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At least 127 records · Page 7

Optical 14 C Tracing for Biological and Pharmaceutical Applications Using Two-Color Cavity Ringdown Spectroscopy

Laser-based 14 C quantitation has been proposed as a more affordable, higher-throughput, table-top alternative to accelerator mass spectrometry (AMS). Here, we demonstrate the feasibility of a mid-IR 14 C detector based on two-color cavity ringdown spectroscopy (2C-CRDS) for low-level 14 C isotope tracing in biological studies. The 2C-CRDS technique quantifies the sample 14 C content by measuring the 14 CO 2 absorption signals from the combusted samples with mid-IR lasers. With 2C-CRDS, we previously demonstrated the most sensitive and accurate optical measurements of 14 CO 2 . The current detection sensitivity and quantitation accuracy of the instrument, at a few parts per quadrillion (where a quadrillion = 10 15 ) 14 C/C mole fraction, is competitive against AMS. Here, by applying the 2C-CRDS 14 C sensor to two applications relevant to 14 C-labeled biochemical analysis and pharmaceutical studies, we demonstrate sub-fCi level (where 1 fCi = 10 –15 Ci) quantitation of sample 14 C activity, with a minimum sample-size requirement of 3 mg of carbon. The current measurement throughput, ~25 min/sample, is largely limited by the sampling efficiency of the online combustion and CO 2 processing interface to the 2C-CRDS instrument. The possibility of a significantly improved measurement throughput of a few minutes per sample is suggested by the results of a flow-through 14 CO 2 sampling scheme. In conclusion, this improved measurement efficiency, combined with the relatively low cost and compact size of a 2C-CRDS sensor, could potentially revolutionize high-sensitivity 14 C tracing in biological, pharmaceutical, and clinical studies.

60 APPLIED LIFE SCIENCES

Advancing Aerosol Chemical Characterization and Vertical Profiling over the Southern Great Plains Using Uncrewed Aerial Sampling and Offline Aerosol Mass Spectrometry

Recent advancements in uncrewed aerial systems (UASs) and particulate matter (PM) analytical techniques have provided opportunities for atmospheric research. In this study, we deployed the Department of Energy’s fixed-wing ArcticShark UAS to examine PM 2.5 composition at varying altitudes─within and above the planetary boundary layer (PBL)─over the Southern Great Plains atmospheric observatory (SGP). A total of 22 flights were conducted across March, June, and August 2023. Composite filter samples were collected during each flight and analyzed with offline aerosol mass spectrometry (AMS), complemented by on-board real-time sensors and ground-based instrumentation, to provide a comprehensive view of regional aerosol characteristics. Results show clear vertical and seasonal differences in the aerosol composition. Relative to ground-level measurements, aloft samples exhibited shifts in the distribution of organic and inorganic PM, with the organic composition varying distinctly across seasons. Particulate organic nitrogen (ON) was elevated, with bulk compositions similar in March and June but strongly altered in August, likely driven by biomass burning and enhanced photochemical activity. Combined AMS and chemical ionization mass spectrometry analyses detected amines, amides, and amino acids. PM above the planetary boundary layer was enriched in oxidized organic aerosols, while ground-level PM contained higher nitrate and sulfate. Seasonal differences in aqueous-phase processing were also observed, which were strongest in March during persistent cloud cover and weaker in the drier August period, suggesting a shift from aqueous- to gas-phase SOA formation. In conclusion, these findings highlight the value of UAS in advancing PM measurements and vertical profiling of aerosol composition.

54 ENVIRONMENTAL SCIENCES

Properties of Heavy Cosmic Nuclei Phosphorus, Chlorine, Argon, Potassium, and Calcium: Results from the Alpha Magnetic Spectrometer

We report the unique properties of cosmic phosphorus (P), chlorine (Cl), argon (Ar), potassium (K), and calcium (Ca) fluxes in the GV to TV rigidity range collected by the Alpha Magnetic Spectrometer (AMS) on the International Space Station. With a total of one million events collected over 13.5 years, we observed that the rigidity dependencies of the five fluxes are well described by the sums of a primary cosmic ray component and a secondary cosmic ray component. The abundance ratios of all five elements to Si at the source are accurately determined independent of cosmic ray propagation. The source abundance of Ar and Ca (even-𝑍 elements) is larger than P, Cl, and K (odd-𝑍 elements). The secondary components of the P and the Cl fluxes are each ∼1/3 of the F flux, and the secondary components of the Ar, K, and Ca fluxes are each ∼1/2 of the F flux. The twenty elements measured by AMS, from He to Ca and Fe, can be categorized into four classes, two primary and two secondary, based on their rigidity dependence.

cosmic ray acceleration

Fireball antinucleosynthesis

The tentative identification of approximately ten relativistic antihelium ( He ¯ ) cosmic-ray events at AMS-02 would, if confirmed, challenge our understanding of the astrophysical synthesis of heavy antinuclei. We propose a novel scenario for the enhanced production of such antinuclei that is triggered by isolated, catastrophic injections of large quantities of energetic Standard Model (SM) antiquarks in our galaxy by physics beyond the Standard Model (BSM). We demonstrate that SM antinucleosynthetic processes that occur in the resulting rapidly expanding, thermalized fireballs of SM plasma can, for a reasonable range of parameters, produce the reported tentative ∼ 2 : 1 ratio of He ¯ 3 to He ¯ 4 events at AMS-02, as well as their relativistic boosts. Moreover, we show that this can be achieved without violating antideuterium or antiproton flux constraints for the appropriate antihelium fluxes. A plausible BSM paradigm for the catastrophic injections is the collision of macroscopic composite dark-matter objects carrying large net antibaryon number. Such a scenario would require these objects to be cosmologically stable, but to destabilize upon collision, promptly releasing a fraction of their mass energy into SM antiparticles within a tiny volume. We show that, in principle, the injection rate needed to attain the necessary antihelium fluxes and the energetic conditions required to seed the fireballs appear possible to obtain in such a paradigm. We leave open the question of constructing a BSM particle physics model to realize this, but we suggest two concrete scenarios as promising targets for further investigation. Published by the American Physical Society 2024

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS

Conceptual Design of Passive Neutron Albedo Reactivity and Active Neutron Albedo Reactivity Instruments for Various Arrangements of Pebble Bed Reactor Pebbles

MCNP6 simulations were performed to assess the anticipated capability of the Passive Neutron Albedo Reactivity technique for nuclear safeguards measurements of irradiated pebble/pebbles. Two physical setups were examined. One with a single pebble of three different burnups and one with 27 pebbles in a cube. For all cases the sensitivity to removing all the fissile material was examined. For both of the physical setups, 4 assay cases were examined: (a) singles count rates for which the only source neutrons were the inherent neutrons in the fuel, (b) singles count rates again except this time two relatively weak AmLi sources were placed above and below the top central pebble and the combined effect of both neutron source terms were examined, (c) doubles count rates for which the only source neutrons were the inherent neutrons in the fuel, and (d) doubles count rates again except this time two relatively weak AmLi sources were placed above and below the top central pebble and the combined effect of both neutron source terms were examined. Finally, a few parameters such as Cd near the 3 He tubes were perturbed to see if the results could be improved.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS

Communications terminal breadboard

A baseline design is presented of a digital communications link between an advanced manned spacecraft (AMS) and an earth terminal via an Intelsat 4 type communications satellite used as a geosynchronous orbiting relay station. The fabrication, integration, and testing of terminal elements at each end of the link are discussed. In the baseline link design, the information carrying capacity of the link was estimated for both the forward direction (earth terminal to AMS) and the return direction, based upon orbital geometry, relay satellite characteristics, terminal characteristics, and the improvement that can be achieved by the use of convolutional coding/Viterbi decoding techniques.

Source record

Teleoperators and EVA for Shuttle missions

Review of the methods currently being contemplated for enabling the Space Shuttle to perform the Shuttle and payload support missions. Two general approaches to carrying out such activity are discussed - namely, the use of teleoperators and astronaut extravehicular activity (EVA). Detailed descriptions are given of an attached manipulator system (AMS) and a free-flying teleoperator (FFTO), noting the applications, capabilities, and limitations of each. The primary technology development areas for the AMS are in the areas of stabilization, structure, and manual control, while the technology areas of primary concern in the case of the FFTO include the manipulator-grappler system, the control system, the video system, and the mobility system. Four modes of EVA that are possible for the Shuttle are cited, noting the unlikelihood of direct applicability of EVA to payload deployment and retrieval and its feasibility for payload servicing and experiment support.

Malone, T. B.

Lyman-alpha imagery of comet Kohoutek, and far-UV magnitudes of stars

The Apollo-16 S201 electronographic camera backup model was modified for use on the Skylab AMS-SAL, which reduced its 20 deg FOV to about 7 deg unvignetted. Over 500 frames were exposed by automatic sequencer through LiF and CaF2. The Lyman-alpha halo of comet Kohoutek has been analyzed for nine occasions, and its long, pointed tail was imaged in 1250-1600 A only near perihelion. Far-UV magnitudes and colors are being derived for about 200 stars, nebulae, and galaxies. Redshifted Lyman-alpha emission from intergalactic atomic hydrogen was not detected in 7 clusters of galaxies. About 25% of the exposed frames were degraded by water damage, electrical discharges, decline in photocathode sensitivity, and loss of AMS mirror reflectance.

Page, T.

Effects of refrigerating preinoculated Vitek cards on microbial physiology and antibiotic susceptibility

Reference cultures of 16 microorganisms obtained from the American Type Culture Collection and four clinical isolates were used in standardized solutions to inoculate 60 cards for each test strain. A set of three ID and three susceptibility cards was processed in the Vitek AutoMicrobic System (AMS) immediately after inoculation. The remaining cards were refrigerated at 4 C, and sets of six cards were removed and processed periodically for up to 17 days. The preinoculated AMS cards were evaluated for microorganism identification, percent probability of correct identification, length of time required for final result, individual substrate reactions, and antibiotic minimal inhibitory/concentration (MIC) values. Results indicate that 11 of the 20 microbes tested withstood refrigerated storage up to 17 days without detectable changes in delineating characteristics. MIC results appear variable, but certain antibiotics proved to be more stable than others. The results of these exploratory studies will be used to plan a microgravity experiment designed to study the effect of microgravity on microbial physiology and antibiotic sensitivity.

Skweres, Joyce A.

Measurements of cosmogenic nuclides in lunar rock 64455

Eleven samples were ground from the glass coated surface of lunar rock 64455,82 with an average depth resolution of 50 microns and were measured for Be-10, Al-26, and Cl-36 using AMS (accelerator mass spectrometry). Results show no evidence of SCR (solar cosmic ray) effects. The flat cosmogenic nuclide profiles and activity levels are consistent with a 2 My exposure history for the rock and a sample location on the bottom of the rock. These AMS measurements are some of the most precise ever obtained for these three nuclides. This precision and the demonstrated fine depth resolution will enable us to conduct a number of detailed studies of depth effects in lunar and meteoritic samples, including investigating SCR effects in the surface exposed top of the glass coating of 64455 and possibly in the underlying rock.

Arnold, J. R.

Measurement of proton production cross sections of (sup 10)Be and (sup 26)Al from elements found in lunar rocks

Cosmic rays penetrate the lunar surface and interact with the lunar rocks to produce both radionuclides and stable nuclides. Production depth profiles for long-lived radionuclides produce in lunar rocks are measured using Accelerator Mass Spectrometry (AMS). For a particular radionuclide these production depth profiles can be interpreted to give an estimate for the solar proton flux over a time period characterized by the half life of the radionuclide under study. This analysis is possible if and only if all the cross sections for the interactions of all cosmic ray particles with all elements found in lunar rocks are well known. In practice, the most important cross sections needed are the proton production cross sections, because 98% of solar cosmic rays and (similar to)87% of galactic cosmic rays are protons. The cross sections for the production of long-lived radionuclides were very difficult to measure before the development of AMS and only in recent years has significant progress been made in determining these essential cross sections. Oxygen and silicon are major constituents of lunar rocks. We have reported already C-14 production cross sections from O and Si for proton energies 25-500 MeV, and O(p,x)(sup 10)Be from 58 160 MeV[6]. Here we present new measurements for the cross sections O(p,x)Be-10,O(p,x)Be-7, Si(p,x)Be-7,Si(p,x)Al-26, and Si(p,x)Na-22 from approximately 30 - 500 MeV.

Sisterson, J. M.

Validation of Galactic Cosmic Radiation and Geomagnetic Transmissions

The Alpha Magnet Spectrometer (AMS) was flown on Shuttle flight STS-91 in June 1998 near solar minimum. This unique spectrometer has provided very high resolution, calibrated data on the galactic hydrogen and helium rigidity spectra form approx. 100 MeV/n to approx. 200 GeV/n as a function of magnetic latitude. This paper describes a comparison of the AMS data with the Badhwar-O'Neill GCR model and the geomagnetic transmission calculated using the quiescent DGRF 1990 cutoffs. The results have strong bearing on radiation modeling for the International Space Station.

Badhwar, Gautam D.

BOREAS RSS-14 Level -3 Gridded Radiometer and Satellite Surface Radiation Images

The BOREAS RSS-14 team collected and processed GOES-7 and -8 images of the BOREAS region as part of its effort to characterize the incoming, reflected, and emitted radiation at regional scales. This data set contains surface radiation parameters, such as net radiation and net solar radiation, that have been interpolated from GOES-7 images and AMS data onto the standard BOREAS mapping grid at a resolution of 5 km N-S and E-W. While some parameters are taken directly from the AMS data set, others have been corrected according to calibrations carried out during IFC-2 in 1994. The corrected values as well as the uncorrected values are included. For example, two values of net radiation are provided: an uncorrected value (Rn), and a value that has been corrected according to the calibrations (Rn-COR). The data are provided in binary image format data files. Some of the data files on the BOREAS CD-ROMs have been compressed using the Gzip program. See section 8.2 for details. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

Hall, Forrest G.

Assessments of Total Lightning Data Utility in Weather Forecasting

National Weather Service forecasters in Huntsville, Alabama have had access to total lightning data from the North Alabama Lightning Mapping Array (LMA) since 2003. Forecasters can monitor real-time total lightning observations on their AWIPS (Advanced Weather Interactive Processing System (AWIPS) workstations. The lightning data is used to supplement other observations such as radar and satellite data. The lightning data is updated every 2 min, providing more timely evidence of storm growth or decay than is available from 5 min radar scans. Total lightning observations have been used to positively impact warning decisions in a number of instances. A number of approaches are being pursued to assess the usefulness of total lightning measurements to the operational forecasting community in the warning decision process. These approaches, which include both qualitative and quantitative assessment methods, will be discussed. submitted to the American Meteorological Society (AMS) Conference on Meteorological Applications of Lightning Data to be held in San Diego, CA January 9-13,2005. This will be a presentation and an extended abstract will be published on a CD available from the AMS.

Buechler, Dennis E.

Asynchronous Message Service for Deep Space Mission Operations

While the CCSDS (Consultative Committee for Space Data Systems) File Delivery Protocol (CFDP) provides internationally standardized file transfer functionality that can offer significant benefits for deep space mission operations, not all spacecraft communication requirements are necessarily best met by file transfer. In particular, continuous event-driven asynchronous message exchange may also be useful for communications with, among, and aboard spacecraft. CCSDS has therefore undertaken the development of a new Asynchronous Message Service (AMS) standard, designed to provide common functionality over a wide variety of underlying transport services, ranging from shared memory message queues to CCSDS telemetry systems. The present paper discusses the design concepts of AMS, their applicability to deep space mission operations problems, and the results of preliminary performance testing obtained from exercise of a prototype implementation.

asynchronous message exchanges

Environmental Physiology at the Johnson Space Center: Past, Present, and Future

This viewgraph presentation reviews the work in environmental physiology done at Johnson Space Center (JSC). The work is aimed at keeping astronauts healthy. This is a different approach than treating the sick, and is more of an occupational health model. The reduction of risks is the main emphasis for this work. They emphasis is to reduce the risk of decompression sickness (DCS) and acute mountain sickness (AMS). The work in environmental physiology encompasses the following areas: (1) Pressure: hypobaric and hyperbaric (2) Gases: hypoxia and hyperoxia, hypercapnia--closed space issues, inert gas physiology / respiration (3) Temperature: hypothermia and hyperthermia, thermal comfort, Protective clothing diving, aviation, mountaineering, and space (4) Acceleration (5) Noise and Vibration (6) Exercise / Performance (6) Acclimatization / Adaptation: engineering solutions when necessary. This presentation reviews the work done at JSC in the areas of DCS and AMS.

Conkin, Johnny

Motion Imagery and Robotics Application (MIRA)

Objectives include: I. Prototype a camera service leveraging the CCSDS Integrated protocol stack (MIRA/SM&C/AMS/DTN): a) CCSDS MIRA Service (New). b) Spacecraft Monitor and Control (SM&C). c) Asynchronous Messaging Service (AMS). d) Delay/Disruption Tolerant Networking (DTN). II. Additional MIRA Objectives: a) Demo of Camera Control through ISS using CCSDS protocol stack (Berlin, May 2011). b) Verify that the CCSDS standards stack can provide end-to-end space camera services across ground and space environments. c) Test interoperability of various CCSDS protocol standards. d) Identify overlaps in the design and implementations of the CCSDS protocol standards. e) Identify software incompatibilities in the CCSDS stack interfaces. f) Provide redlines to the SM&C, AMS, and DTN working groups. d) Enable the CCSDS MIRA service for potential use in ISS Kibo camera commanding. e) Assist in long-term evolution of this entire group of CCSDS standards to TRL 6 or greater.

Martinez, Lindolfo