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At least 1,297 records · Page 72
All sourcesNASA NTRSDOE OSTI
NASA NTRS2003

A Survey of Logic Formalisms to Support Mishap Analysis

Mishap investigations provide important information about adverse events and near miss incidents. They are intended to help avoid any recurrence of previous failures. Over time, they can also yield statistical information about incident frequencies that helps to detect patterns of failure and can validate risk assessments. However, the increasing complexity of many safety critical systems is posing new challenges for mishap analysis. Similarly, the recognition that many failures have complex, systemic causes has helped to widen the scope of many mishap investigations. These two factors have combined to pose new challenges for the analysis of adverse events. A new generation of formal and semi-formal techniques have been proposed to help investigators address these problems. We introduce the term mishap logics to collectively describe these notations that might be applied to support the analysis of mishaps. The proponents of these notations have argued that they can be used to formally prove that certain events created the necessary and sufficient causes for a mishap to occur. These proofs can be used to reduce the bias that is often perceived to effect the interpretation of adverse events. Others have argued that one cannot use logic formalisms to prove causes in the same way that one might prove propositions or theorems. Such mechanisms cannot accurately capture the wealth of inductive, deductive and statistical forms of inference that investigators must use in their analysis of adverse events. This paper provides an overview of these mishap logics. It also identifies several additional classes of logic that might also be used to support mishap analysis.

Johnson, Chris↗
NASA NTRSDate not supplied

Rational Design of Nanoplasmonic Array Geometries for Biosensing

Background: Molecular diagnostics provide early and accurate diagnosis, which is essential for the prevention and treatment of infectious as well as chronic diseases. These tests are designed to detect disease-specific bioanalytes such as nucleic acid (DNA or RNA) or protein (antigens, antibodies) biomarkers. In the context of infectious disease diagnosis, nucleic acid-based detection methods are known to provide more specific and sensitive results. Here, the presence of a unique sequence belonging to the pathogenic genomic material is targeted to identify species, organism, genera and/or antimicrobial resistant gene markers. The majority of the common nucleic acid based diagnostic techniques require amplification (polymerase chain reaction, isothermal amplification etc.) of the pathogenic genetic material prior to detection impacting diagnostic speed, complexity, and cost thereby limiting ease of use. Thus, the development of simplified nucleic acid-based diagnostics that can be even used in resource-poor settings may hugely benefit patients across the globe. Nanopath is a molecular diagnostics company utilizing a solid-state nanosensor to enable sequence-specific detection of target nucleic acids without the need of amplification. These nanostructures enable ultra-sensitive biomarker detection using geometric, feature-dependent properties highly dependent on the local dielectric environment, allowing them to be sensitive to low concentration binding events. This paper describes an application of this approach to provide highly relevant clinical information within a single doctor’s office visit. Intro: The Nanopath team is in collaboration with NASA (National Aeronautics and Space Administration) and NIST (National Institute of Standards and Technology) to push the bounds of the fundamental physics associated with their biosensing platform. The ability of metals to support electromagnetic surface waves gives rise to surface plasmons when optically illuminated. This property, and its strong sensitivity to changes in the local refractive index, allows for the use of metal nanoparticles as ultra-sensitive transducers. In prior work by members of this team, ensembles of randomly oriented nanoparticles (i.e., colloidal nanorods dispersed on chip) were employed for sequence-specific nucleic acid sensing (1-3). While these particle sensors have the advantage of rapid fabrication, they suffer from low sensitivity and quality factor due to the random particle dispersity. In contrast, in this study we employ ordered array nanoparticle ensembles which can be used to improve sensor sensitivity and figure-of-merit. Study Methods Overview: In this talk, we detail the results of sensing experiments and computational simulations to outline a rational design of the structure of these plasmonic nanoparticle arrays for biomolecular sensing. Through simulation and experiment, we iteratively tailor nanostructure dimension to provide high quality signal and large resonance shifts upon modeled nucleic acid binding. In particular, full-wave electromagnetic simulations were conducted using Lumerical photonic simulation software in which periodic boundary conditions were applied in the x- and y- dimensions for each of the nanoplasmonic sensor geometries. To simulate the resonance response to changes in the bulk solution in contact with the sensor surface, the refractive index of the surrounding media was changed appropriately. Nucleic acid hybridization events were modeled using either using spherical structures approximating the relevant radius of genomic material as estimated by polymer models, or as conformal layers with the known refractive indices for nucleic acids. On the basis of initial simulations, nanosensors were fabricated using traditional electron-beam lithography protocols at NIST. To evaluate consensus between simulations and experiments, bulk sensing experiments were carried out in which the resonance peaks were obtained by submerging the sensors in refractive index standards. Key nanosensor characteristics including resonance peak locations, resonance peak shifts as a function of refractive index, and figure of merit (FOM) of extinction curves were examined between the experimental and simulation results prior to proceeding with simulations on additional geometries and more complex solution conditions, and further device fabrication. This iterative process is repeated toward a rational design of nanoplasmonic array geometries for biosensing optimizing response for targeted disease detection. In summary, this study puts forth a methodology for rational design and characterization of regularly spaced nanoparticle arrays for optics-based biosensing. The results of this study will allow for more informed design of nanostructure geometries towards sequence-specific nucleic acid detection. These improved designs have the potential to improve clinical sensitivity and limit-of-detection across disease indication.

sensor↗
NASA NTRSDate not supplied

Detection of CH 4 Hotspots from NASA’s GEOS Composition Analysis System

Recent research indicates that 8 to 12% of the global oil and gas production methane emissions could be attributed to ultra-emitters, which result in high concentration ‘hotspots’ near point sources. Identifying these emissions in near real time provides useful information to the policy makers and private industry, who are working to reduce their impact. To meet this need, scientists are increasingly analyzing satellite data from the TROPOspheric Monitoring Instrument (TROPOMI) instrument aboard ESA’s Sentinel 5-Precursor mission. While direct analysis of TROPOMI level 2 swath data has been successful in identifying some large emission events, identifying hotpots is challenging because of the imaging noise due to a variety of artifacts and limits in daily coverage. Here we explore possible methodologies to detect methane hotspots using a new, gap-filled, and temporally continuous methane product from NASA’s Goddard Earth Observing System (GEOS) Constituent Data Assimilation System (CoDAS), which assimilates column averaged methane mole fractions from the TROPOMI with capabilities to assimilate other remote sensing measurements. The CoDAS has been expanded from a heritage of stratospheric composition and carbon dioxide assimilation allowing for the support of regional modeling, validation with non-coincident operations, and merging variety of datasets. The current work mainly explores Observing System Simulation Experiments with methane GEOS simulations without assimilation to prepare the groundwork for further experiments with assimilated TROPOMI. First, known hotspots based on the known inventory are identified to demonstrate the capability of the system to point out emission hotspots. In the next step, a variety of machine learning techniques such as Self-Organizing Maps and Deep Learning are explored to automate detection of the plumes. Finally, a few approaches to quantify emissions from the identified hotspots are presented and are evaluated against the inventory. The effort is directed toward a future evaluation of the CoDAS based methane monitoring system’s ability to successfully detect and quantify hotspots.

Nikolay Balashov↗
NASA NTRS1980

Impact of Saturn ring particles on Pioneer 11

The detection of particles near the rings of Saturn by the meteoroid detection instrument on board Pioneer 11 is discussed. The instrument consists of 234 penetration detectors, distributed between two independent data channels each of which is designed to become inhibited for a period of 77 min after the registration of a penetration event in that channel. At least four particles penetrated the detectors in the 4.5 h period around Saturn periapsis at radial distances between 1.36 and 3.1 Saturn radii, a radial distribution inconsistent with the gravitational focusing of meteoroids. The detection of particles which may have been part of the E ring before the crossing of the ring plane suggests that this ring may be 1800 km thick, with an optical thickness greater than 10 to the -8th.

Humes, D. H.↗
NASA NTRS1996

Expression of spicule matrix protein gene SM30 in embryonic and adult mineralized tissues of sea urchin Hemicentrotus pulcherrimus

We have isolated a cDNA clone for spicule matrix protein, SM30, from sea urchin Hemicentrotus pulcherrimus and have studied the expression of this gene in comparison with that of another spicule matrix protein gene, SM50. In cultured micromeres as well as in intact embryos transcripts of SM30 were first detectable around the onset of spicule formation and rapidly increased with the growth of spicules, which accompanied accumulation of glycosylated SM30 protein(s). When micromeres were cultured in the presence of Zn2+, spicule formation and SM30 expression were suppressed, while both events resumed concurrently after the removal of Zn2+ from the culture medium. Expression of SM50, in contrast, started before the appearance of spicules and was not sensitive to Zn2+. Differences were also observed in adult tissues; SM30 mRNA was detected in spines and tube feet but not in the test, while SM50 mRNA was apparent in all of these mineralized tissues at similar levels. These results strongly suggest that the SM30 gene is regulated by a different mechanism to that of the SM50 gene and that the products of these two genes are differently involved in sea urchin biomineralization. A possible role of SM30 protein in skeleton formation is discussed.

NASA Discipline Musculoskeletal↗
NASA NTRS1974

Instantaneous distortion in a Mach 2.5, 40-percent-internal-contraction inlet and its effect on turbojet stall margin

An experimental wind tunnel investigation was conducted to determine the effects of time-variant distortions produced in a supersonic inlet on a J85-GE-13 turbojet engine. Results are presented principally in terms of instantaneous distortion amplitudes and total-pressure contours measured through compressor stall. They indicate that, although a time-averaged distortion may be far from a stall-inducing value, corresponding instantaneous distortion amplitudes can approach or exceed this value. Seven engine stall events were studied. In six of these events instantaneous distortion peaks of sufficient magnitude to cause stall were observed in the time period shortly before stall was detected.

Burstadt, P. L.↗
NASA NTRS1985

Beyond the sterile cockpit

Consideration is given to some of the negative aspects of the trend toward increased automation of aircraft flight decks. The history of automated devices for navigation, communications and detection on board aircraft is reviewed. Instances of automatic system failure are identified which have led to accidents, and the events surrounding the downing of Korean Airlines Flight 747 are reexamined within the context of a computer-based system failure. Finally, new software and interactive systems to reduce navigational error due to inadequate computer-assisted flight instruction (CAI) are described, with emphasis given to speech processing and intelligent CAI systems.

Wiener, E. L.↗
NASA NTRS1986

Interiors of the giant planets

The interior structure of the Jovian planets was studied by means of observational data obtained by ground-based astronomy. Recent work was oriented toward a determination of oblateness from occultation measurements of the shape of planetary atmospheres. This provides a determination of the degree of central condensation of the planet, which is then compared with interior models and theoretical equations of state. As a serendipitous result of the attempts to measure the oblateness of Neptune, a partial Neptune ring (or arc) was discovered following an occultation observation on July 22, 1984. During 1985, older observations were reexamined to determine whether Neptune arcs had been detected (but not identified) during previous occultations. It appears that Neptunian arcs may locally imitate Uranian rings, with an 1981 event resembling Uranus' epsilon ring, while an 1984 event was more similar to the thinner Uranian rings such as the alpha ring.

Hubbard, W. B.↗
NASA NTRS1986

Gamma-ray bursters at cosmological distances

It is proposed that some, perhaps most, gamma-ray bursters are at cosmological distances, like quasars, with a redshift of about 1 or 2. This proposition requires a release of supernova-like energy of about 10 to the 51st ergs within less than 1 s, making gamma-ray bursters the brightest objects known in the universe, many orders of magnitude brighter than any quasars. This power must drive a highly relativistic outflow of electron-positron plasma and radiation from the source. It is proposed that three gamma-ray bursts, all with identical spectra, detected from B1900 + 14 by Mazets, Golenetskii, and Gur'yan and reported in 1979, were all due to a single event multiply imaged by a gravitational lens. The time intervals between the successive bursts, 10 hr to 3 days, were due to differences in the light travel time for different images.

Paczynski, B.↗
NASA NTRS1987

Conditionally-averaged structures in wall-bounded turbulent flows

The quadrant-splitting and the wall-shear detection techniques were used to obtain ensemble-averaged wall layer structures. The two techniques give similar results for Q4 events, but the wall-shear method leads to smearing of Q2 events. Events were found to maintain their identity for very long times. The ensemble-averaged structures scale with outer variables. Turbulence producing events were associated with one dominant vortical structure rather than a pair of counter-rotating structures. An asymmetry-preserving averaging scheme was devised that allowed a picture of the average structure which more closely resembles the instantaneous one, to be obtained.

Guezennec, Yann G.↗
NASA NTRS1989

A relationship between peak temperature drop and velocity differential in a microburst

Results from numerical microburst simulations using the Terminal Area Simulation System (Proctor, 1987) are used to develop a relationship between wind velocity differential and peak temperature drop. The numerical model and the relationships derived from the model are described. The relationship between peak temperature drop and differential wind velocity is shown to be valid during microburst development, for all precipitation shaft intensities and diameters. It is found that the relationship is not valid for low-reflectivity microburst events or in the presence of ground-based stable layers. The use of the relationship in IR wind shear detection systems is considered.

Proctor, Fred H.↗
NASA NTRS1992

Implementation of an intelligent control system

A laboratory testbed facility which was constructed at NASA LeRC for the development of an Intelligent Control System (ICS) for reusable rocket engines is described. The framework of the ICS consists of a hierarchy of various control and diagnostic functions. The traditional high speed, closed-loop controller resides at the lowest level of the ICS hierarchy. Above this level resides the diagnostic functions which identify engine faults. The ICS top level consists of the coordination function which manages the interaction between an expert system and a traditional control system. The purpose of the testbed is to demonstrate the feasibility of the OCS concept by implementing the ICS as the primary controller in a simulation of the Space Shuttle Main Engine (SSME). The functions of the ICS which are implemented in the testbed are as follows: an SSME dynamic simulation with selected fault mode models, a reconfigurable controller, a neural network for sensor validation, a model-based failure detection algorithm, a rule based failure detection algorithm, a diagnostic expert system, an intelligent coordinator, and a user interface which provides a graphical representation of the event occurring within the testbed. The diverse nature of the ICS has led to the development of a distributed architecture consisting of specialized hardware and software for the implementation of the various functions. This testbed is made up of five different computer systems. These individual computers are discussed along with the schemes used to implement the various ICS components. The communication between computers and the timing and synchronization between components are also addressed.

Simon, D. L.↗
NASA NTRS1993

Recurrent burst activity from the soft gamma-ray repeater SGR 1900 + 14

Three short very soft gamma-ray (SGR) transient events from a location consistent with that of the SGR 1900 + 14, first described by Mazets et al. (1979), were detected by the Burst and Transient Source Experiment. The results of observations of the temporal and spectral properties of the SGR 1900 + 14 suggest that the SGR phase lasts at least 13 years, lending support to the suggestion by Kouveliotou et al. (1987) and Fishman et al. (1989) that SGRs are related to galactic (possibly population I) objects, perhaps neutron stars.

Kouveliotou, C.↗
NASA NTRS1998

The Locations of Gamma-Ray Bursts Measured by Comptel

The COMPTEL instrument on the Compton Gamma Ray Observatory is used to measure the locations of gamma-ray bursts through direct imaging of MeV photons. In a comprehensive search, we have detected and localized 29 bursts observed between 1991 April 19 and 1995 May 31. The average location accuracy of these events is 1.25 deg (1 sigma), including a systematic error of approx. 0.5 deg, which is verified through comparison with Interplanetary Network (IPN) timing annuli. The combination of COMPTEL and IPN measurements results in locations for 26 of the bursts with an average "error box" area of only approx. 0.3 deg (1 sigma). We find that the angular distribution of COMPTEL burst locations is consistent with large-scale isotropy and that there is no statistically significant evidence of small-angle autocorrelations. We conclude that there is no compelling evidence for burst repetition since no more than two of the events (or approx. 7% of the 29 bursts) could possibly have come from the same source. We also find that there is no significant correlation between the burst locations and either Abell clusters of galaxies or radio-quiet quasars. Agreement between individual COMPTEL locations and IPN annuli places a lower limit of approx. 100 AU (95% confidence) on the distance to the stronger bursts.

Kippen, R. Marc↗
NASA NTRS1999

Immunocytochemical localization of latent transforming growth factor-beta1 activation by stimulated macrophages

Transforming growth factor-beta1 (TGF-beta) is secreted in a latent form consisting of mature TGF-beta noncovalently associated with its amino-terminal propeptide, which is called latency associated peptide (LAP). Biological activity depends upon the release of TGF-beta from the latent complex following extracellular activation, which appears to be the key regulatory mechanism controlling TGF-beta action. We have identified two events associated with latent TGF-beta (LTGF-beta) activation in vivo: increased immunoreactivity of certain antibodies that specifically detect TGF-beta concomitant with decreased immunoreactivity of antibodies to LAP. Macrophages stimulated in vitro with interferon-gamma and lipopolysaccharide reportedly activate LTGF-beta via cell membrane-bound protease activity. We show through dual immunostaining of paraformaldehyde-fixed macrophages that such physiological TGF-beta activation is accompanied by a loss of LAP immunoreactivity with concomitant revelation of TGF-beta epitopes. The induction of TGF-beta immunoreactivity colocalized with immunoreactive betaglycan/RIII in activated macrophages, suggesting that LTGF-beta activation occurs on the cell surface. Confocal microscopy of metabolically active macrophages incubated with antibodies to TGF-beta and betaglycan/RIII prior to fixation supported the localization of activation to the cell surface. The ability to specifically detect and localize LTGF-beta activation provides an important tool for studies of its regulation.

NASA Discipline Radiation Health↗
NASA NTRS2010

NASA Tech Briefs, September 2010

Topics covered include: Instrument for Measuring Thermal Conductivity of Materials at Low Temperatures; Multi-Axis Accelerometer Calibration System; Pupil Alignment Measuring Technique and Alignment Reference for Instruments or Optical Systems; Autonomous System for Monitoring the Integrity of Composite Fan Housings; A Safe, Self-Calibrating, Wireless System for Measuring Volume of Any Fuel at Non-Horizontal Orientation; Adaptation of the Camera Link Interface for Flight-Instrument Applications; High-Performance CCSDS Encapsulation Service Implementation in FPGA; High-Performance CCSDS AOS Protocol Implementation in FPGA; Advanced Flip Chips in Extreme Temperature Environments; Diffuse-Illumination Systems for Growing Plants; Microwave Plasma Hydrogen Recovery System; Producing Hydrogen by Plasma Pyrolysis of Methane; Self-Deployable Membrane Structures; Reactivation of a Tin-Oxide-Containing Catalys; Functionalization of Single-Wall Carbon Nanotubes by Photo-Oxidation; Miniature Piezoelectric Macro-Mass Balance; Acoustic Liner for Turbomachinery Applications; Metering Gas Strut for Separating Rocket Stages; Large-Flow-Area Flow-Selective Liquid/Gas Separator; Counterflowing Jet Subsystem Design; Water Tank with Capillary Air/Liquid Separation; True Shear Parallel Plate Viscometer; Focusing Diffraction Grating Element with Aberration Control; Universal Millimeter-Wave Radar Front End; Mode Selection for a Single-Frequency Fiber Laser; Qualification and Selection of Flight Diode Lasers for Space Applications; Plenoptic Imager for Automated Surface Navigation; Maglev Facility for Simulating Variable Gravity; Hybrid AlGaN-SiC Avalanche Photodiode for Deep-UV Photon Detection; High-Speed Operation of Interband Cascade Lasers; 3D GeoWall Analysis System for Shuttle External Tank Foreign Object Debris Events; Charge-Spot Model for Electrostatic Forces in Simulation of Fine Particulates; Hidden Statistics Approach to Quantum Simulations; Reconstituted Three-Dimensional Interactive Imaging; Determining Atmospheric-Density Profile of Titan; Digital Microfluidics Sample Analyzer; Radiation Protection Using Carbon Nanotube Derivatives; Process to Selectively Distinguish Viable from Non-Viable Bacterial Cells; and TEAMS Model Analyzer.

Source record↗
NASA NTRS2021

A Large Fraction of Hydrogen-rich Supernova Progenitors Experience Elevated Mass Loss Shortly Prior to Explosion

Spectroscopic detection of narrow emission lines traces the presence of circumstellar mass distributions around massive stars exploding as core-collapse supernovae. Transient emission lines disappearing shortly after the supernova explosion suggest that the material spatial extent is compact and implies an increased mass loss shortly prior to explosion. Here, we present a systematic survey for such transient emission lines (Flash Spectroscopy) among Type II supernovae detected in the first year of the Zwicky Transient Facility survey. We find that at least six out of ten events for which a spectrum was obtained within two days of the estimated explosion time show evidence for such transient flash lines. Our measured flash event fraction (>30% at 95% confidence level) indicates that elevated mass loss is a common process occurring in massive stars that are about to explode as supernovae.

Rachel J. Bruch↗