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At least 127 records · Page 7

TRACER-CAT-LANL Aerosol Optics and Chemical Speciation - SP2

Aerosol size distribution, optical properties, and speciation data collected in La Port TX, during TRACER-CAT-LANL, July 2022, with basic trace gas measurements. All sampling was conducted with an identical aerosol inlet as the standard ARM-AOS systems. The TRacking Aerosol Convection interactions ExpeRiment Carbonaceous Aerosols Thrust by Los Alamos National Laboratory (TRACER-CAT-LANL, July 2022) was designed to complement the larger ARM TRACER science goals to understand convective cloud lifecycles and aerosol-convection interactions. TRACER-CAT-LANL is focused on understanding the relationship between particle composition and light absorption and the influence of water uptake on this relationship. This aerosol and trace gas data can be used to understand the relationship between particle composition and light absorption and the influence of water uptake on this relationship. Instruments Include: Picarro GHG Photoacoustic Soot Spectrometer (PASS-3) Humidified-cavity attenuated phase shift-single scattering albedo particulate matter monitor (H-CAPS-PMSSA) Soot Particle Aerosol Mass Spectrometer (SPAMS) Single-Particle Soot Photometer (SP2) Cloud Condensation Nuclei Counter (CCNc) Aerodynamic Particle Sizer (APS) Scanning Mobility Particle Sizer (SMPS)

54 ENVIRONMENTAL SCIENCES↗

TRACER-CAT-LANL Aerosol Optics and Chemical Speciation - SPAMS

Aerosol size distribution, optical properties, and speciation data collected in La Port TX, during TRACER-CAT-LANL, July 2022, with basic trace gas measurements. All sampling was conducted with an identical aerosol inlet as the standard ARM-AOS systems. The TRacking Aerosol Convection interactions ExpeRiment Carbonaceous Aerosols Thrust by Los Alamos National Laboratory (TRACER-CAT-LANL, July 2022) was designed to complement the larger ARM TRACER science goals to understand convective cloud lifecycles and aerosol-convection interactions. TRACER-CAT-LANL is focused on understanding the relationship between particle composition and light absorption and the influence of water uptake on this relationship. This aerosol and trace gas data can be used to understand the relationship between particle composition and light absorption and the influence of water uptake on this relationship. Instruments Include: Picarro GHG Photoacoustic Soot Spectrometer (PASS-3) Humidified-cavity attenuated phase shift-single scattering albedo particulate matter monitor (H-CAPS-PMSSA) Soot Particle Aerosol Mass Spectrometer (SPAMS) Single-Particle Soot Photometer (SP2) Cloud Condensation Nuclei Counter (CCNc) Aerodynamic Particle Sizer (APS) Scanning Mobility Particle Sizer (SMPS)

54 ENVIRONMENTAL SCIENCES↗

TRACER-CAT-LANL Aerosol Optics and Chemical Speciation - SMPS

Aerosol size distribution, optical properties, and speciation data collected in La Port TX, during TRACER-CAT-LANL, July 2022, with basic trace gas measurements. All sampling was conducted with an identical aerosol inlet as the standard ARM-AOS systems. The TRacking Aerosol Convection interactions ExpeRiment Carbonaceous Aerosols Thrust by Los Alamos National Laboratory (TRACER-CAT-LANL, July 2022) was designed to complement the larger ARM TRACER science goals to understand convective cloud lifecycles and aerosol-convection interactions. TRACER-CAT-LANL is focused on understanding the relationship between particle composition and light absorption and the influence of water uptake on this relationship. This aerosol and trace gas data can be used to understand the relationship between particle composition and light absorption and the influence of water uptake on this relationship. Instruments Include: Picarro GHG Photoacoustic Soot Spectrometer (PASS-3) Humidified-cavity attenuated phase shift-single scattering albedo particulate matter monitor (H-CAPS-PMSSA) Soot Particle Aerosol Mass Spectrometer (SPAMS) Single-Particle Soot Photometer (SP2) Cloud Condensation Nuclei Counter (CCNc) Aerodynamic Particle Sizer (APS) Scanning Mobility Particle Sizer (SMPS)

54 ENVIRONMENTAL SCIENCES↗

TRACER-CAT-LANL Aerosol Optics and Chemical Speciation - PASS

Aerosol size distribution, optical properties, and speciation data collected in La Port TX, during TRACER-CAT-LANL, July 2022, with basic trace gas measurements. All sampling was conducted with an identical aerosol inlet as the standard ARM-AOS systems. The TRacking Aerosol Convection interactions ExpeRiment Carbonaceous Aerosols Thrust by Los Alamos National Laboratory (TRACER-CAT-LANL, July 2022) was designed to complement the larger ARM TRACER science goals to understand convective cloud lifecycles and aerosol-convection interactions. TRACER-CAT-LANL is focused on understanding the relationship between particle composition and light absorption and the influence of water uptake on this relationship. This aerosol and trace gas data can be used to understand the relationship between particle composition and light absorption and the influence of water uptake on this relationship. Instruments Include: Picarro GHG Photoacoustic Soot Spectrometer (PASS-3) Humidified-cavity attenuated phase shift-single scattering albedo particulate matter monitor (H-CAPS-PMSSA) Soot Particle Aerosol Mass Spectrometer (SPAMS) Single-Particle Soot Photometer (SP2) Cloud Condensation Nuclei Counter (CCNc) Aerodynamic Particle Sizer (APS) Scanning Mobility Particle Sizer (SMPS)

54 ENVIRONMENTAL SCIENCES↗

TRACER-CAT-LANL Aerosol Optics and Chemical Speciation - CCN

Aerosol size distribution, optical properties, and speciation data collected in La Port TX, during TRACER-CAT-LANL, July 2022, with basic trace gas measurements. All sampling was conducted with an identical aerosol inlet as the standard ARM-AOS systems. The TRacking Aerosol Convection interactions ExpeRiment Carbonaceous Aerosols Thrust by Los Alamos National Laboratory (TRACER-CAT-LANL, July 2022) was designed to complement the larger ARM TRACER science goals to understand convective cloud lifecycles and aerosol-convection interactions. TRACER-CAT-LANL is focused on understanding the relationship between particle composition and light absorption and the influence of water uptake on this relationship. This aerosol and trace gas data can be used to understand the relationship between particle composition and light absorption and the influence of water uptake on this relationship. Instruments Include: Picarro GHG Photoacoustic Soot Spectrometer (PASS-3) Humidified-cavity attenuated phase shift-single scattering albedo particulate matter monitor (H-CAPS-PMSSA) Soot Particle Aerosol Mass Spectrometer (SPAMS) Single-Particle Soot Photometer (SP2) Cloud Condensation Nuclei Counter (CCNc) Aerodynamic Particle Sizer (APS) Scanning Mobility Particle Sizer (SMPS)

54 ENVIRONMENTAL SCIENCES↗

Dark matter in the galactic disk

Observational data on the distributions of tracer stars, F dwarfs and K giants were used as input to obtain self-consistent solutions for the Poisson and Vlasov equations to set bounds on the amount of missing matter in the solar neighborhood. The numerical computations were carried out using Galaxy models which feature multiple disk components and an unseen massive halo. The star data included the mass components and velocity dispersions. Consideration of various possible distributions of the unseen matter leads to the conjecture that half of the disk material in the solar neighborhood has yet to be observed. Techniques for determining if brown dwarfs are a significant component of the missing mass are discussed, as are improved models which would use limited numbers of tracer stars to set further constraints on the amount and distribution of the missing mass.

Bahcall, John N.↗

Study of the Cosmic Rays and Interstellar Medium in Local H I Clouds Using Fermi -LAT Gamma-Ray Observations

An accurate estimate of the interstellar gas density distribution is crucial to understanding the interstellar medium (ISM) and Galactic cosmic rays (CRs). To comprehend the ISM and CRs in a local environment, a study of the diffuse $γ$-ray emission in a midlatitude region of the third quadrant was performed. Specifically, the $γ$-ray data in the 0.1–25.6 GeV energy range of the Fermi Large Area Telescope (LAT) and other interstellar gas tracers such as the HI4PI survey data and the Planck dust thermal emission model were used, and the northern and southern regions were analyzed separately. The variation of the dust emission D em with the total neutral gas column density N H was studied in high dust temperature areas, and the N H /D em ratio was calibrated using $γ$-ray data under the assumption of a uniform CR intensity in the studied regions. The measured integrated $γ$-ray emissivities above 100 MeV are (1.58 ± 0.04) x 10 -26 photons s -1 sr -1 H-atom-1 and (1.59 ± 0.02) x 10-26 photons s-1 sr-1 H-atom -1 in the northern and southern regions, respectively, supporting the existence of a uniform CR intensity in the vicinity of the solar system. While most of the gas can be interpreted to be H I with a spin temperature of T S = 125 K or higher, an area dominated by optically thick H I with T S ~ 40 K was identified.

79 ASTRONOMY AND ASTROPHYSICS↗

TRACER-CAT-LANL Aerosol Optics and Chemical Speciation - CAPS-SSA

Aerosol size distribution, optical properties, and speciation data collected in La Port TX, during TRACER-CAT-LANL, July 2022, with basic trace gas measurements. All sampling was conducted with an identical aerosol inlet as the standard ARM-AOS systems. The TRacking Aerosol Convection interactions ExpeRiment Carbonaceous Aerosols Thrust by Los Alamos National Laboratory (TRACER-CAT-LANL, July 2022) was designed to complement the larger ARM TRACER science goals to understand convective cloud lifecycles and aerosol-convection interactions. TRACER-CAT-LANL is focused on understanding the relationship between particle composition and light absorption and the influence of water uptake on this relationship. This aerosol and trace gas data can be used to understand the relationship between particle composition and light absorption and the influence of water uptake on this relationship. Instruments Include: Picarro GHG Photoacoustic Soot Spectrometer (PASS-3) Humidified-cavity attenuated phase shift-single scattering albedo particulate matter monitor (H-CAPS-PMSSA) Soot Particle Aerosol Mass Spectrometer (SPAMS) Single-Particle Soot Photometer (SP2) Cloud Condensation Nuclei Counter (CCNc) Aerodynamic Particle Sizer (APS) Scanning Mobility Particle Sizer (SMPS)

54 ENVIRONMENTAL SCIENCES↗

TRACER CLAMPS1 AERI TROPoe Retrievals

These files contain 24 hour periods of retrieved thermodynamic profiles derived from observations collected by the CLAMPS1 Atmospheric Emitted Radiance Interferometer (AERI). The TROPoe algorithm is a python equivalent to the AERIoe algorithm (see Turner and Loehnert 2014; Turner and Blumberg 2019). These data were collected during the TRACER-CUBIC project. Due to issues with the CLAMPS1 microwave radiometer, only retrievals that used AERI data are available.

54 ENVIRONMENTAL SCIENCES↗

Robust Carbon Dioxide Plume Imaging Using Joint Tomographic Inversion of Seismic Onset Time and Distributed Pressure and Temperature Measurements (Final Report)

We develop and demonstrate rapid and cost-effective methodologies for spatiotemporal tracking of CO2 plumes during geologic sequestration using joint inversion of seismic data and distributed pressure and temperature measurements. Key elements of our methodology are: (a) a computationally efficient approach to pressure and temperature propagation, (b) analysis of time lapse seismic data using a novel ‘seismic onset time’ approach to detect fluid front propagation, and (c) data assimilation and uncertainty assessment via joint inversion of pressure, temperature and time lapse seismic data, and (d) validating the numerical tomographic inversion using a CO2 injection demonstration projects, specifically data collected from the from the Petra Nova Parish Holdings CCUS project in the West Ranch Field, Texas and the Chester-16 reef CO2 injection site in Northern Michigan which is part of the DOE Midwestern Carbon Sequestration Project. The research team is led by Texas A&M University and includes Battelle as a subcontractor with support from Shell, Anadarko, Chevron and JX Nippon. A carbon dioxide (CO2) water-alternating-gas (WAG) pilot was conducted to gain insights into tertiary oil recovery potential via CO2 flood in the West Ranch Field as part of the Petra Nova project, the world’s largest post-combustion CO2 capture and utilization initiative. With a fluvial formation geology and large contrasts in permeability, this is a challenging and novel application of CO2 enhanced oil recovery (EOR). We build a predictive dynamic model of the subsurface that incorporates the multiphase and compositional data acquired during the pilot operation. The calibrated model is used for the carbon dioxide plume imaging. The study began with an initialization of the pilot sector model extracted from a calibrated full-field model. The pilot model calibration follows a two-step hierarchical workflow. First, we performed a large-scale update of the permeability distribution by integrating available bottomhole pressure and multiphase production data. In the second step, local permeability field is fine-tuned using a streamline-based method to match CO2 breakthrough times at the producers. The predictive capability of the calibrated model was verified through two blind validation tests: (1) the model showed good agreement with saturation logs acquired at two observation wells; and (2) the model reproduced the CO2 recovery as a fraction of the injected CO2. The use of seismic onset times has shown great promise for integrating near-continuous seismic surveys for updating geologic models. In this study, we analyze the impact of seismic survey frequency on the onset time approach aiming to extend the application of onset time to infrequent seismic surveys. In addition, we quantitatively examine the nonlinearity of the onset time method and compare it to the commonly used amplitude inversion method. We carry out a sensitivity analysis of seismic survey frequency based on the complete seismic survey data (over 175 surveys) of steam injection in a heavy oil reservoir (Peace River Unit) in Canada. Our results show that an adequate onset time map can be obtained from the infrequent seismic surveys by interpolation between seismic surveys as long as there is no change in the dominant underlying physics between the successive surveys. The study also shows that nonlinearity of the onset time method can be -smaller than that of the amplitude inversion method by several orders of magnitude. Application to the Brugge benchmark case shows that the onset time method obtains comparable permeability update as the traditional seismic amplitude inversion method with faster computation and improved convergence characteristics. We extend the streamline-based data integration approach to incorporate distributed temperature sensor (DTS) data using the concept of thermal tracer travel time. Then, a hierarchical workflow composed of evolutionary and streamline methods is employed to jointly history match the DTS and pressure data. Finally, CO2 saturation and streamline maps are used to visualize the CO2 plume movement during the sequestration process. The hierarchical workflow is applied to a carbon sequestration project in a carbonate reef reservoir within the Northern Niagaran Pinnacle Reef Trend in Michigan, USA. The monitoring data set consists of distributed temperature sensing (DTS) data acquired at the injection well and a monitoring well, flowing bottom-hole pressure data at the injection well, and time-lapse pressure measurements at several locations along the monitoring well. The history matching results indicate that the CO2 movement is mostly restricted to the intended zones of injection which is consistent with an independent warm-back analysis of the temperature data. In addition to employing simulation models and inverse methods for CO2 plume imaging, we also initialized a data-driven technology for detecting inter-well connectivity based on production and pressure data. Our machine-learning framework is built on the statistical recurrent unit (SRU) model and interprets well-based injection/production data into inter-well connectivity without relying on a geologic model. We test it on synthetic and field-scale CO2 EOR projects utilizing the water-alternating-gas (WAG) process. The validation of the proposed data-driven inter-well connectivity assessment is performed using synthetic data from simulation models where inter-well connectivity can be easily measured using the streamline-based flux allocation. The SRU model is shown to offer excellent prediction performance on the synthetic case. Despite significant measurement noise and frequent well shut-ins imposed in the field-scale case, the SRU model offers good prediction accuracy, the overall relative error of the phase production rates at most producers ranges from 10% to 30%. It is shown that the dominant connections identified by the data-driven method and streamline method are in close agreement. Texas A&M University, the lead organization in the project, was primarily responsible for the development of tomographic approaches for CO2 plume mapping in conjunction with distributed pressure, temperature and seismic onset time data. Battelle, as a subcontractor, was primarily responsible for the development of analytical and empirical methods for analyzing transient injection rate and pressure data from point/line sources such as injection and monitoring wells. An additional area of emphasis for Battelle was the use of machine learning for such tasks as inferring reservoir connectivity information from injection-production data, and identifying variable importance for machine learning-based proxy models developed from full-physics simulations. The two organizations also collaborated on the application of the tomographic inversion methodology for a field data set.

02 PETROLEUM↗

Artificial Gravity as a Bone Loss Countermeasure in Simulated Weightlessness

The impact of microgravity on the human body is a significant concern for space travelers. We report here initial results from a pilot study designed to explore the utility of artificial gravity (AG) as a countermeasure to the effects of microgravity, specifically to bone loss. After an initial phase of adaptation and testing, 15 male subjects underwent 21 days of 6 head-down bed rest to simulate the deconditioning associated with space flight. Eight of the subjects underwent 1 h of centrifugation (AG, 1 gz at the heart, 2.5 gz at the feet) each day for 21 days, while 7 of the subjects served as untreated controls (CN). Blood and urine were collected before, during, and after bed rest for bone marker determinations. At this point, preliminary data are available on the first 8 subjects (6 AG, and 2 CN). Comparing the last week of bed rest to before bed rest, urinary excretion of the bone resorption marker n-telopeptide increased 95 plus or minus 59% (mean plus or minus SD) in CN but only 32 plus or minus 26% in the AG group. Similar results were found for another resorption marker, helical peptide (increased 57 plus or minus 0% and 35 plus or minus 13% in CN and AG respectively). Bone-specific alkaline phosphatase, a bone formation marker, did not change during bed rest. At this point, sample analyses are continuing, including calcium tracer kinetic studies. These initial data demonstrate the potential effectiveness of short-radius, intermittent AG as a countermeasure to the bone deconditioning that occurs during bed rest.

Smith, S. M.↗

Improved galactic foreground removal for B-mode detection with clustering methods

ABSTRACT Characterizing the sub-mm Galactic emission has become increasingly critical especially in identifying and removing its polarized contribution from the one emitted by the cosmic microwave background (CMB). In this work, we present a parametric foreground removal performed on to sub-patches identified in the celestial sphere by means of spectral clustering. Our approach takes into account efficiently both the geometrical affinity and the similarity induced by the measurements and the accompanying errors. The optimal partition is then used to parametrically separate the Galactic emission encoding thermal dust and synchrotron from the CMB one applied on two nominal observations of forthcoming experiments from the ground and from the space. Moreover, the clustering is performed on tracers that are different from the data used for component separation, e.g. the spectral index maps of dust and synchrotron. Performing the parametric fit singularly on each of the clustering derived regions results in an overall improvement: both controlling the bias and the uncertainties in the CMB B-mode recovered maps. We finally apply this technique using the map of the number of clouds along the line of sight, $\mathcal {N}_c$, as estimated from H i emission data and perform parametric fitting on to patches derived by clustering on this map. We show that adopting the $\mathcal {N}_c$ map as a tracer for the patches related to the thermal dust emission, results in reducing the B-mode residuals post-component separation. The code is made publicly available https://github.com/giuspugl/fgcluster.

79 ASTRONOMY AND ASTROPHYSICS↗

The EGS Collab Project: Status and Accomplishments

The EGS Collab project, supported by the US Department of Energy, is addressing challenges in implementing enhanced geothermal systems (EGS). This includes improving understanding of the stimulation of crystalline rock to create appropriate flow pathways, and the ability to effectively simulate both the stimulation and the flow and transport processes in the resulting fracture network. The project is performing intensively monitored rock stimulation and flow tests at the 10-m scale in an underground research laboratory. Data and observations from the field test are compared to simulations to understand processes and to build confidence in numerical modeling of the processes. In Experiment 1, we examined hydraulic fracturing an underground test bed at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, at a depth of approximately 1.5 km. We drilled eight sub-horizontal boreholes in a well-characterized phyllite. Six of the boreholes were instrumented with many sensor types to allow careful monitoring of stimulation events and flow tests, and the other two boreholes were used for water injection and production. We performed a number of stimulations and flow tests in the testbed. Our monitoring systems allowed detailed observations and collection of numerous data sets of processes occurring during stimulation and during dynamic flow tests. Long-term ambient temperature and chilled water flow tests were performed in addition to many tracer tests to examine system behavior. Data were rapidly analyzed, allowing adaptive control of the tests. Numerical simulation was used to answer key experimental design questions, to forecast fracture propagation trajectories and extents, and to analyze and evaluate results. Many simulations were performed in near-real-time in conjunction with the field experiments, with more detailed process study simulations performed on a longer timeframe. Experiment 2 will examine hydraulic shearing in a test bed being built at the SURF at a depth of about 1.25 km in amphibolite under a different set of stress and fracture conditions than Experiment 1. Five sets of fracture orientations were considered in design, and three orientations seem to be consistently observed.

EGS Collab↗

Understanding long-term groundwater flow at Pahute Mesa and vicinity, Nevada National Security Site, USA, from naturally occurring geochemical and isotopic tracers

Abstract Recently collected naturally occurring geochemical and isotopic groundwater tracers were combined with historic data from the Pahute Mesa area of the Nevada National Security Site (NNSS), Nevada, USA, to provide insights into long-term regional groundwater flow patterns, mixing and recharge. Pahute Mesa was the site of 85 nuclear detonations between 1965 and 1992, many of them deeply buried devices that introduced radionuclides directly into groundwater. The dataset examined included major ions and field measurements, stable isotopes of hydrogen (δ 2 H), oxygen (δ 18 O), carbon (δ 13 C) and sulfur (δ 34 S), and radioisotopes of carbon ( 14 C) and chloride ( 36 Cl). Analysis of the patterns of groundwater 14 C data and the δ 2 H and δ 18 O signatures indicates that groundwater recharge is predominantly of Pleistocene age, except for a few localized areas near major ephemeral drainages. Steep gradients in sulfate (SO 4 ) and chloride (Cl) define a region near the western edge of the NNSS where high-concentration groundwater flowing south from north of the NNSS merges with dilute groundwater flowing west from eastern Pahute Mesa in a mixing zone that coincides with a groundwater trough associated with major faults. The 36 Cl/Cl and δ 34 S data suggest that the source of the high Cl and SO 4 in the groundwater was a now-dry, pluvial-age playa lake north of the NNSS. Patterns of groundwater flow indicated by the combined data sets show that groundwater is flowing around the northwest margin of the now extinct Timber Mountain Caldera Complex toward regional discharge areas in Oasis Valley.

58 GEOSCIENCES↗

Quantifying the Thermodynamic Impacts on the Atmospheric Boundary Layer due to the Sea Breeze in the Coastal Houston Region

The atmospheric boundary layer (ABL) is unique in coastal regions because of kinematic and thermodynamic influences from continental and marine environments. Sea-breeze (SB) circulations act to equilibrate the land–sea temperature gradient through advecting marine air onshore. The strength of the SB varies in terms of stability, temperature, and moisture advection and influences air quality and weather forecasts. The Tracking Aerosol Convection Interactions Experiment (TRACER) collected a wealth of data on coastal boundary layer evolution, including observations from uncrewed aerial systems (UASs). Vertical profiles of temperature, humidity, and winds were collected by the OU CopterSonde UAS from June to September in the coastal region of Houston. These profiles offer 5-m vertical resolution, on average, every 30 min through diurnal transitions, SB events, and nearby deep convection. During the campaign, CopterSonde observations were gathered through 17 SB events, six of which led to convection initiation. The UAS data can resolve the thermodynamic evolution and interactions between the SB and the preexisting convective boundary layer. Results show large variability across observed SBs and their impacts on temperature and moisture. The intensity of thermodynamic changes depends on the time of sea-breeze passage and influence from the Galveston Bay Breeze, a secondary marine circulation commonly observed in this region. In quantifying the spectrum of SB impacts, equivalent potential temperature θ e is used to contextualize its role in convection initiation and evolution. In conclusion, while all SBs tend to increase θ e from moisture advection, the rate and timing of the θ e rise can distinguish convective from nonconvective cases.

54 ENVIRONMENTAL SCIENCES↗

Baseline [ 18 F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer’s disease

Background: The role and implementation of tau PET imaging for predicting subsequent cognitive decline in Alzheimer’s disease (AD) remains uncertain. This study was designed to evaluate the relationship between baseline [ 18 F]GTP1 tau PET and subsequent longitudinal change across multiple cognitive measures over 18 months. Methods: Our analyses incorporated data from 67 participants, including cognitively normal controls (n = 10) and β-amyloid (Aβ)-positive individuals ([ 18 F] florbetapir Aβ PET) with prodromal (n = 26), mild (n = 16), or moderate (n = 15) AD. Baseline measurements included cortical volume (MRI), tau burden ([ 18 F]GTP1 tau PET), and cognitive assessments [Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), 13-item version of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog13), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)]. Cognitive assessments were repeated at 6-month intervals over an 18-month period. Associations between baseline [ 18 F]GTP1 tau PET indices and longitudinal cognitive performance were assessed via univariate (Spearman correlations) and multivariate (linear mixed effects models) approaches. The utility of potential prognostic tau PET cut points was assessed with ROC curves. Results: Univariate analyses indicated that greater baseline [ 18 F]GTP1 tau PET signal was associated with faster rates of subsequent decline on the MMSE, CDR, and ADAS-Cog13 across regions of interest (ROIs). In multivariate analyses adjusted for baseline age, cognitive performance, cortical volume, and Aβ PET SUVR, the prognostic performance of [ 18 F]GTP1 SUVR was most robust in the whole cortical gray ROI. When AD participants were dichotomized into low versus high tau subgroups based on baseline [ 18 F]GTP1 PET standardized uptake value ratios (SUVR) in the temporal (cutoff = 1.325) or whole cortical gray (cutoff = 1.245) ROIs, high tau subgroups demonstrated significantly more decline on the MMSE, CDR, and ADAS-Cog13. Conclusions: Our results suggest that [ 18 F]GTP1 tau PET represents a prognostic biomarker in AD and are consistent with data from other tau PET tracers. Tau PET imaging may have utility for identifying AD patients at risk for more rapid cognitive decline and for stratification and/or enrichment of participant selection in AD clinical trials.

60 APPLIED LIFE SCIENCES↗

S $^{5}$: The Orbital and Chemical Properties of One Dozen Stellar Streams

We report the kinematic, orbital, and chemical properties of 12 stellar streams with no evident progenitors using line-of-sight velocities and metallicities from the Southern Stellar Stream Spectroscopic Survey (S $^{5}$), proper motions from Gaia EDR3, and distances derived from distance tracers or the literature. This data set provides the largest homogeneously analyzed set of streams with full 6D kinematics and metallicities. All streams have heliocentric distances between ∼10 and 50 kpc. The velocity and metallicity dispersions show that half of the stream progenitors were disrupted dwarf galaxies (DGs), while the other half originated from disrupted globular clusters (GCs), hereafter referred to as DG and GC streams. Based on the mean metallicities of the streams and the mass–metallicity relation, the luminosities of the progenitors of the DG streams range between those of Carina and Ursa Major I (−9.5 ≲ M $_{V}$ ≲ −5.5). Four of the six GC streams have mean metallicities of Fe/H < −2, more metal poor than typical Milky Way (MW) GCs at similar distances. Interestingly, the 300S and Jet GC streams are the only streams on retrograde orbits in our dozen-stream sample. Finally, we compare the orbital properties of the streams with known DGs and GCs in the MW, finding several possible associations. Some streams appear to have been accreted with the recently discovered Gaia–Enceladus–Sausage system, and others suggest that GCs were formed in and accreted together with the progenitors of DG streams whose stellar masses are similar to those of Draco to Carina (∼10$^{5}$–10$^{6}$ M $_{⊙}$).

79 ASTRONOMY AND ASTROPHYSICS↗