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NASA NTRS1996

STS-77 Space Shuttle Mission Report

The STS-77 Space Shuttle Program Mission Report summarizes the Payload activities as well as the: Orbiter, External Tank (ET), Solid Rocket Booster (SRB), Reusable Solid Rocket Motor (RSRM), and the Space Shuttle Main Engine (SSME) systems performance during the seventy-seventh flight of the Space Shuttle Program, the fifty-second flight since the return-to-flight, and the eleventh flight of the Orbiter Endeavour (OV-105). STS-77 was also the last flight of OV-105 prior to the vehicle being placed in the Orbiter Maintenance Down Period (OMDP). In addition to the Orbiter, the flight vehicle consisted of an ET that was designated ET-78; three SSME's that were designated as serial numbers 2037, 2040, and 2038 in positions 1, 2, and 3, respectively; and two SRB's that were designated BI-080. The RSRM's, designated RSRM-47, were installed in each SRB and the individual RSRM's were designated as 360TO47A for the left SRB, and 360TO47B for the right SRB. The STS-77 Space Shuttle Program Mission Report fulfills the Space Shuttle Program requirement as documented in NSTS 07700, Volume VII, Appendix E. The requirement stated in that document is that each organizational element supporting the Program will report the results of their hardware (and software) evaluation and mission performance plus identify all related in-flight anomalies. The primary objectives of this flight were to successfully perform the operations necessary to fulfill the requirements of Spacehab-4, the SPARTAN 207/inflatable Antenna Experiment (IAE), and the Technology Experiments Advancing Missions in Space (TEAMS) payload. Secondary objectives of this flight were to perform the experiments of the Aquatic Research Facility (ARF), Brilliant Eyes Ten-Kelvin Sorption Cryocooler Experiment (BETSCE), Biological Research in Canisters (BRIC), Get-Away-Special (GAS), and GAS Bridge Assembly (GBA). The STS-77 mission was planned as a 9-day flight plus 1 day, plus 2 contingency days, which were available for weather avoidance or Orbiter contingency operations. The sequence of events for the STS-77 mission is shown in Table 1, and the Space Shuttle Vehicle Management Office Problem Tracking List is shown in Table 11. The Government Fumished Equipment/Flight Crew Equipment (GFE/FCE) Problem Tracking List is shown in Table II. Appendix A lists the sources of data, both formal and informal, that were used to prepare this report. Appendix B provides the definition of acronyms and abbreviations used throughout the report. All times during the flight are given in Greenwich mean time (G.m.t.) and mission elapsed time (MET). The six-person crew for STS-77 consisted of John H. Casper, Col., U. S. Air Force, Commander; Curtis L. Brown, Jr., Lt. Col., U. S. Air Force, Pilot; Andrew S. W. Thomas, Civilian, Ph.D., Mission Specialist 1; Daniel W. Bursch, CDR., U. S. Navy, Mission Specialist 2; Mario Runco, Jr., Civilian, Mission Specialist 3; and Marc Gameau, Civilian, PhD, Mission Specialist 4.

Fricke, Robert W., Jr.↗
NASA NTRS1996

STS-78 Space Shuttle Mission Report

The STS-78 Space Shuttle Program Mission Report summarizes the Payload activities as well as the Orbiter, External Tank (ET), Solid Rocket Booster (SRB), Reusable Solid Rocket Motor (RSRM), and the Space Shuttle main engine (SSME) systems performance during the seventy-eighth flight of the Space Shuttle Program, the fifty-third flight since the return-to-flight, and the twentieth flight of the Orbiter Columbia (OV-102). In addition to the Orbiter, the flight vehicle consisted of an ET that was designated ET-79; three SSME's that were designated as serial numbers 2041, 2039, and 2036 in positions 1, 2, and 3, respectively; and two SRB's that were designated BI-081. The RSRM's, designated RSRM-55, were installed in each SRB and the individual RSRM's were designated as 360L055A for the left SRB, and 360L055B for the right SRB. The STS-78 Space Shuttle Program Mission Report fulfills the Space Shuttle Program requirement as documented in NSTS 07700, Volume 7, Appendix E. The requirement stated in that document is that each organizational element supporting the Program will report the results of their hardware (and software) evaluation and mission performance plus identify all related in-flight anomalies. The primary objective of this flight was to successfully perform the planned operations of the Life and Microgravity Spacelab experiments. The secondary objectives of this flight were to complete the operations of the Orbital Acceleration Research Experiment (OARE), Biological Research in Canister Unit-Block II (BRIC), and the Shuttle Amateur Radio Experiment II-Configuration C (SAREX-II). The STS-78 mission was planned as a 16-day, plus one day flight plus two contingency days, which were available for weather avoidance or Orbiter contingency operations. The sequence of events for the STS-78 mission is shown in Table 1, and the Space Shuttle Vehicle Management Office Problem Tracking List is shown in Table 2. The Government Furnished Equipment/Flight Crew Equipment (GFE/FCE) Problem Tracking List is shown in Table 3. The Marshall Space Flight Center (MSFC) Problem Tracking List is shown in Table 4. Appendix A lists the sources of data, both formal and informal, that were used to prepare this report. Appendix B provides the definition of acronyms and abbreviations used throughout the report. All times during the flight are given in Greenwich mean time (G.m.t.) and mission elapsed time (MET).

Fricke, Robert W., Jr.↗
NASA NTRS1997

Asynchronous Communication of TLNS3DMB Boundary Exchange

This paper describes the recognition of implicit serialization due to coarse-grain, synchronous communication and demonstrates the conversion to asynchronous communication for the exchange of boundary condition information in the Thin-Layer Navier Stokes 3-Dimensional Multi Block (TLNS3DMB) code. The implementation details of using asynchronous communication is provided including buffer allocation, message identification, and barrier control. The IBM SP2 was used for the tests presented.

Hammond, Dana P.↗
NASA NTRS1997

Efficient Parallel Kernel Solvers for Computational Fluid Dynamics Applications

Distributed-memory parallel computers dominate today's parallel computing arena. These machines, such as Intel Paragon, IBM SP2, and Cray Origin2OO, have successfully delivered high performance computing power for solving some of the so-called "grand-challenge" problems. Despite initial success, parallel machines have not been widely accepted in production engineering environments due to the complexity of parallel programming. On a parallel computing system, a task has to be partitioned and distributed appropriately among processors to reduce communication cost and to attain load balance. More importantly, even with careful partitioning and mapping, the performance of an algorithm may still be unsatisfactory, since conventional sequential algorithms may be serial in nature and may not be implemented efficiently on parallel machines. In many cases, new algorithms have to be introduced to increase parallel performance. In order to achieve optimal performance, in addition to partitioning and mapping, a careful performance study should be conducted for a given application to find a good algorithm-machine combination. This process, however, is usually painful and elusive. The goal of this project is to design and develop efficient parallel algorithms for highly accurate Computational Fluid Dynamics (CFD) simulations and other engineering applications. The work plan is 1) developing highly accurate parallel numerical algorithms, 2) conduct preliminary testing to verify the effectiveness and potential of these algorithms, 3) incorporate newly developed algorithms into actual simulation packages. The work plan has well achieved. Two highly accurate, efficient Poisson solvers have been developed and tested based on two different approaches: (1) Adopting a mathematical geometry which has a better capacity to describe the fluid, (2) Using compact scheme to gain high order accuracy in numerical discretization. The previously developed Parallel Diagonal Dominant (PDD) algorithm and Reduced Parallel Diagonal Dominant (RPDD) algorithm have been carefully studied on different parallel platforms for different applications, and a NASA simulation code developed by Man M. Rai and his colleagues has been parallelized and implemented based on data dependency analysis. These achievements are addressed in detail in the paper.

Sun, Xian-He↗
NASA NTRS1997

[Advanced Development for Space Robotics With Emphasis on Fault Tolerance Technology]

This report describes work developing fault tolerant redundant robotic architectures and adaptive control strategies for robotic manipulator systems which can dynamically accommodate drastic robot manipulator mechanism, sensor or control failures and maintain stable end-point trajectory control with minimum disturbance. Kinematic designs of redundant, modular, reconfigurable arms for fault tolerance were pursued at a fundamental level. The approach developed robotic testbeds to evaluate disturbance responses of fault tolerant concepts in robotic mechanisms and controllers. The development was implemented in various fault tolerant mechanism testbeds including duality in the joint servo motor modules, parallel and serial structural architectures, and dual arms. All have real-time adaptive controller technologies to react to mechanism or controller disturbances (failures) to perform real-time reconfiguration to continue the task operations. The developments fall into three main areas: hardware, software, and theoretical.

Tesar, Delbert↗
NASA NTRS1997

Development of an Antimicrobial Susceptibility Testing Method Suitable for Performing During Space Flight

Very little is known regarding the affects of the microgravity environment of space flight upon the action of antimicrobial agents on bacterial pathogens. This study was undertaken to develop a simple method for conducting antibacterial susceptibility tests during a Space Shuttle mission. Specially prepared susceptibility test research cards (bioMerieux Vitek, Hazelwood, MO) were designed to include 6-11 serial two-fold dilutions of 14 antimicrobial agents, including penicillins, cephalosporins, a Beta-lactamase inhibitor, vancomycin, erythromycin, tetracycline, gentamicin, ciprofloxacin, and trimethoprim/sulfamethoxazole. Minimal inhibitory concentrations (MICS) of the drugs were determined by visual reading of color endpoints in the Vitek research cards made possible by incorporation of a colorimetric growth indicator (alamarBlue(Trademark), Accumed International, Westlake, OH). This study has demonstrated reproducible susceptibility results when testing isolates of Staphylococcus aurezis, Group A Streptococcus, Enterococcusfaecalis, Escherichia coli (beta-lactamase positive and negative strains), Klebsiella pneumoniae, Enterobacter cloacae, and Pseudomoiias aeruginosa. In some instances, the MICs were comparable to those determined using a standard broth microdilution method, while in some cases the unique test media and format yielded slightly different values, that were themselves reproducible. The proposed in-flight experiment will include inoculation of the Vitek cards on the ground prior to launch of the Space Shuttle, storage of inoculated cards at refrigeration temperature aboard the Space Shuttle until experiment initiation, then incubation of the cards for 18-48 h prior to visual interpretation of MICs by the mission's astronauts. Ground-based studies have shown reproducible MICs following storage of inoculated cards for 7 days at 4-8 C to accommodate the mission's time schedule and the astronauts' activities. For comparison, ground-based control (normal gravity) MIC values will be generated by simultaneous inoculation and incubation of a second set of test cards in a laboratory at the launch site. This procedure can provide a safe and compact experiment that should yield new information on the affects of microgravity on the biological activities of various classes of antibiotics.

Jorgensen, James H.↗
NASA NTRS1997

Inherent Conservatism in Deterministic Quasi-Static Structural Analysis

The cause of the long-suspected excessive conservatism in the prevailing structural deterministic safety factor has been identified as an inherent violation of the error propagation laws when reducing statistical data to deterministic values and then combining them algebraically through successive structural computational processes. These errors are restricted to the applied stress computations, and because mean and variations of the tolerance limit format are added, the errors are positive, serially cumulative, and excessively conservative. Reliability methods circumvent these errors and provide more efficient and uniform safe structures. The document is a tutorial on the deficiencies and nature of the current safety factor and of its improvement and transition to absolute reliability.

Verderaime, V.↗
NASA NTRS1994

Regular Topologies for Gigabit Wide-Area Networks: Congestion Avoidance Testbed Experiments

This document is Volume 3 of the final technical report on the work performed by SRI International (SRI) on SRI Project 8600. The document includes source listings for all software developed by SRI under this effort. Since some of our work involved the use of ST-II and the Sun Microsystems, Inc. (Sun) High-Speed Serial Interface (HSI/S) driver, we have included some of the source developed by LBL and BBN as well. In most cases, our decision to include source developed by other contractors depended on whether it was necessary to modify the original code. If we have modified the software in any way, it is included in this document. In the case of the Traffic Generator (TG), however, we have included all the ST-II software, even though BBN performed the integration, because the ST-II software is part of the standard TG release. It is important to note that all the code developed by other contractors is in the public domain, so that all software developed under this effort can be re-created from the source included here.

Denny, Barbara A.↗
NASA NTRS1998

How to Introduce the Imperfection Sensitivity Concept into Design 2

The previous review on stochastic buckling of structures was written by Amazigo in 1976. The present review summarizes some of the developments which took place in recent two decades. A brief overview is given of the effect on uncertainty in the initial geometric imperfections, elastic moduli, applied forces, and thickness variation. For the benefit of the thinking reader, the review has a critical nature. Present essay should be viewed as a direct continuation of our previous paper (1983) with the same title. In order not to repeat what was covered there, it appears instructive to read it although not necessarily prior to dwelling on this article. Accordingly the title is appended with the serial number. It is not promised that the third review will follow since the university science, both fortunately and unfortunately, stands on three things: relevance, interest, and grants.

Elishakoff, Isaac↗
NASA NTRS1998

High Rate Digital Demodulator ASIC

The architecture of High Rate (600 Mega-bits per second) Digital Demodulator (HRDD) ASIC capable of demodulating BPSK and QPSK modulated data is presented in this paper. The advantages of all-digital processing include increased flexibility and reliability with reduced reproduction costs. Conventional serial digital processing would require high processing rates necessitating a hardware implementation in other than CMOS technology such as Gallium Arsenide (GaAs) which has high cost and power requirements. It is more desirable to use CMOS technology with its lower power requirements and higher gate density. However, digital demodulation of high data rates in CMOS requires parallel algorithms to process the sampled data at a rate lower than the data rate. The parallel processing algorithms described here were developed jointly by NASA's Goddard Space Flight Center (GSFC) and the Jet Propulsion Laboratory (JPL). The resulting all-digital receiver has the capability to demodulate BPSK, QPSK, OQPSK, and DQPSK at data rates in excess of 300 Mega-bits per second (Mbps) per channel. This paper will provide an overview of the parallel architecture and features of the HRDR ASIC. In addition, this paper will provide an over-view of the implementation of the hardware architectures used to create flexibility over conventional high rate analog or hybrid receivers. This flexibility includes a wide range of data rates, modulation schemes, and operating environments. In conclusion it will be shown how this high rate digital demodulator can be used with an off-the-shelf A/D and a flexible analog front end, both of which are numerically computer controlled, to produce a very flexible, low cost high rate digital receiver.

Ghuman, Parminder↗
NASA NTRS1998

The Tera Multithreaded Architecture and Unstructured Meshes

The Tera Multithreaded Architecture (MTA) is a new parallel supercomputer currently being installed at San Diego Supercomputing Center (SDSC). This machine has an architecture quite different from contemporary parallel machines. The computational processor is a custom design and the machine uses hardware to support very fine grained multithreading. The main memory is shared, hardware randomized and flat. These features make the machine highly suited to the execution of unstructured mesh problems, which are difficult to parallelize on other architectures. We report the results of a study carried out during July-August 1998 to evaluate the execution of EUL3D, a code that solves the Euler equations on an unstructured mesh, on the 2 processor Tera MTA at SDSC. Our investigation shows that parallelization of an unstructured code is extremely easy on the Tera. We were able to get an existing parallel code (designed for a shared memory machine), running on the Tera by changing only the compiler directives. Furthermore, a serial version of this code was compiled to run in parallel on the Tera by judicious use of directives to invoke the "full/empty" tag bits of the machine to obtain synchronization. This version achieves 212 and 406 Mflop/s on one and two processors respectively, and requires no attention to partitioning or placement of data issues that would be of paramount importance in other parallel architectures.

Bokhari, Shahid H.↗
NASA NTRS1998

The Third Flight Magnet

A self-shielded superconducting magnet was designed for the NASA Goddard Space Flight Center Adiabatic Demagnetization Refrigerator Program. This is the third magnet built from this design. The magnets utilize Cryomagnetics' patented ultra-low current technology. The magnetic system is capable of reaching a central field of two tesla at slightly under two amperes and has a total inductance of 1068 henries. This final report details the requirements of the magnet, the specifications of the resulting magnet, the test procedures and test result data for the third magnet (Serial # C-654-M), and recommended precautions for use of the magnet.

McGhee, R. Wayne↗
NASA NTRS1998

A Geometry Based Infra-Structure for Computational Analysis and Design

The computational steps traditionally taken for most engineering analysis suites (computational fluid dynamics (CFD), structural analysis, heat transfer and etc.) are: (1) Surface Generation -- usually by employing a Computer Assisted Design (CAD) system; (2) Grid Generation -- preparing the volume for the simulation; (3) Flow Solver -- producing the results at the specified operational point; (4) Post-processing Visualization -- interactively attempting to understand the results. For structural analysis, integrated systems can be obtained from a number of commercial vendors. These vendors couple directly to a number of CAD systems and are executed from within the CAD Graphical User Interface (GUI). It should be noted that the structural analysis problem is more tractable than CFD; there are fewer mesh topologies used and the grids are not as fine (this problem space does not have the length scaling issues of fluids). For CFD, these steps have worked well in the past for simple steady-state simulations at the expense of much user interaction. The data was transmitted between phases via files. In most cases, the output from a CAD system could go to Initial Graphics Exchange Specification (IGES) or Standard Exchange Program (STEP) files. The output from Grid Generators and Solvers do not really have standards though there are a couple of file formats that can be used for a subset of the gridding (i.e. PLOT3D data formats). The user would have to patch up the data or translate from one format to another to move to the next step. Sometimes this could take days. Specifically the problems with this procedure are:(1) File based -- Information flows from one step to the next via data files with formats specified for that procedure. File standards, when they exist, are wholly inadequate. For example, geometry from CAD systems (transmitted via IGES files) is defined as disjoint surfaces and curves (as well as masses of other information of no interest for the Grid Generator). This is particularly onerous for modern CAD systems based on solid modeling. The part was a proper solid and in the translation to IGES has lost this important characteristic. STEP is another standard for CAD data that exists and supports the concept of a solid. The problem with STEP is that a solid modeling geometry kernel is required to query and manipulate the data within this type of file. (2) 'Good' Geometry. A bottleneck in getting results from a solver is the construction of proper geometry to be fed to the grid generator. With 'good' geometry a grid can be constructed in tens of minutes (even with a complex configuration) using unstructured techniques. Adroit multi-block methods are not far behind. This means that a million node steady-state solution can be computed on the order of hours (using current high performance computers) starting from this 'good' geometry. Unfortunately, the geometry usually transmitted from the CAD system is not 'good' in the grid generator sense. The grid generator needs smooth closed solid geometry. It can take a week (or more) of interaction with the CAD output (sometimes by hand) before the process can begin. One way Communication. (3) One-way Communication -- All information travels on from one phase to the next. This makes procedures like node adaptation difficult when attempting to add or move nodes that sit on bounding surfaces (when the actual surface data has been lost after the grid generation phase). Until this process can be automated, more complex problems such as multi-disciplinary analysis or using the above procedure for design becomes prohibitive. There is also no way to easily deal with this system in a modular manner. One can only replace the grid generator, for example, if the software reads and writes the same files. Instead of the serial approach to analysis as described above, CAPRI takes a geometry centric approach. This makes the actual geometry (not a discretized version) accessible to all phases of the analysis. The connection to the geometry is made through an Application Programming Interface (API) and NOT a file system. This API isolates the top-level applications (grid generators, solvers and visualization components) from the geometry engine. Also this allows the replacement of one geometry kernel with another, without effecting these top-level applications. For example, if UniGraphics is used as the CAD package then Parasolid (UG's own geometry engine) can be used for all geometric queries so that no solid geometry information is lost in a translation. This is much better than STEP because when the data is queried, the same software is executed as used in the CAD system. Therefore, one analyzes the exact part that is in the CAD system. CAPRI uses the same idea as the commercial structural analysis codes but does not specify control. Software components of the CAD system are used, but the analysis suite, not the CAD operator, specifies the control of the software session. This also means that the license issues (may be) minimized and individuals need not have to know how to operate a CAD system in order to run the suite.

Haimes, Robert↗
NASA NTRS1998

Parallel 3D Multi-Stage Simulation of a Turbofan Engine

A 3D multistage simulation of each component of a modern GE Turbofan engine has been made. An axisymmetric view of this engine is presented in the document. This includes a fan, booster rig, high pressure compressor rig, high pressure turbine rig and a low pressure turbine rig. In the near future, all components will be run in a single calculation for a solution of 49 blade rows. The simulation exploits the use of parallel computations by using two levels of parallelism. Each blade row is run in parallel and each blade row grid is decomposed into several domains and run in parallel. 20 processors are used for the 4 blade row analysis. The average passage approach developed by John Adamczyk at NASA Lewis Research Center has been further developed and parallelized. This is APNASA Version A. It is a Navier-Stokes solver using a 4-stage explicit Runge-Kutta time marching scheme with variable time steps and residual smoothing for convergence acceleration. It has an implicit K-E turbulence model which uses an ADI solver to factor the matrix. Between 50 and 100 explicit time steps are solved before a blade row body force is calculated and exchanged with the other blade rows. This outer iteration has been coined a "flip." Efforts have been made to make the solver linearly scaleable with the number of blade rows. Enough flips are run (between 50 and 200) so the solution in the entire machine is not changing. The K-E equations are generally solved every other explicit time step. One of the key requirements in the development of the parallel code was to make the parallel solution exactly (bit for bit) match the serial solution. This has helped isolate many small parallel bugs and guarantee the parallelization was done correctly. The domain decomposition is done only in the axial direction since the number of points axially is much larger than the other two directions. This code uses MPI for message passing. The parallel speed up of the solver portion (no 1/0 or body force calculation) for a grid which has 227 points axially.

Turner, Mark G.↗
NASA NTRS1999

Parallelization of an Object-Oriented Unstructured Aeroacoustics Solver

A computational aeroacoustics code based on the discontinuous Galerkin method is ported to several parallel platforms using MPI. The discontinuous Galerkin method is a compact high-order method that retains its accuracy and robustness on non-smooth unstructured meshes. In its semi-discrete form, the discontinuous Galerkin method can be combined with explicit time marching methods making it well suited to time accurate computations. The compact nature of the discontinuous Galerkin method also makes it well suited for distributed memory parallel platforms. The original serial code was written using an object-oriented approach and was previously optimized for cache-based machines. The port to parallel platforms was achieved simply by treating partition boundaries as a type of boundary condition. Code modifications were minimal because boundary conditions were abstractions in the original program. Scalability results are presented for the SCI Origin, IBM SP2, and clusters of SGI and Sun workstations. Slightly superlinear speedup is achieved on a fixed-size problem on the Origin, due to cache effects.

Baggag, Abdelkader↗
NASA NTRS1999

ADPAC v1.0: User's Manual

The overall objective of this study was to evaluate the effects of turbulence models in a 3-D numerical analysis on the wake prediction capability. The current version of the computer code resulting from this study is referred to as ADPAC v7 (Advanced Ducted Propfan Analysis Codes -Version 7). This report is intended to serve as a computer program user's manual for the ADPAC code used and modified under Task 15 of NASA Contract NAS3-27394. The ADPAC program is based on a flexible multiple-block and discretization scheme permitting coupled 2-D/3-D mesh block solutions with application to a wide variety of geometries. Aerodynamic calculations are based on a four-stage Runge-Kutta time-marching finite volume solution technique with added numerical dissipation. Steady flow predictions are accelerated by a multigrid procedure. Turbulence models now available in the ADPAC code are: a simple mixing-length model, the algebraic Baldwin-Lomax model with user defined coefficients, the one-equation Spalart-Allmaras model, and a two-equation k-R model. The consolidated ADPAC code is capable of executing in either a serial or parallel computing mode from a single source code.

Hall, Edward J.↗
NASA NTRS1999

Communications, Signal Processing, and Telemetering Research Program Review

A Communications, Signal Processing, and Telemetering Research Program Review was held on February 23, 1999. Research conducted under the grant was presented and reviewed, for progress, and for possible technology transfers. The research reviewed was in the following areas: (1) Bandwidth-efficient Modulation and nonlinear equalization; (2) Investigation of an architecture for parallel signal processing applicable to communications problems; (3)Coded partial response over satellites; (4) synchronization at Low SNR; (5) Serial concatenated convolutional codes and some implementation issues on high rate turbo codes; (6) Flight experiments; (7) Real time doppler tracking; (8) Space protocol testing; (9) Lightweight optical communications without carrying a laser in space. The presentations are given by the graduate students who performed the research.

Source record↗
NASA NTRS1998

Prebiotic Polymer Synthesis and the Origin of Glycolytic Metabolism

Our research resulted in several discoveries which contributed to understanding the origin and operation of life. (1) Most importantly, we discovered a new pathway of prebiotic amino acid synthesis in which formaldehyde and glycolaldehyde (formose reaction substrates) react with ammonia to give alanine and homoserine in the presence of thiol catalysts. The thiol-dependent synthesis of amino acids undoubtedly occurs via amino acid thioester intermediates capable of forming peptides. This 'one-pot' reaction system operates under mild aqueous conditions, and like modern amino acid biosynthesis, uses sugar intermediates which are converted to amino acids by energy-yielding redox disproportionation. Preliminary evidence suggests that this type of process can be "evolved" by a serial transfer methods that lead to enrichment of autocatalytic molecules. (2) We established that prebiotic peptide polymers can be made by condensation of amino acid thioesters (homocysteine thiolactone and S-(N-beta-orotidyl- diaminopropionic acid) ethanethiol), and that prebiotic polydisulfide polymers can be generated by oxidation of dithiols with iron(III) in minerals. (3) In our analysis of metabolism we discovered the primary energy source of biosynthesis -- chemical energy made available by the redox disproportionation of substrate carbon groups. We concluded that the energy and reactivity of sugars make them the optimal substrate for the origin and operation of terrestrial (or extraterrestrial) life. (4) Since it is likely that the use of optimal sugar substrates in biosynthesis sets the average oxidation number of functional biocarbon throughout the Universe near 0.0 (the reduction level of formaldehyde), we proposed that a line(s) in the microwave spectrum of formaldehyde could be rationally selected as a frequency for interstellar communication that symbolizes life. (5) Finally, in preparation for the analysis of Martian meteorite samples, we upgraded our HPLC system to one femtomole sensitivity, and developed a new electrophoretic method of sample preparation for HPLC analysis of the meteoritic amino acids. In a sample of the KT boundary layer from Sussex Wyoming, we found about 300 picomoles per gram of meteoritic alpha-aminoisobutyric acid per gram of KT layer.

Weber, Arthur L.↗