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At least 127 records · Page 7

RadBREAD: Radiation Biology Research at an Elevated Altitude through Dosimetry – A student-designed payload

NASA uses extreme environment platforms (ground testing facilities, high-altitude balloons and aircraft, and CubeSats) to provide greater understanding of the conditions and limitations of extra-terrestrial environments. As part of a two-week flight planned for summer 2021, RadBREAD (Radiation Biology Research at an Elevated Altitude through Dosimetry) will fly as a secondary payload consisting of a M-42C (German Aerospace Center, DLR) ionizing radiation dosimeter, UV micro-logger, and multiple desiccated yeast samples. The platform is a novel high-altitude solar-powered aircraft: the Swift Engineering High-Altitude samples. The platform is a novel high-altitude solar-powered aircraft: the Swift Engineering High-Altitude Long-Endurance Unmanned Aircraft System (HALE UAS), which offers significantly longer flight durations than other high-altitude platforms. The yeast Saccharomyces cerevisiae will provide meaningful biological correlation for the sensor readings, due to its resistance to extremely low temperature and pressure when desiccated, ease of genetic manipulation, and homology to human genes. The RadBREAD team comprises the 2020 cohort of NASA’s Space Life Sciences Training Program (SLSTP) research associates as well as NASA scientists, engineers and radiation experts from NASA and the DLR. Yeast survival, metabolic, and transcriptomic changes will be correlated with environmental data collected during long-term exposure to the upper atmosphere. Additionally, the team will evaluate the upper atmospheric environment (radiation, pressure, and temperature) provided by the HALE UAS platform as a Mars surface analog for biological payloads. We hypothesize that exposure to upper atmospheric conditions during the HALE UAS flight will alter the survival, metabolism, and transcriptome of desiccated wild-type S. cerevisiae upon rehydration compared to sensitive and tolerant yeast strains exposed to the same conditions, and between the flight samples compared to asynchronous ground controls.

radiation exposure↗

Shields-1 Dosimetry Measurements in Polar Low Earth Orbit

Shields-1, NORAD ID 43850, has been operating in polar low earth orbit since December 2018 at 85 degrees inclination and an initial altitude of 500 kilometers, beginning in solar minimum activity. It launched with the NASA CubeSat Launch Initiative (CSLI) ELaNaXIX mission. Shields-1 has 8 Teledyne dosimeters on board behind different shielding thicknesses. It is a technology demonstration of an atomic number (Z)-grade shielded electronics enclosure, 3 Z-grade shielding samples baselined with 4 aluminum samples having dosimeters behind each sample and inside the electronics enclosure. In addition to the technology demonstration, Shields-1 has been providing scientific dosimetry of energetic particles in the polar low earth orbit space radiation environment.

Shields-1↗

Godiva-IV Dosimetry Exercise 2022 Preliminary Results

Integral Experiment Request (IER) 538 is part of a series of dose characterization and nuclear accident dosimetry (NAD) exercises performed under the Department of Energy (DOE) Nuclear Criticality Safety Program (NCSP). This is the second NAD exercise using the Godiva-IV critical assembly and the third NAD exercise overall. The participating laboratories provided their own dosimeters that were mounted on the Lawrence Livermore National Laboratory (LLNL) BOttle Manikin ABsorption (BOMAB) phantoms and aluminum plates. The BOMABs and plates were placed at two, three, and four meters away from the center of Godiva. Alongside the NADs, there was a LLNL Passive Neutron Spectrometer (PNS), Atomic Weapons Establishment (AWE) PNS, and Y-12 Sphere present to measure the neutron dose from Godiva. Two irradiations were conducted to test the NAD performance from each laboratory and assesses their performance to the DOE-STD-1098-2017 part 515 criteria. Neutron and gamma doses were measured prior to this exercise. This work presents a model for the neutron and gamma dose respectively to serve as the reference value. A code written in C/C++/ROOT was used to fit the measured neutron and gamma dose with the new models. It was assumed that the neutron and gamma doses are proportional to the change in temperature of Godiva after a burst irradiation. Uncertainties for the reference values were calculated using error propagation of the model’s parameters. Preliminary results (within twenty-four hours) and final results were compared for each laboratory. On average of all the participating laboratories, 32% of neutron doses and 78% of gamma doses were outside the DOE standards. One laboratory did not report their dose readings and were not included in this average. There is a bias for a lower neutron dose and a higher gamma dose based on the distribution of results. In comparison with the past Godiva-IV NAD exercise, there is an improvement in neutron dose readings by 20%.

BOttle Manikin ABsorption (BOMAB)↗

Radiological Characterization of Selected Thermal Centres Based on Indoor Radon Dosimetry - 17507

In countries with long historical tradition in thermal water therapy and with several mineral-medicinal thermal sources, workplaces within thermal centers may be a source of radon exposure which may be intensified if these are located in regions of high level of natural radiation. According to the EU Directive 96/29/Euratom (repealed by the Directive 2013/59/EURATOM) each Member State shall identify, by means of survey or any other adequate mean, the work activities where a significant increase in the exposure from natural radiation sources may occur, including thermal centers where the exposure to thoron/radon daughters or gamma radiation may occur. The purpose of this work was to perform a radiological characterization of selected thermal centers based on indoor dosimetry. The effective doses received by workers due to radon inhalation were estimated and gamma dose rates were measured through continuous periods. The radon risk for indoor exposure was assessed on a probabilistic basis both on thermal centers and workers' dwellings. Radon levels within the thermal centers ranged from 73 to 4335 Bq/m{sup 3} and the values within the workers dwellings are of the same order of magnitude, 68-4051 Bq/m{sup 3}. Approximately 66 % of indoor radon concentration values are above the maximum EU reference (300 Bq/m{sup 3}) and 94 % of the effective dose is higher than 1 mSv/year. In some situations, radon levels at residential environments are much higher than at workplaces and effective doses are higher than 6 mSv/year, both at residential and work environments. (authors)

61 RADIATION PROTECTION AND DOSIMETRY↗

A317_Fast and Thermal Neutron Spectrum Dosimetry Measurements in the Advanced Test Reactor large-B and small-I Positions Following the Sixth Core Internals Change-out

The Advanced Test Reactor (ATR) has a wide variety of irradiation positions that have had experiments that were developed by users from around the world. Most experiment irradiations rely on thoroughly benchmarked numerical models. However, some irradiation positions in ATR are not as well- characterized and are complicated by spectral perturbations from control cylinder orientation. The “small I” and “large-B” irradiation positions are located nearby control cylinders and suffer from these flux perturbations from control cylinder orientations that change during an irradiation cycle to maintain the desired core power distribution. Models predicted that these types of position would exhibit both spectral shifts and amplitude changes in neutron flux, but few measurements have been conducted to benchmark these predictions. Recently, requalification testing was performed to confirm the operational readiness of the ATR following the completion of the Core Internals Change-out (CIC). These tests provided a unique opportunity to validate the analytical methods used to simulate the ATR because nearly all components in the reactor were in a clean as-built state, significantly reducing modelling uncertainties. One subset of the testing included characterization of the fast and thermal neutron flux in the “small-I” and “large-B” positions using silver, cobalt, and nickel neutron dosimetry. In contrast to typical irradiation cycles, the control cylinders were held in position during the post-CIC nuclear testing. The specific activity of these dosimeter wires was measured following two low-power tests with different control cylinder positions.

21 - SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLAN↗

Translating nanoparticle dosimetry from conventional in vitro systems to occupational inhalation exposures

As encouraged by Toxicity Testing in the 21st Century, researchers increasingly apply high-throughput in vitro approaches to identify and characterize nanoparticle hazards, including conventional aqueous cell culture systems to assess respiratory hazards. Translating nanoparticle dose from conventional toxicity testing systems to relevant human exposures remains a major challenge for assessing occupational risk of nanoparticle exposures. Here, we explored existing computational tools and data available to translate nanoparticle dose metrics from cellular test systems to inhalation exposures of silver nanoparticles in humans. We used the Multiple-Path Particle Dosimetry (MPPD) Model to predict deposition of humans exposed to 20 and 110 nm silver nanoparticles at 0.9 µg/m3 over an 8 hr period, the proposed a National Institute of Occupational Safety and Health (NIOSH) recommended exposure limit (REL). MPPD predicts 1.88 and 0.98 µg of silver deposited in an 8 hr period for 20 and 110 nm nanoparticles, respectively, with 20 nm particles displaying nearly 11-fold higher total surface area deposited. Peak nanoparticle concentrations occurred more proximal in the pulmonary tract compared to mass deposition patterns (generation 5 vs. generations 20-21, respectively) due to regional differences in lung lining fluid volumes. Assuming 0.4% nanoparticle dissolution by mass as previously measured, we predict peak concentrations of silver ions in cells of 0.24 and 0.17 µg/mL for 20 and 110 nm particles, respectively. Both predicted concentrations are below the measured toxic threshold of 1.7 µg/mL of silver ions in cells from in vitro assessments. Assuming 4% dissolution by mass, we predict 10-fold higher silver concentrations in tissues, peaking at 2.4 and 1.7 µg/mL, for 20 and 110 nm nanoparticles respectively, exceeding the observed in vitro toxic threshold and highlighting the importance and sensitivity of dissolution rates. Overall, this approach offers a framework for extrapolating nanotoxicity results from in vitro cell culture systems to human exposures. Aligning appropriate dose metrics from in vitro and in vivo hazard characterizations and human pulmonary doses from occupational exposures are critical components for successful nanoparticle risk assessment and worker protection and provide guidance for designing future in vitro studies aimed at relevant human exposures.

Smith, Jordan N.↗

Automated bidirectional coupling of multiscale models of aerosol dosimetry: Validation with subject-specific deposition data

Assessing the toxicity of airborne particulate matter or the efficacy of inhaled drug depends upon accurate estimates of deposited fraction of inhaled materials. In silico approaches can provide important insights into site- or airway-specific deposition of inhaled aerosols in the respiratory system. In this study, we improved on our recently developed 3D/1D model that simulate aerosol transport and deposition in the whole lung over multiple breath cycles. A subject-specific multiscale lung model of a healthy male subject using computational fluid-particle dynamics (CFPD) in a 3D model of the oral cavity through the large bronchial airways entering each lobe was bidirectionally coupled with a recently improved Multiple Path Particle Dosimetry (MPPD) model to predict aerosol deposition over the entire respiratory tract over multiple breaths for four conditions matching experimental aerosol exposures in the same subject from which the model was developed. These include two particle sizes (1 and 2.9 μm) and two subject-specific breathing rates of ~300 ml/s (slow breathing) and ~750 ml/s (fast breathing) at a target tidal volume of 1 L. In silico predictions of retained fraction were 0.31 and 0.29 for 1 μm and 0.66 and 0.62 for 2.9 μm during slow and fast breathing, respectively, and compared well with experimental data (1 μm: 0.31 ± 0.01 (slow) and 0.27 ± 0.01 (fast), 2.9 μm: 0.63 ± 0.03 (slow) and 0.68 ± 0.02 (fast)). Furthermore, these results provide a great deal of confidence in the validity and reliability of our approach.

60 APPLIED LIFE SCIENCES↗

Calibration and Initial Results of Space Radiation Dosimetry Using the iMESA-R

The integrated Miniaturized Electrostatic Analyzer-Reflight (iMESA-R) is a space weather instrument designed to measure plasma density, temperature, and spacecraft charging, along with total ionizing dose and dose rate. A constellation consisting of five nearly identical instruments has been designed and developed to act as science payloads hosted on-board Department of Defense satellites operating in low-Earth orbit. To validate the dosimetry component of the iMESA-R, a radiation test study was performed to calibrate the dosimeter and ascertain the attenuation due to the instrument aluminum housing. An 80 curie Cobalt-60 radioisotope source emitting beta, X-ray, and gamma ray radiation decay products was used to calibrate the dosimeter response as a function of distance and instrument shielding. We present results of the calibration study along with initial on-orbit data presented from the first operational iMESA-R hosted on-board Space Test Program Satellite 5 in a polar Earth orbit. The initial on-orbit data demonstrate the ability to map the radiation environment, particularly the South Atlantic Anomaly and the auroral regions using total ionizing dose rate due to electrons of E > 1.5 MeV and protons of E > 25 MeV.

79 ASTRONOMY AND ASTROPHYSICS↗

Application of research reactor environments for validation of the IRDFF-II dosimetry cross section library

Activation data from seven different reactor-based reference neutron fields are examined to provide enhanced validation evidence for the newly released IRDFF-II library. A least-squares based spectrum adjustment methodology is used and rigorous statistical metrics demonstrate the consistency of the set of IRDFF-II dosimetry cross sections. The use of these reactor-based neutron fields provides validation evidence for nine more reactions than have been addressed in the 252 Cf(sf) and 235 U(th) benchmark validation testing. The use of covers to shift their energy response increases the power of the response validation but makes it challenging to properly capture response correlations.

Griffin, Patrick↗

Setup and Characterization of a 137 CS Dosimetry Calibration Source in a Space-constrained Environment

Proper characterization of 137 Cs sources used for dosimeter calibration and performance testing is crucial for accurate and precise knowledge of air kerma rate and delivered dose. A 269 GBq 137 Cs source was relocated to a new facility, which had a footprint of approximately 2.8 m × 3.6 m and a 3.4 m high ceiling. A small room size, such as in the new facility, may significantly increase backscatter from the walls or room return. Due to the limited source strength, a relatively close irradiation position of 1.00 m from the source was selected to decrease required exposure times. Proximity to the small but cylindrical source has the potential to alter the 1/r 2 relationship (inverse square law) of air kerma rate with distance associated with point sources. Practical tutorials concerning dosimetry irradiation facilities are largely absent from the archival literature. For those reasons, standard characterization experiments were repeated multiple times, great care was taken with positioning, several experiments were added to the standard ones, an ion chamber and dosimeters were used rather than film for greater accuracy and precision, and practical details of the process were recorded. The impacts of room size and finite source dimensions were quantified and mitigated by the efforts reported here. Finally, recommendations for simple but thorough facility characterization, beam calibration, and quality control resulted.

42 ENGINEERING↗

ENHANCEMENTS IN THE TECHA RIVER DOSIMETRY SYSTEM: TRDS-2016D CODE FOR RECONSTRUCTION OF DETERMINISTIC ESTIMATES OF DOSE FROM ENVIRONMENTAL EXPOSURES

Waterborne releases to the Techa River from the Mayak plutonium facility in Russia during 1949–1956 resulted in significant doses to persons living downstream. The dosimetry system TRDS-2016D has been developed which provides individual doses of external and internal exposure for the members of the Techa River Cohort (TRC) and other persons, who were exposed to releases of radioactive material to the Southern Urals. The results of computation of individual doses absorbed in red bone marrow and extra-skeletal tissues for the TRC members (29,647 persons) are presented, which are based on residence histories on the contaminated Techa River and the East Urals Radioactive Trace (EURT) which was formed in 1957 as a result of the Kyshtym Accident. Available 90Sr-body-burden measurements and available information on individual household locations have been used for refinement of individual dose estimates. TRDS-2016D-based dose estimates will be used for verification of risk of low-dose-rate effects of ionizing radiation in the TRC.

dose reconstruction, environmental contamination, ↗

Stochastic parametric skeletal dosimetry model for humans: Anatomical-morphological basis and parameter evaluation

Radiation exposure of the hematopoietic system that results in a radiation dose to bone marrow of more than 100 mGy leads to an increase in the risk of leukemia in humans. Excess relative risk of leukemia was observed in cohorts whose members lived in the territories of the Southern Urals that were radioactively contaminated in the 1950s. As part of the dosimetric support of epidemiological studies of these cohorts, an original methodology for stochastic bone dosimetric modeling was developed, termed the Stochastic Parametric Skeletal Dosimetry (SPSD) model. The purpose of this work was to present the anatomical and morphological bases of the SPSD model, which includes an assessment of the parameters of the microstructure of the trabecular bone in the hematopoietic areas of the human skeleton, as well as a description of the macrostructural division (segmentation) of hematopoietic areas into simple bone segments. As a result, an anatomical-morphological basis of the SPSD model was created based on published data. Data collection work included the analysis of original articles, atlases, manuals, monographs and the formation of primary data files. Data on the duration of hematopoiesis in various parts of the skeleton; and data on age-related changes in the microstructure and linear dimensions of human bones and their segments were analyzed. The paper describes the full set of parameters to be used for the dosimetric model for newborns, children aged 1, 5 and 10 years, as well as for adolescents aged 15 years and adults; for the latter, sex differences in bone size were considered. In total, the SPSD model includes 289 unique basic (bone) phantom segments, each of which is described by 7 or more parameters describing the microstructure, thickness of the cortical layer and linear dimensions. Population variability was estimated for each parameter. The approach to SPSD modeling, i.e., the use of simple geometric shapes, was successfully verified using independent datasets on bone masses and volumes.

Science & Technology - Other Topics↗

Neutron Activation Self-Shielding Factors for Common Dosimetry Foils in an ACRR Equivalent Environment

The results of a computational analysis of self-shielding factors are presented. The analysis highlights the total self-shielding, which is a combination of energy and spatial self-shielding, associated with different neutron detection materials. The Monte Carlo N-Particle (MCNP) transport code was used in conjunction with the Evaluated Nuclear Data File (ENDF) and the International Reactor Dosimetry and Fusion Files (IRDFF). This analysis was done with neutron activation analysis in mind, and therefore is modeled and presented in a similar fashion.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Neutron Dosimetry for the Boise State University JW 15-8242 Irradiation in ATR (Rev.1)

PNNL project 79550 provides for the analysis of neutron fluence monitors irradiated in the Advanced Test Reactor (ATR) at Idaho National Laboratory in accordance with MPO 00269673and Statement of Work No. 19704, Rev. 0, PNNL Analysis of NSUF Flux Capsules. This report is for the Boise State University (BSU) JW 15-8242 irradiations which were conducted in positions A6, A7 and A8 of the ATR. We previously reported data for this experiment after about 1 dpa in a report issued in January 2021 (1). This report is for longer irradiations to about 3 dpa. Other experiments included in the statement of work for this project will be reported separately. The neutron fluence monitors were prepared by PNNL and loaded into the BSU assemblies prior to irradiation. Following irradiation, the capsules were returned to PNNL for analysis. The neutron dosimetry capsules were opened, the flux wires were removed for gamma or x-ray analysis, and the measured activities were used to determine the activation rates for various activation products. Following suitable corrections, the measured activation rates were used to adjust calculated neutron spectra at each fluence monitor location. The adjusted neutron spectra were then used to determine displacement per atom (dpa) and gas production for irradiated materials.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Results of Neutron Dosimetry Measurements for the Advanced Test Reactor Cycle 173-C

Results of neutron dosimetry measurements in ATR for cycle 173-C are presented. Cobalt and nickel wires were installed in numerous irradiation locations for the duration of the cycle. The specific activity of these wire segments can be used in conjunction with the presented cycle history information to determine the thermal- and fast-neutron fluence rates for each irradiation position during the cycle using the referenced standard test methods.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Advancements in PTFE/EPR Reactor Dosimetry

Discussion of current efforts by Radiation Metrology Laboratory at Sandia to continue development and deployment of an EPR/PTFE dosimetry system.

Vehar, David W. [Sandia National Laboratories (SNL↗

Advanced Test Reactor Neutron Dosimetry Report – 174 A & B

Results of neutron dosimetry measurements in ATR for cycle 174 A B are presented. Cobalt and nickel wires were installed in numerous irradiation locations for the duration of the cycle. The specific activity of these wire segments can be used in conjunction with the presented cycle history information to determine the thermal- and fast-neutron fluence rates for each irradiation position during the cycle using the referenced standard test methods.

11 - NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗