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At least 127 records · Page 7

Fission gas bubble identification using MATLAB's image processing toolbox

Automated image processing routines have the potential to aid in the fuel performance evaluation process by eliminating bias in human judgment that may vary from person-to-person or sample-to-sample. This study presents several MATLAB based image analysis routines designed for fission gas void identification in post-irradiation examination of uranium molybdenum (U–Mo) monolithic-type plate fuels. Frequency domain filtration, enlisted as a pre-processing technique, can eliminate artifacts from the image without compromising the critical features of interest. This process is coupled with a bilateral filter, an edge-preserving noise removal technique aimed at preparing the image for optimal segmentation. Adaptive thresholding proved to be the most consistent gray-level feature segmentation technique for U–Mo fuel microstructures. The Sauvola adaptive threshold technique segments the image based on histogram weighting factors in stable contrast regions and local statistics in variable contrast regions. Once all processing is complete, the algorithm outputs the total fission gas void count, the mean void size, and the average porosity. The final results demonstrate an ability to extract fission gas void morphological data faster, more consistently, and at least as accurately as manual segmentation methods. - Highlights: •Automated image processing can aid in the fuel qualification process. •Routines are developed to characterize fission gas bubbles in irradiated U–Mo fuel. •Frequency domain filtration effectively eliminates FIB curtaining artifacts. •Adaptive thresholding proved to be the most accurate segmentation method. •The techniques established are ready to be applied to large scale data extraction testing.

36 MATERIALS SCIENCE↗

Spatial-Spectral Representation for X-Ray Fluorescence Image Super-Resolution

X-ray fluorescence (XRF) scanning of works of art is becoming an increasing popular nondestructive analyticalmethod. The high quality XRF spectra is necessary to obtain significant information on both major and minor elements used for characterization and provenance analysis. However, there is a tradeoff between the spatial resolution of an XRF scan and the signalto- noise ratio (SNR) of each pixel’s spectrum, due to the limited scanning time. In this project, we propose an XRF image super-resolution method to address this tradeoff; thus, obtaining a high spatial resolution XRF scan with high SNR. We fuse a lowresolution XRF image and a conventional RGB high-resolution image into a product of both high spatial and high spectral resolution XRF image. There is no guarantee of a one to one mapping between XRF spectrum and RGB color since, for instance, paintings with hidden layers cannot be detected in visible but can in X-ray wavelengths. We separate the XRF image into the visible and nonvisible components. The spatial resolution of the visible component is increased utilizing the high-resolution RGB image, whereas the spatial resolution of the non-visible component is increased using a total variation super-resolution method. Finally, the visible and nonvisible components are combined to obtain the final result.

Dai, Qiqin↗

Optical Imaging on Z LDRD: Design and Development of Self-Emission and Debris Imagers

We present an overview of the design and development of optical self-emission and debris imaging diagnostics for the Z Machine at Sandia National Laboratories. These diagnostics were designed and implemented to address several gaps in our understanding of visibly emitting phenomenon on Z and the post-shot debris environment. Optical emission arises from plasmas that form on the transmission line that delivers energy to Z loads and on the Z targets themselves; however, the dynamics of these plasmas are difficult to assess without imaging data. Addressing this, we developed a new optical imager called SEGOI (Self-Emission Gated Optical Imager) that leverages the eight gated optical imagers and two streak cameras of the Z Line VISAR system. SEGOI is a low cost, side-on imager with a 1 cm field of view and 30-50 µm spatial resolution, sensitive to green light (540-600 nm). This report outlines the design considerations and development of this diagnostic and presents an overview of the first diagnostic data acquired from four experimental campaigns. SEGOI was fielded on power flow experiments to image plasmas forming on and between transmission lines, on an inertial confinement fusion experiment called the Dynamic Screw Pinch to image low density plasmas forming on return current posts, on an experiment designed to measure the magneto Rayleigh-Taylor instability to image the instability bubble trajectory and self-emission structures, and finally on a Magnetized Liner Inertial Fusion (MagLIF) experiment to image the emission from the target. The second diagnostic developed, called DINGOZ (Debris ImagiNG on Z), was designed to improve our understanding of the post-shot debris environment. DINGOZ is an airtight enclosure that houses electronics and batteries to operate a high-speed (10-400 kfps) camera in the Z Machine center section. We report on the design considerations of this new diagnostic and present the first high-speed imaging data of the post-shot debris environment on Z.

42 ENGINEERING↗

Image Labeler: Label Earth Science Images for Machine Learning

The application of machine learning for image-based classification of earth science phenomena, such as hurricanes, is relatively new. While extremely useful, the techniques used for image-based phenomena classification require storing and managing an abundant supply of labeled images in order to produce meaningful results. Existing methods for dataset management and labeling include maintaining categorized folders on a local machine, a process that can be cumbersome and not scalable. Image Labeler is a fast and scalable web-based tool that facilitates the rapid development of image-based earth science phenomena datasets, in order to aid deep learning application and automated image classification/detection. Image Labeler is built with modern web technologies to maximize the scalability and availability of the platform. It has a user-friendly interface that allows tagging multiple images relatively quickly. Essentially, Image Labeler improves upon existing techniques by providing researchers with a shareable source of tagged earth science images for all their machine learning needs. Here, we demonstrate Image Labeler’s current image extraction and labeling capabilities including supported data sources, spatiotemporal subsetting capabilities, individual project management and team collaboration for large scale projects.

Acharya, Ashish↗

From optical to X-ray ghost imaging

Recent advances in ghost imaging techniques and X-ray sources such as synchrotrons and, more recently, X-ray free-electron lasers (XFEL) have made X-ray ghost imaging a growing topic of interest. One specific type of ghost imaging utilizes thermal radiation and the measurement of intensity fluctuation correlation to form a true image without the need of a lens. This technique allows for much higher resolution than traditional X-ray imaging for a mesoscopic or even a microscopic object. In addition to this benefit of not requiring a lens, a surprising experiment has shown that, when set up correctly, this type of ghost imaging can provide clear images through the measurement of intensity fluctuation correlation when traditional images through measurements of intensity are blurred due to optical turbulence and vibrations. This turbulence-free technique will help maintain the high resolution of X-ray ghost imaging. How is an image formed from fluctuations in light? And what makes it turbulence-free? Using the concept of two-photon interference, this article provides an introduction to these fundamentally interesting concepts and X-ray ghost imaging.

ghost imaging↗

Geometry planning and image registration in magnetic particle imaging using bimodal fiducial markers

Purpose: Magnetic particle imaging (MPI) is a quantitative imaging modality that allows the distribution of superparamagnetic nanoparticles to be visualized. Compared to other imaging techniques like x-ray radiography, computed tomography (CT), and magnetic resonance imaging (MRI), MPI only provides a signal from the administered tracer, but no additional morphological information, which complicates geometry planning and the interpretation of MP images. The purpose of the authors’ study was to develop bimodal fiducial markers that can be visualized by MPI and MRI in order to create MP–MR fusion images. Methods: A certain arrangement of three bimodal fiducial markers was developed and used in a combined MRI/MPI phantom and also during in vivo experiments in order to investigate its suitability for geometry planning and image fusion. An algorithm for automated marker extraction in both MR and MP images and rigid registration was established. Results: The developed bimodal fiducial markers can be visualized by MRI and MPI and allow for geometry planning as well as automated registration and fusion of MR–MP images. Conclusions: To date, exact positioning of the object to be imaged within the field of view (FOV) and the assignment of reconstructed MPI signals to corresponding morphological regions has been difficult. The developed bimodal fiducial markers and the automated image registration algorithm help to overcome these difficulties.

60 APPLIED LIFE SCIENCES↗

SU-F-J-76: Evaluation of the Performance of Different Deformable Image Registration Algorithms in Helical, Axial and Cone-Beam CT Images of a Mobile Phantom

Purpose: To investigate quantitatively the performance of different deformable-image-registration algorithms (DIR) with helical (HCT), axial (ACT) and cone-beam CT (CBCT) by evaluating the variations in the CT-numbers and lengths of targets moving with controlled motion-patterns. Methods: Four DIR-algorithms including demons, fast-demons, Horn-Schunk and Locas-Kanade from the DIRART-software are used to register CT-images of a mobile-phantom. A mobile-phantom is scanned with different imaging techniques that include helical, axial and cone-beam CT. The phantom includes three targets with different lengths that are made from water-equivalent material and inserted in low-density-foam which is moved with adjustable motion-amplitudes and frequencies. Results: Most of the DIR-algorithms are able to produce the lengths of the stationary-targets, however, they do not produce the CT-number values in CBCT. The image-artifacts induced by motion are more regular in CBCT imaging where the mobile-target elongation increases linearly with motion-amplitude. In ACT and HCT, the motion-artifacts are irregular where some mobile -targets are elongated or shrunk depending on the motion-phase during imaging. The DIR-algorithms are successful in deforming the images of the mobile-targets to the images of the stationary-targets producing the CT-number values and length of the target for motion-amplitudes < 20 mm. Similarly in ACT, all DIR-algorithms produced the actual CT-number and length of the stationary-targets for motion-amplitudes < 15 mm. As stronger motion-artifacts are induced in HCT and ACT, DIR-algorithms fail to produce CT-values and shape of the stationary-targets and fast-demons-algorithm has worst performance. Conclusion: Most of DIR-algorithms produce the CT-number values and lengths of the stationary-targets in HCT and ACT images that has motion-artifacts induced by small motion-amplitudes. As motion-amplitudes increase, the DIR-algorithms fail to deform mobile-target images to the stationary-images in HCT and ACT. In CBCT, DIR-algorithms are successful in producing length and shape of the stationary-targets, however, they fail to produce the accurate CT-number level.

60 APPLIED LIFE SCIENCES↗

Characteristics of a New X-Ray Imaging System for Interventional Procedures: Improved Image Quality and Reduced Radiation Dose

PurposeTo compare image quality and radiation exposure between a new angiographic imaging system and the preceding generation system during uterine artery embolization (UAE).Materials and MethodsIn this retrospective, IRB-approved two-arm study, 54 patients with symptomatic uterine fibroids were treated with UAE on two different angiographic imaging systems. The new system includes optimized acquisition parameters and real-time image processing algorithms. Air kerma (AK), dose area product (DAP) and acquisition time for digital fluoroscopy (DF) and digital subtraction angiography (DSA) were recorded. Body mass index was noted as well. DF image quality was assessed objectively by image noise measurements. DSA image quality was rated by two blinded, independent readers on a four-rank scale. Statistical differences were assessed with unpaired t tests and Wilcoxon rank-sum tests.ResultsThere was no significant difference between the patients treated on the new (n = 36) and the old system (n = 18) regarding age (p = 0.10), BMI (p = 0.18), DF time (p = 0.35) and DSA time (p = 0.17). The new system significantly reduced the cumulative AK and DAP by 64 and 72%, respectively (median 0.58 Gy and 145.9 Gy*cm{sup 2} vs. 1.62 Gy and 526.8 Gy*cm{sup 2}, p < 0.01 for both). Specifically, DAP for DF and DSA decreased by 59% (75.3 vs. 181.9 Gy*cm{sup 2}, p < 0.01) and 78% (67.6 vs. 312.2 Gy*cm{sup 2}, p < 0.01), respectively. The new system achieved a significant decrease in DF image noise (p < 0.01) and a significantly better DSA image quality (p < 0.01).ConclusionsThe new angiographic imaging system significantly improved image quality and reduced radiation exposure during UAE procedures.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Chitah: Strong-gravitational-lens hunter in imaging surveys

Strong gravitationally lensed quasars provide powerful means to study galaxy evolution and cosmology. Current and upcoming imaging surveys will contain thousands of new lensed quasars, augmenting the existing sample by at least two orders of magnitude. To find such lens systems, we built a robot, Chitah, that hunts for lensed quasars by modeling the configuration of the multiple quasar images.

79 ASTRONOMY AND ASTROPHYSICS↗

SU-F-J-209: Quantification of Image-Guidance Benefit in Image-Guided Radiotherapy of Cancers

Purpose: Image-guidance has been widely used in radiation oncology for accurate radiotherapy. The goal of this study is to quantify the benefit of image-guidance in image-guided radiotherapy (IGRT) of cancers. Methods: In this study, a new index termed image-guidance benefit (IGB), was proposed to quantify the benefit of image-guidance in cancer radiotherapy. It is calculated as a ratio of the square sum of dose differences between planning dose matrix and actual delivery dose matrix post image-guidance to the square sum of dose summation between the two matrixes, summing over all dose scoring voxels. Ranging from 0 to 1, larger IGB values indicate larger benefit out of image-guidance. With IRB approval, the DICOM RT files and 3D couch shifts applied during IGRT of 2219 patients were collected, based on which patient-specific IGB values were calculated with an in-house MATLAB code. Results: In this study, the mean IGB value was found to be 0.0398 (0.000583–0.999) with a positive correlation between IGB value and 3D couch shift vector at 0.0435 per cm (P<0.0001). With 2 mm shift as a threshold above which an image-guidance is deemed clinically necessary, the corresponding mean IGB value was 0.00457, much less than 0.0398 (P<0.001). However, the IGB values of 56 cases based on couch shifts were less than those based on 2 mm shift. Conclusion: The IGB values were patient-specific and site-dependent. Using 2 mm shifts as criterion for applying image-guidance, the applied image-guidance procedures were found clinically necessary and highly beneficial in 97.5% of cancer patients. However, image-guidance procedures were found over-used in about 2.5% of cancer patients in our current practices of IGRT, which should be avoided as they added no benefit in improving delivery accuracy while increasing cancer risk.

60 APPLIED LIFE SCIENCES↗

TU-H-CAMPUS-JeP1-04: Deformable Image Registration Performances in Pelvis Patients: Impact of CBCT Image Quality

Purpose: To investigate the accuracy and robustness, against image noise and artifacts (typical of CBCT images), of a commercial algorithm for deformable image registration (DIR), to propagate regions of interest (ROIs) in computational phantoms based on real prostate patient images. Methods: The Anaconda DIR algorithm, implemented in RayStation was tested. Two specific Deformation Vector Fields (DVFs) were applied to the reference data set (CTref) using the ImSimQA software, obtaining two deformed CTs. For each dataset twenty-four different level of noise and/or capping artifacts were applied to simulate CBCT images. DIR was performed between CTref and each deformed CTs and CBCTs. In order to investigate the relationship between image quality parameters and the DIR results (expressed by a logit transform of the Dice Index) a bilinear regression was defined. Results: More than 550 DIR-mapped ROIs were analyzed. The Statistical analysis states that deformation strenght and artifacts were significant prognostic factors of DIR performances, while noise appeared to have a minor role in DIR process as implemented in RayStation as expected by the image similarity metric built in the registration algorithm. Capping artifacts reveals a determinant role for the accuracy of DIR results. Two optimal values for capping artifacts were found to obtain acceptable DIR results (DICE> 075/ 0.85). Various clinical CBCT acquisition protocol were reported to evaluate the significance of the study. Conclusion: This work illustrates the impact of image quality on DIR performance. Clinical issues like Adaptive Radiation Therapy (ART) and Dose Accumulation need accurate and robust DIR software. The RayStation DIR algorithm resulted robust against noise, but sensitive to image artifacts. This result highlights the need of robustness quality assurance against image noise and artifacts in the commissioning of a DIR commercial system and underlines the importance to adopt optimized protocols for CBCT image acquisitions in ART clinical implementation.

60 APPLIED LIFE SCIENCES↗

Imaging of the hip joint. Computed tomography versus magnetic resonance imaging

The authors reviewed the applications and limitations of computed tomography (CT) and magnetic resonance (MR) imaging in the assessment of the most common hip disorders. Magnetic resonance imaging is the most sensitive technique in detecting osteonecrosis of the femoral head. Magnetic resonance reflects the histologic changes associated with osteonecrosis very well, which may ultimately help to improve staging. Computed tomography can more accurately identify subchondral fractures than MR imaging and thus remains important for staging. In congenital dysplasia of the hip, the position of the nonossified femoral head in children less than six months of age can only be inferred by indirect signs on CT. Magnetic resonance imaging demonstrates the cartilaginous femoral head directly without ionizing radiation. Computed tomography remains the imaging modality of choice for evaluating fractures of the hip joint. In some patients, MR imaging demonstrates the fracture even when it is not apparent on radiography. In neoplasm, CT provides better assessment of calcification, ossification, and periosteal reaction than MR imaging. Magnetic resonance imaging, however, represents the most accurate imaging modality for evaluating intramedullary and soft-tissue extent of the tumor and identifying involvement of neurovascular bundles. Magnetic resonance imaging can also be used to monitor response to chemotherapy. In osteoarthrosis and rheumatoid arthritis of the hip, both CT and MR provide more detailed assessment of the severity of disease than conventional radiography because of their tomographic nature. Magnetic resonance imaging is unique in evaluating cartilage degeneration and loss, and in demonstrating soft-tissue alterations such as inflammatory synovial proliferation.

Review↗

Quantitative Mapping of Nanoscale Chemical Dynamics in Sub-sampled Operando (S)TEM Images Using Spatio-Temporal Analytics

One of the main limitations in the use of operando scanning transmission electron microscopes to study dynamic chemical processes is the effect of the electron beam on the kinetics of the reaction being observed. Here we demonstrate that a flexible Gaussian mixture model can be used to extract quantitative information directly from sub-sampled images, i.e.~images where not all the pixels in the image are illuminated with the beam. The use of this method is demonstrated for the charge/discharge cycle of a Li-battery, where the deposition and dissolution of Li at the anode can be accurately quantified for sub-sampling levels down to 1%. Performing operando imaging using a small fraction of the pixels means that the observations can significantly reduce the effect of the beam, automatically increase the imaging speed and decrease the total data transfer rate required. Such new software capabilities offer the potential to significantly widen the application of operando hardware approaches to study nanoscale dynamics in materials.

Stanfill, Bryan A.↗

Final Project Report: Imaging Fault Zones Using a Novel Elastic Reverse-Time Migration Imaging Technique

Imaging fault zones and fractures is crucial for geothermal operators, providing important information for reservoir evaluation and management strategies. However, there are no existing techniques available for directly and clearly imaging fault zones, particularly for steeply dipping faults and fracture zones. In this project, we developed novel acoustic- and elastic-waveform inversion methods for high-resolution velocity model building. In addition, we developed acoustic and elastic reverse-time migration methods for high-resolution subsurface imaging of complex subsurface structures and steeply-dipping fault/fracture zones. We first evaluated and verified the improved capabilities of our newly developed seismic inversion and migration imaging methods using synthetic seismic data. Our numerical tests verified that our new methods directly image subsurface fracture/fault zones using surface seismic reflection data. We then applied our novel seismic inversion and migration imaging methods to a field 3D surface seismic dataset acquired at the Soda Lake geothermal field using Vibroseis sources. Our migration images of the Soda Lake geothermal field obtained using our seismic inversion and migration imaging algorithms revealed several possible fault/fracture zones. AltaRock Energy, Inc. is working with Cyrq Energy, Inc. to refine the geologic interpretation at the Soda Lake geothermal field. Trenton Cladouhos, Senior Vice President R&D of AltaRock, was very interested in our imaging results of 3D surface seismic data from the Soda Lake geothermal field. He planed to perform detailed interpretation of our images in collaboration with James Faulds and Holly McLachlan of University of Nevada at Reno. Using our high-resolution seismic inversion and migration imaging results can help determine the optimal locations to drill wells for geothermal energy production and reduce the risk of geothermal exploration.

47 OTHER INSTRUMENTATION↗

CLAIRE—Parallelized Diffeomorphic Image Registration for Large-Scale Biomedical Imaging Applications

We study the performance of CLAIRE—a diffeomorphic multi-node, multi-GPU image-registration algorithm and software—in large-scale biomedical imaging applications with billions of voxels. At such resolutions, most existing software packages for diffeomorphic image registration are prohibitively expensive. As a result, practitioners first significantly downsample the original images and then register them using existing tools. Our main contribution is an extensive analysis of the impact of downsampling on registration performance. We study this impact by comparing full-resolution registrations obtained with CLAIRE to lower resolution registrations for synthetic and real-world imaging datasets. Our results suggest that registration at full resolution can yield a superior registration quality—but not always. For example, downsampling a synthetic image from 10243 to 2563 decreases the Dice coefficient from 92% to 79%. However, the differences are less pronounced for noisy or low contrast high resolution images. CLAIRE allows us not only to register images of clinically relevant size in a few seconds but also to register images at unprecedented resolution in reasonable time. The highest resolution considered are CLARITY images of size 2816×3016×1162. To the best of our knowledge, this is the first study on image registration quality at such resolutions.

Himthani, Naveen↗

Stereo Imaging Miniature Endoscope with Single Imaging Chip and Conjugated Multi-Bandpass Filters

A dual objective endoscope for insertion into a cavity of a body for providing a stereoscopic image of a region of interest inside of the body including an imaging device at the distal end for obtaining optical images of the region of interest (ROI), and processing the optical images for forming video signals for wired and/or wireless transmission and display of 3D images on a rendering device. The imaging device includes a focal plane detector array (FPA) for obtaining the optical images of the ROI, and processing circuits behind the FPA. The processing circuits convert the optical images into the video signals. The imaging device includes right and left pupil for receiving a right and left images through a right and left conjugated multi-band pass filters. Illuminators illuminate the ROI through a multi-band pass filter having three right and three left pass bands that are matched to the right and left conjugated multi-band pass filters. A full color image is collected after three or six sequential illuminations with the red, green and blue lights.

Shahinian, Hrayr Karnig↗

Towards High-Resolution Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry Coupled to Shear Force Microscopy

Constant mode ambient mass spectrometry imaging (MSI) of tissue sections with high lateral resolution of better than 10 μm was performed by combining shear force microscopy with nanospray desorption electrospray ionization (nano-DESI). Shear force microscopy enabled precise control of the distance between the sample and nano-DESI probe during MSI experiments and provided information on sample topography. Proof-of-concept experiments were performed using lung and brain tissue sections representing spongy and dense tissues, respectively. Topography images obtained using shear force microscopy were comparable to the results obtained using contact profilometry over the same region of the tissue section. Variations in tissue height were found to be dependent on the tissue type and were in the range of 0–5 μm for lung tissue and 0–3 μm for brain tissue sections. Ion images of phospholipids obtained in this study are in good agreement with literature data. Normalization of nano-DESI MSI images to the signal of the internal standard added to the extraction solvent allowed us to construct high-resolution ion images free of matrix effects. .

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

X-ray imaging for studying behavior of liquids at high pressures and high temperatures using Paris-Edinburgh press

Several X-ray techniques for studying structure, elastic properties, viscosity, and immiscibility of liquids at high pressures have been integrated using a Paris-Edinburgh press at the 16-BM-B beamline of the Advanced Photon Source. In this paper, we report the development of X-ray imaging techniques suitable for studying behavior of liquids at high pressures and high temperatures. White X-ray radiography allows for imaging phase separation and immiscibility of melts at high pressures, identified not only by density contrast but also by phase contrast imaging in particular for low density contrast liquids such as silicate and carbonate melts. In addition, ultrafast X-ray imaging, at frame rates up to ~10 5 frames/second (fps) in air and up to ~10 4 fps in Paris-Edinburgh press, enables us to investigate dynamics of liquids at high pressures. Very low viscosities of melts similar to that of water can be reliably measured. These high-pressure X-ray imaging techniques provide useful tools for understanding behavior of liquids or melts at high pressures and high temperatures.

47 OTHER INSTRUMENTATION↗