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At least 127 records · Page 7

Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model

Background Wildfire events are increasing in frequency and intensity, and aging individuals demonstrate heightened biological susceptibility to air pollution exposures including increased risk of neurological sequelae. Declining ovarian hormones levels that occur with aging in females along with associated systemic physiological and inflammatory changes may contribute to increased cerebral vulnerability to air pollution, representing a potential but underexplored mechanism. Menopause and the menopausal transition represent a period of profound physiological change that affects cardiovascular, neurological, and immune health. Methods We tested whether peri-menopausal–like hormonal status amplifies hippocampal responses to acute wood smoke (WS) using an ovary-intact, 4-vinylcyclohexene diepoxide (VCD) model of moderate accelerated ovarian failure (AOF) in female C57BL/6 mice. Animals were exposed to HEPA-filtered air (FA) or WS for 4 h/day over 2 consecutive days (∼0.5 mg/m³). Exposure characterization confirmed a complex mixture of combustion products with significant levels of both trace metals and gas release during WS exposure. Results Spatial transcriptomics (10x Visium; n = 4 sections/group) with automated cell-type annotation identified astrocytes, GABAergic and glutamatergic neurons, oligodendrocytes, revealed cell type-specific transcriptional alterations following WS exposure. Distinct transcriptional patterns were observed across all identified neuronal and glial cell populations. Conclusion Together, these findings define a cell-type specific transcriptomic framework describing how WS exposure and ovarian hormone decline interact to influence hippocampal responses and identify potential cellular pathways relevant to hippocampal vulnerability.

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTAN↗

Computed lateral rate and acceleration power spectral response of conventional and STOL airplanes to atmospheric turbulence

Power-spectral-density calculations were made of the lateral responses to atmospheric turbulence for several conventional and short take-off and landing (STOL) airplanes. The turbulence was modeled as three orthogonal velocity components, which were uncorrelated, and each was represented with a one-dimensional power spectrum. Power spectral densities were computed for displacements, rates, and accelerations in roll, yaw, and sideslip. In addition, the power spectral density of the transverse acceleration was computed. Evaluation of ride quality based on a specific ride quality criterion was also made. The results show that the STOL airplanes generally had larger values for the rate and acceleration power spectra (and, consequently, larger corresponding root-mean-square values) than the conventional airplanes. The ride quality criterion gave poorer ratings to the STOL airplanes than to the conventional airplanes.

Lichtenstein, J. H.↗

Baffle Effect on Sloshing-Modulated Torques Responsed to Orbital Accelerations in Microgravity

The behavior of sloshing-dynamics-modulated fluid systems driven by orbital accelerations including gravity gradient and jitter accelerations has been studied. Partly liquid-filled rotating Dewars applicable to a full-scale Gravity Probe-B Spacecraft container with and without baffle are considered. Results show that a slosh wave excited along the liquid-vapor interface induced by jitter-acceleration-dominated orbital accelerations provides a torsional moment with an up-and-down movement of bubble oscillations in the rotating Dewar. The fluctuations of fluid forces and fluid moment (torque) exerted on the Dewar wall of the container caused by slosh-wave excitation driven by orbital accelerations are also investigated. Since the viscous force across a liquid-solid interface and the surface-tension force across a liquid-vapor or liquid-solid interface can greatly contribute to the damping effect of slosh-wave excitation, a rotating Dewar with a baffle provides more areas of liquid-solid, and liquid-vapor, and solid-vapor interfaces than does a rotating Dewar without a baffle. Results show that the damping effect provided by the baffle reduces the amplitudes of force and moment feedback from the fluids to the container-in particular, the components of fluctuations transverse to the direction of the baffle boards.

Pan, H. L.↗

Effect of prolonged bedrest and plus Gz acceleration on peripheral visual response time

Peripheral visual response time changes during +G sub z acceleration following fourteen days of bedrest are considered as well as what effect prolonged bedrest has upon this response. Eighteen test lights, placed 10 deg are apart along the horizontal meridian of the subject's field of view, were presented in a random sequence. The subject was instructed to press a button as soon as a light appeared. Response time testing occurred periodically during bedrest and continuously during centrifugation testing. The results indicate that: (1) mean response time is significantly longer to stimuli imaged in the far periphery than to stimuli imaged closer to the line of sight; (2) mean response time at each stimulus position tends to be longer at plateau g than during the preacceleration baseline period; (3) mean response time tends to lengthen as the g level is increased; (4) peripheral visual response time during +G sub x acceleration at 2, 3.2, and 3.8 g was not a reliable advanced indicator that blackout was going to occur; and (5) the subject's field of view collapsed rapidly just before blackout. Bedrest data showed that the distribution of response times to stimuli imaged across the subject's horizontal retinal meridian remained remarkably constant from day to day during both the bedrest and recovery periods.

Haines, R. F.↗

On the Onset Delays of Solar Energetic Electrons and Protons: Evidence for a Common Accelerator

The processes responsible for the acceleration of solar energetic particles (SEPs) are still not well understood, including whether SEP electrons and protons are accelerated by common or separate processes. Using a numerical particle transport model that includes both pitch-angle and perpendicular spatial diffusion, we simulate, among other quantities, the onset delay for MeV electrons and protons and compare the results to observations of SEPs from widely separated spacecraft. Such observations have previously been interpreted, in a simple scenario assuming no perpendicular diffusion, as evidence for different electron and proton sources. We show that, by assuming a common particle source together with perpendicular diffusion, we are able to simultaneously reproduce the onset delays for both electrons and protons. We argue that this points toward a common accelerator for these particles. Moreover, a relatively broad particle source is required in the model to correctly describe the observations. This is suggestive of diffusive shock acceleration occurring at large shock structures playing a significant role in the acceleration of these SEPs.

R D Strauss↗

Combined Modeling of Acceleration, Transport, and Hydrodynamic Response in Solar Flares: The Numerical Model - 1

Acceleration and transport of high-energy particles and fluid dynamics of atmospheric plasma are interrelated aspects of solar flares, but for convenience and simplicity they were artificially separated in the past. We present here self consistently combined Fokker-Planck modeling of particles and hydrodynamic simulation of flare plasma. Energetic electrons are modeled with the Stanford unified code of acceleration, transport, and radiation, while plasma is modeled with the Naval Research Laboratory flux tube code. We calculated the collisional heating rate directly from the particle transport code, which is more accurate than those in previous studies based on approximate analytical solutions. We repeated the simulation of Mariska et al. with an injection of power law, downward-beamed electrons using the new heating rate. For this case, a -10% difference was found from their old result. We also used a more realistic spectrum of injected electrons provided by the stochastic acceleration model, which has a smooth transition from a quasi-thermal background at low energies to a non thermal tail at high energies. The inclusion of low-energy electrons results in relatively more heating in the corona (versus chromosphere) and thus a larger downward heat conduction flux. The interplay of electron heating, conduction, and radiative loss leads to stronger chromospheric evaporation than obtained in previous studies, which had a deficit in low-energy electrons due to an arbitrarily assumed low-energy cutoff. The energy and spatial distributions of energetic electrons and bremsstrahlung photons bear signatures of the changing density distribution caused by chromospheric evaporation. In particular, the density jump at the evaporation front gives rise to enhanced emission, which, in principle, can be imaged by X-ray telescopes. This model can be applied to investigate a variety of high-energy processes in solar, space, and astrophysical plasmas.

STOCHASTIC ACCELERATION MODEL↗

Experiment specific processing of residual acceleration data

To date, most Spacelab residual acceleration data collection projects have resulted in data bases that are overwhelming to the investigator of low-gravity experiments. This paper introduces a simple passive accelerometer system to measure low-frequency accelerations. Model responses for experiments using actual acceleration data are produced and correlations are made between experiment response and the accelerometer time history in order to test the idea that recorded acceleration data and experimental responses can be usefully correlated. Spacelab 3 accelerometer data are used as input to a variety of experiment models, and sensitivity limits are obtained for particular experiment classes. The modeling results are being used to create experiment-specific residual acceleration data processing schemes for interested investigators.

Rogers, Melissa J. B.↗

Splanchnic blood flow and plus or minus Gx acceleration.

Experimental data show that there is a neurogenic response to acceleration stress in the front to back direction and that this response is intensified during higher accelerative forces. The afferent limb of this response is unknown but possibilities are suggested. The integrated response at high acceleration levels might serve to conserve oxygen during the stress time. The effector limb is the constriction of less critical vascular beds to preserve blood flow to the heart and brain. The concomitant increase in vagal activity causes a slowing down of the heart.

Stone, H. L.↗

Perception and performance in flight simulators: The contribution of vestibular, visual, and auditory information

The pilot's perception and performance in flight simulators is examined. The areas investigated include: vestibular stimulation, flight management and man cockpit information interfacing, and visual perception in flight simulation. The effects of higher levels of rotary acceleration on response time to constant acceleration, tracking performance, and thresholds for angular acceleration are examined. Areas of flight management examined are cockpit display of traffic information, work load, synthetic speech call outs during the landing phase of flight, perceptual factors in the use of a microwave landing system, automatic speech recognition, automation of aircraft operation, and total simulation of flight training.

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