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At least 127 records · Page 7

Planar turbulent wakes under pressure gradient: Integral and self-similarity analyses

By using a combination of integral and self-similarity analyses, the generalized analytical solutions for the mean transverse velocity and Reynolds shear stress are rigorously derived for the first time for the far field of planar turbulent wakes under arbitrary pressure gradients. Specifically, by assuming self-similarity for the mean axial velocity, the analytical formulation for the mean transverse velocity is obtained from the integral of the mean continuity equation, and the analytical formulation for the Reynolds shear stress is obtained from the integral of the momentum equation. The generalized analytical formulations for the mean transverse velocity and Reynolds shear stress consist of multiple components, each with its unique scale and physical mechanism. In the zero pressure gradient limit, the generalized formulations recover the single-scale equations reported by Wei, Liu, and Livescu. Furthermore, simpler approximate formulations for the mean transverse velocity and Reynolds shear stress are also obtained, and show excellent agreement with the experimental measurements. Here, the findings provide new insights into the properties of planar turbulent wakes under pressure gradients, filling some long-standing gaps in the existing literature.

42 ENGINEERING↗

Nuclear Forensics

Nuclear forensics is a key part of the nuclear security strategy for the United States and the international community. The NACS Division is central to the leadership role that LLNL has had in nuclear forensics over the past 25 years. Our current nuclear forensic program includes conducting R&D on provenance and attribution signatures, collaborating with international partners, training the next generation of nuclear forensic experts, developing test materials for verification and validation exercises, and providing expert advice to national and international policy makers. Key to our success in these areas has been the strong and continuing involvement in nuclear forensic casework obtained through law enforcement and intelligence channels as well as our outstanding analytical capabilities. NACS must continue to conduct forward-thinking R&D in nuclear forensics that supports operational programs and addresses intelligence gaps. To maintain leadership in nuclear forensics, we must attract, develop, and retain the best talent. The NNSA has a central leadership role in developing educational initiatives for nuclear forensics. In concert with the Glenn T. Seaborg Institute, the NACS Division will continue to participate in all nuclear forensic educational initiatives (undergraduate, graduate, postdoctoral) and incorporate LLNL’s D&I vision into its student and postdoc recruitment efforts. We will continue to build formal relationships with key academic partners and institutions with active and emerging nuclear forensic research interests. We will also strengthen relationships with NNSA DNN and SSAA funded university consortia (e.g. NSSC, ACE, CNEC, CVT, ETI, MTV), helping them conduct research of interest and relevance to nuclear forensics, while at the same time evaluating and recruiting promising talent from these programs.

07 ISOTOPE AND RADIATION SOURCES↗

An Analytic Benchmark for Neutron Boltzmann Transport with Downscattering—Part IV: PFNS and $\bar{ν}$ Uncertainty Propagation

An analytic benchmark with continuous-energy cross sections was previously derived to validate criticality calculations. Here, to extend the utility of the analytic benchmark to verify the implementation of $\bar{ν}$ and prompt fission neutron spectrum (PFNS) uncertainty propagation methods, new simplified forms that are dependent on the incident (fission-causing) neutron energy, as well as the outgoing neutron energy for the PFNS, are introduced in this work. The analytical forms for the flux and adjoint flux are derived for the extended benchmark and used to determine the 𝑘-eigenvalue sensitivity to $\bar{ν}$ and PFNS. The 𝑘-eigenvalue uncertainty due to $\bar{ν}$ and PFNS is calculated for the analytic benchmark using simplified$\bar{ν}$ and PFNS representations based on the ENDF-B/VIII.0 239 Pu evaluation. Because of the low sensitivity of the analytic benchmark to the physical PFNS, a nonphysical high-sensitivity PFNS is also presented.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Stepping into the Midwest Bioeconomy: Stakeholder Engagement and Geospatial Tools to Assist in Perennial Bioenergy Crop Decision Making and Entrepreneurship

This project, “Ecosystem Services and Farm Entrepreneurship Technical Assistance,” was a three-year project originally planned for FY22–FY24. Due to a late start and a few extensions, it is being completed in early FY25. This project explored opportunities to support the deployment of a bioeconomy with a circular, more sustainable supply chain. Using a tool developed by Argonne to identify agricultural areas suitable for use in the bioeconomy, we sought to create opportunities in the bioeconomy as biomass producers, bioenergy users, and environmental entrepreneurs. We proposed to focus at the beginning on enhancing the tool’s capabilities, while engaging with key stakeholders to improve and expand the tool’s functionality for all potential stakeholders in the bioeconomy. We believe that expanding our tools and technologies, coupled with conversations in agricultural spaces, will be needed as we continue to explore how best to offer farmers whole-of supply-chain opportunities to participate in the bioeconomy. Through this project we have continued to gain a better understanding of the ways in which farmers, landowners, bioenergy users, and environmental entrepreneurs may approach the bioeconomy. In addition, as we improve our analytic toolkit, we can continue to refine our communication and the ways in which we can valuate the bioeconomy. Refining these tools allows us to dive deeper into conversations around plausible policies and drivers for future bioeconomy investment and engagement by stakeholders. By working with farmers and agricultural landowners to enable a sustainable bioeconomy business model, enhance their energy options, and recover resources from their waste streams, this project directly responds to the Bioenergy Technology Office’s (BETO) priorities of building a resilient energy economy. It addresses BETO’s focus on fostering the development and adoption of energy technologies that enable the conversion of waste to energy, efficient land use, and robust job creation. By establishing a technical assistance program that develops capabilities and practices in agricultural areas to implement a bioeconomy future, this program will develop an important linkage between technology being developed at U.S. Department of Energy national laboratories and the agricultural communities of the Midwest. This project focuses on farmers with lower productivity farmland. Because less productive lands create a more difficult revenue stream for conventional crops, these farmers may therefore be more open to alternative agricultural land management regimes. Consequently, the technical assistance program and the methodologies for targeting perennial bioenergy crop application on marginal land provide a distinct opportunity to engage with and invest in the bioeconomy in these economically stressed areas. Stakeholders in this project include farmers and landowners, local conservation organizations (NRCS, SWCS, etc.), universities, non-profit environmental and agricultural entities, farm consultants, environmental regulators, and industry, including the industries working on conversion technologies, anaerobic digestion, pyrolysis, and biochar generation, and the companies interested in trading or purchasing/supporting the valuation of ecosystem services (ES).

09 BIOMASS FUELS↗

Toward Drilling the Perfect Geothermal Well: An International Research Coordination Network for Geothermal Drilling Optimization Supported by Deep Machine Learning and Cloud Based Data Aggregation

The EDGE project, supported by the U.S. Department of Energy Geothermal Technologies Office under award DE-EE0008793, established a data-driven framework for improving the efficiency, cost-effectiveness, and reliability of geothermal well drilling. The project focused on developing scalable data infrastructure, advanced machine learning and probabilistic models, and integrated analytics tools to support continuous drilling optimization. A central objective was to reduce geothermal drilling costs by up to seventy percent while minimizing the risk of well failure through predictive diagnostics and adaptive planning. Over the project period, a comprehensive data repository was designed and deployed, incorporating records from over one hundred geothermal wells across varied geological settings. This repository supported both structured and unstructured data and adhered to FAIR data principles, enabling provenance tracking, quality control, and standardized metadata. The project introduced automated ingestion pipelines and a cloud-hosted platform that facilitated access to raw, processed, and derived datasets. This infrastructure served as the foundation for model development and analysis. Machine learning workflows were developed to predict key drilling metrics including rate of penetration, non-productive time, and total drilling costs. Self-organizing maps and dimensionality reduction methods were used to uncover operational patterns and outliers, while supervised learning algorithms such as random forests and deep neural networks were applied to forecast performance outcomes. The models were validated on heterogeneous datasets from both U.S. and Icelandic fields, demonstrating variable but significant predictive accuracy. The results indicated that finer temporal resolution, inclusion of lithological data, and consistency in operational annotations could substantially improve model performance. The project also implemented process mining techniques to reconstruct state-transition models from drilling event logs. These models enabled the identification of deviations from optimal workflows and provided insights into recurring failure modes. Analysis of non-productive time highlighted the impact of equipment failures, geological challenges, and human factors, offering opportunities for targeted mitigation strategies. The EDGE Dashboard was developed as a web-based expert system integrating data visualization, model outputs, and user-driven queries. It provided an accessible interface for operators to explore historical data, evaluate predicted outcomes, and compare drilling scenarios. Initial feedback from project partners suggested that the dashboard could serve as a foundation for more advanced advisory and optimization tools. Overall, the EDGE project demonstrated the feasibility and value of applying modern data science techniques to geothermal drilling. It delivered a set of interoperable tools and models that can support more efficient, lower-risk well development. The findings point toward a viable path for transitioning from advisory analytics to semi-autonomous drilling systems, contingent on continued collaboration, expanded datasets, and field validation. The project results have immediate relevance for drilling operations, data management practices, and future geothermal R&D efforts aimed at achieving reliable, cost-competitive geothermal energy at scale.

15 GEOTHERMAL ENERGY↗

Switching from batch to continuous granulation: A case study of metoprolol succinate ER tablets

Continuous manufacturing (CM) has been used to produce several immediate release drug products. No extended-release (ER) product manufactured employing CM technology has been approved yet. Herein this study investigated the critical aspects of switching from the batch mode of high shear granulation to the continuous operation of twin-screw granulation for extended-release tablets. Metoprolol succinate ER tablets was used as a model ER formulation for this purpose. A central composite design (CCD) was employed to determine the effects of high shear granulator (HSG) parameters, namely impeller speed, granulation time, and binder liquid feeding rate, on the critical granulation characteristics important for product performance. These critical granulation characteristics served as a guide for switching from the batch processing to the continuous operation for achieving the same breaking strength and dissolution for this ER metoprolol tablets. The granulation time was the most critical factor affecting the bulk properties of granules which contributed to tablet dissolution. The higher density and lower compressibility of granules were attained at the longest granulation time of 5.4 min with the fastest liquid feeding rate of 75 g/min. The granules’ density was the primary factor negatively affecting the dissolution of metoprolol tablets. However, the breaking strength of tablets confounded the effect of granules density on metoprolol dissolution. Switching the processing parameters of high shear granulation to twin-screw granulation achieved similar dissolution profiles (F2 greater than 50). The screw speed was not found to affect bulk properties of granules. The root cause of granulation failures in twin-screw granulation, such as premature consolidation, excessive swelling, poor cohesion, inconsistent shearing effects, and formation of deformed agglomerates, were identified. In conclusion, the use of critical granulation characteristics through a performance-based approach of ER tablets facilitated the switching of manufacturing of an ER formulation form batch to continuous operation.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

String correlators on $\text{AdS}_3$: Analytic structure and dual CFT

We continue our study of string correlators on Euclidean \text{AdS}_3 AdS 3 with pure NS-NS flux. The worldsheet and spacetime correlators have a rich analytic structure, which we analyse completely for genus 0 four-point functions. We show that correlators exhibit a simple behaviour near their singularities. The spacetime correlators are meromorphic functions in the \mathrm{SL}(2,\mathbb{R}) S L ( 2 , ℝ ) -spins, whose pole structure is shown to agree with the prediction of a recent proposal for the dual \text{CFT}_2 CFT 2 . Moreover, we also compute the residues of the spacetime correlators for some of the poles exactly and find again a perfect match with the proposal for the dual \text{CFT}_2 CFT 2 , thereby checking the duality for some non-trivial four-point functions exactly. Our computations simplify drastically in the tensionless limit of \mathrm{AdS}_3 \times \mathrm{S}^3 \times \mathbb{T}^4 A d S 3 × S 3 × 𝕋 4 where the behaviour near the poles gives in fact the exact answer. This paper is the third in a series with several installments.

74 ATOMIC AND MOLECULAR PHYSICS↗

LLNL ES&H Analytical Services and Instrumentation Analytical Laboratory (ALAB) (CY2022 Management Review Report)

"An annual review shall be conducted of the analytical activities to ensure continuing suitability, adequacy, and effectiveness." (ALAB-01 Rev 6 ALQAP section 6.11.2) "The laboratory management shall review its management system at planned intervals, in order to ensure its continuing suitability, adequacy and effectiveness..."(ISO/IEC 17025:2017 Section 8.9.1) "In accordance with a predetermined schedule and procedure, the laboratory's top management shall periodically conduct a review of the laboratory's management system and testing and/or calibration activities to ensure their continuing suitability and effectiveness, and to introduce necessary changes or improvements. "(TNI Standard EL-V1M2-2016-Rev2.1:Quality Systems General Requirements)

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Rethinking the ill-posedness of the spectral function reconstruction — Why is it fundamentally hard and how Artificial Neural Networks can help

Reconstructing hadron spectral functions through Euclidean correlation functions are of the important missions in lattice QCD calculations. However, in a Källen–Lehmann (KL) spectral representation, the reconstruction is observed to be ill-posed in practice. It is usually ascribed to the fewer observation points compared to the number of points in the spectral function. In this paper, by solving the eigenvalue problem of continuous KL convolution, we show analytically that the ill-posedness of the inversion is fundamental and it exists even for continuous correlation functions. We discussed how to introduce regulators to alleviate the predicament, in which include the Artificial Neural Networks (ANNs) representations recently proposed by the Authors in another study. The uniqueness of solutions using ANNs representations is manifested analytically and validated numerically. Reconstructed spectral functions using different regularization schemes are also demonstrated, together with their eigen-mode decomposition. We observe that components with large eigenvalues can be reliably reconstructed by all methods, whereas those with low eigenvalues need to be constrained by regulators.

97 MATHEMATICS AND COMPUTING↗

Autonomy Loops for Monitoring, Operational Data Analytics, Feedback, and Response in HPC Operations

Many High Performance Computing (HPC) facilities have developed and deployed frameworks in support of continuous monitoring and operational data analytics (MODA) to help improve efficiency and throughput. Because of the complexity and scale of systems and workflows and the need for low-latency response to address dynamic circumstances, automated feedback and response have the potential to be more effective than current human-in-the-loop approaches which are laborious and error prone. Progress has been limited, however, by factors such as the lack of infrastructure and feedback hooks, and successful deployment is often site- and case-specific. In this position paper we report on the outcomes and plans from a recent Dagstuhl Seminar, seeking to carve a path for community progress in the development of autonomous feedback loops for MODA, based on the established formalism of similar (MAPE-K) loops in autonomous computing and self-adaptive systems. By defining and developing such loops for significant cases experienced across HPC sites, we seek to extract commonalities and develop conventions that will facilitate interoperability and interchangeability with system hardware, software, and applications across different sites, and will motivate vendors and others to provide telemetry interfaces and feedback hooks to enable community development and pervasive deployment of MODA autonomy loops.

autonomy loops↗

Engineered $\mathrm{Ru}$ on $\mathrm{HY}$ zeolite catalyst for continuous and selective hydrodeoxygenation of lignin phenolics to cycloalkanes under moderate conditions

Here we report a continuous selective hydrodeoxygenation (HDO) process of guaiacol conversion to cycloalkanes under 180 °C/1 MPa, which results in improved HDO chemistry for lignin-based jet fuel production. The incipient wetness impregnation method was modified to prepare an HY zeolite-supported Ru catalyst with better metal dispersion and acid site uniformity, which overcomes the low conversion and selectivity of previous literature. The modified catalyst (Ru-HY-60-MI) was tested in a continuous fixed bed reactor, resulting in increased HDO conversion of guaiacol to cycloalkanes compared to the unmodified catalyst. Pressure, temperature, and weight hourly space velocity-dependent tests validate guaiacol HDO over Ru-HY-60-MI catalyzed ring hydrogenation of guaiacol to 2-methoxycyclohexanol, acid-catalyzed demethoxylation and dehydration to cyclohexene, and further hydrogenation of cyclohexene to cyclohexane. These experiments enable exploring a continuous HDO process, demonstrate effectiveness for other ß-ß and a-O-4 lignin representatives and real lignin bio-oil, and pave the way towards commercialization of lignin-based jet fuel

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Hydrogenolysis of n -eicosane over Ru-based catalysts in a continuous flow reactor

The hydrogenolysis of n-eicosane (C 20 H 42 ) was studied under differential conditions over Ru-based catalysts including Ru/SiO 2 , Ru/TiO 2 , and Ru/SBA-15, using a continuous flow reactor that was specially designed for large hydrocarbon reactants that are solids at room temperature. Similar rates and product distributions were obtained for Ru/SiO 2 and Ru/SBA-15 at 433 K, with the most abundant products being C 1 and C 19 hydrocarbons and smaller amounts of C 8 to C 18 also being produced. The higher yield of C 1 and C 19 indicates that cleavage of the terminal C-C bond is somewhat more facile than an internal C-C bond. At 473 K the product distribution shifted to mostly C 1 suggesting that, at this temperature, the adsorbed alkyl fragments undergo complete C-C bond scission prior to desorbing. Here, the conversion was also found to be inversely proportional to the H 2 pressure. Similar results were obtained for Ru/TiO 2 except this catalyst was found to be less active than both Ru/SiO 2 and Ru/SBA-15.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Continuous Enzymatic Hydrolysis Development for Improved Saccharification Performance

The Continuous Enzymatic Hydrolysis Development (CEHD) project aims to reduce the cost and commercialization risks of Gen2 biorefinery sugar/lignin/ethanol production through development of a deployable continuous enzymatic hydrolysis process. Recent changes in the technical landscape of commercial enzymatic hydrolysis of Gen2 pretreated biomass dictate that the existing hybrid SSF approach be reconsidered. Most importantly, the current practice of "finishing hydrolysis" in SSF must be abandoned due to the fact that new cellulase/hemicellulose formulations from Novozymes, now the sole supplier of commercial Gen2 enzymes in North America, are now not rated for SSF (see NZ CTec3HS product bulletin). We have recently developed bench scale CEH tools to optimize saccharification of DMR pretreated biomass where, unlike SSF with yeast or Zymomonas, the pH, temperature, oxygen tension, LPMO mediator concentration, and/or removal of end-product inhibitors can be precisely controlled. In scale up, the goal is to use existing commercial cross flow ceramic membrane filtration external loops coupled to enzymatic hydrolysis (EH) reactors. Pretreated biomass solids and enzymes are retained for reaction while solubilized product sugars are removed in situ, with high extents of conversion and longer enzyme lifetimes achieved through a series of reactor-membrane unit stages. The CEHD project is focused on advancing CEH as a transformational, process-intensified, lower-cost method for producing soluble clarified biomass sugars and insoluble lignin-rich streams.

BIOMASS FUELS,INORGANIC, ORGANIC, PHYSICAL, AND AN↗

Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map

Twin-screw granulation (TSG) is an emerging continuous wet granulation technique that has not been widely applied in the industry due to a poor mechanistic understanding of the process. This study focuses on improving this mechanistic understanding by analyzing the effects of the mixing dynamics on the granule quality attributes (PSD, content uniformity, and microstructure). Mixing is an important dynamic process that simultaneously occurs along with the granulation rate mechanisms during the wet granulation process. An improved mechanistic understanding was achieved by identifying and quantifying the physically relevant intermediate parameters that affect the mixing dynamics in TSG, and then their effects on the granule attributes were analyzed by investigating their effects on the granulation rate mechanisms. The fill level, granule liquid saturation, extent of nucleation, and powder wettability were found to be the key physically relevant intermediate parameters that affect the mixing inside the twin-screw granulator. An improved geometrical model for the fill level was developed and validated against existing experimental data. Finally, a process map was developed to depict the effects of mixing on the temporal and spatial evolution of the materials inside the twin-screw granulator. This process map illustrates the mechanism of nucleation and the growth of the granules based on the fundamental material properties of the primary powders (solubility and wettability), liquid binders (viscosity), and mixing dynamics present in the system. Furthermore, it was shown that the process map can be used to predict the granule product quality based on the granule growth mechanism.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Chemical Safety and Security Education in ACS-Approved Chemistry Programs

To date, chemical security education practices in postsecondary institutions are poorly understood. The purpose of this study is to provide an initial understanding of the practices, attitudes, and barriers toward chemical security education for undergraduate and graduate programs in the United States (US) by surveying representatives of American Chemical Society (ACS)-approved programs. All programs with ACS-approved undergraduate chemistry programs (n = 691) were contacted for participation: 21% (n = 148) fully completed and 6% (n = 41) partially completed the survey for a combined total of 27% complete and/or partially complete surveys (n = 189). We observed that most programs currently teach chemical safety (undergraduate >99%, graduate 73%); however, only about one-third of programs teach chemical security at any education level (undergraduate 32%, graduate 34%). We also observed that safety education is provided more frequently than security education. Further, ACS-approved programs reported that their chemical safety culture was stronger than chemical security culture and felt that safety should be taught differently than security. The overwhelming majority of respondents (96%) indicated that chemical safety should be mandatory at some level, while only about half of respondents (57%) indicated that chemical security should be mandatory at some level. More efforts are needed by the chemistry community to raise awareness of the importance of chemical security education so that more institutions commit to training their faculty and students on the topic. The authors suggest that adoption of chemical security education could be increased if ACS were to advocate for chemical security by including it in its guidelines for educational program approval.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Unlocking the secret of lignin-enzyme interactions: Recent advances in developing state-of-the-art analytical techniques

Bioconversion of renewable lignocellulosics to produce liquid fuels and chemicals is one of the most effective ways to solve the problem of fossil resource shortage, energy security, and environmental challenges. Among the many biorefinery pathways, hydrolysis of lignocellulosics to fermentable monosaccharides by cellulase is arguably the most critical step of lignocellulose bioconversion. In the process of enzymatic hydrolysis, the direct physical contact between enzymes and cellulose is an essential prerequisite for the hydrolysis to occur. However, lignin is considered one of the most recalcitrant factors hindering the accessibility of cellulose by binding to cellulase unproductively, which reduces the saccharification rate and yield of sugars. This results in high costs for the saccharification of carbohydrates. The various interactions between enzymes and lignin have been explored from different perspectives in literature, and a basic lignin inhibition mechanism has been proposed. However, the exact interaction between lignin and enzyme as well as the recently reported promotion of some types of lignin on enzymatic hydrolysis is still unclear at the molecular level. Multiple analytical techniques have been developed, and fully unlocking the secret of lignin-enzyme interactions would require a continuous improvement of the currently available analytical techniques. This review summarizes the current commonly used advanced research analytical techniques for investigating the interaction between lignin and enzyme, including quartz crystal microbalance with dissipation (QCM-D), surface plasmon resonance (SPR), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, atomic force microscopy (AFM), nuclear magnetic resonance (NMR) spectroscopy, fluorescence spectroscopy (FLS), and molecular dynamics (MD) simulations. Interdisciplinary integration of these analytical methods is pursued to provide new insight into the interactions between lignin and enzymes. Finally, this review will serve as a resource for future research seeking to develop new methodologies for a better understanding of the basic mechanism of lignin-enzyme binding during the critical hydrolysis process.

59 BASIC BIOLOGICAL SCIENCES↗

State-of-the-art of data collection, analytics, and future needs of transmission utilities worldwide to account for the continuous growth of sensing data

Nowadays, transmission system operators require higher degree of observability in real-time to gain situational awareness and improve the decision-making process to guarantee a safe and reliable operation. Digitalization of energy systems allows utilities to monitor the system dynamic performance in real-time at fast time scales. The use of such technologies has unlocked new opportunities to introduce new data driven algorithms for improving the stability assessment and control of the system. Motivated by these challenges, a group of experts have worked together to highlight and establish a baseline set of these common concerns, which can be used as motivation to propose innovative analytics and data-driven solutions. In this document, the results of a survey on 10 transmission system operators around the world are presented and it aims to understand the current practices of the participating companies, in terms of data acquisition, handling, storage, modelling and analytics. The overall objective of this document is to capture the actual needs from the interviewed utilities, thereby laying the groundwork for setting valid assumptions for the development of advanced algorithms in this field.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Developing an AI-Powered Zero-Trust Cybersecurity Framework for Malware Prevention in Nuclear Power Plants

This study presents the development of an AI-powered Zero-Trust cybersecurity framework for malware prevention in nuclear power plants. The framework aims to enhance the security of critical systems within nuclear power plants by adopting the principles of Zero-Trust and leveraging artificial intelligence (AI) technologies. By assuming no implicit trust in any user or device and continuously authenticating and authorizing access, the framework ensures a robust defense against malware attacks. The integration of AI allows for the detection and prevention of malware through behavioral analytics, endpoint protection, network segmentation, and continuous monitoring. The paper discusses the key considerations, steps, and technologies involved in developing this framework, emphasizing the importance of regular updates, training, compliance, and auditing. The proposed framework serves as a comprehensive approach to safeguarding nuclear power plants from sophisticated malware threats and protecting the integrity and safety of critical infrastructure.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗