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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,315 records · Page 73
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

Spectroscopy and Scattering Studies Using Interpolated Ab Initio Potentials

The Born–Oppenheimer potential energy surface (PES) has come a long way since its introduction in the 1920s, both conceptually and in predictive power for practical applications. Nevertheless, nearly 100 years later—despite astonishing advances in computational power—the state-of-the-art first-principles prediction of observables related to spectroscopy and scattering dynamics is surprisingly limited. For example, the water dimer, (H 2 O) 2 , with only six nuclei and 20 electrons, still presents a formidable challenge for full-dimensional variational calculations of bound states and is considered out of reach for rigorous scattering calculations. The extremely poor scaling of the most rigorous quantum methods is fundamental; however, recent progress in development of approximate methodologies has opened the door to fairly routine high-quality predictions, unthinkable 20 years ago. In this review, in relation to the workflow of spectroscopy and/or scattering studies, we summarize progress and challenges in the component areas of electronic structure calculations, PES fitting, and quantum dynamical calculations.

Chemistry↗
DOE OSTI2025

Pivotal trial characteristics and types of endpoints used to support Food and Drug Administration rare disease drug approvals between 2013 and 2022

Background/aims Rare disease drug development faces unique challenges, such as genotypic and phenotypic heterogeneity within small patient populations and a lack of established outcome measures for conditions without previously successful drug development programs. These challenges complicate the process of selecting the appropriate trial endpoints and conducting clinical trials in rare diseases. In this descriptive study, we examined novel drug approvals for non-oncologic rare diseases by the U.S. Food and Drug Administration’s Center for Drug Evaluation and Research over the past decade and characterized key regulatory and trial design elements with a focus on the primary efficacy endpoint utilized as the basis of approval. Methods Using the Food and Drug Administration’s Data Analysis Search Host database, we identified novel new drug applications and biologics license applications with orphan drug designation that were approved between 2013 and 2022 for non-oncologic indications. From Food and Drug Administration review documents and other external databases, we examined characteristics of pivotal trials for the included drugs, such as therapeutic area, trial design, and type of primary efficacy endpoints. Differences in trial design elements associated with primary efficacy endpoint type were assessed such as randomization and blinding. Then, we summarized the primary efficacy endpoint types utilized in pivotal trials by therapeutic area, approval pathway, and whether the disease etiology is well defined. Results One hundred and seven drugs that met our inclusion criteria were approved between 2013 and 2022. Assessment of the 107 drug development programs identified 150 pivotal trials that were subsequently analyzed. The pivotal trials were mostly randomized (80%) and blinded (69.3%). Biomarkers (41.1%) and clinical outcomes (42.1%) were commonly utilized as primary efficacy endpoints. Analysis of the use of clinical trial design elements across trials that utilized biomarkers, clinical outcomes, or composite endpoints did not reveal statistically significant differences. The choice of primary efficacy endpoint varied by the drug’s therapeutic area, approval pathway, and whether the indicated disease etiology was well defined. For example, biomarkers were commonly selected as primary efficacy endpoints in hematology drug approvals (70.6%), whereas clinical outcomes were commonly selected in neurology drug approvals (69.6%). Further, if the disease etiology was well defined, biomarkers were more commonly used as primary efficacy endpoints in pivotal trials (44.7%) than if the disease etiology was not well defined (27.3%). Discussion In the past 10 years, numerous novel drugs have been approved to treat non-oncologic rare diseases in various therapeutic areas. To demonstrate their efficacy for regulatory approval, biomarkers and clinical outcomes were commonly utilized as primary efficacy endpoints. Biomarkers were not only frequently used as surrogate efficacy endpoints in accelerated approvals, but also in traditionally approved rare disease drugs. The choice of primary efficacy endpoints varied by therapeutic area, approval pathway, and understanding of disease etiology.

Hong, Kyungwan [Rare Diseases Team, Office of New ↗
DOE OSTI2025

Architecture of the personnel protection systems for Spallation Neutron Source Second Target Station

The Oak Ridge National Laboratory (ORNL) is implementing a major upgrade to the Spallation Neutron Source (SNS) facility, encompassing the addition of the Second Target Station (STS). Preliminary design reviews have been conducted on several STS Personnel Protection Systems (PPS). The reviews focused primarily on the integration with the existing SNS PPS, the new proton transport tunnel, and the target areas. Development of the PPS is ongoing, to ensure a coherent safety system with the mission of protecting users and workers from prompt radiation hazards while providing high beam availability to operations. The STS PPS element in the Integrated Control System (ICS) is a facility-wide system composed of multiple safety subsystems, including the Ring to Second Target (RTST) beam transport tunnel, Target, Bunker and Instruments. Personnel working in all these geographic areas are protected by modular reliable PPS solutions. The safety system enforces access controls, radiation monitoring, beam destination control, and application of critical device inhibit upon detection of abnormal condition. It uses well-documented processes, Common Industrial Protocol (CIP) safety, pulsed test, and redundancy to achieve the desired Safety Integrity Level (SIL). This paper gives an architectural overview of the STS PPS and a detailed safety plan for the SNS facility, addressing safety solutions and human factors.

Michaelides, Tommy [ORNL] (ORCID:0000000190499869)↗
DOE OSTI2020

Integrated Risk-Informed Condition Based Maintenance Capability and Automated Platform: Technical Report 1

Due to continuing global energy market trends, driven heavily by the abundant preserves of natural gas, there is an immediate need to reduce costs associated with operation and maintenance (O&M) for the current domestic nuclear power industry and for future reactor developments. This is to ensure that nuclear power generation remains an economically competitive and viable option in the energy market. O&M costs include labor-intensive preventive maintenance (PM) programs, which involve manually-performed inspection, calibration, testing, and maintenance of plant assets at periodic frequency and time-based replacement of assets, irrespective of their condition. This has resulted in an expensive, labor-centric business model to achieve high capacity factors. Fortunately, there are technologies (advanced sensors, data analytics, and risk assessment methodologies) that can enable the transition from a labor-centric business model to a technology-centric business model. The technology-centric business model will result in a significant reduction of PM activities, laying the foundation for real-time condition assessment of plant assets, reducing overall labor and part costs. To enable this transition, PKMJ Technical Services LLC is partnering with the U.S. Department of Energy’s Idaho National Laboratory (operated by the Battelle Energy Alliance, LLC) and the Public Services Enterprise Group (PSEG) Nuclear, LLC in the Integrated Risk-Informed Condition-Based Maintenance Capability and Automated Platform Project. In this report, the configuration of a digital cloud platform using Microsoft Azure is discussed, data from the PSEG Salem Nuclear Generating Station Units 1 & 2 are imported into a digital cloud platform, and the data is used for an evaluation of several key areas: cost impact analysis, risk-informed model development, and preventive maintenance strategy optimization. First, the cost impact analysis reviews which plant assets are potential good candidates for condition-based monitoring. Next, INL utilized the data in their local environment to develop the risk-informed model; which provides estimates of failure rates and probability of failures of assets based upon their past performance. The developed model is performed on assets selected from the cost impact analysis. Lastly, engineers assess the preventive maintenance strategy for the selected assets at PSEG against maintenance strategies in the nuclear industry for similar assets to potentially identify acceptable justification for the extension of current maintenance frequencies.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2019

Closure Relations of Gamma-Ray Bursts in High Energy Emission

The synchrotron external shock model predicts the evolution of the spectral (β) and temporal (α) indices during the gamma-ray burst (GRB) afterglow for different environmental density profiles, electron spectral indices, electron cooling regimes, and regions of the spectrum. We review the relationship between α and β, the so-called "closure relations" with GRBs detected by Fermi Large Area Telescope (Fermi-LAT) from 2008 August to 2018 August. The spectral and temporal indices for the >100 MeV emission from the Fermi-LAT as determined in the Second Fermi-LAT Gamma-Ray Burst Catalog (2FLGC) are used in this work. We select GRBs whose spectral and temporal indices are well constrained (58 long-duration GRBs and 1 short-duration GRBs) and classify each GRB into the best-matched relation. As a result, we found that a number of GRBs require a very small fraction of the total energy density contained in the magnetic field (ϵ B ≲ 10 –7 ). The estimated mean and standard deviation of electron spectral index p are 2.40 and 0.44, respectively. The GRBs satisfying a closure relation of the slow cooling tend to have a softer p value compared to those of the fast cooling. Furthermore, the Kolmogorov–Smirnov test of the two p distributions from the fast and slow coolings rejects a hypothesis that the two distributions are drawn from the single reference distribution with a significance of 3.2σ. Lastly, the uniform density medium is preferred over the medium that decreases like the inverse of distance squared for long-duration GRBs.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS1974

Application of a Kalman filter identification technique to flight data from the X-22A variable stability V/STOL aircraft

A digital identification technique based on Kalman filter theory was developed for the estimation of V/STOL aircraft stability and control parameters from flight data. The application of this technique to flight data from flying qualities experiments using the variable stability X-22A V/STOL aircraft is discussed. The estimation algorithm is briefly reviewed, experimental and data acquisition procedures used in the X-22A flight programs are outlined, and specific problem areas such as the determination of noise statistics and selection of pilot inputs to enhance identifiability are discussed. Results are presented for a wide range of simulated dynamic configurations.

Lebacqz, J. V.↗
NASA NTRS1975

The study of single crystals for space processing and the effect of zero gravity

A study was undertaken to analyze different growth techniques affected by a space environment. Literature on crystal growth from melt, vapor phase and float zone was reviewed and the physical phenomena important for crystal growth in zero-gravity environment was analyzed. Recommendations for potential areas of crystal growth feasible for space missions are presented and a bibliography of articles in the area of crystal growth in general is listed.

Lal, R. B.↗
NASA NTRS1975

Neural models on temperature regulation for cold-stressed animals

The present review evaluates several assumptions common to a variety of current models for thermoregulation in cold-stressed animals. Three areas covered by the models are discussed: signals to and from the central nervous system (CNS), portions of the CNS involved, and the arrangement of neurons within networks. Assumptions in each of these categories are considered. The evaluation of the models is based on the experimental foundations of the assumptions. Regions of the nervous system concerned here include the hypothalamus, the skin, the spinal cord, the hippocampus, and the septal area of the brain.

Horowitz, J. M.↗
NASA NTRS1977

The first Spacelab payload - A joint NASA/ESA venture

Planning for the 1980 qualification flight of Spacelab, which will involve a long module and one pallet, is discussed. The mission will employ two payload specialists, one sponsored by NASA and the other by ESA. Management of the Spacelab mission functions, including definition and execution of the on-board experiments, development of the experimental hardware and training of the payload specialists, is considered; studies proposed in the areas of atmospheric physics, space plasma physics, solar physics, earth observations, astronomy, astrophysics, life sciences and material sciences are reviewed. Analyses of the Spacelab environment and the Spacelab-to-orbiter and Spacelab-to-experiment interactions are also planned.

Kennedy, R.↗
NASA NTRS1980

Attitude and articulation control solutions for Project Galileo

Design problems and the solutions adopted for them in the attitude and articulation control subsystem for the Galileo spacecraft are discussed as an illustration of the application of dual-spin control to an interplanetary spacecraft. Following a review of the baseline design of the Galileo system and mission, consideration is given to problems encountered in the areas of autonomous attitude determination, attitude control, spacecraft dynamics and software margins. Design issues raised by subsequent changes in spacecraft configuration are also indicated. It is pointed out that although difficulties associated with control system complexity in a dual-spin interplanetary spacecraft have been satisfactorily resolved for the Galileo mission, the future application of dual spin in interplanetary flight is in doubt.

Rasmussen, R. D.↗
NASA NTRS1983

Study of LANDSAT-D thematic mapper performance as applied to hydrocarbon exploration

Many scenes of particular interest have a light dusting of snow cover. The possible use of hue-saturation-intensity transformations to reduce the effect of snow cover is being investigated. A tape of the Greeley, Colorado scene was reviewed on the interactive system and image types to be produced (decorrelated 2,3,4; natural color 1,2,3,; hue separation value 5/2,5/7 eigen 1; 4,5,7 in two color combinations) were selected. In several instances, a 1,3,4 combination produces a more useful false color infrared version of TM data than the more common 2,3,4 arrangement, probably because band 1 is less highly correlated with the band 3 and 4 than is band 2. A review of spacecraft performance suggests that the standard corrections applied at GSFC are more complicated than necessary in some areas and insufficient in other cases. The image motion compensation device on the TM works so well that bow-typing effects are very small; there are differences in the radiometry of forward and backward scans that make additional calibration necessary.

Source record↗
NASA NTRS1984

BDLI memorandum on the future of space flight in the Federal Republic of Germany

The future of the aerospace effort in the Federal Republic of Germany is reviewed. The status of the aerospace industry in the FRG is compared with that in other countries and various areas of research are explored in terms of their relevance to the German economy and to the FRG's position as a competitor in the world market.

Source record↗
NASA NTRS1984

Concepts and algorithms for terminal-area traffic management

The nation's air-traffic-control system is the subject of an extensive modernization program, including the planned introduction of advanced automation techniques. This paper gives an overview of a concept for automating terminal-area traffic management. Four-dimensional (4D) guidance techniques, which play an essential role in the automated system, are reviewed. One technique, intended for on-board computer implementation, is based on application of optimal control theory. The second technique is a simplified approach to 4D guidance intended for ground computer implementation. It generates advisory messages to help the controller maintain scheduled landing times of aircraft not equipped with on-board 4D guidance systems. An operational system for the second technique, recently evaluated in a simulation, is also described.

Erzberger, H.↗
NASA NTRS1986

SIRTF and the Space Station

An evaluation is made of the technical prospects and scientific goals of the Space IR Telescope Facility (SIRTF), whose telescope is of 1-m aperture and cryogenically cooled and will be able to improve on IRAS performance in such areas as wavelength coverage, spectral and spatial resolution, and sensitivity. Attention is given to the findings of an intensive review of the long-life SIRTF mission, with a view to new determinations on its orbit, scientific performance requirements, and baseline design concepts, as well as the ways in which it will employ elements of the NASA Space Station.

Werner, M. W.↗
NASA NTRS1986

Utility interconnection issues for wind power generation

This document organizes the total range of utility related issues, reviews wind turbine control and dynamic characteristics, identifies the interaction of wind turbines to electric utility systems, and identifies areas for future research. The material is organized at three levels: the wind turbine, its controls and characteristics; connection strategies as dispersed or WPSs; and the composite issue of planning and operating the electric power system with wind generated electricity.

Herrera, J. I.↗
NASA NTRS1988

An overview of current approaches and future challenges in physiological monitoring

Sufficient evidence exists from laboratory studies to suggest that physiological measures can be useful as an adjunct to behavioral and subjective measures of human performance and capabilities. Thus it is reasonable to address the conceptual and engineering challenges that arise in applying this technology in operational settings. Issues reviewed include the advantages and disadvantages of constructs such as mental states, the need for physiological measures of performance, areas of application for physiological measures in operational settings, which measures appear to be most useful, problem areas that arise in the use of these measures in operational settings, and directions for future development.

Horst, Richard L.↗
NASA NTRS1989

Cryogenic wind tunnels

Cryogenic wind tunnels and their use for high Reynolds number testing are reviewed. Emphasis is given to operational and aerodynamic testing experience in the NASA Langley 0.3-m Transonic Cryogenic Tunnel. Areas covered include development of test techniques and aerodynamic testing in cryogenic tunnels. The use of advanced testing techniques to increase the value of cryogenic tunnels is recommended. These include adaptive wall test sections, using solid but flexible top and bottom walls, and magnetic suspension and balance systems.

Kilgore, Robert A.↗
NASA NTRS1990

Potential use of tiltrotor aircraft in Canadian aviation

The aviation system in Canada is described as it relates to the potential applicability of tiltrotor technology. Commuter service in two corridors, the Vancouver-Victoria route on the west coast and the heavily traveled Montreal-Toronto corridor in eastern Canada, are examined. The operation of air service from the near-downtown Toronto STOLport and from the Vancouver-Victoria downtown heliport facilities is described. The emergency medical services, search and rescue, and natural resources development sectors are described with regard to the needs that tiltrotor technology could uniquely meet in these areas. The airport construction program in isolated communities of northern Quebec and possible tiltrotor service in northern regions are reviewed. The Federal and provincial governments' financial support policy regarding the aeronautical industry is to encourage the establishment and expansion of businesses in the field of aeronautics and to make possible the acquisition of new technology. This policy has implications for the tiltrotor program.

Gazdag, Denyse↗