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At least 127 records · Page 7

Interactions between muscle and the immune system during modified musculoskeletal loading

Interactions between the immune system and skeletal muscle may play a significant role in modulating the course of muscle injury and repair after modified musculoskeletal loading. Current evidence indicates that activation of the complement system is an early event during modified loading, which then leads to inflammatory cell invasion. However, the functions of those inflammatory cells are complex and they seem to be capable of promoting additional injury and repair. Recent findings implicate an early invading neutrophil population in increasing muscle damage that is detected by the presence of muscle membrane lesions. Macrophages that invade subsequently serve to remove cellular debris, and seem to promote repair. However, macrophages also have the ability to increase damage in muscle in which there is an impaired capacity to generate nitric oxide. In vivo and in vitro evidence indicates that muscle-derived nitric oxide can serve an important role in protecting muscle from membrane damage by invading inflammatory cells. Collectively, these findings indicate that the dynamic balance between inflammatory cells, the complement system, and muscle-derived free radicals can play important roles in the secondary damage of muscle during modified musculoskeletal loading.

Review↗

Studies in Transition and Time Varying Turbulent Flows

The research focused on two areas: (a) the dynamics of forced turbulent flows and (b) time filtered Large Eddy Simulations (TLES). The dynamics of turbulent flows arising from external forcing of the turbulence are poorly understood. In particular, here are many unanswered questions relating the basic dynamical balances and the existence or nonexistence of statistical equilibrium of forced turbulent flows. The research used direct numerical simulations to explore these questions. The properties of the temporally filtered Navier-Stokes equations were also studied.

Grosch, Chester E.↗

Fossilization processes in siliceous thermal springs: trends in preservation along thermal gradients

To enhance our ability to extract palaeobiological and palaeoenvironmental information from ancient thermal spring deposits, we have studied the processes responsible for the development and preservation of stromatolites in modern subaerial thermal spring systems in Yellowstone National Park (USA). We investigated specimens collected from silica-depositing thermal springs along the thermal gradient using petrographic techniques and scanning electron microscopy. Although it is known that thermophilic cyanobacteria control the morphogenesis of thermal spring stromatolites below 73 degrees C, we have found that biofilms which contain filamentous thermophiles contribute to the microstructural development of subaerial geyserites that occur along the inner rims of thermal spring pools and geyser effluents. Biofilms intermittently colonize the surfaces of subaerial geyserites and provide a favoured substrate for opaline silica precipitation. We have also found that the preservation of biotically produced microfabrics of thermal spring sinters reflects dynamic balances between rates of population growth, decomposition of organic matter, silica deposition and early diagenesis. Major trends in preservation of thermophilic organisms along the thermal gradient are defined by differences in the mode of fossilization, including replacement, encrustation and permineralization.

NASA Discipline Exobiology↗

Extended Operation of Stirling Convertors

A high-efficiency 110 W Stirling Radioisotope Generator 110 (SRG110) is being developed for potential NASA exploration missions. The SRG system efficiency is greater than 20%, making it an attractive candidate power system for deep space missions and unmanned rovers. The Department of Energy SRG110 Project team consists of the System Integrator, Lockheed Martin (LM), Stirling Technology Company (STC), and NASA Glenn Research Center (GRC). One of the GRC roles is to provide Independent Verification and Validation of the Stirling TDC s. At the request of LM, a part of this effort includes the Extended Operation of the TDC s in the dynamically balanced dual-opposed configuration. Performance data of Stirling Convertors over time is required to demonstrate that an SRG110 can meet long-duration mission requirements. A test plan and test system were developed to evaluate TDC s #13 and #14 steady-state performance for a minimum of 5000 hours. Hardware, software and TDC preparation processes were developed to support this test and insure safe, round-the-clock operation of the TDC s. This paper will discuss the design and development, and status of the Extended Operation Test.

Roth, Mary Ellen↗

Investigation in Simulated Vertical Descent of the Characteristics of a Cargo-Dropping Device having Extensible Rotating Blades

The characteristics of a cargo-dropping device having extensible rotating blades as load-carrying surfaces have been studied in simulated vertical descent in the Langley 20-foot free-spinning tunnel. The investigation included tests to determine the variation in vertical sinking speed with load. A study of the blade characteristics and of the test results indicated a method of dynamically balancing the blades to permit proper functioning of the device.

Stone, Ralph W., Jr.↗

Extended Operation of Stirling Convertors

A high-efficiency 110 watt Stirling Radioisotope Generator 110 (SRG110) is being developed for potential NASA exploration missions. The SRG system efficiency is greater than 20%, making it an attractive candidate power system for deep space missions and unmanned rovers. The Department of Energy SRG110 Project team consists of the System Integrator, Lockheed Martin (LM), Stirling Technology Company (STC), and NASA Glenn Research Center (GRC). One of the GRC roles is to provide Independent Verification and Validation of the Stirling TDC's. At the request of LM, a part of this effort includes the extended operation of the TDC's in the dynamically balanced dual-opposed configuration. Performance data of the Stirling Converters over time is required to demonstrate that an SRG110 can meet long-duration mission requirements. A test plan and test system were developed to evaluate TDC's #13 and #14 steady-state performance for a minimum of 5000 hours and insure safe, round-the-clock operation of the TDC's. This paper will discuss the design and development, and status of the Extended Operation Test.

Roth, Mary Ellen↗

Studies in Forced and Time Varying Turbulent Flows

The reasearch focused on two areas; (a) the dynamics of forced turbulent flows and (b) time filtered Large Eddy Simulations (TLES). The dynamics of turbulent flows arising from external forcing of the turbulence are poorly understood. In particular, here are many unanswered questions relating the basic dynamical balances and the existence or nonexistence of statistical equilibrium of forced turbulent flows. This research used rapid distortion theory and direct numerical simulations to explore these questions. The properties of the temporally filtered Navier-Stokes equations were also studied.

Grosch, Chester E.↗

New 5 Kilowatt Free-Piston Stirling Space Convertor Developments

NASA has recently funded development of a 5 kW (or greater) free-piston Stirling conversion system for reactor power systems. A nominal 5 kW convertor allows two of these units to be dynamically balanced. A group of three dual-convertor combinations would yield the desired 30 kW. The status of this program will be presented. Goals include a specific power in excess of 140 W/kg at the convertor level, lifetime in excess of five years and AC output. The initial step is the design and development of a nominal 5 kW per cylinder Stirling convertor assembly (SCA) which will serve as a prototype of one or more SCAs that will make up the final 30 kW Stirling Convertor Power System. Assumed requirements for this new convertor for lunar fission power systems will be presented. The primary objective of this development effort will be to demonstrate a 5 kW SCA that can be tested to validate the viability of Stirling technology for space fission surface power systems.

Brandhorst, Henry W.↗

The Development of a Control System for a 5 Kilowatt Free Piston Stirling Space Convertor

The new NASA Vision for Exploration, announced by President Bush in January 2004, proposes an ambitious program that plans to return astronauts to the moon by the 2018 time frame. A recent NASA study entitled "Affordable Fission Surface Power Study" recommended a 40 kWe, 900 K, NaK-cooled, Stirling conversion for 2020 launch. Use of two of the nominal 5 kW converters allows the system to be dynamically balanced. A group of four dual-converter combinations that would yield 40 kWe can be tested to validate the viability of Stirling technology for space fission surface power systems. The work described in this paper deals specifically with the control system for the 5 kW convertor described in the preceding paragraph. This control system is responsible for maintaining piston stroke to a setpoint in the presence of various disturbances including electrical load variations. Pulse starting of the FSPE convertor is also an inherent part of such a control system. Finally, the ability to throttle the engine to match the required output power is discussed in terms of setpoint control. Several novel ideas have been incorporated into the piston stroke control strategy that will engender a stable response to disturbances in the presence of midpoint drift while providing useful data regarding the position of both the power piston and displacer.

Kirby, Raymond L.↗

The Development of a Control System for a 5 Kilowatt Free Piston Stirling Engine Convertor

The new NASA Vision for Exploration, announced by President Bush in January 2004, proposes an ambitious program that plans to return astronauts to the moon by the 2018 time frame. A recent NASA study entitled "Affordable Fission Surface Power Study" recommended a 40 kWe, 900 K, NaK-cooled, Stirling convertors for 2020 launch. Use of two of the nominal 5 kW convertors allows the system to be dynamically balanced. A group of four dual-convertor combinations that would yield 40 kWe can be tested to validate the viability of Stirling technology for space fission surface power systems. The work described in this paper deals specifically with the control system for the 5 kW convertor described in the preceding paragraph. This control system is responsible for maintaining piston stroke to a setpoint in the presence of various disturbances including electrical load variations. Pulse starting of the Free Piston Stirling Engine (FPSE) convertor is also an inherent part of such a control system. Finally, the ability to throttle the engine to match the required output power is discussed in terms of setpoint control. Several novel ideas have been incorporated into the piston stroke control strategy that will engender a stable response to disturbances in the presence of midpoint drift while providing useful data regarding the position of both the power piston and displacer.

Kirby, Raymond L.↗

A Framework for Parallel Unstructured Grid Generation for Complex Aerodynamic Simulations

A framework for parallel unstructured grid generation targeting both shared memory multi-processors and distributed memory architectures is presented. The two fundamental building-blocks of the framework consist of: (1) the Advancing-Partition (AP) method used for domain decomposition and (2) the Advancing Front (AF) method used for mesh generation. Starting from the surface mesh of the computational domain, the AP method is applied recursively to generate a set of sub-domains. Next, the sub-domains are meshed in parallel using the AF method. The recursive nature of domain decomposition naturally maps to a divide-and-conquer algorithm which exhibits inherent parallelism. For the parallel implementation, the Master/Worker pattern is employed to dynamically balance the varying workloads of each task on the set of available CPUs. Performance results by this approach are presented and discussed in detail as well as future work and improvements.

Zagaris, George↗

Data Assimilation Cycling for Weather Analysis

This software package runs the atmospheric model MM5 in data assimilation cycling mode to produce an optimized weather analysis, including the ability to insert or adjust a hurricane vortex. The program runs MM5 through a cycle of short forecasts every three hours where the vortex is adjusted to match the observed hurricane location and storm intensity. This technique adjusts the surrounding environment so that the proper steering current and environmental shear are achieved. MM5cycle uses a Cressman analysis to blend observation into model fields to get a more accurate weather analysis. Quality control of observations is also done in every cycle to remove bad data that may contaminate the analysis. This technique can assimilate and propagate data in time from intermittent and infrequent observations while maintaining the atmospheric field in a dynamically balanced state. The software consists of a C-shell script (MM5cycle.driver) and three FORTRAN programs (splitMM5files.F, comRegrid.F, and insert_vortex.F), and are contained in the pre-processor component of MM5 called "Regridder." The model is first initialized with data from a global model such as the Global Forecast System (GFS), which also provides lateral boundary conditions. These data are separated into single-time files using splitMM5.F. The hurricane vortex is then bogussed in the correct location and with the correct wind field using insert_vortex.F. The modified initial and boundary conditions are then recombined into the model fields using comRegrid.F. The model then makes a three-hour forecast. The three-hour forecast data from MM5 now become the analysis for the next short forecast run, where the vortex will again be adjusted. The process repeats itself until the desired time of analysis is achieved. This code can also assimilate observations if desired.

Tran, Nam↗

The Role of Adaptation in Body Load-Regulating Mechanisms During Locomotion

Body loading is a fundamental parameter that modulates motor output during locomotion, and is especially important for controlling the generation of stepping patterns, dynamic balance, and termination of locomotion. Load receptors that regulate and control posture and stance in locomotion include the Golgi tendon organs and muscle spindles at the hip, knee, and ankle joints, and the Ruffini endings and the Pacinian corpuscles in the soles of the feet. Increased body weight support (BWS) during locomotion results in an immediate reorganization of locomotor control, such as a reduction in stance and double support duration and decreased hip, ankle, and knee angles during the gait cycle. Previous studies on the effect during exposure to increased BWS while walking showed a reduction in lower limb joint angles and gait cycle timing that represents a reorganization of locomotor control. Until now, no studies have investigated how locomotor control responds after a period of exposure to adaptive modification in the body load sensing system. The goal of this research was to determine the adaptive properties of body load-regulating mechanisms in locomotor control during locomotion. We hypothesized that body load-regulating mechanisms contribute to locomotor control, and adaptive changes in these load-regulating mechanisms require reorganization to maintain forward locomotion. Head-torso coordination, lower limb movement patterns, and gait cycle timing were evaluated before and after a 30-minute adaptation session during which subjects walked on a treadmill at 5.4 km/hr with 40% body weight support (BWS). Before and after the adaptation period, head-torso and lower limb 3D kinematic data were obtained while performing a goal directed task during locomotion with 0% BWS using a video-based motion analysis system, and gait cycle timing parameters were collected by foot switches positioned under the heel and toe of the subjects shoes. Subjects showed adaptive modification in the body load-regulating mechanisms that included increased head movement amplitude, increased knee and ankle flexion, and increased stance, stride, and double support time, with no change in the performance of the task with respect to that measured before exposure to BWS. These changes in locomotor control are opposite to that reported during 40% BWS exposure and indicative of an after-effect after removal of the adaptive stimulus. Therefore, it is evident that just 30 minutes of 40% BWS during locomotion was sufficient to induce adaptive modifications in the body load sensing systems that contribute to reorganization of sensory contributions to stable locomotor control.

Ruttley, Tara↗

Selected Papers on Protoplanetary Disks

Three papers present studies of thermal balances, dynamics, and electromagnetic spectra of protoplanetary disks, which comprise gas and dust orbiting young stars. One paper addresses the reprocessing, in a disk, of photons that originate in the disk itself in addition to photons that originate in the stellar object at the center. The shape of the disk is found to strongly affect the redistribution of energy. Another of the three papers reviews an increase in the optical luminosity of the young star FU Orionis. The increase began in the year 1936 and similar increases have since been observed in other stars. The paper summarizes astronomical, meteoric, and theoretical evidence that these increases are caused by increases in mass fluxes through the inner portions of the protoplanetary disks of these stars. The remaining paper presents a mathematical-modeling study of the structures of protostellar accretion disks, with emphasis on limits on disk flaring. Among the conclusions reached in the study are that (1) the radius at which a disk becomes shadowed from its central stellar object depends on radial mass flow and (2) most planet formation has occurred in environments unheated by stellar radiation.

Bell, K. R.↗

Multi-Scale Three-Dimensional Variational Data Assimilation System for Coastal Ocean Prediction

A multi-scale three-dimensional variational data assimilation system (MS-3DVAR) has been formulated and the associated software system has been developed for improving high-resolution coastal ocean prediction. This system helps improve coastal ocean prediction skill, and has been used in support of operational coastal ocean forecasting systems and field experiments. The system has been developed to improve the capability of data assimilation for assimilating, simultaneously and effectively, sparse vertical profiles and high-resolution remote sensing surface measurements into coastal ocean models, as well as constraining model biases. In this system, the cost function is decomposed into two separate units for the large- and small-scale components, respectively. As such, data assimilation is implemented sequentially from large to small scales, the background error covariance is constructed to be scale-dependent, and a scale-dependent dynamic balance is incorporated. This scheme then allows effective constraining large scales and model bias through assimilating sparse vertical profiles, and small scales through assimilating high-resolution surface measurements. This MS-3DVAR enhances the capability of the traditional 3DVAR for assimilating highly heterogeneously distributed observations, such as along-track satellite altimetry data, and particularly maximizing the extraction of information from limited numbers of vertical profile observations.

Li, Zhijin↗

Low-Cost, Rugged High-Vacuum System

A need exists for miniaturized, rugged, low-cost high-vacuum systems. Recent advances in sensor technology have led to the development of very small mass spectrometer detectors as well as other analytical instruments such as scanning electron microscopes. However, the vacuum systems to support these sensors remain large, heavy, and power-hungry. To meet this need, a miniaturized vacuum system was developed based on a very small, rugged, and inexpensive-to-manufacture molecular drag pump (MDP). The MDP is enabled by a miniature, very-high-speed (200,000 rpm), rugged, low-power, brushless DC motor optimized for wide temperature operation and long life. The key advantages of the pump are reduced cost and improved ruggedness compared to other mechanical hig-hvacuum pumps. The machining of the rotor and stators is very simple compared to that necessary to fabricate rotor and stator blades for other pump designs. Also, the symmetry of the rotor is such that dynamic balancing of the rotor will likely not be necessary. Finally, the number of parts in the unit is cut by nearly a factor of three over competing designs. The new pump forms the heart of a complete vacuum system optimized to support analytical instruments in terrestrial applications and on spacecraft and planetary landers. The MDP achieves high vacuum coupled to a ruggedized diaphragm rough pump. Instead of the relatively complicated rotor and stator blades used in turbomolecular pumps, the rotor in the MDP consists of a simple, smooth cylinder of aluminum. This will turn at approximately 200,000 rpm inside an outer stator housing. The pump stator comprises a cylindrical aluminum housing with one or more specially designed grooves that serve as flow channels. To minimize the length of the pump, the gas is forced down the flow channels of the outer stator to the base of the pump. The gas is then turned and pulled toward the top through a second set of channels cut into an inner stator housing that surrounds the motor. The compressed gas then flows down channels in the motor housing to the exhaust port of the pump. The exhaust port of the pump is connected to a commercially available diaphragm or scroll pump.

Sorensen, Paul↗

Very-Low-Cost, Rugged Vacuum System

NASA, DoD, DHS, and commercial industry have a need for miniaturized, rugged, low-cost vacuum systems. Recent advances in sensor technology have led to the development of very small mass spectrometer detectors as well as other miniature analytical instruments. However, the vacuum systems to support these sensors remain large, heavy, and power-hungry. To meet this need, a miniaturized vacuum system was created based on a very small, rugged, and inexpensive- to-manufacture molecular drag pump (MDP). The MDP is enabled by the development of a miniature, veryhigh- speed, rugged, low-power, brushless DC motor optimized for wide temperature operation and long life. Such a pump represents an order-of-magnitude reduction in mass, volume, and cost over current, commercially available, state-ofthe- art vacuum pumps. The vacuum system consists of the MDP coupled to a ruggedized rough pump (for terrestrial applications or for planets with substantial atmospheres). The rotor in the MDP consists of a simple smooth cylinder of aluminum spinning at approximately 200,000 RPM inside an outer stator housing. The pump stator comprises a cylindrical aluminum housing with one or more specially designed grooves that serve as flow channels. To minimize the length of the pump, the gas is forced down the flow channels of the outer stator to the base of the pump. The gas is then turned and pulled toward the top through a second set of channels cut into an inner stator housing that surrounds the motor. The compressed gas then flows down channels in the motor housing to the exhaust port of the pump. The exhaust port of the pump is connected to a diaphragm or scroll pump. This pump delivers very high performance in a very small envelope. The design was simplified so that a smaller compression ratio, easier manufacturing process, and enhanced ruggedness can be achieved at the lowest possible cost. The machining of the rotor and stators is very simple compared to that necessary to fabricate TMP (turbo molecular pump) rotor and stator blades. Also, the symmetry of the rotor is such that dynamic balancing of the rotor is greatly simplified. Finally, because of the simplified design, the number of parts in the unit is cut by nearly a factor of three. In fact, there are only five parts, not counting the motor and off-the-shelf screws and O-rings. This reduces the amount of machining and also makes fit-up much simpler while allowing the maintenance of close tolerances.

Kline-Schoder, Robert↗

Use of an OSSE to Evaluate Background Error Covariances Estimated by the 'NMC Method'

The NMC method has proven utility for prescribing approximate background-error covariances required by variational data assimilation systems. Here, untunedNMCmethod estimates are compared with explicitly determined error covariances produced within an OSSE context by exploiting availability of the true simulated states. Such a comparison provides insights into what kind of rescaling is required to render the NMC method estimates usable. It is shown that rescaling of variances and directional correlation lengths depends greatly on both pressure and latitude. In particular, some scaling coefficients appropriate in the Tropics are the reciprocal of those in the Extratropics. Also, the degree of dynamic balance is grossly overestimated by the NMC method. These results agree with previous examinations of the NMC method which used ensembles as an alternative for estimating background-error statistics.

Data Assimilation↗