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At least 1,261 records · Page 70

Predicting Cell Death and Mutation Frequency for a Wide Spectrum of LET by Assuming DNA Break Clustering Inside Repair Domains

The high relative biological effectiveness (RBE) of high charged and energy (HZE) particles for cell death, DNA mutations and cancer remain based on experimental data. In this work, we propose that the existence of DNA repair domains is sufficient to predict both cell death and mutation frequencies for any LET by only taking into account experimental data from low-LET, offering one mechanism for RBE across LET. We hypothesize that whenever multiple DNA double-strand breaks (DSBs) are generated within the same DNA repair domain, DSBs are actively regrouped for more efficient repair [1]. This hypothesis has been supported by the low-LET sublinear dose response observed at doses greater than ~1Gy for 53BP1 radiation-induced foci (RIF) reflecting increasing DSB/RIF with dose [2]. Previously, we modeled radiation-induced cell death of human breast cells by first inferring the size of these domains from the dose dependence of low-LET RIF, and by associating a lethality factor to the number of pairs of DSBs in each RIF [1]. In this work, we first integrate the new NASA computer models RITCARD (Relativistic Ion Tracks, Chromosome Aberrations, Repair, and Damage) [3] and BDSTracks (Biological Damage by Stochastic Tracks) for a more accurate microdosimetry and a better model of the nuclear organization to predict the location of DSBs. A large array of particles and energy are simulated, covering more than three orders of magnitude for LET (~1-1000 keV/µm). Next, we extend our previous model to predict mutation frequencies by assuming that clustered DSBs increase mutation probability, which is formalized by the mutation frequency being linearly dependent on both the number of DSBs and the number of pairs of DSBs inside individual RIF. Linear coefficients are estimated so that simulations predict accurately mutation frequencies observed in Chinese hamster cells exposed to low-LET. Keeping these coefficients unchanged, we then predict mutation frequencies induced by HZE by simulating DSBs and obtain RBEs for mutations and cell death following the expected experimental bell shape for LET dependence. We also observe an orientation effect that needs to be confirmed, showing different RBE depending on the angle of the HZE beam hitting the main axis of the cell.

Plante, Ianik↗

Investigation of irradiation damage and heat deposition: a comparative analysis for HEU-to-LEU conversion in HFIR

The planned conversion of the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory from highly enriched uranium (HEU) to low-enriched uranium (LEU) fuel requires detailed evaluation of experiment-relevant parameters to ensure continued performance for materials testing and isotope production. Here, this study presents the first comprehensive assessment of displacements per atom (dpa) and heat deposition rates in target materials within the HFIR flux trap with both HEU and candidate LEU core configurations. Seven analyses were conducted to evaluate key performance metrics, including fast neutron flux distribution, cross section response functions, cross section data, and local dpa and heat deposition rates using mesh- and cell-based tallies. Simulations employed Shift, Monte Carlo N-Particle (MCNP), and the HIFR Controller (HFIRCON) tool suite for high-fidelity transport and depletion modeling. The LEU designs—using U 3 Si 2 -Al dispersion fuel and operating at 95 MW—were compared to the current 85 MW HEU configuration. Results show that while the candidate LEU cores exhibit higher dpa rates due to a harder spectrum and extended cycle lengths, they also demonstrate reduced heat deposition rates in irradiation experiments, primarily due to increased gamma self-shielding from higher 238 U content in the core. These findings confirm that LEU conversion can maintain HFIR’s materials irradiation capabilities but may require redesigning existing experimental hardware.

HEU↗

Toroidal modeling of runaway electron loss due to 3-D fields in DIII-D and COMPASS

The 3-D field induced relativistic runaway electron (RE) loss has been simulated for DIII-D, COMPASS and ITER plasmas, utilizing the MARS-F code incorporated with the recently developed and updated RE orbit module (REORBIT). Modeling shows effectively 100% loss of a post-disruption, high-current runaway beam in DIII-D, due to the 1 kG level of magnetic field perturbation produced by a fast growing n = 1 resistive kink instability. The RE loss is shown to be independent of the particle energy or the initial location of particles in the configuration space. Applied resonant magnetic perturbation (RMP) fields from in-vessel coils are not effective for RE beam mitigation in DIII-D, but do produce finite (>10%) RE loss in COMPASS, consistent with experimental observations in above two devices. The major reasons for this difference in RE control by RMP between these two devices are (i) the coil proximity to the RE beam and (ii) the effective coil current scaling versus the machine size and the toroidal magnetic field. About 10% RE loss fraction is also predicted for an ITER 15 MA scenario with pre-disruption plasma, highlighting the role of the plasma response. Up to 30% loss is computed, however, by artificially scaling the equilibrium pressure to zero. This is due to the more resistive plasma response and stronger resulting field line stochasticity. Distributions of the lost REs to the limiting surface show poloidally peaked profile near the high-field-side in both DIII-D and COMPASS, covering about 100o poloidal angle. Higher perturbation field level and/or higher particle energy also result in REs being lost to the low-field-side of the limiting surface of these two devices, increasing the effective wetted area. Finally, for the modeled ITER plasmas, the applied RMP field, with optimal poloidal spectrum that maximizes the edge localized mode control, leads to REs being lost to the lower divertor region of the limiting surface within a narrow poloidal band.

3-D field↗

Low-energy calibration of SuperCDMS HVeV cryogenic silicon calorimeters using Compton steps

Cryogenic calorimeters for low-mass dark matter searches have achieved sub-eV energy resolutions, driving advances in both low-energy calibration techniques and our understanding of detector physics. The energy deposition spectrum of gamma rays scattering off target materials exhibits step-like features, known as Compton steps, near the binding energies of atomic electrons. Here, we demonstrate a successful use of Compton steps for sub-keV calibration of cryogenic silicon calorimeters, utilizing four SuperCDMS High-Voltage eV-resolution detectors operated with 0 V bias across the crystal. This new calibration at 0 V is compared with the established high-voltage calibration using optical photons. The comparison indicates that the detector response at 0 V is about 30% weaker than expected, highlighting challenges in detector response modeling for low-mass dark matter searches.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Fluorescence of the gamma, epsilon, and delta systems of nitric oxide - Polarization and use of calculated intensities for spectrometer calibration.

Results of a study in which fluorescence of the gamma system of nitric oxide was obtained by excitation from both the 2144 A line of ionized cadmium and a continuum source. Individual rotational lines of the 2144 A excited fluorescence spectrum were found to be partially polarized and to have polarizations of differ ing sign. Measured relative vibrational band intensities from line and continuum excitation were compared to calculated Franck-Condon factors. Those Franck-Condon factors based on a single potential for the two spin states of the X super pi state agreed better with measured values than those based on separate potentials for the two spin states. Calculated intensities of the v prime = 3 progression were used to calibrate the instrument response in the wavelength region from 2000 to 2500 A and were checked with measured intensities of the v prime = 0.1, and 2 progressions. Fluorescence of the epsilon and delta bands obtained with continuum lamp excitation also were compared to calculated intensities.

Poland, H. M.↗

Multisensor analysis of hydrologic features in the Wind River Range, Wyoming with emphasis on the SEASAT SAR

The author has identified the following significant results. Analysis of imagery obtained over west-central Wyoming indicates that Seasat SAR has capability for hydrologic mapping. Both the L-Band (Seasat) and the X-Band (aircraft) SAR imagery were useful for observing drainage detail. Streams have bright signatures on the SAR imagery because the riparian vegetation produces a rough surface and thus high radar returns. Lakes appear relatively bright on the Seasat image presumably in response to surface ripples and waves induced by wind action. SAR imagery did not reveal snow at either the 23.5 cm (L-Band) or 2.8 cm (X-Band) wavelengths. Comparing Seasat and X-Band aircraft SAR imagery to LANDSAT RBV imagery, U-2 photography, and topographic maps of the Wind River Range, it appears that the SAR data do not seem to provide as much hydrologic information as do the other sensors in the visible and near infrared portions of the spectrum.

Foster, J. L.↗

Testing of 30-GHz low noise receivers

NASA-sponsored studies of the growth in communications traffic have indicated that the frequency spectrum allocated to fix-service satellites at the C and Ku bands will reach saturation by the early 1990's. The next higher frequency bands allocated for communications satellties are 27.5 to 30 GHz for the uplink and 17.7 to 20.2 GHz for the downlink. Current plans for developing satellite systems that use these bands include a NASA demonstration satellite (ACTS). One of the components identified as critical to the success of that mission is a 27.5 to 30 GHz satellite receiver. In response to that identification, NASA has sponsored the development of such a receiver to the proof-of-concept (POC) level. Design and fabrication of such POC model receivers was carried out under parallel contracts awarded to LNR Communications, Inc. of Hauppauge, New York and to ITT Defense Communications Division of Nutley, New Jersey. The most significant of the performance goals were a 5 db maximum noise figure, a 2.5 GHz passband, and e0 dB Rf to If gain. Following delivery of hardware from each of the contractors, an in-house test program was undertaken at NASA's Lewis Research Center in order to verify the contractor-reported performance and to provide a comparison of the two receivers under identical test conditions. The present paper reports the results of those tests.

Conroy, M. J.↗

Testing of 30-GHz low noise receivers

NASA-sponsored studies of the growth in communications traffic have indicated that the frequency spectrum allocated to fix-service satellites at the C and Ku bands will reach saturation by the early 1990's. The next higher frequency bands allocated for communications satellites are 27.5 to 30 GHz for the uplink and 17.7 to 20.2 GHz for the downlink. Current plans for developing satellite systems that use these bands include a NASA demonstration satellite (ACTS). One of the components identified as critical to the success of that mission is a 27.5 to 30 GHz satellite receiver. In response to that identification, NASA has sponsored the development of such a receiver to the proof-of-concept (POC) level. Design and fabrication of such POC model receivers was carried out under parallel contracts awarded to LNR Communications, Inc. of Hauppauge, New York and to ITT Defense Communications Division of Nutley, New Jersey. The most significant of the performance goals were a 5 dB maximum noise figure, a 2.5 GHz passband, and 20 dB RF to IF gain. Following delivery of hardware from each of the contractors, an in-house test program was undertaken at NASA's Lewis Research Center in order to verify the contractor-reported performance and to provide a comparison of the two receivers under identical test conditions. The present paper reports the results of those tests.

Conroy, M. J.↗

Simulation of Ground Winds Time Series for the NASA Crew Launch Vehicle (CLV)

Simulation of wind time series based on power spectrum density (PSD) and spectral coherence models for ground wind turbulence is described. The wind models, originally developed for the Shuttle program, are based on wind measurements at the NASA 150-m meteorological tower at Cape Canaveral, FL. The current application is for the design and/or protection of the CLV from wind effects during on-pad exposure during periods from as long as days prior to launch, to seconds or minutes just prior to launch and seconds after launch. The evaluation of vehicle response to wind will influence the design and operation of constraint systems for support of the on-pad vehicle. Longitudinal and lateral wind component time series are simulated at critical vehicle locations. The PSD model for wind turbulence is a function of mean wind speed, elevation and temporal frequency. Integration of the PSD equation over a selected frequency range yields the variance of the time series to be simulated. The square root of the PSD defines a low-pass filter that is applied to adjust the components of the Fast Fourier Transform (FFT) of Gaussian white noise. The first simulated time series near the top of the launch vehicle is the inverse transform of the adjusted FFT. Simulation of the wind component time series at the nearest adjacent location (and all other succeeding next nearest locations) is based on a model for the coherence between winds at two locations as a function of frequency and separation distance, where the adjacent locations are separated vertically and/or horizontally. The coherence function is used to calculate a coherence weighted FFT of the wind at the next nearest location, given the FFT of the simulated time series at the previous location and the essentially incoherent FFT of the wind at the selected location derived a priori from the PSD model. The simulated time series at each adjacent location is the inverse Fourier transform of the coherence weighted FFT. For a selected design case, the equations, the process and the simulated time series at multiple vehicle stations are presented.

Adelfang, Stanley I.↗

Latent Representation Learning for Structural Characterization of Catalysts

Supervised machine learning-enabled mapping of the X-ray absorption near edge structure (XANES) spectra to local structural descriptors offers new methods for understanding the structure and function of working nanocatalysts. We briefly summarize a status of XANES analysis approaches by supervised machine learning methods. We present an example of an autoencoder-based, unsupervised machine learning approach for latent representation learning of XANES spectra. This new approach produces a lower-dimensional latent representation, which retains a spectrum–structure relationship that can be eventually mapped to physicochemical properties. Furthermore, the latent space of the autoencoder also provides a pathway to interpret the information content “hidden” in the X-ray absorption coefficient. Our approach (that we named latent space analysis of spectra, or LSAS) is demonstrated for the supported Pd nanoparticle catalyst studied during the formation of Pd hydride. By employing the low-dimensional representation of Pd K-edge XANES, the LSAS method was able to isolate the key factors responsible for the observed spectral changes.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Aberrant light sensing and motility in the green alga Chlamydomonas priscuii from the ice-covered Antarctic Lake Bonney

The Antarctic green alga Chlamydomonas priscuii is an obligate psychrophile and an emerging model for photosynthetic adaptation to extreme conditions. Endemic to the ice-covered Lake Bonney, this alga thrives at highly unusual light conditions characterized by very low light irradiance (<15 μmol m -2 s -1 ), a narrow wavelength spectrum enriched in blue light, and an extreme photoperiod. Genome sequencing of C. priscuii exposed an unusually large genome, with hundreds of highly similar gene duplicates and expanded gene families, some of which could be aiding its survival in extreme conditions. In contrast to the described expansion in the genetic repertoire in C. priscuii, here we suggest that the gene family encoding for photoreceptors is reduced when compared to related green algae. This alga also possesses a very small eyespot and exhibits an aberrant phototactic response, compared to the model Chlamydomonas reinhardtii. We also investigated the genome and behavior of the closely related psychrophilic alga Chlamydomonas sp. ICE-MDV, that is found throughout the photic zone of Lake Bonney and is naturally exposed to higher light levels. Our analyses revealed a photoreceptor gene family and a robust phototactic response similar to those in the model Chlamydomonas reinhardtii. These results suggest that the aberrant phototactic response in C. priscuii is a result of life under extreme shading rather than a common feature of all psychrophilic algae. We discuss the implications of these results on the evolution and survival of shade adapted polar algae.

59 BASIC BIOLOGICAL SCIENCES↗

Multi-Wavelength Analysis of the March 26, 1991: Solar Flare

We have engaged in detailed multi-wavelength analysis of the March 26, 1991, solar flare in order to develop a method of diagnostics of the physical processes responsible for the efficient acceleration of charged particles to high energies and also for diagnostics of the photospheric response to the injection of the accelerated particles. Consideration of this particular flare is of special interest because to date it is the only flare in which the gamma-ray emission with energies of 20-1000 MeV was registered throughout the entire development of the event in the optical, radio and soft x-ray bands. individual registration by the GAMMA-1 telescope of the energy and precise time for each registered gamma-ray photon allowed the maximum detailed investigation of the energy spectrum and flux evolution during the flare.

Kurt, V. G.↗

The Unidentified Infrared Emission Bands: Identified

The so-called Unidentified Infrared or simply UIR bands, the infrared emission band spectrum associated with a wide variety of interstellar objects, can be modeled in detail by laboratory spectra of neutral and positively charged polycyclic aromatic hydrocarbon (PAH) mixtures. Fits are presented for the UIR emission from the protoplanetary nebula IRAS 22272+5435, the diffuse galactic medium, and the Orion HII/photodissociation front - a selection of objects which span the evolutionary range of interstellar material. These data directly address the spectroscopic criticisms previously leveled at the PAH hypothesis and demonstrate that PAH-related molecular species are indeed responsible for this widespread emission. Furthermore, these fits reflect the structure, abundance, and ionization state of the interstellar PAHs and, in turn, provide direct insight into the processes of carbon nucleation, growth and evolution in circumstellar shells and the interstellar medium. To date, no other candidate material which has been proposed to account for the UIR emission can as readily and specifically reproduce these spectral variations. Given the ubiquity of these species, this work demonstrates the tremendous potential of these species as probes of a new and heretofore largely unexplored facet of astrochemistry - potential which should make PAHs the probe of the next millennium much as CO has been for the last quarter century.

Hudgins, Douglas M.↗

Image Characterization of Reactions Generated by an Aeroengine Micromixing Injector for Lean Direct Injection of Hydrogen and Hydrogen/Natural Gas Blend

An aeroengine micromixing injector, originally designed for lean direct injection of jet fuel, was adapted to work with hydrogen, natural gas, and any blend in between. The ultimate goal of the design was to achieve low NOx emissions when operated on pure hydrogen; to better characterize its performance, flame imaging diagnostics was implemented. Three types of cameras mounted parallel to the injector base and pointing towards the quartz combustor cylinder with the same angle were operated simultaneously: Nikon D90, Dynacolor FB-N9-U, and Phantom v7.1, to capture the visible spectrum, OH* chemiluminescence, and dynamic behavior of the flames, respectively. The current work also includes the overlapping of visible spectrum and OH* chemiluminescence, as an effort to qualitatively define the heat release over the flame area, i.e., UV over visible domain. Additionally, a z-type schlieren configuration was employed to reinforce the presence of some small-scale details occurring near the injector outlet ports. Using the airbox pressure drop, preheat temperature, fuel composition and flame temperature as the factors of study, a Box Behnken model was designed yielding into a 16-points matrix for the operability region, at atmospheric pressure. The main responses were extracted from the OH* images, because of its correlation with the flame heat release, these being the flame area and its average brightness, the heat release area and its center of gravity and leading edge. To assess the importance of the main factors and their interactions, an analysis of variance (ANOVA) was performed for each response, considering as significant each contributor with a p-value below 0.05. For these five responses it was found that all four main factors need to be included into the model (most of them because its own significance, others to ensure the model hierarchy), as well as some common interactions as the preheat and flame temperatures or pressure drop and fuel composition, and quadratic terms from fuel composition or flame temperature. Three of the five models presented R2 and coefficient of variance (C.V.) indicators around 0.97 and 5%, respectively; the leading edge ANOVA yielded into R2=0.78 and C.V.=18.88%; and the heat release area showed R2=0.91 and C.V.=24.13%. Lastly, the confinement ratio effect of the combustor over the flame structure was quantified, for three different conditions: the original 80 mm inner diameter and 200 mm length cylinder was compared against a shorter 150 mm tube (same inner diameter) and a narrower 47 mm inner diameter one (same 200 mm length). The length had a smaller effect than the inner diameter, even though both factors were not strong enough to make a significant deviation on most of the flame parameters: the difference was within the repeatability margin of error for the brightness, flame area, and center of gravity and leading edge of the heat release area.

Imaging diagnostics, flame characterization, OH* c↗

Acoustic emission characteristics of copper alloys under low-cycle fatigue conditions

The acoustic emission (AE) characteristics of pure copper, zirconium-copper, and several copper alloys were determined to develop nondestructive evaluation schemes of thrust chambers through AE techniques. The AE counts rms voltages, frequency spectrum, and amplitude distribution analysis evaluated AE behavior under fatigue loading conditions. The results were interpreted with the evaluation of wave forms, crack propagation characteristics, as well as scanning electron fractographs of fatigue-tested samples. AE signals at the beginning of a fatigue test were produced by a sample of annealed alloys. A sample of zirconium-containing alloys annealed repeatedly after each fatigue loading cycle showed numerous surface cracks during the subsequent fatigue cycle, emitting strong-burst AE signals. Amplitude distribution analysis exhibits responses that are characteristic of certain types of AE signals.

Krampfner, Y.↗

Soft X-ray line profiles in the impulsive phase of electron-heated solar flares

Using a model of the hydrodynamic response of a flare loop to energy input in the form of a nonthermal electron beam, the predicted line profile of the Ca XIX resonance line at 3.177 A is computed. The results are compared with observations and are shown to generally agree, both qualitatively and quantitatively, with these observations. The model does, however, predict an overall blueshift in the line profile, a result which differs with earlier interpretations of the observations, and which remains to be tested by absolutely calibrated measurements of the Ca XIX spectrum. It is concluded that electron-heated models of solar flares quite naturally predict the observed features in the Ca XIX line profile, without the need to introduce nonthermal motions or an artificial division of the flare plasma into two distinct components, as suggested by previous authors.

Emslie, Gordon A.↗

Low-frequency mobility response functions for the central plasma sheet with application to tearing modes

Consideration is given to the effect of constant cross-tail magnetic field By on the collisionless conductivity produced by chaotic scattering and stochastic diffusion of particles in the current sheet for a parabolic geometry. It is shown that the correlation time scales as (By/Bz)-squared, and from this strong By scaling a strong tendency toward stabilization of the linear tearing modes with increasing values of By is inferred. This effect of increased dawn-dusk mobility is particularly dramatic when electrons are introduced in the calculation, and is in agreement with the results of kinetic particle simulations. The collisionless conductivity is expressed in terms of the ensemble-averaged power spectrum of the single particle trajectories, which makes it possible to calculate directly the linear conductivity instead of deriving it from the calculation of the irreversible heating rates.

Hernandez, J.↗

A model of the pre-Sedov expansion phase of supernova remnant-ambient plasma coupling and X-ray emission from SN 1987A

This paper examines the mechanism responsible for coupling supernova (SN) remnant to the ambient medium during the pre-Sedov or the so-called free expansion phase, immediately following the progenitor explosion. A theory is developed for the interaction of an SN piston with the ambient medium during the pre-Sedov phase. The possibility of X-ray production by the high-speed portion of the piston during this phase is investigated. The relevant observations of high-energy emissions from the SN 1987A, including the X-ray spectrum, luminosity, and temporal development, are considered. It is shown that the commonly assumed snowplow model for SNR evolution is valid, because of the action of a variety of collisionless two-stream instabilities that permit the coupling of the ambient plasma with SNR.

Spicer, D. S.↗