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At least 127 records · Page 7

Optimization of the BDX experiment for Light Dark Matter searches at JLab

The Light Dark Matter (LDM) hypothesis postulates the existence of a new class of sub GeV particles, neutral under Standard Model (SM) interactions. In its simplest form, LDM consists of particles ¿ with masses below 1 GeV/c2, interacting with SM particles via a new force mediated by a light, spin-1 boson A0, commonly referred to as “Dark Photon”. This framework envisions a distinct “Dark Sector” with its own particles and interactions, offering a theoretically well motivated explanation for Dark Matter, consistent with astrophysical observations and a thermal production mechanism. The Beam Dump eXperiment (BDX) is an approved experiment at Jefferson Lab designed to search for Light Dark Matter. BDX will utilize an 11 GeV electron beam impinging on a thick target to produce a forward-boosted secondary beam of Light Dark Matter particles, which will then be detected by a dedicated downstream detector. Approved in 2018, BDX is expected to be commissioned in 2026 and run in 2027-2029. My thesis focuses on the preparatory work to deploy the BDX experiment. The detector design has been optimized to balance practicality with enhanced Light Dark Matter detection capabilities. Extensive characterization of detector components has been performed to ensure a precise understanding of detector response. A custom Monte Carlo framework has been developed to simulate Light Dark Matter signal and explore various theoretical models of interest. Additionally, a comprehensive data analysis framework has been developed to maximize the experiment sensitivity to Light Dark Matter, with optimizations based on expected detector performance. The ultimate goal of this thesis is to optimize BDX as a flagship experiment in Light Dark Matter searches, enabling it to probe different Dark Matter models.

Spreafico, M. [Univ. of Genova (Italy)]↗

Discovering Electroweak Interacting Dark Matter at Muon Colliders Using Soft Tracks

Minimal dark matter models feature one neutral particle that serves as a thermal relic dark matter candidate, as well as quasidegenerate charged states with TeV masses. When the charged states are produced at colliders, they can decay into dark matter and a low-momentum (soft) charged particle, which is challenging to reconstruct at hadron colliders. We demonstrate that a 3 TeV muon collider is capable of detecting these soft tracks, enabling the discovery of thermal Higgsinos and similar dark matter candidates that constitute highly motivated scenarios for future collider searches.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Dark Sector Physics at High-Intensity Experiments

Is Dark Matter part of a Dark Sector? The possibility of a dark sector neutral under Standard Model (SM) forces furnishes an attractive explanation for the existence of Dark Matter (DM), and is a compelling new-physics direction to explore in its own right, with potential relevance to fundamental questions as varied as neutrino masses, the hierarchy problem, and the Universe's matter-antimatter asymmetry. Because dark sectors are generically weakly coupled to ordinary matter, and because they can naturally have MeV-to-GeV masses and respect the symmetries of the SM, they are only mildly constrained by high-energy collider data and precision atomic measurements. Yet upcoming and proposed intensity-frontier experiments will offer an unprecedented window into the physics of dark sectors, highlighted as a Priority Research Direction in the 2018 Dark Matter New Initiatives (DMNI) BRN report. Support for this program -- in the form of dark-sector analyses at multi-purpose experiments, realization of the intensity-frontier experiments receiving DMNI funds, an expansion of DMNI support to explore the full breadth of DM and visible final-state signatures (especially long-lived particles) called for in the BRN report, and support for a robust dark-sector theory effort -- will enable comprehensive exploration of low-mass thermal DM milestones, and greatly enhance the potential of intensity-frontier experiments to discover dark-sector particles decaying back to SM particles.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Dynamic Line Rating Models and Their Potential for a Cost‐Effective Transition to Carbon‐Neutral Power Systems

Most transmission system operators (TSOs) currently use seasonally steady-state models considering limiting weather conditions that serve as reference to compute the transmission capacity of overhead power lines. The use of dynamic line rating (DLR) models can avoid the construction of new lines, market splitting, false congestions, and the degradation of lines in a cost-effective way. DLR can also be used in the long run in grid extension and new power capacity planning. In the short run, it should be used to help operate power systems with congested lines. The operation of the power systems is planned to have the market trading into account; thus, it computes transactions hours ahead of real-time operation, using power flow forecasts affected by large errors. In the near future, within a “smart grid” environment, in real-time operation conditions, TSOs should be able to rapidly compute the capacity rating of overhead lines using DLR models and the most reliable weather information, forecasts, and line measurements, avoiding the current steady-state approach that, in many circumstances, assumes ampacities above the thermal limits of the lines. Here, this work presents a review of the line rating methodologies in several European countries and the United States. Furthermore, it presents the results of pilot projects and studies considering the application of DLR in overhead power lines, obtaining significant reductions in the congestion of internal networks and cross-border transmission lines.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Custodial symmetry breaking and Higgs boson signatures at the LHC

We discuss the simplest model that predicts a tree-level modification of the ρ parameter from a shift in the W -mass without changing the prediction for the Z mass. This model predicts a new neutral Higgs and two charged Higgses, with very similar masses and suppressed couplings to the Standard Model fermions. We discuss the decay properties of these new scalar bosons, and the main signatures at the Large Hadron Collider. Comparing these signatures for the first time to the latest measurements, we show that while masses around 200 GeV are excluded for some scenarios, over a wide range of model parameter space the new bosons can have a mass close to the electroweak scale without violating existing limits from experimental searches or destroying the agreement with measurements. We investigate the scenario where the new neutral Higgs is fermiophobic and has a large branching ratio into W gauge bosons and/or photons, and show that this could lead to a signal in the diphoton mass spectrum at low Higgs masses. We discuss the different signatures that can motivate new measurements and searches at the Large Hadron Collider. Published by the American Physical Society 2024

Astronomy & Astrophysics↗

Modeling the Low-Pressure High-Voltage Branch of the Paschen Curve for Hydrogen and Deuterium

A physical and numerical model of the Townsend discharge in molecular hydrogen and deuterium has been developed to meet the needs of designing a plasma-based switching device for power grid applications. Here, the model allows to predict the low-pressure branch of the Paschen curve for applied voltage in the range of several hundred kilovolts. In the regime of interest, electrons are in a runaway state and ionization by ions and fast neutrals sustains the discharge. It was essential to correctly account for both gas-phase and surface interactions (electron emission and electron backscattering), especially in terms of their dependence on particle energy. The model yields results consistent with prior data obtained for lower voltage. The three-species (electrons, ions, and fast neutrals) model successfully captures the essential physics of the process.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Time-dependent collisional radiative modeling of tungsten in the magnetic sheath for erosion diagnosis

Abstract Tungsten is the material of choice for the divertors in ITER, SPARC and future fusion reactors. Accurate diagnosis of tungsten erosion and migration is important for first wall life time, slag production and core performance. The addition of a magnetic presheath requires time-dependent collisional radiative effects to be included for accurate neutral tungsten collisional radiative modeling. Gross erosion measurements could be modified by a factor of 10 due to the inclusion of time-dependent effects for ITER relevant divertor conditions. A simple sputtering model and sheath density model are developed to investigate time-dependent collisional radiative effects. Neutral tungsten spectral lines populated from different metastable levels depend on model parameters leading to potential spectroscopic diagnostics of plasma parameters. Electron temperatures inferred from spectroscopic line ratios are in agreement with Langmuir probe measurements in the Compact Toroidal Hybrid.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Neutral beams for the burning plasma era: Simulations and modeling of deuterium ion beams for plasma heating (CRADA Final Report)

Together with Realta Fusion, we set up several simulation scenarios and ran simulations using the WarpX code which is developed by LBNL and especially by members of the LBNL team. We investigated beam transport and beam neutralization and ran optimization and benchmark simulations. To achieve this, several new features were added to the warpX code. These code additions will also be beneficial to other users of warpX including several fusion companies and researchers at National Laboratories. Furthermore, we supported Realta Fusion in setting up their own instances of WarpX. We presented our results at the American Physical Society Division of Plasma Physics meeting and are in the process of writing a publication that will be submitted to a peer-reviewed journal to share our results with the broader community.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Enhanced pedestal transport driven by edge collisionality on Alcator C-Mod and its role in regulating H-mode pedestal gradients

Experimental measurements of plasma and neutral profiles across the pedestal are used in conjunction with 2D edge modeling to examine pedestal stiffness in Alcator C-Mod H-mode plasmas. Enhanced D α experiments on Alcator C-Mod observed pedestal degradation and loss in confinement below a critical value of net power crossing the separatrix, P net = $P^{crit}_{net}$ ≈ 2.3 MW, in the absence of any external fueling. New analysis of ionization and particle flux profiles reveal saturation of the pedestal electron density, $n^{ped}_{e}$, despite continuous increases in ionization throughout the pedestal, inversely related to P net . A limi to the pedestal $\nabla$n e emerges as the particle flux, Γ D , continues to grow, implying increases in the effective particle diffusivity, D eff . This is well-correlated with the separatrix collisionality, $v^*_{sep}$ and a turbulence control parameter, α t , implying a possible transition in type of turbulence. The transition is well correlated with the experimentally observed value of $P^{crit}_{net}$. SOLPS-ITER modeling is performed for select discharges from the power scan, constrained with experimental electron and neutral densities, measured at the outer midpane. The modeling confirms general growth in D eff , consistent with experimental findings, and additionally suggests even larger growth in Χ e at the same $P^{crit}_{net}$.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Intrinsic rotation modulation by diffusive neutral particles in tokamaks

Abstract The modulated transport model, a model kinetic ion transport equation for the pedestal and scrape-off layer (SOL), is generalized to self-consistently include effects of a single neutral particle species. The neutrals contribute additional transport terms, modifying the v ∥ -dependent orbit-averaged ion diffusivities of the original work and the resulting predicted intrinsic rotation of the ions. After making simplifying assumptions of the neutral transport, in particular taking the continuous transport limit via a short charge-exchange step expansion, we derive relatively simple analytic expressions that capture the diffusive neutral physics. Within the scope of the model’s validity, the neutral-driven intrinsic rotation can compete with the turbulence-driven intrinsic rotation. However, for physically motivated parameters, the neutral-driven intrinsic rotation appears negligible, either on a term-by-term basis or due to a strong cancellation between the neutral-driven momentum diffusion and pinch terms. It appears that a treatment containing finite charge-exchange steps is necessary to capture neutral transport of strong flow momentum into the confined region from the SOL.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Modeling HIV-1 Within-Host Dynamics After Passive Infusion of the Broadly Neutralizing Antibody VRC01

VRC01 is a broadly neutralizing antibody that targets the CD4 binding site of HIV-1 gp120. Passive administration of VRC01 in humans has assessed the safety and the effect on plasma viremia of this monoclonal antibody (mAb) in a phase 1 clinical trial. After VRC01 infusion, the plasma viral load in most of the participants was reduced but had particular dynamics not observed during antiretroviral therapy. In this paper, we introduce different mathematical models to explain the observed dynamics and fit them to the plasma viral load data. Based on the fitting results we argue that a model containing reversible Ab binding to virions and clearance of virus-VRC01 complexes by a two-step process that includes (1) saturable capture followed by (2) internalization/degradation by phagocytes, best explains the data. This model predicts that VRC01 may enhance the clearance of Ab-virus complexes, explaining the initial viral decay observed immediately after antibody infusion in some participants. Because Ab-virus complexes are assumed to be unable to infect cells, i.e., contain neutralized virus, the model predicts a longer-term viral decay consistent with that observed in the VRC01 treated participants. By assuming a homogeneous viral population sensitive to VRC01, the model provides good fits to all of the participant data. However, the fits are improved by assuming that there were two populations of virus, one more susceptible to antibody-mediated neutralization than the other.

60 APPLIED LIFE SCIENCES↗

Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP(1,2) in a position elevated from the virion membrane

Abstract Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP 1,2 ) are the standard of care for Ebola virus disease (EVD). Anti-GP 1,2 mAbs targeting the stalk and membrane proximal external region (MPER) potently neutralize EBOV in vitro and are protective in a mouse model of EVD. However, their neutralization mechanism is poorly understood because they target a GP 1,2 epitope that has evaded structural characterization. Using X-ray crystallography and cryo-electron tomography of mAb 3A6 complexed with its stalk–MPER epitope, we reveal a previously undescribed mechanism in which 3A6 binds to a conformation of GP 1,2 that is lifted from the virion membrane. We further show that in both domestic guinea pig and rhesus monkey EVD models, 3A6 provides therapeutic benefit at high-viremia advanced disease stages and at the lowest dose yet demonstrated for any anti-EBOV mAb-based monotherapy. The findings reported here can guide design of next-generation highly potent anti-EBOV therapeutics and vaccines.

Science & Technology - Other Topics↗

Combining computational modeling and experimental library screening to affinity-mature VEEV-neutralizing antibody F5

Engineered monoclonal antibodies have proven to be highly effective therapeutics in recent viral outbreaks. However, despite technical advancements, an ability to rapidly adapt or increase antibody affinity and by extension, therapeutic efficacy, has yet to be fully realized. We endeavored to stand-up such a pipeline using molecular modeling combined with experimental library screening to increase the affinity of F5, a monoclonal antibody with potent neutralizing activity against Venezuelan Equine Encephalitis Virus (VEEV), to recombinant VEEV (IAB) E1E2 antigen. We modeled the F5/E1E2 binding interface and generated predictions for mutations to improve binding using a Rosetta-based approach and dTERMen, an informatics approach. The modeling was complicated by the fact that a high-resolution structure of F5 is not available and the H3 loop of F5 exceeds the length for which current modeling approaches can determine a unique structure. A subset of the predicted mutations from both methods were incorporated into a phage display library of scFvs. This library and a library generated by error-prone PCR were screened for binding affinity to the recombinant antigen. Results from the screens identified favorable mutations which were incorporated into 12 human-IgG1 variants. The best variant, containing eight mutations, improved KD from 0.63 nM (parental) to 0.01 nM. While this did not improve neutralization or therapeutic potency of F5 against IAB, it did increase cross-reactivity to other closely related VEEV epizootic and enzootic strains, demonstrating the potential of this method to rapidly adapt existing therapeutics to emerging viral strains.

affinity-maturation↗

(Invited) Understanding Multi-Component Transport and Reaction Phenomena in Bipolar Membranes Used for Electrosynthesis

Bipolar membranes (BPMs), which have long seen usage in electrodialysis reactors for the generation of acid and base, have recently demonstrated potential to become critical components in electrochemical synthesis devices. Because they can operate under large pH gradients, BPMs enable favorable environments for electrocatalysis at the individual electrodes. Critical to the implementation of BPMs in these devices is understanding the kinetics of water dissociation that occurs within the BPM junction as well as the co- and counter-ion crossover through the BPM, which both present significant obstacles to developing efficient and stable BPM-devices for electrosynthesis applications. Prior work has modeled ion transport in bipolar membranes in neutral salt solutions for electrodialysis. However, no model exists for the BPM under the harsh applied pH gradients that would be present in electrosynthesis, and there is significant need to explore the effects of the internal hydration on the lifetime and performance of BPMs in such environments. Additionally, a mechanistic understanding of water dissociation catalysis will be required to develop interfacial catalysts that enable the high current density operation required for scalable electrosynthesis of fuels. In this talk, we discuss modeling methodologies and physics inherent in BPMs and present our recent model of ion transport and water dissociation catalysis in BPMs across the pH scale. Specifically, we simulate multi-ion transport for a BPM with various electrolyte combinations on each side of the membrane, demonstrating the significance of co- and counter-ion crossover in BPMs operating under harsh pH gradients. We then investigate effects caused by hydration gradients that occur due to internal ion-exchange and examine potential methods for improving performance and mitigating crossover. Finally, we examine the impact of the interfacial water dissociation catalyst and perform sensitivity analysis on the key properties (catalyst point of zero charge and pKa) that dictate catalyst performance. These results provide information that is critical to developing a comprehensive understanding of multi-component phenomena in BPMs and to informing the design and implementation of BPMs in next-generation devices for the numerous electrosynthesis chemistries that benefit from operation under an applied pH gradient.

Bui, Justin C↗

Leveraging the Higgs to Discover Physics Beyond the Standard Model (Final Technical Report)

The discovery of an apparently Standard Model-like Higgs at the Large Hadron Collider (LHC) heralds the start of a new era in particle physics. While the Higgs marks the completion of the Standard Model framework, it offers far more opportunities in the search for physics beyond the Standard Model. The Higgs boson raises a pressing theoretical problem known as the hierarchy problem: why is an elementary scalar particle so light when quantum corrections tie its mass to the highest energy scales? The Higgs also provides an unprecedented experimental opportunity as a bellwether of new physics: it may be merely the first of several states in the electroweak symmetry breaking sector, while its production and decays may provide unique evidence for additional particles. Research supported by this award leveraged the Higgs boson to explore new physics from both directions, developing novel approaches to solving the hierarchy problem posed by the Higgs boson and directly employing the Higgs as a new tool for discovery. Given that null results at the LHC and other experiments have begun to endanger conventional approaches to the hierarchy problem, research supported by the award identified original solutions to the hierarchy problem wherein the lightest degrees of freedom protecting the Higgs boson carry no Standard Model quantum numbers and thus evade existing searches. The PI's approach combined standard tools of quantum field theory with novel applications of the orbifold reduction of continuous symmetries to define the framework of "neutral naturalness'' and explore its experimental consequences across the energy, intensity, and cosmic frontiers. In employing the Higgs directly as a tool for discovery, research supported by this award articulated a systematic approach to searching for extensions of the Higgs sector at the LHC and pursued four key avenues through which the Higgs can be used to uncover new physics across a range of experiments: (1) as a direct final state probe; (2) as an indirect probe through its couplings; (3) as a portal to states neutral under the Standard Model; and (4) as a source of exotic processes in displaced decays.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Multiphase outflows in post-starburst E+A galaxies - II. A direct connection between the neutral and ionized outflow phases

ABSTRACT Post-starburst E+A galaxies are systems that hosted a powerful starburst that was quenched abruptly. Simulations suggest that these systems provide the missing link between major merger ULIRGs and red and dead ellipticals, where AGN feedback is responsible for the expulsion or destruction of the molecular gas. However, many details remain unresolved and little is known about AGN-driven winds in this short-lived phase. We present spatially resolved IFU spectroscopy with MUSE/VLT of SDSS J124754.95-033738.6, a post-starburst E+A galaxy with a recent starburst that started 70 Myr ago and ended 30 Myr ago, with a peak SFR of $\sim 150\, \mathrm{M_{\odot }\,yr^{ -1}}$. We detect disturbed gas throughout the entire field of view, suggesting triggering by a minor merger. We detect fast-moving multiphased gas clouds, embedded in a double-cone face-on outflow, which are traced by ionized emission lines and neutral NaID emission and absorption lines. We find remarkable similarities between the kinematics, spatial extents, and line luminosities of the ionized and neutral gas phases, and propose a model in which they are part of the same outflowing clouds, which are exposed to both stellar and AGN radiation. Our photoionization model provides consistent ionized line ratios, NaID absorption optical depths and EWs, and dust reddening. Using the model, we estimate, for the first time, the neutral-to-ionized gas mass ratio (about 20), the sodium neutral fraction, and the size of the outflowing clouds. This is one of the best ever observed direct connections between the neutral and ionized outflow phases in AGN.

Baron, Dalya↗