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Socioeconomically-inspired modeling to justify use of fine-grain mobility data

When designing measures to control infectious disease spread, it is crucial to understand the structure of the population for which interventions are being implemented. Recent work has highlighted the need for models that incorporate demographic heterogeneity not just in age structure but also by socioeconomic status (SES). Appropriately capturing additional sources of population heterogeneity requires considerable data and model development. To understand the potential disagreement between SES-explicit or SES-agnostic disease models, we adapted Sandia’s Adaptive Recovery Model (ARM) model to consider differences in contact structure and mortality by Social Vulnerability Index (SVI) on a theoretical network. We also incorporated an Average network that did not consider SVI. By exploring disparities in vaccine and PPE uptake by SES and comparing to Average networks, as well as analyzing the influence of global vs. local contact, we found that the two model constructions often predicted different outcomes. Whether these differences are truly reflective of incorporating SES, and which model most closely represents reality, merits further investigation.

99 GENERAL AND MISCELLANEOUS↗

Fluid Redistribution and Heart Rate in Humans During Whole-Body Tilting, G(z) Centrifugation, and Lower Body Negative Pressure

Gravity creates blood pressure gradients which redistribute body fluids towards the feet. Positive G(z) centrifugation and lower body negative pressure (LBNP) have been proposed to simulate these and other effects of gravity during long-term existence in microgravity. We hypothesized that the magnitude of upper-to-lower body fluid redistribution would increase according to the following order: short-arm centrifugation (SAC), long-arm centrifugation (LAC), head-up tilt (HUT), and LBNP. To test this hypothesis, we employed strain gauge plethysmography of the neck, thigh and calf during HUT and supine SAC and LAC up to lG(z) at the feet, and during supine LBNP to 100 mm Hg. Supine 100 mm Hg LBNP generates footward force and produces transmural blood pressures in the foot approximately equal to 1 G(z) (90 deg) HUT. Heart rate was measured via cardiotachometry. Control measurements were made while supine. SAC and LAC elicited similar increases in thigh volume at 1 G(z) (2.3 +/- 0.4 and 2.1 +/- 0.1%, respectively; mean +/- se, n greater than or equal to 7). At 100 mm Hg LBNP, thigh volume increased (3.4 +/- 0.3%) significantly more than during l G(z) centrifugation (p less than 0.05). Surprisingly, due to a paradoxical 0.6% reduction of thigh volume between 0.8 and 1.0 G(z) HUT, thigh volume was increased only 0.6 +/- 0.3% at 1 G(z) HUT. The calf demonstrated similar, although less definitive, responses to the various gravitational stimuli. Neck volume tended to decrease less during HUT than during the other stimuli. Heart rate increased similarly during HUT (18 +/- 2 beats/min) and LAC (12 +/- 2 beats/min), and exhibited still greater elevation during LBNP (29 +/- 4 beats/min), yet did not increase during SAC. These results suggest upright posture activates mechanisms that counteract footward fluid redistribution which are not activated during supine applications of simulated gravity. LAC more closely approximated effects of normal gravity (HUT) than LBNP. Therefore, when considering LBNP to simulate gravity, these findings support efforts to reduce the cardiovascular stress imposed by LBNP, while preserving the gravity-like force generated by LBNP.

Watenpaugh, D. E.↗

Sensory motor coordination in an artificial gravity environment

The authors review and summarize research on the adaptation of limb movement control to Coriolis forces generated by body movements during rotation. They conclude that limb movement control can adapt to rotation rates as high as 10 rpm and that adaptation is rapid regardless of the presence or absence of visual and tactile feedback.

NASA Discipline Neuroscience↗

AmeriFlux FLUXNET-1F US-AR1 ARM USDA UNL OSU Woodward Switchgrass 1

This is the AmeriFlux Management Project (AMP) created FLUXNET-1F version of the carbon flux data for the site US-AR1 ARM USDA UNL OSU Woodward Switchgrass 1. This is the FLUXNET version of the carbon flux data for the site US-AR1 ARM USDA UNL OSU Woodward Switchgrass 1 produced by applying the standard ONEFlux (1F) software. Site Description - The ARM USDA UNL OSU Woodward Switchgrass 1 tower is located on public land owned by the USDA-ARS Southern Plains Range Research Station in Woodward, Oklahoma. The site is on a former native prairie that is in the process of changing to switchgrass. A second companion site (ARM USDA UNL OSU Woodward Switchgrass 2) is on a former wheat field. In Spring 2009, the former native prairie site was burned, cattle were put on the pasture to graze down emergent grass, and broadleaf herbicide was sprayed. In Summer 2009, the cattle were removed from the pasture, and the site was sprayed with herbicide to kill all grass. In Spring 2010, prior to the planting of switchgrass, final herbicide was sprayed to kill cheat grass and to control broadleaf plants.

Billesbach, Dave↗

Development of a sensor coordinated kinematic model for neural network controller training

A robotic benchmark problem useful for evaluating alternative neural network controllers is presented. Specifically, it derives two camera models and the kinematic equations of a multiple degree of freedom manipulator whose end effector is under observation. The mapping developed include forward and inverse translations from binocular images to 3-D target position and the inverse kinematics of mapping point positions into manipulator commands in joint space. Implementation is detailed for a three degree of freedom manipulator with one revolute joint at the base and two prismatic joints on the arms. The example is restricted to operate within a unit cube with arm links of 0.6 and 0.4 units respectively. The development is presented in the context of more complex simulations and a logical path for extension of the benchmark to higher degree of freedom manipulators is presented.

Jorgensen, Charles C.↗

2012 Alabama Lunabotics Systems Engineering Paper

Excavation will hold a key role for future lunar missions. NASA has stated that "advances in lunar regolith mining have the potential to significantly contribute to our nation's space vision and NASA space exploration operations." [1]. The Lunabotics Mining Competition is an event hosted by NASA that is meant to encourage "the development of innovative lunar excavation concepts from universities which may result in clever ideas and solutions which could be applied to an actual lunar excavation device or payload." [2]. Teams entering the competition must "design and build a remote controlled or autonomous excavator, called a lunabot, that can collect and deposit a minimum of 10 kilograms of lunar simulant within 10 minutes." [2]. While excavation will play an important part in lunar missions, there will still be many other tasks that would benefit from robotic assistance. An excavator might not be as well suited for these tasks as other types of robots might be. For example a lightweight rover would do well with reconnaissance, and a mobile gripper arm would be fit for manipulation, while an excavator would be comparatively clumsy and slow in both cases. Even within the realm of excavation it would be beneficial to have different types of excavators for different tasks, as there are on Earth. The Alabama Lunabotics Team at the University of Alabama has made it their goal to not only design and build a robot that could compete in the Lunabotics Mining Competition, but would also be a multipurpose tool for future NASA missions. The 2010-2011 resulting robot was named the Modular Omnidirectional Lunar Excavator (MOLE). Using the Systems Engineering process and building off of two years of Lunabotics experience, the 20ll-2012 Alabama Lunabotics team (Team NASACAR) has improved the MOLE 1.0 design and optimized it for the 2012 Lunabotics Competition rules [I]. A CAD model of MOLE 2.0 can be seen below in Fig. 1.

Baker, Justin↗

Spectro-Microscopy Studies of Atmospheric Particles

Our project investigated composition and physical properties of individual atmospheric particles collected in field campaigns organized by the DOE Atmospheric Systems Research and Atmospheric Radiation Measurement (ASR/ARM) programs, such as the Green Ocean Amazon (GoAmazon, 2014/5), the Holistic Interactions of Shallow Clouds, Aerosols, and Land-Ecosystems (HI-SCALE, 2016/7), the Aerosol and Cloud Experiment in the Eastern North Atlantic (ACE-ENA, 2017/8), the Aerosol–Ice Formation Closure Pilot Study (AEROICESTUDY, 2019) and in additional small-scale supporting field experiments focused on the investigation of the light-absorbing (aka brown carbon) atmospheric particles. In these studies, we investigated the contribution of natural and anthropogenic sources to populations of atmospheric particles during representative atmospheric conditions; characterized particle composition and evaluated their hygroscopic properties and propensity to act as cloud condensation nuclei (CCN) and ice nuclei (IN); correlated typical particle-type and mixing state characteristics with real-time measurements in the areas of studies. We used multi-modal spectro-microscopy techniques to examine elemental and molecular composition, mixing state, size, and higher order morphology for individual particles. Specifically, we used computer-controlled scanning electron microscopy and X-ray microanalysis for quantitative analysis of particle elemental composition, and we used transmission electron microscopy to provide additional information on the distribution of different components within individual particles (particle heterogeneity). We used synchrotron-based scanning transmission X-ray microscopy for quantitative description of the mixing state and molecular bonding of carbon in particles. The particle composition, mixing state, and morphology from analyzed periods was then combined with the real-time ARM measurements of aerosol size distribution, CCN concentration, hygroscopicity, and aerosol bulk composition. Combined together, results of our studies allowed us to assess the major particle sources (biogenic vs. anthropogenic, primary vs secondary) and gain insight into the atmospheric processing of aerosol particles resulting from condensation, coagulation, oxidative aging, and cloud processing. In collaboration with other scientists involved in field campaigns, we carried out statistical analysis of particle properties and their source-specific contributions to regional aerosol loading under representative air mass, meteorological, and cloud conditions.

scanning transmission X-ray microscopy↗

Project Interface Requirements Process Including Shuttle Lessons Learned

Most failures occur at interfaces between organizations and hardware. Processing interface requirements at the start of a project life cycle will reduce the likelihood of costly interface changes/failures later. This can be done by adding Interface Control Documents (ICDs) to the Project top level drawing tree, providing technical direction to the Projects for interface requirements, and by funding the interface requirements function directly from the Project Manager's office. The interface requirements function within the Project Systems Engineering and Integration (SE&I) Office would work in-line with the project element design engineers early in the life cycle to enhance communications and negotiate technical issues between the elements. This function would work as the technical arm of the Project Manager to help ensure that the Project cost, schedule, and risk objectives can be met during the Life Cycle. Some ICD Lessons Learned during the Space Shuttle Program (SSP) Life Cycle will include the use of hardware interface photos in the ICD, progressive life cycle design certification by analysis, test, & operations experience, assigning interface design engineers to Element Interface (EI) and Project technical panels, and linking interface design drawings with project build drawings

Bauch, Garland T.↗

Reflectivity Control Device (RCD) Roll Momentum Management for Solar Cruiser and Beyond

Reflectivity control devices (RCDs), thin film optical devices that are actuated (by application of a voltage across the device) to control the reflection of sunlight on their surfaces, can effectively enable roll momentum management (MM) of a solar sail operating in deep space, outside any magnetic field. This enables solar sails to maintain adequate attitude control in these challenging environments without sacrificing mission life by using expendables. They were planned and developed for use on Solar Cruiser, operating sunward of the Sun-Earth Lagrange Point 1 (sub-L1) in a propulsion-intensive artificial halo orbit. Located in pairs of panels near the distal end of each of four booms, each articulated at a slight angle out of the sail plane to produce a force tangent to the sail at a large moment arm, the RCDs provide roll torque capabilities by using simple switching logic to determine which panels should be activated (voltage applied) to produce torque in the desired direction. The performance capabilities and constraints of these devices across a range of operating conditions, namely sun-relative attitude, is well characterized, granting designers insight on how to properly size the system and optimize the system and component designs to maximize roll torque per unit area. With an informed design, RCDs can be very effective actuators for managing roll momentum with minimal detrimental system impacts (mass, power, complexity, etc.) on Solar Cruiser and other future deep space solar sail missions.

Andrew F Heaton↗

Investigation of Hardware and Instrumentation to Measure Hand Grasp Activity with the Spacesuit Gloves

Introduction: During the 2022 suited injury summit, it was hypothesized that there will be concerns for hand and glove injuries for future exploration space missions, especially given the fact that the “total number of Extravehicular activity (EVA) hours and frequency” for lunar surface missions is expected to vastly increase [1]. It has been reported that the hands experienced the greatest “absolute numbers” of reported injuries and far exceeds other injuries during EVA [1, 2]. It was reported that the most fatiguing part of the surface EVA was the repetitive gripping tasks [3]. It was recommended that a “glove sub-team” be created to look at possible injury mechanism and mitigation strategies. Some of the recommendations that were suggested [1] are as follows: examine hand fatigue, utilize motion capture, examine the duration and frequency of hand movements, and identify frequent hand motions. We started assessing hardware and instrumentation to measure hand grasp activity in the pressurized glove environment. The purpose of this test was to perform a hardware evaluation for motion capture (MoCap) gloves obtained from StretchSense (Auckland, New Zealand). The specific gloves used were the Pro Fidelity and SuperSplay to determine the repeatability, reliability, feasibility, and useability inside of a pressurized gloved environment. Methods: The MoCap gloves were customized (e.g., battery/Bluetooth pack relocated to upper arm) to better suit the pressurized testing environment and protect the subject from unintentional injury (Fig. 1). Fourteen total subjects from different demographics (i.e., gender and pressurized glove experience level) participated in this test series. Testing included one session each of a baseline data collection (NASA Johnson Space Center (JSC) building 21) and a spacesuit glove box (Fig. 2 at JSC building 7 room 2027) data collection (under vacuum down to 4.3 psid), where each session lasted 3-5 hours. Controlled and reproducible tasks to systematically evaluate the repeatability and reliability of the hardware were performed during baseline data collection. Additionally, subjects performed simulated EVA-like tasks in a pressurized gloved environment. For all sessions, MoCap gloves were placed on each of the subjects’ hands and the signal from it, or the raw capacitance (Fig. 3), was analysed. The raw capacitance was used to estimate the open and closed hand states between the testing conditions and allow us to provide an offset caused by the pressurized environment. Results & Discussion: Initial observation with the bare hands (baseline) condition showed that the MoCap gloves appeared to track grasping and releasing of the fingers (opening and closing fist) with both high- and low-speed conditions, while adduction and abduction of the fingers were not relatively tracked. A hardware evaluation was done outside of the glove box to assess the reliability and repeatability of the MoCap glove. In one task, a point force was applied to various locations on the back of the hand. When the point force was applied to the space between the 1st digit and the pointer finger, there was a noticeable distortion to the MoCap data. Another task examining an increasing force from a 10 lb. sandbag applied to the back of the hand while lying flat on a table, showed a constant flat line with only a distortion when the weight was increased or added to the back of the hand. Fig. 3 shows an object relocation task where you can see when each individual finger “opened” and “closed” (changed position) when picking up and setting down the dumbbell. When the fingers were stationary, the signal remained relatively flat compared to the peaks and valleys that can be observed in Fig. 3. This study showed promising results and imperative input into an attempt to discriminate between hand states across various functional tasks and should be evaluated with context to the repeatability and reliability outcomes. Depending on the task done inside of the pressurized glove box environment and outside, the results appear to be affected by many different factors (i.e., drift, pressure, hand size, etc.). Significance: If this hardware proves to be reliable and repeatable in determining the open and closed hand states then this may provide critical insight into assisting in the characterization of the pressurized gloved environment and the effect on crew member exertion level. Ultimately, this tool will provide useful data for quantifying the repetitive nature of EVA training and tasks. Acknowledgments: The authors would like to acknowledge the NASA Mars Campaign Office for providing funding for this research. Lastly, thanks to all the engineers and technicians at NASA JSC who helped with this data collection. References: [1] Reiber, et al. (2022), NASA/TM-20220007605; [2] Scheuring, et al. (2009), Av., Sp., and Envir. Med. 80(2). [3] Scheuring, et al. (2007), NASA/TM–2007–214755.

Rachel L Thompson↗

A Woven Supramolecular Metal‐Organic Framework Comprising a Ruthenium Bis(terpyridine) Complex and Cucurbit[8]uril: Enhanced Catalytic Activity toward Alcohol Oxidation

Abstract The self‐assembly of a diamondoid woven supramolecular metal–organic framework wSMOF‐1 has been achieved from intertwined [Ru(tpy) 2 ] 2+ (tpy=2,2′,6′,2′′‐terpyridine) complex M1 and cucurbit[8]uril (CB[8]) in water, where the intermolecular dimers formed by the appended aromatic arms of M1 are encapsulated in CB[8]. wSMOF‐1 exhibits ordered pore periodicity in both water and the solid state, as confirmed by a combination of 1 H NMR spectroscopy, UV‐vis absorption, isothermal titration calorimetry, dynamic light scattering, small angle X‐ray scattering and selected area electron diffraction experiments. The woven framework has a pore aperture of 2.1 nm, which allows for the free access of both secondary and primary alcohols and tert ‐butyl hydroperoxide (TBHP). Compared with the control molecule [Ru(tpy) 2 ]Cl 2 , the [Ru(tpy) 2 ] 2+ unit of wSMOF‐1 exhibits a remarkably higher heterogeneous catalysis activity for the oxidation of alcohols by TBHP in n ‐hexane. For the oxidation of 1‐phenylethan‐1‐ol, the yield of acetophenone was increased from 10 % to 95 %.

Zhang, Yun‐Chang↗

Experiments in robotic catching

Real-time coordination of visual information with high-speed manipulator control is studied in the context of three-dimensional robotic catching. All path planning for the catch occurs in real-time during the half-second that the targeted object is airborne. A trajectory-matching algorithm is used that combines an observer with a varying-strength filter, an error estimator, and an initial motion algorithm. The results are demonstrated experimentally using a real-time vision system and a four-degree-of-freedom, cable-driven arm with a workspace of 4.2 m3 and speed capabilities of up to 2.0 m/s.

Hove, Barbara↗

The Role of Asparagine as a Gatekeeper Residue in the Selective Binding of Rare Earth Elements by Lanthanide‐Binding Peptides

Abstract Lanthanide‐binding tag (LBT) peptides selectively complex lanthanide cations (Ln 3+ ) in their binding pockets and are promising for lanthanide separation. However, designing LBTs that selectively target specific Ln 3+ cations remains a challenge due to limited molecular‐level understanding and control of interactions within the lanthanide‐binding pocket. In this study, we reveal that the N5 asparagine residue acts as a gatekeeper in the binding pocket, resulting in a 100‐fold selectivity for smaller Lu 3+ over larger La 3+ cations. Nuclear magnetic resonance spectroscopy and molecular dynamics simulations show that the N5 residue weakly binds to the larger La 3+ cation, permitting H 2 O molecules inside the pocket. For the smaller Lu 3+ cations, the N5 residue forms an inter‐arm hydrogen bond with the E14 glutamic acid residue, locking the Lu 3+ cation in the pocket and preventing H 2 O infiltration. Mutating the N5 asparagine to a D5 aspartic acid prevents such a hydrogen bond, eliminating the gatekeeping mechanism and precipitously reducing selectivity. The resulting binding affinity to Ln 3+ cations is non‐monotonic but generally increases with cation size. These results suggest a molecular design paradigm: the reduced affinity for larger lanthanides is due to open pocket conformations, while the selectivity of smaller Ln 3+ cations over larger ones is due to the gatekeeping hydrogen bond.

Chemistry↗

Application of AI methods to aircraft guidance and control

A research program for integrating artificial intelligence (AI) techniques with tools and methods used for aircraft flight control system design, development, and implementation is discussed. The application of the AI methods for the development and implementation of the logic software which operates with the control mode panel (CMP) of an aircraft is presented. The CMP is the pilot control panel for the automatic flight control system of a commercial-type research aircraft of Langley Research Center's Advanced Transport Operating Systems (ATOPS) program. A mouse-driven color-display emulation of the CMP, which was developed with AI methods and used to test the AI software logic implementation, is discussed. The operation of the CMP was enhanced with the addition of a display which was quickly developed with AI methods. The display advises the pilot of conditions not satisfied when a mode does not arm or engage. The implementation of the CMP software logic has shown that the time required to develop, implement, and modify software systems can be significantly reduced with the use of the AI methods.

Hueschen, Richard M.↗

Development of the Orion Crew-Service Module Umbilical Retention and Release Mechanism

The Orion CSM umbilical retention and release mechanism supports and protects all of the cross-module commodities between the spacecrafts crew and service modules. These commodities include explosive transfer lines, wiring for power and data, and flexible hoses for ground purge and life support systems. The mechanism employs a single separation interface which is retained with pyrotechnically actuated separation bolts and supports roughly two dozen electrical and fluid connectors. When module separation is commanded, either for nominal on-orbit CONOPS or in the event of an abort, the mechanism must release the separation interface and sever all commodity connections within milliseconds of command receipt. There are a number of unique and novel aspects of the design solution developed by the Orion mechanisms team. The design is highly modular and can easily be adapted to other vehiclesmodules and alternate commodity sets. It will be flight tested during Orions Exploration Flight Test 1 (EFT-1) in 2014, and the Orion team anticipates reuse of the design for all future missions. The design packages fluid, electrical, and ordnance disconnects in a single separation interface. It supports abort separations even in cases where aerodynamic loading prevents the deployment of the umbilical arm. Unlike the Apollo CSM umbilical which was a destructive separation device, the Orion design is resettable and flight units can be tested for separation performance prior to flight.Initial development testing of the mechanisms separation interface resulted in binding failures due to connector misalignments. The separation interface was redesigned with a robust linear guide system, and the connector separation and boom deployment were separated into two discretely sequenced events. These changes addressed the root cause of the binding failure by providing better control of connector alignment. The new design was tuned and validated analytically via Monte Carlo simulation. The analytical validation was followed by a repeat of the initial test suite plus test cases at thermal extremes and test cases with imposed mechanical failures demonstrating fault tolerance. The mechanism was then exposed to the qualification vibration environment. Finally, separation testing was performed at full speed with live ordnance.All tests of the redesigned mechanism resulted in successful separation of the umbilical interface with adequate force margins and timing. The test data showed good agreement with the predictions of the Monte Carlo simulation. The simulation proved invaluable due to the number of variables affecting the separation and the uncertainty associated with each. The simulation allowed for rapid assessment of numerous trades and contingency scenarios, and can be easily reconfigured for varying commodity sets and connector layouts.

Separation↗

Arterial Structure and Function in Women and Men Following Long Duration Bed Rest

Orthostatic intolerance is a well-recognized consequence of space flight and bed rest (BR), with a greater incidence reported in women. We hypothesized that leg, but not arm, arterial structure and function would be altered following prolonged BR, as a model of space flight, and that women would be more susceptible to BR-induced deconditioning than men. METHODS: Ten volunteers (5 males, 5 females) completed 90 d of 6 head-down BR. Subjects participated in tests of brachial (BA) and anterior tibial (AT) artery endothelium-dependent (flow mediated dilation [FMD] following 5-7 min of arterial occlusion) and endothelium-independent (0.4 mg sublingual nitroglycerin [SN]) vasodilation before BR (PRE) and on days 7 (BR7), 21 (BR21), and 90 (BR90) of BR. Vessel diameter and intimal medial thickness (IMT) were measured by ultrasound. IMT, baseline diameter, and percent change in diameter from baseline during FMD and SN tests were compared across BR and between genders using repeated measures two-way ANOVA with Bonferroni post-hoc tests in which PRE and women were control conditions. RESULTS: Baseline vessel diameter was lower in women than in men in both the BA (p=0.005) and AT (p=0.01) across all days. Baseline AT diameter decreased during BR (p=0.01) and tended to be more profound in women (interaction, p=0.06). AT diameter was reduced in women at BR21 and BR90 (p<0.01) but not in men. In contrast, there was no BR effect on baseline BA diameter. IMT also decreased in the AT (p<0.001) but not in the BA during BR; AT IMT was reduced by BR21 (p<0.05). As a group, there was no effect of BR on AT FMD, BA FMD, and AT SN-dilation, although BA SN-dilation was significantly reduced on BR21 (p=0.01). Across all BR days, women exhibited higher AT FMD (p=0.03), BA FMD (p=0.02), and BA SN-dilation (p=0.01) and tended to demonstrate greater AT SN-dilation (p=0.11). CONCLUSIONS: These preliminary results suggest that arterial remodeling occurs during BR in the leg (decreased diameter and IMT), but not in the arm, and that women appear to be more responsive to BR than men. These changes in the leg, coupled with larger responses to direct and indirect stimulation of the arterial smooth muscle, may be related to the greater incidence of orthostatic intolerance in women after BR and space flight.

Lee, Stuart M. C.↗

Structured analysis and modeling of complex systems

The Aircrew Evaluation Sustained Operations Performance (AESOP) facility at Brooks AFB, Texas, combines the realism of an operational environment with the control of a research laboratory. In recent studies we collected extensive data from the Airborne Warning and Control Systems (AWACS) Weapons Directors subjected to high and low workload Defensive Counter Air Scenarios. A critical and complex task in this environment involves committing a friendly fighter against a hostile fighter. Structured Analysis and Design techniques and computer modeling systems were applied to this task as tools for analyzing subject performance and workload. This technology is being transferred to the Man-Systems Division of NASA Johnson Space Center for application to complex mission related tasks, such as manipulating the Shuttle grappler arm.

Strome, David R.↗

Muscle metaboreceptor modulation of cutaneous active vasodilation

PURPOSE: Isometric handgrip exercise in hyperthermia has been shown to reduce cutaneous vascular conductance (CVC) by inhibiting the cutaneous active vasodilator system. METHODS: To identify whether this response was initiated by muscle metaboreceptors, in seven subjects two 3-min bouts of isometric handgrip exercise in hyperthermia were performed, followed by 2 min of postexercise ischemia (PEI). An index of forearm skin blood flow (laser-Doppler flowmetry) was measured on the contralateral arm at an unblocked site and at a site at which adrenergic vasoconstrictor function was blocked via bretylium iontophoresis to reveal active cutaneous vasodilator function unambiguously. Sweat rate was measured via capacitance hygrometry, CVC was indexed from the ratio of skin blood flow to mean arterial pressure and was expressed as a percentage of maximal CVC at that site. In normothermia, neither isometric exercise nor PEI affected CVC (P > 0.05). RESULTS: The first bout of isometric handgrip exercise in hyperthermia reduced CVC at control sites and this reduction persisted through PEI (pre-exercise: 59.8 +/- 5.4, exercise: 49.8 +/- 4.9, PEI: 49.7 +/- 5.3% of maximum; both P < 0.05), whereas there were no significant changes in CVC at the bretylium treated sites. The succeeding bout of isometric exercise in hyperthermia significantly reduced CVC at both untreated (pre-exercise: 59.0 +/- 4.8, exercise: 47.3 +/- 4.0, PEI: 50.1 +/- 4.1% of maximum; both P < 0.05) and bretylium treated sites (pre-exercise: 61.4 +/- 7.3, exercise: 50.6 +/- 5.1, PEI: 53.9 +/- 6.0% of maximum, both P < 0.05). At both sites, CVC during PEI was lower than during the pre-exercise period (P < 0.05). Sweat rate rose significantly during both bouts of isometric exercise and remained elevated during PEI. CONCLUSIONS: These data suggest that the reduction in CVC during isometric exercise in hyperthermia, including the inhibition of the active vasodilator system, is primarily mediated by muscle metaboreceptors, whereas central command or muscle mechanoreceptors have less influence.

Non-NASA Center↗