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The presentation outlines the results of the preliminary design activities undertaken to support the Molten salt Reactor Temperature-controlled Irradiation vehicle and its initial irradiation.
The overall objectives of this project were (1) to develop methods for the production and separation of a diagnostic and therapeutic or “theranostic” pair of radioisotopes, terbium-155 ( 155 Tb) and terbium-161 ( 161 Tb) and (2) to train graduate students and postdoctoral fellows in technologies and methods used in radionuclide production. Radionuclides can be incorporated into drugs called radiopharmaceuticals that target a specific disease (e.g., cancer). The need for theranostic radionuclides is escalating with the clinical translation of radiopharmaceuticals due to their implementation in personalized medicine, which has demonstrated enhanced patient treatments. High purity and high specific activity radionuclides are critical for theranostic agent development, for example to maintain diagnostic image quality, to minimize radiation dose to the patient, and to increase uptake in the targeted tissue (e.g., tumor), especially in the case of receptor- and antigen-targeted agents. The 155 Tb (diagnostic) and 161 Tb (therapeutic) radioisotopes that were generated through this project are a theranostic pair with demonstrated potential for the development and translation into individualized, targeted, and dosimetry-driven radiotherapies. However, the development of such radiotherapies has been hindered by the lack of a routine and reliable supply of these isotopes in the United States. Methods for the production, separation, and supply of 155 Tb and 161 Tb were investigated and developed in this project. Further, the strong emphasis throughout the project on the training of graduate students and postdoctoral fellows has helped to ensure and enhance the nuclear science workforce through the training of the next generation of highly qualified scientists in nuclear and radiochemistry. This grant also continued a collaboration between scientists at the University of Washington (UW), the University of Missouri (MU) and Brookhaven National Laboratory (BNL). All three institutions were involved in the project, but to different degrees on the various tasks through which the overall objectives were met.
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The research effort was continued to design and characterize superconducting transmission line structures. The research during this period was concentrated on the implementation of a superconductor into coplanar waveguide structures. First, the superconducting coplanar waveguide was examined, and compared with a superconducting microstrip line in terms of loss characteristics and their design aspects. Then, the research was carried on the design and characterization of the coplanar waveguide family in the packaging environment. The transition between the coaxial line to the conductor backed coplanar waveguide was also designed for the measurement of the superconducting conductor backed coplanar waveguide.
State-of-the-art visual analytics models and frameworks mostly assume a static snapshot of the data, while in many cases it is a stream with constant updates and changes. Exploration of streaming data poses unique challenges as machine-level computations and abstractions need to be synchronized with the visual representation of the data and the temporally evolving human insights. In the visual analytics literature, we lack a thorough characterization of streaming data and analysis of the challenges associated with task abstraction, visualization design, and adaptation of the role of human-in-the-loop for exploration of data streams. We aim to fill this gap by conducting a survey of the state-of-the-art in visual analytics of streaming data for systematically describing the contributions and shortcomings of current techniques and analyzing the research gaps that need to be addressed in the future. Our contributions are: i) problem characterization for identifying challenges that are unique to streaming data analysis tasks, ii) a survey and analysis of the state-of-the-art in streaming data visualization research with a focus on the visualization design space for dynamic data and the role of the human-in-the-loop, and iii) reflections on the design-trade-offs for streaming visual analytics techniques and their practical applicability in real-world application scenarios.
This research project was designed to fill a critical void in our understanding of the state of energy research and innovation in China. It seeks to provide a comprehensive review and accounting of the various elements of the Chinese government and non-governmental sectors (commercial, university, research institutes) that are engaged in energy-related R&D and various aspects of energy innovation, including specific programs and projects designed to promote renewable energy innovation and energy conservation. The project provides an interrelated descriptive, statistical, and econometric account of China's overall energy innovation activities and capabilities, spanning the full economy with a particular focus on the dynamic industrial sector.
This University Engagement project challenged engineering students at universities, that do not have Bachelor degrees in nuclear engineering but do have research reactors and some nuclear engineering coursework, to incorporate Safeguards by Design concepts into their Senior Capstone Design Project. This University Engagement project was part of the U. S. Department of Energy’s (DOE) National Nuclear Security Administration (NNSA), Office of Defense Nuclear Nonproliferation, Office of International Nuclear Safeguards, Next Generation Safeguards Initiative, Human Capital Development: University Engagement Program. This program exposed university students with Mechanical Engineering majors and Nuclear Engineering minors to the concepts of international nuclear safeguards. FY20, three teams at the University of Rhode Island and one team at the University of Texas - Austin participated in researching, designing, building, and testing projects to support international nuclear safeguards measurements or verification. The projects involved engaging in activities at the university’s research reactors. All the projects engaged students with prototyping a design and/or tool for application at the Universities’ reactor. At the end of the course, most of the students expressed the experience was a positive and they learned more about international nuclear safeguards and applying requirements than they had previously encountered. This school year the projects were further complicated by the COVID-19 pandemic. Both universities cancelled in class room classes, and limited direct student/professor interactions. Furthermore, Los Alamos National Laboratory (LANL) greatly restricted travel, therefore making it impossible to visit the students at the end of the semester for the review of their design projects. The final design and review meeting for the projects happened via the internet. Additionally, while the teams planned to build prototypes this did not happen since there was a social distancing ban on students meeting in person.
The Sikorsky Aircraft division of United Aircraft Corporation is constructing two uniquely designed Rotor Systems Research Aircraft (RSRA). These aircraft will be used through the 1980's to comparatively test many different types of rotors - articulated, hingeless, teetering, and gimballed, as well as advanced rotor concepts, such as reverse velocity and variable diameter rotors. The RSRA combines a new airframe with existing Sikorsky H-3 (S-61) dynamic components. A force measurement system is incorporated to permit accurate evaluation of significant rotor characteristics. Both rotor and fixed-wing control systems are provided, appropriately integrated for operation in the pure helicopter mode, compound helicopter mode, and fixed-wing mode. The RSRA is the first rotary wing aircraft designed with a crew escape system, including a pyrotechnic system to sever the main rotor blades.
A survey of the effect of environmental surface winds and gusts on aircraft design and operation is presented. A listing of the very large number of problems that are encountered is given. Attention is called to the many studies that have been made on surface winds and gusts, but development in the engineering application of these results to aeronautical problems is pointed out to be still in the embryonic stage. Control of the aircraft is of paramount concern. Mathematical models and their application in simulation studies of airplane operation and control are discussed, and an attempt is made to identify their main gaps or deficiencies. Key reference material is cited. The need for better exchange between the meteorologist and the aeronautical engineer is discussed. Suggestions for improvements in the wind and gust models are made.
A rapid and simple inviscid technique for designing forebodies which produce uniformly precompressed flows at the entrance for bottom-mounted scramjets was developed so that geometric constraints resulting from design trade-offs can be effectively evaluated. The flow fields resulting from several forebody designs generated in support of a conceptual design for a hypersonic research airplane have been analyzed in detail. Three-dimensional characteristics calculations were used to verify the uniform flow conditions. For the designs analyzed, uniform flow was maintained over a wide range of flight conditions (Mach numbers from 4 to 10; angles of attack of 6 and 10 deg) corresponding to the scramjet operation flight envelope of the research airplane.
A predominant research focus in the free flight community has been on the type of information required on the flight deck to enable pilots to "autonomously" maintain separation from other aircraft. At issue are the relative utility and requirement for information exchange between aircraft regarding the current "state" and/or the "intent" of each aircraft. This paper presents the experimental design and some initial findings of an experimental research study designed to provide insight into the issue of intent information exchange in constrained en-route operations and its effect on pilot decision making and flight performance. Two operational modes for autonomous operations were compared in a piloted simulation. The tactical mode was characterized primarily by the use of state information for conflict detection and resolution and an open-loop means for the pilot to meet operational constraints. The strategic mode involved the combined use of state and intent information, provided the pilot an additional level of alerting, and allowed a closed-loop approach to meeting operational constraints. Potential operational benefits of both modes are illustrated through several scenario case studies. Subjective data results are presented that generally indicate pilot consensus in favor of the strategic mode.
The primary objective of the three year research effort was to explore advanced, non-deterministic aerospace system design methods that may have relevance to designers and analysts. The research pursued emerging areas in design methodology and leverage current fundamental research in the area of design decision-making, probabilistic modeling, and optimization. The specific focus of the three year investigation was oriented toward methods to identify and analyze emerging aircraft technologies in a consistent and complete manner, and to explore means to make optimal decisions based on this knowledge in a probabilistic environment. The research efforts were classified into two main areas. First, Task A of the grant has had the objective of conducting research into the relative merits of possible approaches that account for both multiple criteria and uncertainty in design decision-making. In particular, in the final year of research, the focus was on the comparison and contrasting between three methods researched. Specifically, these three are the Joint Probabilistic Decision-Making (JPDM) technique, Physical Programming, and Dempster-Shafer (D-S) theory. The next element of the research, as contained in Task B, was focused upon exploration of the Technology Identification, Evaluation, and Selection (TIES) methodology developed at ASDL, especially with regards to identification of research needs in the baseline method through implementation exercises. The end result of Task B was the documentation of the evolution of the method with time and a technology transfer to the sponsor regarding the method, such that an initial capability for execution could be obtained by the sponsor. Specifically, the results of year 3 efforts were the creation of a detailed tutorial for implementing the TIES method. Within the tutorial package, templates and detailed examples were created for learning and understanding the details of each step. For both research tasks, sample files and tutorials are attached in electronic form with the enclosed CD.
The primary objective of the three year research effort was to explore advanced, non-deterministic aerospace system design methods that may have relevance to designers and analysts. The research pursued emerging areas in design methodology and leverage current fundamental research in the area of design decision-making, probabilistic modeling, and optimization. The specific focus of the three year investigation was oriented toward methods to identify and analyze emerging aircraft technologies in a consistent and complete manner, and to explore means to make optimal decisions based on this knowledge in a probabilistic environment. The research efforts were classified into two main areas. First, Task A of the grant has had the objective of conducting research into the relative merits of possible approaches that account for both multiple criteria and uncertainty in design decision-making. In particular, in the final year of research, the focus was on the comparison and contrasting between three methods researched. Specifically, these three are the Joint Probabilistic Decision-Making (JPDM) technique, Physical Programming, and Dempster-Shafer (D-S) theory. The next element of the research, as contained in Task B, was focused upon exploration of the Technology Identification, Evaluation, and Selection (TIES) methodology developed at ASDL, especially with regards to identification of research needs in the baseline method through implementation exercises. The end result of Task B was the documentation of the evolution of the method with time and a technology transfer to the sponsor regarding the method, such that an initial capability for execution could be obtained by the sponsor. Specifically, the results of year 3 efforts were the creation of a detailed tutorial for implementing the TIES method. Within the tutorial package, templates and detailed examples were created for learning and understanding the details of each step. For both research tasks, sample files and tutorials are attached in electronic form with the enclosed CD.
A research study on the topology design and performance analysis for the Space Station Information System (SSIS) network is conducted. It is begun with a survey of existing research efforts in network topology design. Then a new approach for topology design is presented. It uses an efficient algorithm to generate candidate network designs (consisting of subsets of the set of all network components) in increasing order of their total costs, and checks each design to see if it forms an acceptable network. This technique gives the true cost-optimal network, and is particularly useful when the network has many constraints and not too many components. The algorithm for generating subsets is described in detail, and various aspects of the overall design procedure are discussed. Two more efficient versions of this algorithm (applicable in specific situations) are also given. Next, two important aspects of network performance analysis: network reliability and message delays are discussed. A new model is introduced to study the reliability of a network with dependent failures. For message delays, a collection of formulas from existing research results is given to compute or estimate the delays of messages in a communication network without making the independence assumption. The design algorithm coded in PASCAL is included as an appendix.
The program to design and build a Buffalo/Spey Augmentor-Wing research aircraft is presented. The development of an internally blown flap system for the generation of powered lift is discussed. Modification, development, and testing of the Rolls-Royce Spey engine are reported. The ground tests and first flights of the aircraft are described and the application of the internally blown flap concept for short takeoff military transport aircraft is proposed.
Research was carried out on existing and new designs for minimally intrusive measurement of flow fields in the Geophysical Fluid Flow Cell and the proposed Atmospheric General Circulation Experiment. The following topics are discussed: (1) identification and removal of foreign particles, (2) search for higher dielectric photochromic solutions, (3) selection of uv light source, (4) analysis of refractive techniques and (5) examination of fresnel lens applicability.
The model grass Brachypodium distachyon (Brachypodium) is an excellent system for studying the basic biology underlying traits relevant to the use of grasses as food, forage and energy crops. To add to the growing collection of Brachypodium resources available to plant scientists, we further optimized our Agrobacterium tumefaciens-mediated high-efficiency transformation method and generated 8,491 Brachypodium T-DNA lines. We used inverse PCR to sequence the DNA flanking the insertion sites in the mutants. Using these flanking sequence tags (FSTs) we were able to assign 7,389 FSTs from 4,402 T-DNA mutants to 5,285 specific insertion sites (ISs) in the Brachypodium genome. More than 29% of the assigned ISs are supported by multiple FSTs. T-DNA insertions span the entire genome with an average of 19.3 insertions/Mb. The distribution of T-DNA insertions is non-uniform with a larger number of insertions at the distal ends compared to the centromeric regions of the chromosomes. Insertions are correlated with genic regions, but are biased toward UTRs and non-coding regions within 1 kb of genes over exons and intron regions. More than 1,300 unique genes have been tagged in this population. Information about the Western Regional Research Center Brachypodium insertional mutant population is available on a searchable website (http://brachypodium.pw.usda.gov) designed to provide researchers with a means to order T-DNA lines with mutations in genes of interest.
The Mechanisms Engineering Test Loop (METL) was built to streamline and accelerate the in-sodium testing of systems and components under conditions that simulate a sodium-cooled fast reactor pool environment. The METL team at Argonne National Laboratory (ANL) can assist experimenters in achieving their technical goals by providing liquid-metal expertise and access to infrastructure required for most alkali metal related research. This document offers a brief overview of METL and provides a basic design guide for researchers interested in conducting research at the facility. Additional information regarding the history and operations of METL can be found in §6.1. Furthermore, high resolution images found in this document as well as CAD files of aforementioned vessels can be provided upon request.