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At least 127 records · Page 7

Ames interactive molecular model building system - A 3-D computer modelling system applied to the study of the origin of life

The investigation of specific interactions among biological molecules must take into consideration the stereochemistry of the structures. Thus, models of the molecules are essential for describing the spatial organization of potentially interacting groups, and estimations of conformation are required for a description of spatial organization. Both the function of visualizing molecules, and that of estimating conformation through calculations of energy, are part of the molecular modeling system described in the present paper. The potential uses of the system in investigating some aspects of the origin of life rest on the assumption that translation of conformation from genetic elements to catalytic elements would have been required for the development of the first replicating systems subject to the process of biological evolution.

Coeckelenbergh, Y.↗

LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport

An interactive computer program, LabHEART, was developed to simulate the action potential (AP), ionic currents, and Ca handling mechanisms in a rabbit ventricular myocyte. User-oriented, its design allows switching between voltage and current clamp and easy on-line manipulation of key parameters to change the original formulation. The model reproduces normal rabbit ventricular myocyte currents, Ca transients, and APs. We also changed parameters to simulate data from heart failure (HF) myocytes, including reduced transient outward (I(to)) and inward rectifying K currents (I(K1)), enhanced Na/Ca exchange expression, and reduced sarcoplasmic reticulum Ca-ATPase function, but unaltered Ca current density. These changes caused reduced Ca transient amplitude and increased AP duration (especially at lower frequency) as observed experimentally. The model shows that the increased Na/Ca exchange current (I(NaCa)) in HF lowers the intracellular [Ca] threshold for a triggered AP from 800 to 540 nM. Similarly, the decrease in I(K1) reduces the threshold to 600 nM. Changes in I(to) have no effect. Combining enhanced Na/Ca exchange with reduced I(K1) (as in HF) lowers the threshold to trigger an AP to 380 nM. These changes reproduce experimental results in HF, where the contributions of different factors are not readily distinguishable. We conclude that the triggered APs that contribute to nonreentrant ventricular tachycardia in HF are due approximately equally (and nearly additively) to alterations in I(NaCa) and I(K1). A free copy of this software can be obtained at http://www.meddean.luc.edu/lumen/DeptWebs/physio/bers.html.

NASA Discipline Cardiopulmonary↗

Including Finite Surface Span Effects in Empirical Jet-Surface Interaction Noise Models

The effect of finite span on the jet-surface interaction noise source and the jet mixing noise shielding and reflection effects is considered using recently acquired experimental data. First, the experimental setup and resulting data are presented with particular attention to the role of surface span on far-field noise. These effects are then included in existing empirical models that have previously assumed that all surfaces are semi-infinite. This extended abstract briefly describes the experimental setup and data leaving the empirical modeling aspects for the final paper.

Jet↗

Including Finite Surface Span Effects in Empirical Jet-Surface Interaction Noise Models

The effect of finite span on the jet-surface interaction noise source and the jet mixing noise shielding and reflection effects is considered using recently acquired experimental data. First, the experimental setup and resulting data are presented with particular attention to the role of surface span on far-field noise. These effects are then included in existing empirical models that have previously assumed that all surfaces are semi-infinite. This extended abstract briefly describes the experimental setup and data leaving the empirical modeling aspects for the final paper.

Aircraft↗

Including Finite Surface Span Effects in Empirical Jet-Surface Interaction Noise Models

The effect of finite span on the jet-surface interaction noise source and the jet mixing noise shielding and reflection effects is considered using recently acquired experimental data. First, the experimental setup and resulting data are presented with particular attention to the role of surface span on far-field noise. These effects are then included in existing empirical models that have previously assumed that all surfaces are semi-infinite. This extended abstract briefly describes the experimental setup and data leaving the empirical modeling aspects for the final paper.

Aircraft↗

An interacting loop model for solar flare bursts

A schematic model is presented which attempts to explain the quasi-periodic behavior (on a timescale of less than or approximately equal to 10 s) frequency observed in solar hard X-ray bursts. It is shown how, as a result of the strong heating produced during a solar flare burst, the local gas pressure can transiently attain very large values in regions corresponding to the upper preflare chromosphere. The effectiveness of the surrounding magnetic field at confining this high pressure plasma is therefore reduced and the flaring loop becomes free to expand laterally. In so doing it may drive magnetic field lines into neighboring, non-flaring, loops in the same active region, causing magnetic reconnection to take place and triggering another flare burst. The features of this interacting loop model are found to be in good agreement with the energetics and time structure of flare-associated solar hard X-ray bursts.

Emslie, A. G.↗

An experiment with interactive planning models

Experiments on decision making in planning problems are described. Executives were tested in dealing with capital investments and competitive pricing decisions under conditions of uncertainty. A software package, the interactive risk analysis model system, was developed, and two controlled experiments were conducted. It is concluded that planning models can aid management, and predicted uses of the models are as a central tool, as an educational tool, to improve consistency in decision making, to improve communications, and as a tool for consensus decision making.

Beville, J.↗

Investigation of Longitudinal Aero-Propulsive Interactions of a Small Quadrotor Unmanned Aircraft System

Aerodynamic propulsive and airframe interactions significantly influence the forces and moments of multirotor vehicles. This paper presents recent results studying the influence of these effects on a small quadrotor vehicle in hover and forward flight. Aerodynamic interaction model development was explored utilizing system identification tools and incorporated into a previously developed NASA quadrotor flight dynamic simulation. The aerodynamic interaction model improved accuracy of the simulation in comparison to free-flight and static wind tunnel results. Comparisons between models of different fidelity were completed to demonstrate the effects of aerodynamic interaction on model accuracy and provide recommendations for modelling requirements.

George Altamirano↗

A numerical study of fundamental shock noise mechanisms

The results of this thesis demonstrate that direct numerical simulation can predict sound generation in unsteady aerodynamic flows containing shock waves. Shock waves can be significant sources of sound in high speed jet flows, on helicopter blades, and in supersonic combustion inlets. Direct computation of sound permits the prediction of noise levels in the preliminary design stage and can be used as a tool to focus experimental studies, thereby reducing cost and increasing the probability of a successfully quiet product in less time. This thesis reveals and investigates two mechanisms fundamental to sound generation by shocked flows: shock motion and shock deformation. Shock motion is modeled by the interaction of a sound wave with a shock. During the interaction, the shock wave begins to move and the sound pressure is amplified as the wave passes through the shock. The numerical approach presented in this thesis is validated by the comparison of results obtained in a quasi-one dimensional simulation with linear theory. Analysis of the perturbation energy demonstrated for the first time that acoustic energy is generated by the interaction. Shock deformation is investigated by the numerical simulation of a ring vortex interacting with a shock. This interaction models the passage of turbulent structures through the shock wave. The simulation demonstrates that both acoustic waves and contact surfaces are generated downstream during the interaction. Analysis demonstrates that the acoustic wave spreads cylindrically, that the sound intensity is highly directional, and that the sound pressure level increases significantly with increasing shock strength. The effect of shock strength on sound pressure level is consistent with experimental observations of shock noise, indicating that the interaction of a ring vortex with a shock wave correctly models a dominant mechanism of shock noise generation.

Meadows, Kristine R.↗

Modeling of interactions between biosphere and atmosphere on the global scale

Simulations of weather and climate with general circulation models show that the circulation and rainfall are sensitive to the transfers of radiation, sensible heat, water vapor, and momentum across the atmosphere land surface interface. Because, in nature, these transfers depend in large measure on the morphological and physiological characteristics of the surface vegetation, an interactive biosphere is needed for GCM's. The simple model of the biosphere (SiB) that the authors have constructed is based on the recognized difference between ground cover vegetation (grasses and other herbaceous plants) and canopy vegetation (trees and shrubs), where the latter act like elevated blocks of porous material which efficiently extract momentum from the air that flows through them; by a large number of multiple reflections enhance the absorption of the incident solar radiation; when the canopy is wet, act like well ventilated psychrometers which extract sensible heat from the air and produce a negative Bowen ratio; and, in all of these ways, behave differently from ground cover vegetation. The complete set of governing equations of SiB, whereby the various allowable combinations of trees, ground covers, and bare ground, in interaction with the atmosphere, determine all of the vegetation dependent transfers at the land surface, have been presented and described.

Baer, Ferdinand↗

Interactive graphics for geometry modeling

An interactive vector capability to create geometry and a raster color shaded rendering capability to sample and verify interim geometric design steps through color snapshots is described. The development is outlined of the underlying methodology which facilitates computer aided engineering and design. At present, raster systems cannot match the interactivity and line-drawing capability of refresh vector systems. Consequently, an intermediate step in mechanical design is used to create objects interactively on the vector display and then scan convert the wireframe model to render it as a color shaded object on a raster display. Several algorithms are presented for rendering such objects. Superquadric solid primitive extend the class of primitives normally used in solid modelers.

Wozny, M. J.↗

A New Procedure for Simulating Unsteady Flows Through Turbomachinery Blade Passages

The development of two new unsteady wake-blade row aerodynamic interaction models and of a rotor-stator unsteady aerodynamic interaction model are outlined. The solutions of Adamczyk's average-passage flow model were used. The responses to the potential disturbances through a blade row were calculated using the MSUTC code. This code can run with and without the use of wall functions. The solver is an implicit finite volume method with flux Jacobians which are evaluated by the flux-vector splitting and the residual fluxes by the Roe's flux-difference splitting.

Chen, Jen Ping↗

Runway Exit Designs for Capacity Improvement Demonstrations. Phase 1: Algorithm Development

A description and results are presented of a study to locate and design rapid runway exits under realistic airport conditions. The study developed a PC-based computer simulation-optimization program called REDIM (runway exit design interactive model) to help future airport designers and planners to locate optimal exits under various airport conditions. The model addresses three sets of problems typically arising during runway exit design evaluations. These are the evaluations of existing runway configurations, addition of new rapid runway turnoffs, and the design of new runway facilities. The model is highly interactive and allows a quick estimation of the expected value of runway occupancy time. Aircraft populations and airport environmental conditions are among the multiple inputs to the model to execute a viable runway location and geometric design solution. The results presented suggest that possible reductions on runway occupancy time (ROT) can be achieved with the use of optimally tailored rapid runway designs for a given aircraft population. Reductions of up to 9 to 6 seconds are possible with the implementation of 30 m/sec variable geometry exits.

Trani, A. A.↗

Application of a global solar wind/planetary obstacle interaction computational model: Earth, Venus, Mars, Jupiter and Saturn studies

This work relates to a series of collaborative investigations involving the application of a computational model for the determination of the detailed plasma and magnetic field properties associated with the global interaction of the solar wind with various planetary obstacles throughout the solar system. The theoretical method is based on an established single fluid, steady, dissipationless, magnetohydrodynamic continuum model, and is appropriate for the calculation of supersonic, super-Alfvenic solar wind flow past planetary obstacles. The investigations undertaken relate to studies of various solar wind interaction phenomena with Venus, Earth, Jupiter, and Saturn.

Stahara, S. S.↗

The Man-machine Integration Design and Analysis System (MIDAS) Software Training Documentation

This document is a training manual for MIDAS v5 that takes an user through the hardware and software requirements for the MIDAS V5 software, the steps required to download the software, and the steps that a user needs to take to create a MIDAS simulation. The training guide also illustrates how the models interact to generate MIDAS predictions of operator performance along task, workload, and situation awareness timelines and provides the test routines that were conducted to verify the operation of the integrated MIDAS models. The training guide shows the user how the MIDAS task model interacts with and controls an anthropometric model through its use of behavioral primitives. The training documentation also illustrates one approach that has been used to filter and analyze MIDAS output.

Brian F. Gore↗

NASA Engineering and Safety Center Technical Bulletin No. 14-02: Aerodynamic Reaction Control System (RCS) Orientation and Jet Interaction (JI) Model Validation

Careful consideration should be given to placement and orientation of RCS jet thrusters on hypersonic entry vehicles in order to minimize adverse RCS JI. Modern state-of-the-art computational fluid dynamics (CFD) tools should be able to predict the RCS effectiveness and JI accurately when coupled with verification and validation studies, including the use of appropriately designed experimental wind tunnel testing.

Aerodynamic Reaction Control System↗

Modeling the Interactive Effects of Spruce Beetle Infestation and Climate on Subalpine Vegetation

In the subalpine zone of the Rocky Mountains, climate change is predicted to result in an increase in the frequency and severity of spruce beetle outbreaks. Climate change itself may affect vegetation, potentially leading to changes in species composition. The direct and indirect effects of climate and disturbances on forest composition, biomass, and dynamics open the possibility for non-linear ecosystem responses. Modeling studies allow for the study of the interaction of these effects and their impact on the forest system. University of Virginia Forest Model Enhanced (UVAFME), an individual-based gap model that simulates forest dynamics and characteristics, is updated with a spruce beetle subroutine that calculates the probability for beetle infestation and potential mortalityof each tree on a plot. The updated model is then run with multiple scenarios that combine beetle infestation with current or altered climate at sites across the southern Rocky Mountains. Results show that spruce beetle infestations acted to facilitate competition with invading lower-elevation species, resulting in an increase in the biomass of historically lower elevation species and a further decline in Engelmann spruce biomass than occurred with solely bark beetle disturbance or solely climate change. We also found an initial enhancing effect between spruce beetle infestation and climate change; however, by the end of 100 yr of climate change and potential beetle infestation, climate had a dampening effect on spruce beetle infestation, through loss of host trees. These results are an important step in understanding the possible futures for vegetation of the Rocky Mountains as well as for spruce forests across the western United States and Canada.

Foster, Adrianna C.↗