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At least 1,297 records · Page 72

Relaxation oscillations and hierarchy of feedbacks in MAPK signaling

We formulated a computational model for a MAPK signaling cascade downstream of the EGF receptor to investigate how interlinked positive and negative feedback loops process EGF signals into ERK pulses of constant amplitude but dose-dependent duration and frequency. A positive feedback loop involving RAS and SOS, which leads to bistability and allows for switch-like responses to inputs, is nested within a negative feedback loop that encompasses RAS and RAF, MEK, and ERK that inhibits SOS via phosphorylation. This negative feedback, operating on a longer time scale, changes switch-like behavior into oscillations having a period of 1hour or longer. Two auxiliary negative feedback loops, from ERK to MEK and RAF, placed downstream of the positive feedback, shape the temporal ERK activity profile but are dispensable for oscillations. Thus, the positive feedback introduces a hierarchy among negative feedback loops, such that the effect of a negative feedback depends on its position with respect to the positive feedback loop. Furthermore, a combination of the fast positive feedback involving slow-diffusing membrane components with slower negative feedbacks involving faster diffusing cytoplasmic components leads to local excitation/global inhibition dynamics, which allows the MAPK cascade to transmit paracrine EGF signals into spatially non-uniform ERK activity pulses.

59 BASIC BIOLOGICAL SCIENCES↗

Multiple crossovers between positive and negative magnetoresistance versus field due to fragile spin structure in metallic GdPd 3 [Oscillating magnetoresistance due to fragile spin structure in metallic GdPd 3 ]

Here, studies on the phenomenon of magnetoresistance (MR) have produced intriguing and application-oriented outcomes for decades–colossal MR, giant MR and recently discovered extremely large MR of millions of percents in semimetals can be taken as examples. We report here the discovery of novel multiple sign changes versus applied magnetic field of the MR in the cubic intermetallic compound GdPd 3 . Our study shows that a very strong correlation between magnetic, electrical and magnetotransport properties is present in this compound. The magnetic structure in GdPd 3 is highly fragile since applied magnetic fields of moderate strength significantly alter the spin arrangement within the system–a behavior that manifests itself in the oscillating MR. Intriguing magnetotransport characteristics of GdPd 3 are appealing for field-sensitive device applications, especially if the MR oscillation could materialize at higher temperature by manipulating the magnetic interaction through perturbations caused by chemical substitutions.

36 MATERIALS SCIENCE↗

The frequency-dependent response of single aerosol particles to vapour phase oscillations and its application in measuring diffusion coefficients

A new method for measuring diffusion in the condensed phase of single aerosol particles is proposed and demonstrated. The technique is based on the frequency-dependent response of a binary particle to oscillations in the vapour phase of one of its chemical components. Here, we discuss how this physical situation allows for what would typically be a non-linear boundary value problem to be approximately reduced to a linear boundary value problem. For the case of aqueous aerosol particles, we investigate the accuracy of the closed-form analytical solution to this linear problem through a comparison with the numerical solution of the full problem. Then, using experimentally measured whispering gallery modes to track the frequency-dependent response of aqueous particles to relative humidity oscillations, we determine diffusion coefficients as a function of water activity. The measured diffusion coefficients are compared to previously reported values found using the two common experiments: (i) the analysis of the sorption/desorption of water from a particle after a step-wise change to the surrounding relative humidity and (ii) the isotopic exchange of water between a particle and the vapour phase. The technique presented here has two main strengths: first, when compared to the sorption/desorption experiment, it does not require the numerical evaluation of a boundary value problem during the fitting process as a closed-form expression is available. Second, when compared to the isotope exchange experiment, it does not require the use of labeled molecules. Therefore, the frequency-dependent experiment retains the advantages of these two commonly used methods but does not suffer from their drawbacks.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Baryon acoustic oscillations at z = 2.34 from the correlations of Ly α absorption in eBOSS DR14

We measure the imprint of primordial baryon acoustic oscillations (BAOs) in the correlation function of Ly α absorption in quasar spectra from the Baryon Oscillation Spectroscopic Survey (BOSS) and the extended BOSS (eBOSS) in Data Release 14 (DR14) of the Sloan Digital Sky Survey (SDSS)-IV. In addition to 179 965 spectra with absorption in the Lyman- α (Ly α ) region, we use Ly α absorption in the Lyman- β region of 56 154 spectra for the first time. We measure the Hubble distance, D H , and the comoving angular diameter distance, D M , relative to the sound horizon at the drag epoch r d at an effective redshift z = 2.34. Using a physical model of the correlation function outside the BAO peak, we find D H (2.34)/ r d = 8.86 ± 0.29 and D M (2.34)/ r d = 37.41 ± 1.86, within 1 σ from the flat-ΛCDM model consistent with CMB anisotropy measurements. With the addition of polynomial “broadband” terms, the results remain within one standard deviation of the CMB-inspired model. Combined with the quasar-Ly α cross-correlation measurement presented in a companion paper, the BAO measurements at z = 2.35 are within 1.7 σ of the predictions of this model.

79 ASTRONOMY AND ASTROPHYSICS↗

Baryon acoustic oscillations from the cross-correlation of Ly α absorption and quasars in eBOSS DR14

We present a measurement of the baryon acoustic oscillation (BAO) scale at redshift z =2.35 from the three-dimensional correlation of Lyman- α (Ly α ) forest absorption and quasars. The study uses 266 590 quasars in the redshift range 1.77< z < 3.5 from the Sloan Digital Sky Survey (SDSS) Data Release 14 (DR14). The sample includes the first two years of observations by the SDSS-IV extended Baryon Oscillation Spectroscopic Survey (eBOSS), providing new quasars and re-observations of BOSS quasars for improved statistical precision. Statistics are further improved by including Ly α absorption occurring in the Ly β wavelength band of the spectra. From the measured BAO peak position along and across the line of sight, we determined the Hubble distance D H and the comoving angular diameter distance D M relative to the sound horizon at the drag epoch r d : D H ( z =2.35)/ r d =9.20 ± 0.36 and D M ( z =2.35)/ r d =36.3±1.8. These results are consistent at 1.5 σ with the prediction of the best-fit spatially-flat cosmological model with the cosmological constant reported for the Planck (2016) analysis of cosmic microwave background anisotropies. Combined with the Ly α auto-correlation measurement presented in a companion paper, the BAO measurements at z =2.34 are within 1.7 σ of the predictions of this model.

79 ASTRONOMY AND ASTROPHYSICS↗

Implementation of Feldman-Cousins Corrections and Oscillation Calculations in the HPC Environment for the NOvA Experiment

Analysis of neutrino oscillation data involves a combination of complex fitting procedures and statistical correction techniques that are used to determine the full three-flavor PMNS parameters and constraint contours. These techniques rely on computationally intensive “multi-universe” stochastic modeling. The process of calculating these contours and corrections can dominate final stages of the data analysis and become a bottleneck for examining the ef-fect of systematic variations on the final results. As part of the DOE SciDAC-4 sponsored research program, we present a new implementation of a neutrino oscillation fitting and framework to carry out calculations of Feldman-Cousins corrections. This implementation is specifically designed and optimized to operate on modern High-Performance Computing (HPC) facilities. We present the performance of the system in calculating allowed regions for the NOvA experiment based on 8.9 x 1020 and 6.9 x 1020 protons-on-target (POT) neutrino and antineutrino datasets, and compare the performance of this new implementation run at the NERSC supercomputing facility with that from methods used previously by the NOvA collaboration running on grid computing facilities.

Sousa, Alexandre↗

A model combustor for studying a reacting jet in an oscillating crossflow

This paper discusses a novel model combustion experiment that was built for studying the structure and dynamics of a reacting jet in an unsteady crossflow. A natural-gas-fired dump combustor is used to generate and sustain an acoustically oscillating vitiated flow that serves as the crossflow for transverse jet injection. Unlike most other techniques that are limited in operating pressure or acoustic amplitude, this method of generating an unsteady flow field is demonstrated at a pressure of 10 atm with peak-to-peak oscillation amplitudes approaching 20% of the mean pressure. An optically accessible test section designed for these conditions provides access for advanced laser and optical diagnostic measurements. Detailed measurements provide insight into the complex acoustic-hydrodynamic-combustion coupling processes and offer high-quality, high-resolution validation data for numerical simulations. Careful instrumentation port design considerations for the higher amplitude acoustics are detailed. As a whole, this paper focuses on select representative segments of the experiment operational space that highlight our strategy of providing an oscillatory flowfield. This includes presenting the acoustic operational space such as acoustic amplitudes, frequencies, and mode shapes. Select imaging results are then reported to support our strategies capability to produce high-fidelity measurements.

47 OTHER INSTRUMENTATION↗

High-speed feedback control of an oscillating magnetic helicity injector using a graphics processing unit

A real-time control system has been developed to control the amplitude, phase, and offset of bulk plasma parameters inside an oscillating magnetic helicity injector. Control software running entirely on an Nvidia Tesla P40 graphical processing unit is able to receive digitizer inputs and send response patterns to a Pulse Width Modulation (PWM) controller with a minimum control loop period of 12.8μs. With an input digitization rate of 10 MS/s, a three-parameter proportional integral differential controller is shown to be sufficient to inform the PWM controller to drive the desired oscillating plasma waveform with a frequency of 16.6 kHz that is located near the resonance of a coupled RLC circuit. In particular, the temporal phase of the injector waveform is held within 10 degrees of the target value. Control is demonstrated over the toroidal modal structure of the imposed magnetic perturbations of the helicity injection system, allowing a new class of discharges to be studied.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Analysis and mitigation of an oscillating background on hybrid complementary metal-oxide semiconductor (hCMOS) imaging sensors at the National Ignition Facility

Nanosecond-gated hybrid complementary metal-oxide semiconductor imaging sensors are a powerful tool for temporally gated and spatially resolved measurements in high energy density science, including inertial confinement fusion, and in laser diagnostics. However, a significant oscillating background excited by photocurrent has been observed in image sequences during testing and in experiments at the National Ignition Facility (NIF). Characterization measurements and simulation results are used to explain the oscillations as the convolution of the pixel-level sensor response with a sensor-wide RLC circuit ringing. Finally, data correction techniques are discussed for NIF diagnostics, and for diagnostics where these techniques cannot be used, a proof-of-principle image correction algorithm is presented.

42 ENGINEERING↗

Vibrational heat-bath configuration interaction with semistochastic perturbation theory using harmonic oscillator or VSCF modals

Vibrational heat-bath configuration interaction (VHCI)—a selected configuration interaction technique for vibrational structure theory—has recently been developed in two independent works [J. H. Fetherolf and T. C. Berkelbach, J. Chem. Phys. 154, 074104 (2021); A. U. Bhatty and K. R. Brorsen, Mol. Phys. 119, e1936250 (2021)], where it was shown to provide accuracy on par with the most accurate vibrational structure methods with a low computational cost. Here, we eliminate the memory bottleneck of the second-order perturbation theory correction using the same (semi)stochastic approach developed previously for electronic structure theory. This allows us to treat, in an unbiased manner, much larger perturbative spaces, which are necessary for high accuracy in large systems. Stochastic errors are easily controlled to be less than 1 cm−1. We also report two other developments: (i) we propose a new heat-bath criterion and an associated exact implicit sorting algorithm for potential energy surfaces expressible as a sum of products of one-dimensional potentials; (ii) we formulate VHCI to use a vibrational self-consistent field (VSCF) reference, as opposed to the harmonic oscillator reference configuration used in previous reports. Our tests are done with quartic and sextic force fields, for which we find that with VSCF, the minor improvements to accuracy are outweighed by the higher computational cost associated the matrix element evaluations. We expect VSCF-based VHCI to be important for more general potential representations, for which the harmonic oscillator basis function integrals are no longer analytic.

Chemistry↗

Mixed-mode oscillations in a three-timescale coupled Morris–Lecar system

Mixed-mode oscillations (MMOs) are complex oscillatory behaviors of multiple-timescale dynamical systems in which there is an alternation of large-amplitude and small-amplitude oscillations. It is well known that MMOs in two-timescale systems can arise either from a canard mechanism associated with folded node singularities or a delayed Andronov–Hopf bifurcation (DHB) of the fast subsystem. While MMOs in two-timescale systems have been extensively studied, less is known regarding MMOs emerging in three-timescale systems. In this work, we examine the mechanisms of MMOs in coupled Morris–Lecar neurons with three distinct timescales. We investigate two kinds of MMOs occurring in the presence of a singularity known as canard-delayed-Hopf (CDH) and in cases where CDH is absent. In both cases, we examine how features and mechanisms of MMOs vary with respect to variations in timescales. Our analysis reveals that MMOs supported by CDH demonstrate significantly stronger robustness than those in its absence. Moreover, we show that the mere presence of CDH does not guarantee the occurrence of MMOs. This work yields important insights into conditions under which the two separate mechanisms in two-timescale context, canard and DHB, can interact in a three-timescale setting and produce more robust MMOs, particularly against timescale variations.

97 MATHEMATICS AND COMPUTING↗

The effect of temperature oscillations on energy storage rectification in harmonic systems

Abstract Rectification, the preferential transport of a current in one direction through a system, has garnered significant attention in molecules because of its importance for controlling thermal and electronic currents at the nanoscale. Here, we report the presence of energy storage rectification effects in a molecular chain. This phenomenon is generated by subjecting a harmonic molecular chain to an oscillating temperature gradient and showing that the energy absorption rate of the system depends on the direction of the gradient. We examine how the energy storage rectification ratios in the chain are affected by the oscillating gradient, asymmetry in the chain, and the system parameters. We find that energy storage rectification can be observed in harmonic lattice structures with time-dependent temperatures and that, correspondingly, anharmonicity is not required to generate this rectification mechanism in such systems.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

The low frequency edge oscillation in alcator C-Mod and ASDEX upgrade I-mode

The low frequency edge oscillation (LFEO) is a low frequency fluctuation in many plasma quantities in the pedestal region of the I-Mode confinement regime. It is observed on Alcator C-Mod between 10–30 kHz and on ASDEX Upgrade between 5–10 kHz. On both tokamaks it has been previously identified as a geodesic acoustic mode (GAM), however the recent discovery of the edge temperature ring oscillation (ETRO) in a similar frequency and spatial location as the LFEO in I-Modes on EAST has called this identification into question. In this paper we investigate the LFEO on C-Mod and AUG using a variety of different experimental techniques including spectral analysis, magnetic mode number analysis, localization, and direct measurement of the LFEO zonal structure and propagation using a mirror Langmuir probe. This investigation has reconfirmed the identification of the LFEO as a GAM and determined that it has several key differences from the ETRO.

AUG↗

Probing fundamental constant oscillation in the Galactic Center with S-Star Spectroscopy

Astrophysical spectroscopy provides a powerful probe of spacetime variations of fundamental constants, as atomic and ionic emission and absorption lines depend sensitively on the fine-structure constant. In particular, coherent temporal oscillations induced by an ultralight scalar background produce characteristic, time-resolved signatures that can be robustly disentangled from intrinsic variability. In the Galactic Center, such scalar backgrounds can be substantially enhanced, either through the formation of dense scalar clouds powered by black hole rotational energy extraction or as ultralight scalar dark matter forming a soliton-like core. These scalar configurations generically induce oscillations of the fine-structure constant, with periods set by the scalar mass and spatial profiles determined by the scalar wavefunction and its coupling to the electromagnetic sector. We show that precise, time-resolved spectroscopy of S-stars orbiting the supermassive black hole Sgr A^* provides a sensitive test of these effects, enabling constraints on quadratic scalar-photon couplings in the exceptionally high boson-density environment of the Galactic Center.

Bai, Zhaoyu [Weizmann Inst.] (ORCID:00000002075815↗

Core electron temperature turbulence and transport during sawtooth oscillations in the DIII-D tokamak

Abstract Sawteeth are one of the concerning instabilities in ITER and future burning plasma experiments. Sawtooth dynamics and its interaction with broadband plasma turbulence has been a challenge for predictive simulations of core transport in future fusion devices. This study provides new observations of core turbulence behavior during sawtooth oscillations in DIII-D hydrogen L-mode neutral beam injection heated plasmas in an inner wall limited configuration. A strong correlation of electron temperature and density turbulence levels with the sawtooth oscillation phase has been observed at locations inside the T e inversion radius and/or safety factor q = 1 magnetic surface. The T e turbulence amplitude in the core during the sawtooth ramp exhibits a critical T e gradient behavior inside but not near the T e inversion radius/ q = 1 magnetic surface. The most unstable mode calculated from the trapped gyro-landau fluid turbulence simulations reveal a change from low- k ion-type to low-k electron-type modes from pre- to post- sawtooth crash time periods.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Recent three-flavor neutrino oscillation results from the NOvA experiment

NOvA is a long-baseline experiment studying primarily neutrino oscillations in the NuMI beam from Fermi National Laboratory (FNAL), USA. It consists of two functionally identical, finely granulated detectors which are separated by 810 km and situated 14.6 mrad off the NuMI beam axis from FNAL. By measuring the transition probabilities P(vμ → ve) and P(vμ → vμ), NOvA is able to probe the following parameters: , the mixing angle θ23, the CP violating phase δCP and the neutrino mass hierarchy. This document is devoted to the latest NOvA measurements of the neutrino oscillation parameters using neutrino and antineutrino disappearance and appearance obtained in 2020.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Modulation of ENSO teleconnections over North America by the Pacific decadal oscillation

In this study, we investigate whether the Pacific decadal oscillation (PDO) can enhance or diminish El Niño Southern Oscillation (ENSO) temperature and precipitation teleconnections over North America using five single model initial-condition large ensembles (SMILEs). The use of SMILEs facilitates a statistically robust comparison of ENSO events that occur during different phases of the PDO. We find that a positive PDO enhances winter and spring El Niño temperature and precipitation teleconnections and diminishes La Niña teleconnections. A negative PDO has the opposite effect. The modulation of ENSO by the PDO is mediated by differences in the location and strength of the Aleutian Low and Pacific Jet during ENSO events under different phases of the PDO. This modulation is a simple combination of the individual effects of the PDO and ENSO over North America. Finally, we show that ENSO and the PDO can be used to evaluate the likelihood of the occurrence of temperature and precipitation anomalies in different regions, but cannot be used as a deterministic predictor of these anomalies due to the large variability between individual events.

54 ENVIRONMENTAL SCIENCES↗

Iterative quantum optimization of spin glass problems with rapidly oscillating transverse fields

In this work, we introduce a new iterative quantum algorithm, called Iterative Symphonic Tunneling for Satisfiability problems (IST-SAT), which solves quantum spin glass optimization problems using high-frequency oscillating transverse fields. IST-SAT operates as a sequence of iterations, in which bitstrings returned from one iteration are used to set spin-dependent phases in oscillating transverse fields in the next iteration. Over several iterations, the novel mechanism of the algorithm steers the system toward the problem ground state. We benchmark IST-SAT on sets of hard MAX-3-XORSAT problem instances with exact state vector simulation, and report polynomial speedups over Trotterized adiabatic quantum computation and the best known semi-greedy classical algorithm. When IST-SAT is seeded with a sufficiently good initial approximation, the algorithm converges to exact solution(s) in a polynomial number of iterations. Our numerical results identify a critical Hamming radius, or quality of initial approximation, where the time-to-solution crosses from exponential to polynomial scaling in problem size. This work proposes IST-SAT a new quantum algorithm, which improves upon solutions obtained from initial classical or quantum optimization algorithms. The steering mechanism we introduce through IST-SAT presents a new path toward achieving quantum advantage in optimization.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗