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At least 127 records · Page 7

Disseminating technological information on remote sensing to potential users

The Laboratory for Applications of Remote Sensing has developed materials and programs which range from short tutorial brochures to post-doctoral research programs which may span several years. To organize both the content and the instructional techniques, a matrix of instructional materials has been conceptualized. Each row in the matrix represents a subject area in remote sensing and each column in the matrix represents a different type media or instructional strategy.

Russell, J. D.↗

AutoLabs: cognitive multi-agent systems with self-correction for autonomous chemical experimentation

The automation of chemical research through self-driving laboratories (SDLs) promises to accelerate scientific discovery, yet the reliability and granular performance of the underlying AI agents remain critical, under-examined challenges. In this work, we introduce AutoLabs, a self-correcting, multi-agent architecture designed to autonomously translate natural-language instructions into executable protocols for a high-throughput liquid handler. The system engages users in dialogue, decomposes experimental goals into discrete tasks for specialized agents, performs tool-assisted stoichiometric calculations, and iteratively self-corrects its output before generating a hardware-ready file. We present a comprehensive evaluation framework featuring five benchmark experiments of increasing complexity, from simple sample preparation to multi-plate timed syntheses. Through a systematic ablation study of 20 agent configurations, we assess the impact of reasoning capacity, architectural design (single- vs. multi-agent), tool use, and self-correction mechanisms. Our results demonstrate that agent reasoning capacity is the most critical factor for success, reducing quantitative errors in chemical amounts (nRMSE) by over 85% in complex tasks. When combined with a multi-agent architecture and iterative self-correction, AutoLabs approaches expert-authored reference procedures on the benchmark (F1-score > 0.89) on challenging multi-plate syntheses. These findings establish a clear blueprint for developing robust and trustworthy AI partners for autonomous laboratories, highlighting the synergistic effects of modular design, advanced reasoning, and self-correction to ensure both performance and reliability in high-stakes scientific applications. Code: https://github.com/pnnl/autolabs

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

GenomeDepot: data management system for microbial comparative genomics

Summary GenomeDepot is an open-source web-based platform for annotation, management, and comparative analysis of microbial genomic sequences and associated data including ortholog families, protein domains, operons, regulatory interactions, strain taxonomy, and sample metadata. GenomeDepot supports rapid creation of websites for user-defined genome collections that include bioinformatic tools for interactive genome browsing, Basic Local Alignment Search Tool (BLAST) search, annotation search, comparative genomic neighborhood visualization, and sequence download. Gene function annotations are generated by a customizable annotation pipeline. The pipeline runs annotation tools in Conda environments and can be easily extended with additional user-specified tools. Availability and implementation GenomeDepot is open source and distributed under the GNU General Public License via GitHub (https://github.com/aekazakov/genome-depot). GenomeDepot is implemented in Python and was tested in Ubuntu Linux. Full installation instructions and documentation are available at https://aekazakov.github.io/genome-depot/. GenomeDepot demo server is freely accessible at https://iseq.lbl.gov/demogd/.

Kazakov, Alexey [Lawrence Berkeley National Labora↗

Mitigation of SARS-CoV-2 transmission at a large public university

In Fall 2020, universities saw extensive transmission of SARS-CoV-2 among their populations, threatening health of the university and surrounding communities, and viability of in-person instruction. Here we report a case study at the University of Illinois at Urbana-Champaign, where a multimodal “SHIELD: Target, Test, and Tell” program, with other non-pharmaceutical interventions, was employed to keep classrooms and laboratories open. The program included epidemiological modeling and surveillance, fast/frequent testing using a novel low-cost and scalable saliva-based RT-qPCR assay for SARS-CoV-2 that bypasses RNA extraction, called covidSHIELD, and digital tools for communication and compliance. In Fall 2020, we performed >1,000,000 covidSHIELD tests, positivity rates remained low, we had zero COVID-19-related hospitalizations or deaths amongst our university community, and mortality in the surrounding Champaign County was reduced more than 4-fold relative to expected. This case study shows that fast/frequent testing and other interventions mitigated transmission of SARS-CoV-2 at a large public university.

60 APPLIED LIFE SCIENCES↗

2014 Southern Nevada Household Travel Survey

The 2014 Southern Nevada Household Travel Survey collected information from residents in the Las Vegas area to update the regional travel demand model and assess travel behavior. The Regional Transportation Commission of Southern Nevada contracted with Westat to conduct the survey. The survey was conducted in two phases—from March to May 2014 and from August to October 2014. Participants provided demographic and travel data (via a travel log). A 10% subsample (1,694 participants) was randomly selected to take part in a wearable global positioning system (GPS) technology-based component of the study, the purpose of which was to assess the level of trip under-reporting in the self-reported travel logs. Participants in the GPS portion of the study were instructed to record trips in their travel logs on the first day only, while passively recording their travel for three full days.

1Hz data↗

Unlocking Scholarly Insights: Leveraging Machine Learning Approaches for Citation Analysis and Intent Classification

Publicly funded organizations, notably institutions like the Los Alamos National Laboratory (LANL), are deeply vested in acquiring robust productivity metrics to gauge the entirety of their research output. Motivated by the imperative to enhance institutional productivity assessment, this study investigates the utilization of Large Language Models (LLM) such as BERT-based models, as well as local LLaMa-30b-instruct and Mixtral-8x7b-instruct architectures for classifying type of URL referenced resources in academic papers such as software, dataset, as well as authorship intent. Challenges in discerning resource types from context are highlighted, along with the potential of BERT and LLMs to address these challenges. Through comprehensive analysis, this research unveils a notable surge in documents featuring URL citations, indicative of the escalating importance of digital resources in scholarly publications. Moreover, citations to datasets and software demonstrate consistent growth over time, underscoring their increasing significance. Our findings also reveal that LANL authors contribute substantially to accessible science, comprising about 10% of dataset and software mentions in LANL

Large Language Models, BERT, citation classificati↗

Procedure Parsing: A Method for Parsing Handwritten Documents into Computer-Based Procedures

The nuclear industry is heavily procedure driven, where almost everything has a step-by-step instruction that is expected to be followed in detail. Historically, these procedures were printed on paper copies. Recently, the industry transitioned towards electronic copies (i.e., PDFs on tablets). One major drive for this transition is the introduction of human error and loss of situation awareness when using paper copies. However, electronic copies of documents inherently have the same error traps as their paper cousins. Therefore, there is an increased interest in a way to utilize the information in the step-by-step guidance, but to present it in a dynamic manner that guides the user and adapts to any encountered conditions. Researchers at Idaho National Laboratory propose a flexible, automated method based on document parsing and augmented by natural language processing (NLP) techniques, to address these shortcomings and capitalize on these recent advancements in machine learning. The proposed method provides a cost-effective solution for computer-assisted procedure parsing of hand-written control room procedures, originally authored in Word or PDF formats, into instructions that can be displayed as computer-based procedures (CBP) in a modern graphical user interface. The researchers devised, implemented and demonstrated the Operating Procedure Extender for Novel Systems (OPENS) method in 2020. The key to OPENS is to map the original procedure text into a context-free grammar, tying content to equipment, locations, and other steps, actions, etc. This formal grammar is then used to isolate and define keywords and actions verbs, such as “measure” or “evaluate” and tie them to specific equipment referenced within that step or located in other steps, substeps, actions, subactions and tables throughout the procedure. OPENS generates an abstract syntax tree from the document which it uses to store a copy of this information in the open-standard, machine-readable and human-readable file formats XML and JSON. The XML is useful to preserve the relational aspects of the procedure for referencing tables and branching information so the user can be directed to the next appropriate active step based on the values entered for that step and previous steps. The JSON is useful for storing and exchanging data objects used to track responses to previous steps and state changes in simulated environments. In future iterations, these formats can also be used for storing more detailed information about input during plant operation or simulation. The techniques the researcher developed could further be improved by integration of recent advancements in machine learning. NLP methods could standardize documents, correct for grammatical error, and provide automated semantic validation. The researcher expects that self-supervised techniques applied to collections of natural language instructions could strengthen the model with broader context. All these methods together give us a practical way to automatically extract protocols from documents and user interactions, empowering researchers, procedure writers and nuclear operators while moving the industry forward.

99 GENERAL AND MISCELLANEOUS↗

Pyrogenic Organic Matter Laboratory Experiment: Aerobic Respiration and Geochemistry from Variably Inundated Stream Sediments (v3)

This dataset supports a broader study examining the effects of variable inundation and pyrogenic organic matter on ecosystem respiration. The dataset provides data generated from a laboratory batch experiment investigating the interaction between variable inundation conditions (wet and dry sediment) and pyrogenic organic matter (burned and unburned treatments). The contents include time series dissolved oxygen, sediment geochemistry data, and field metadata (including qualitative information on instream and river corridor characteristics). This data package was originally published in November 2025. It was updated in April 2026 (v2; new and modified files) and May 2026 (v3; modified files). See the change history section in the readme for more details For details on how to navigate data packages generated by this project, see https://data.ess-dive.lbl.gov/portals/PNNLRiverCorridorSFA/About. In addition to a readme, this data package also includes a file-level metadata (FLMD) file that describes each file and a data dictionary (DD) that describes all column/row headers and variable definitions. This dataset is comprised of (1) file-level metadata; (2) data dictionary; (3) field metadata; (4) international generic sample number (IGSN) mapping file; (5) readme; (6) field protocol; (7) sample name metadata; (8) an environmental context picture for the dry and inundated sampling locations; and (9) a subfolder with sample data from the sediment incubation experiment. The sample data subfolder contains (1) dissolved organic carbon (DOC, measured as non-purgeable organic carbon, NPOC); (2) total nitrogen (TN); (3) gravimetric moisture; (4) partial pressure and production rates of carbon dioxide, methane, and nitrous oxide; (5) field wet sediment mass, dry sediment mass, water mass, and field wet sediment volume in incubation and sediment NPOC/TN vials; (6) methods codes; (7) respiration rates, pH, and temperature from after the incubation, raw time series dissolved oxygen and temperature, and a subfolder containing associated plots and scripts; (8) ions; (9) FTICR-MS methods; and (10) a subfolder of 12 Tesla (12T) FTICR-MS data. This folder contains the CoreMS processed data and three subfolders, one containing the .xml files, one containing the CoreMS output files, and the other containing instructions and scripts for processing the files in CoreMS (https://github.com/EMSL-Computing/CoreMS). All files are .csv, .pdf, .R, .xml, .html, .Rmd, .py, .cal, .json, or .jpg.

54 ENVIRONMENTAL SCIENCES↗

Lab Manual & Resources for Materials Science, Engineering and Technology on CD-Rom

The National Educators' Workshop (NEW:Update) series of workshops has been in existence since 1986. These annual workshops focus on technical updates and laboratory experiments for materials science, engineering and technology, involving new and traditional content in the field. Scores of educators and industrial and national laboratory personnel have contributed many useful experiments and demonstrations which were then published as NASA Conference Proceedings. This "out poring of riches" creates an ever-expanding shelf of valuable teaching tools for college, university, community college and advanced high school instruction. Now, more than 400 experiments and demonstrations, representing the first thirteen years of NEW:Updates have been selected and published on a CD-ROM, through the collaboration of this national network of materials educators, engineers, and scientists. The CD-ROM examined in this document utilizes the popular Adobe Acrobat Reader format and operates on most popular computer platforms. This presentation provides an overview of the second edition of Experiments in Materials Science, Engineering and Technology (EMSET2) CD-ROM, ISBN 0-13-030534-0.

Jacobs, James A.↗

Development of an Advanced Integrated Operations Concept for Hybrid Control Rooms

The U.S. Nuclear Industry has an urgent need to reduce the operations and maintenance costs to remain economically competitive in today’s energy market. Measures to improve efficiency in operations will need to leverage technology in a way that safely transforms how plants are operated. This work describes the development of an integrated operations concept that integrates data from existing Instrumentation and Control (I&C) infrastructure, upgraded I&C systems, new sensors, and field technologies such as computer-based procedures to provide operators with centralized, streamlined instructions. The concept was developed to allow for an operator to remotely supervise many plant activities and to dramatically streamline plant operations and maintenance. This report describes the design philosophy, the analysis used to inform design, the implementation in the Human Systems Simulation Laboratory, and illustrates the design concept.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

IVA the robot: Design guidelines and lessons learned from the first space station laboratory manipulation system

The first interactive Space Station Freedom (SSF) lab robot exhibit was installed at the Space and Rocket Center in Huntsville, AL, and has been running daily since. IntraVehicular Activity (IVA) the robot is mounted in a full scale U.S. Lab (USL) mockup to educate the public on possible automation and robotic applications aboard the SSF. Responding to audio and video instructions at the Command Console, exhibit patrons may prompt IVA to perform a housekeeping task or give a speaking tour of the module. Other exemplary space station tasks are simulated and the public can even challenge IVA to a game of tic tac toe. In anticipation of such a system being built for the Space Station, a discussion is provided of the approach taken, along with suggestions for applicability to the Space Station Environment.

Konkel, Carl R.↗

WHONDRS 2016 Sediment Organic Matter Characterization Data from Streams across HJ Andrews Experimental Forest, Oregon

This dataset supports a broader synoptic effort to map morphological, hydrological, chemical, and biological conditions across a fifth-order mountain stream network. Samples were generated through a collaborative synoptic sampling effort in 2016. The dataset provides sediment Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS) from 60 sites across the HJ Andrews Experimental Forest, Oregon (https://andrewsforest.oregonstate.edu). Related data were collected as part of the event and were published separately in collaboration with other team members. The data are available at http://www.hydroshare.org/resource/ea6c0832885a46c3939e7bb22e48e754 and are described within https://doi.org/10.5194/essd-11-1567-2019 (Ward et al., 2019). The hydroshare data package contains processed FTICR-MS data from the samples included in this data package. The data were processed via Formultitude (previously called Formularity; https://github.com/PNNL-Comp-Mass-Spec/Formultitude). However, we have re-processed the data using Core-MS and included it in this data package. Additional related data collected in 2025 from a similar effort can be found at https://data.ess-dive.lbl.gov/datasets/doi:10.15485/3023310 and http://www.hydroshare.org/resource/b274c4a234bf4b12b7cb8a54a696c629. For details on how to navigate data packages generated by this project, see https://data.ess-dive.lbl.gov/portals/PNNLRiverCorridorSFA/About. In addition to a readme, this data package also includes a file-level metadata (FLMD) file that describes each file and a data dictionary (DD) that describes all column/row headers and variable definitions. This dataset is comprised of (1) a folder of sample data; (2) data dictionary; (3) file-level metadata; (4); (5) coordinates; and (6) readme. The sample data subfolder contains 12 Tesla (12T) FTICR-MS data. This folder contains the processed data and three subfolders, one containing the .xml files, one containing the CoreMS output files, and the other containing instructions and scripts for processing the files in CoreMS (https://github.com/EMSL-Computing/CoreMS). All files are .csv, .pdf, .R, .xml, .Rmd, .py, .cal, or .json.

Biogeochemistry↗

Computer-Based Mathematics Instructions for Engineering Students

Almost every engineering course involves mathematics in one form or another. The analytical process of developing mathematical models is very important for engineering students. However, the computational process involved in the solution of some mathematical problems may be very tedious and time consuming. There is a significant amount of mathematical software such as Mathematica, Mathcad, and Maple designed to aid in the solution of these instructional problems. The use of these packages in classroom teaching can greatly enhance understanding, and save time. Integration of computer technology in mathematics classes, without de-emphasizing the traditional analytical aspects of teaching, has proven very successful and is becoming almost essential. Sample computer laboratory modules are developed for presentation in the classroom setting. This is accomplished through the use of overhead projectors linked to graphing calculators and computers. Model problems are carefully selected from different areas.

Khan, Mustaq A.↗

Testing of Turner Manufacturing Wastewater Remediation Products in Advanced Bioreactor Systems

LANL received three types of simulated wastewater (oil-contaminated soil within a water matrix; commercial laundry; cheese production), which were treated with a corresponding biological agent (enzyme and/or microbial blend) provided by the company. Experiments were set up according to their instruction within an automated bioreactor/fermenter and monitored over time. Aliquots were obtained for total organic carbon (TOC), flow cytometry, Biological Oxygen Demand, Chemical Oxygen Demand.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Instruction manual for epitaxial apparatus

Instruction manual for apparatus using programmer operation of electronic valves for etching and growth of single crystal silicon, deposition of silicon dioxide, and nucleation site treatment

MANUAL↗

Evaluations of Three Methods for Remote Training

Long duration space missions require a change in training methods and technologies. For Shuttle missions, crew members could train for all the planned procedures, and carry documentation of planned procedures for a variety of contingencies. As International Space Station (ISS) missions of three months or longer are carried out, many more tasks will need to be performed for which little or no training was received prior to launch. Eventually, exploration missions will last several years, and communications with Earth will have long time delays or be impossible at times. This series of three studies was performed to identify the advantages and disadvantages of three types of training for self-instruction: video-conferencing; multimedia; and virtual reality. These studies each compared two types of training methods, on two different types of tasks. In two of the studies, the subject's were in an isolated, confined environment analogous to space flight; the third study was performed in a laboratory.

Woolford, B.↗

Laboratory process control using natural language commands from a personal computer

PC software is described which provides flexible natural language process control capability with an IBM PC or compatible machine. Hardware requirements include the PC, and suitable hardware interfaces to all controlled devices. Software required includes the Microsoft Disk Operating System (MS-DOS) operating system, a PC-based FORTRAN-77 compiler, and user-written device drivers. Instructions for use of the software are given as well as a description of an application of the system.

Will, Herbert A.↗

Is the testing effect ready to be put to work? Evidence from the laboratory to the classroom.

The testing effect refers to the benefits to retention that result from structuring learning activities in the form of a test. As educators consider implementing test-enhanced learning paradigms in real classroom environments, we think it is critical to consider how an array of factors affecting test-enhanced learning in laboratory studies bear on test-enhanced learning in real-world classroom environments. As such, this review discusses the degree to which test feedback, test format (of formative tests), number of tests, level of the test questions, timing of tests (relative to initial learning), and retention duration have import for testing effects in ecologically valid contexts (e.g., classroom studies). Attention is also devoted to characteristics of much laboratory testing-effect research that may limit translation to classroom environments, such as the complexity of the material being learned, the value of the testing effect relative to other generative learning activities in classrooms, an educational orientation that favors criterial tests focused on transfer of learning, and online instructional modalities. We consider how student-centric variables present in the classroom (e.g., cognitive abilities, motivation) may have bearing on the effects of testing-effect techniques implemented in the classroom. We conclude that the testing effect is a robust phenomenon that benefits a wide variety of learners in a broad array of learning domains. Still, studies are needed to compare the benefit of testing to other learning strategies, to further characterize how individual differences relate to testing benefits, and to examine whether testing benefits learners at advanced levels.

60 APPLIED LIFE SCIENCES↗