at NASA Dryden covering the four PSC optimization modes and over the full throttle range. Flight testing of the PSC algorithm, conducted in a series of five flight test phases, has been concluded at NASA Dryden covering all four of the PSC optimization modes. Over a three year period and five flight test phases 72 research flights were conducted. The primary objective of flight testing was to exercise each PSC optimization mode and quantify the resulting performance improvements.

Orme, John S.↗