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NASA NTRS2010

Three Years of on Orbit ISS Oxygen Generation System Operation 2007-2010

The International Space Station (ISS) United States Orbital Segment (USOS) Oxygen Generation System (OGS) has accumulated 240 days of continuous operation at varied oxygen production rates within the US Laboratory Module (LAB) since it was first activated in July 2007. OGS relocated from the ISS LAB to Node 3 during 20A Flight (February 2010). The OGS rack delivery was accelerated for on-orbit checkout in the LAB, and it was launched to ISS in July of 2006. During the on-orbit checkout interval within the LAB from July 2007 to October 2008, OGS operational times were limited by the quantity of feedwater in a Payload Water Reservoir (PWR) bag. Longer runtimes are now achievable due to the continuous feedwater availability after ULF2 delivery and activation of the USOS Water Recovery System (WRS) racks. OGS is considered a critical function to maintaining six crew capability. There have been a number of failures which interrupted or threatened to interrupt oxygen production. Filters in the recirculation loop have clogged and have been replaced, Hydrogen sensors have fallen out of specifications, a pump delta pressure sensor failed, a pump failed to start, and the voltage on the cell stack increased out of tolerance. This paper will discuss the operating experience and characteristics of the OGS, as well as operational issues and their resolution.

Diderich, Greg S.↗

NASA NTRS2011

Advanced Stirling Convertor (ASC-E2) Performance Testing at NASA Glenn Research Center

The National Aeronautics and Space Administration (NASA) Glenn Research Center (GRC) has been supporting development of the Advanced Stirling Radioisotope Generator (ASRG) since 2006. A key element of the ASRG Project is providing life, reliability, and performance testing of the Advanced Stirling Convertor (ASC). For this purpose, four pairs of ASCs capable of operating to 850 C and designated with the model number ASC-E2, were delivered by Sunpower of Athens, OH, to GRC in 2010. The ASC-E2s underwent a series of tests that included workmanship vibration testing, performance mapping, and extended operation. Workmanship vibration testing was performed following fabrication of each convertor to verify proper hardware build. Performance mapping consisted of operating each convertor at various conditions representing the range expected during a mission. Included were conditions representing beginning-of-mission (BOM), end-of-mission (EOM), and fueling. This same series of tests was performed by Sunpower prior to ASC-E2 delivery. The data generated during the GRC test were compared to performance before delivery. Extended operation consisted of a 500-hour period of operation with conditions maintained at the BOM point. This was performed to demonstrate steady convertor performance following performance mapping. Following this initial 500-hour period, the ASC-E2s will continue extended operation, controller development and special durability testing, during which the goal is to accumulate tens of thousands of hours of operation. Data collected during extended operation will support reliability analysis. Performance data from these tests is summarized in this paper.

Oriti, Salvatore↗

NASA NTRS2011

H-II Transfer Vehicle (HTV) and the Operations Concept for Extravehicular Activity (EVA) Hardware

With the retirement of the Space Shuttle fleet imminent in 2011, a new operations concept will become reality to meet the transportation challenges of the International Space Station (ISS). The planning associated with the retirement of the Space Shuttle has been underway since the announcement in 2004. Since then, several companies and government entities have had to look for innovative low-cost commercial orbital transportation systems to continue to achieve the objectives of ISS delivery requirements. Several options have been assessed and appear ready to meet the large and demanding delivery requirements of the ISS. Options that have been identified that can facilitate the challenge include the Russian Federal Space Agency's Soyuz and Progress spacecraft, European Space Agency's Automated Transfer Vehicle (ATV), and the Japan Aerospace Exploration Agency's (JAXA s) H-II Transfer Vehicle (HTV). The newest of these options is the JAXA's HTV. This paper focuses on the HTV, mission architecture and operations concept for Extra-Vehicular Activities (EVA) hardware, the associated launch system, and details of the launch operations approach.

Chullen, Cinda↗

NASA NTRS2011

Concept for Sustained Plant Production on ISS Using VEGGIE Capillary Mat Rooting System

Plant growth in microgravity presents unique challenges associated with maintaining appropriate conditions for seed germination, seedling establishment, maturation and harvest. They include maintaining appropriate soil moisture content, nutrient balance, atmospheric mixing and containment. Sustained production imposes additional challenges of harvesting, replanting, and safety. The VEGGIE is a deployable (collapsible) plant growth chamber developed as part of a NASA SBIR Phase II by Orbitec, Madison, WI. The intent of VEGGIE is to provide a low-resource system to produce fresh vegetables for the crew on long duration missions. The VEGGIE uses and LED array for lighting, an expandable bellows for containment, and a capillary matting system for nutrient and water delivery. The project evaluated a number of approaches to achieve sustained production, and repeated plantings, using the capillary rooting system. A number of different root media, seed containment, and nutrient delivery systems were evaluated and effects on seed germination and growth were evaluated. A number of issues limiting sustained production, such as accumulation of nutrients, uniform water, elevated vapor pressure deficit, and media containment were identified. A concept using pre-planted rooting packs shown to effectively address a number of those issues and is a promising approach for future development as a planting system for microgravity conditions.

Stutte, Gary W.↗

NASA NTRS2011

Developing Flexible, High Performance Polymers with Self-Healing Capabilities

Flexible, high performance polymers such as polyimides are often employed in aerospace applications. They typically find uses in areas where improved physical characteristics such as fire resistance, long term thermal stability, and solvent resistance are required. It is anticipated that such polymers could find uses in future long duration exploration missions as well. Their use would be even more advantageous if self-healing capability or mechanisms could be incorporated into these polymers. Such innovative approaches are currently being studied at the NASA Kennedy Space Center for use in high performance wiring systems or inflatable and habitation structures. Self-healing or self-sealing capability would significantly reduce maintenance requirements, and increase the safety and reliability performance of the systems into which these polymers would be incorporated. Many unique challenges need to be overcome in order to incorporate a self-healing mechanism into flexible, high performance polymers. Significant research into the incorporation of a self-healing mechanism into structural composites has been carried out over the past decade by a number of groups, notable among them being the University of I1linois [I]. Various mechanisms for the introduction of self-healing have been investigated. Examples of these are: 1) Microcapsule-based healant delivery. 2) Vascular network delivery. 3) Damage induced triggering of latent substrate properties. Successful self-healing has been demonstrated in structural epoxy systems with almost complete reestablishment of composite strength being achieved through the use of microcapsulation technology. However, the incorporation of a self-healing mechanism into a system in which the material is flexible, or a thin film, is much more challenging. In the case of using microencapsulation, healant core content must be small enough to reside in films less than 0.1 millimeters thick, and must overcome significant capillary and surface tension forces to flow, mix and react to achieve healing. Vascular networks small enough to fit into such films must also overcome these same flow limitations. Self-healing has also been demonstrated in ionomeric substrates such as Surlyn , wherein the heat generated by a projectile impact triggers the latent ability of this substrate to flow back to its original shape. Recent work using Diels-Alder reactions have shown promise in bringing about actual reforming of broken chemical bonds to achieve self-healing [2]. All self-healing mechanisms that rely on the use of inherent latent substrate properties require some degree of polymer chain flow to achieve any significant level of healing.

Jolley, Scott T.↗

NASA NTRS2011

Performance of Airborne Precision Spacing Under Realistic Wind Conditions and Limited Surveillance Range

With the expected worldwide increase of air traffic during the coming decade, both the Federal Aviation Administration's (FAA's) Next Generation Air Transportation System (NextGen), as well as Eurocontrol's Single European Sky ATM Research (SESAR) program have, as part of their plans, air traffic management (ATM) solutions that can increase performance without requiring time-consuming and expensive infrastructure changes. One such solution involves the ability of both controllers and flight crews to deliver aircraft to the runway with greater accuracy than they can today. Previous research has shown that time-based spacing techniques, wherein the controller assigns a time spacing to each pair of arriving aircraft, can achieve this goal by providing greater runway delivery accuracy and producing a concomitant increase in system-wide performance. The research described herein focuses on one specific application of time-based spacing, called Airborne Precision Spacing (APS), which has evolved over the past ten years. This research furthers APS understanding by studying its performance with realistic wind conditions obtained from atmospheric sounding data and with realistic wind forecasts obtained from the Rapid Update Cycle (RUC) short-range weather forecast. In addition, this study investigates APS performance with limited surveillance range, as provided by the Automatic Dependent Surveillance-Broadcast (ADS-B) system, and with an algorithm designed to improve APS performance when ADS-B surveillance data is unavailable. The results presented herein quantify the runway threshold delivery accuracy of APS under these conditions, and also quantify resulting workload metrics such as the number of speed changes required to maintain spacing.

Wieland, Frederick↗

NASA NTRS2011

Growth of Three Lettuce Cultivars in NASA's HDU PEM During the 2010 DRATS Test

NASA's 2010 Desert Research and Technology Studies (DRATS) of the VEGGIE Food Production System in the Habitat Demonstration Unit (HDU) Pressurized Excursion Module (PEM) was the first operational evaluation of salad crop production technology in a NASA analog test. Rooting media and slow release fertilizers were evaluated for three lettuce cultivars that had shown promise as candidates for a surface based food production system. These tests involved comparing growth, color and quality of the lettuce cultivars grown under VEGGIE LED array (Orbitec, Madison, WI) or Biomass Production System for Education ((BSEe), Orbitec, Madison, WI) compact fluorescent lamps using a gravity feed water delivery system. Mission relevant conditions of CO2, temperature and RH were maintained using controlled environment chambers (EGC, Chagrin Falls, OH). Growth data was obtained for the two red leaf lettuce cultivars, Outredgeous and Firecracker, and the green Bibb lettuce cultivar, Flandria. Growth and quality was evaluated using different concentrations (7.5 g/L and 15 g/L) of commercial slow release fertilizer (Osmocote Plus 15-9-12, Scotts, Maryville, OH) and Nutricote 18-6-8 (Florikan, Sarasota, FL) in either a peat/vermiculite media (sunshine LP5 MiX, Sungro, Bellview, WA) or calcined montmorillonite clay [(arcillite,)Turface Proleague, Profile LLC, Buffalo Grove, IL]. The commercial peat/vermiculite mix generally resulted in larger plants than those grown in arcillite. Increasing the concentration of Osmocote from 7.5 to 15 g/L increased the height, dry mass, and leaf area of lettuce cultivars. In contrast, there was a decrease in growth parameters when concentration of Nutricote was increased from 7.5 to 15 g/L. The best growth was obtained with the 7.5 g/L Nutricote using a commercial peat/vermiculite mixture. This media was used for field testing VEGGIE plant system in the 2010 DRAT test. The VEGGIE nutrient delivery system worked well, was able to be maintained by multiple operators with a minimum of training, and supported excellent lettuce growth for the duration of the 14-day test. The operational DRAT field testing in the HDU identified light quality issues related to morphology and pigment development that will need to be addressed through additional testing. Feedback from the crew, ground support personnel, and human factors leads was uniformly positive on the psychological value of having the crop production system in the pressurized excursion module. Data are being used to design a plant atrium with LED lighting to evaluate salad crop growth during NASA's 2011 DRATS test.

Stutte, Gary W.↗

NASA NTRS2004

Software Implements a Space-Mission File-Transfer Protocol

CFDP is a computer program that implements the CCSDS (Consultative Committee for Space Data Systems) File Delivery Protocol, which is an international standard for automatic, reliable transfers of files of data between locations on Earth and in outer space. CFDP administers concurrent file transfers in both directions, delivery of data out of transmission order, reliable and unreliable transmission modes, and automatic retransmission of lost or corrupted data by use of one or more of several lost-segment-detection modes. The program also implements several data-integrity measures, including file checksums and optional cyclic redundancy checks for each protocol data unit. The metadata accompanying each file can include messages to users application programs and commands for operating on remote file systems.

Rundstrom, Kathleen↗

NASA NTRS2011

Performance of Airborne Precision Spacing Under Realistic Wind Conditions

With the expected worldwide increase of air traffic during the coming decade, both the Federal Aviation Administration s (FAA s) Next Generation Air Transportation System (NextGen), as well as Eurocontrol s Single European Sky ATM Research (SESAR) program have, as part of their plans, air traffic management solutions that can increase performance without requiring time-consuming and expensive infrastructure changes. One such solution involves the ability of both controllers and flight crews to deliver aircraft to the runway with greater accuracy than is possible today. Previous research has shown that time-based spacing techniques, wherein the controller assigns a time spacing to each pair of arriving aircraft, is one way to achieve this goal by providing greater runway delivery accuracy that produces a concomitant increase in system-wide performance. The research described herein focuses on a specific application of time-based spacing, called Airborne Precision Spacing (APS), which has evolved over the past ten years. This research furthers APS understanding by studying its performance with realistic wind conditions obtained from atmospheric sounding data and with realistic wind forecasts obtained from the Rapid Update Cycle (RUC) short-range weather forecast. In addition, this study investigates APS performance with limited surveillance range, as provided by the Automatic Dependent Surveillance-Broadcast (ADS-B) system, and with an algorithm designed to improve APS performance when an ADS-B signal is unavailable. The results presented herein quantify the runway threshold delivery accuracy of APS un-der these conditions, and also quantify resulting workload metrics such as the number of speed changes required to maintain spacing.

Wieland, Frederick↗

NASA NTRS2011

Mars Science Laboratory Interplanetary Navigation Analysis

The Mars Science Laboratory (MSL) is a NASA rover mission that will be launched in late 2011 and will land on Mars in August of 2012. This paper describes the analyses performed to validate the navigation system for launch, interplanetary cruise, and approach. MSL will use guidance during its descent into Mars in order to minimize landing dispersions, and therefore will be able to use smaller landing zones that are closer to terrain of high scientific interest. This will require a more accurate delivery of the spacecraft to the atmospheric entry interface, and a late update of the state of the spacecraft at entry. During cruise and approach the spacecraft may perform up to six trajectory correction maneuvers (TCMs), to target to the desired landing site with the required flight path angle at entry. Approach orbit determination covariance analyses have been performed to evaluate the accuracy that can be achieved in delivering the spacecraft to the entry interface point, and to determine how accurately the state of the spacecraft can be predicted to initialize the guidance algorithm. In addition, a sensitivity analysis has been performed to evaluate which factors most contribute to the improvement or degradation of the navigation performance, for both entry flight path angle delivery and entry state knowledge.

orbit determination↗

NASA NTRS2011

Advanced Stirling Convertor (ASC-E2) Performance Testing at NASA Glenn Research Center

The National Aeronautics and Space Administration (NASA) Glenn Research Center (GRC) has been supporting development of the Advanced Stirling Radioisotope Generator (ASRG) since 2006. A key element of the ASRG Project is providing life, reliability, and performance testing of the Advanced Stirling Convertor (ASC). For this purpose, four pairs of ASCs capable of operating to 850 C and designated with the model number ASC-E2, were delivered by Sunpower of Athens, Ohio, to GRC in 2010. The ASC-E2s underwent a series of tests that included workmanship vibration testing, performance mapping, and extended operation. Workmanship vibration testing was performed following fabrication of each convertor to verify proper hardware build. Performance mapping consisted of operating each convertor at various conditions representing the range expected during a mission. Included were conditions representing beginning-of-mission (BOM), end-of-mission (EOM), and fueling. This same series of tests was performed by Sunpower prior to ASC-E2 delivery. The data generated during the GRC test were compared to performance before delivery. Extended operation consisted of a 500-hr period of operation with conditions maintained at the BOM point. This was performed to demonstrate steady convertor performance following performance mapping. Following this initial 500-hr period, the ASC-E2s will continue extended operation, controller development and special durability testing, during which the goal is to accumulate tens of thousands of hours of operation. Data collected during extended operation will support reliability analysis. Performance data from these tests is summarized in this paper.

Oriti, Salvatore↗

NASA NTRS2011

International Space Station (ISS) Gas Logistics Planning in the Post Shuttle Era

Over its life the International Space Station (ISS) has received gas (nitrogen, oxygen, and air) from various sources. Nitrogen and oxygen are used in the cabin to maintain total pressure and oxygen partial pressures within the cabin. Plumbed nitrogen is also required to support on-board experiments and medical equipment. Additionally, plumbed oxygen is required to support medical equipment as well as emergency masks and most importantly EVA support. Gas are supplied to ISS with various methods and vehicles. Vehicles like the Progress and ATV deliver nitrogen (both as a pure gas and as air) and oxygen via direct releases into the cabin. An additional source of nitrogen and oxygen is via tanks on the ISS Airlock. The Airlock nitrogen and oxygen tanks can deliver to various users via pressurized systems that run throughout the ISS except for the Russian segment. Metabolic oxygen is mainly supplied via cabin release from the Elektron and Oxygen Generator Assembly (OGA), which are water electrolyzers. As a backup system, oxygen candles (Solid Fuel Oxygen Generators-SFOGs) supply oxygen to the cabin as well. In the past, a major source of nitrogen and oxygen has come from the Shuttle via both direct delivery to the cabin as well as to recharge the ISS Airlock tanks. To replace the Shuttle capability to recharge the ISS Airlock tanks, a new system was developed called Nitrogen/Oxygen Recharge System (NORS). NIORS consists of high pressure (7000 psi) tanks which recharge the ISS Airlock tanks via a blowdown fill for both nitrogen and oxygen. NORS tanks can be brought up on most logistics vehicles such as the HTV, COTS, and ATV. A proper balance must be maintained to insure sufficient gas resources are available on-orbit so that all users have the required gases via the proper delivery method (cabin and/or plumbed).

Leonard, Daniel J.↗

NASA NTRS2011

Landsat Data Continuity Mission

The Landsat Data Continuity Mission (LDCM) is currently under development and is on schedule to launch the 8th satellite in the Landsat series in December of 2012. LDCM is a joint project between the National Aeronautics and Space Administration (NASA) and the United States Geological Survey (USGS). NASA is responsible for developing and launching the flight hardware and on-orbit commissioning and USGS is responsible for developing the ground system and operating the system onorbit after commissioning. Key components of the flight hardware are the Operational Land Imager (OLI), nearing completion by Ball Aerospace & Technologies Corp in Boulder, CO, the Thermal Infrared Sensor (TIRS), being built by NASA's Goddard Space Flight Center and the spacecraft, undergoing integration at Orbital Sciences Corp in Gilbert, Arizona. The launch vehicle will be an Atlas-5 with launch services provided by NASA's Kennedy Space Center. Key ground systems elements are the Mission Operations Element, being developed by the Hammers Corporation, and the Collection Activity Planning Element, Ground Network Element, and Data Processing and Archive System, being developed internally by the USGS Earth Resources Observations and Science (EROS) Center. The primary measurement goal of LDCM is to continue the global coverage of moderate spatial resolution imagery providing continuity with the existing Landsat record. The science goal for this imagery is to monitor land use and land cover, particularly as it relates to global climate change. Together the OLI and TIRS instruments on LDCM replace the ETM+ instrument on Landsat-7 with significant enhancements. The OLI is a pushbroom design instrument where the scanning mechanism of the ETM+ is effectively replaced by a long line of detectors. The OLI has 9 spectral bands with similar spatial resolution to ETM+: 7 of them similar to the reflective spectral bands on ETM+ and two new bands. The two new bands cover (1) the shorter wavelength blue part of the spectrum to help with coastal studies and aerosol analyses/atmospheric correction and (2) an atmospheric water absorption band, where the Earth surface is generally not visible, but Cirrus clouds are, to aid in cloud detection and screening. The radiometry of OLI benefits from improved SNR, dynamic range and quantization. OLI is undergoing system testing with a delivery scheduled for Spring 2011. The TIRS is also a pushbroom design and used QWIPS detectors that require cooling to 43K using a cryocooler. It.has two spectral bands, effectively splitting the ETM+ band 6 in half, that can be used as a split window to aid in atmospheric correction. It has nominally 100 m spatial resolution as opposed to the 60 m of Landsat-7 ETM+: TIRS has commenced integration and test, with a delivery to the spacecraft vendor scheduled for Winter 2011-2012. The Orbital spacecraft currently being integrated for LDCM will have improved capabilities for pointing over previous missions. These capabilities will allow the OLI and TIRS instruments to point off-nadir the equivalent of one WRS-2 path to increase the chances of coverage for high priority targets, particularly in the event of natural disasters. Also, the pointing capability will allow the calibration of the OLI using the sun (roughly weekly), the moon (monthly), stars (during commissioning) and the Earth (at 90 deg from normal orientation, a.k.a., side slither) quarterly. The solar calibration will be used for OLI absolute and relative calibration, the moon for trending the stability of the OLI response, the stars will be used for Line of Sight determination and the side slither will be an alternate OLI and relative gain determination methodology. The spacecraft is scheduled to begin integration with the OLI instrument in Summer 2011. The LDCM data processing and archive system (DPAS), located at USGS EROS, generates the products for distribution to users. Like Landsat-7 this includes an image assessment system for characrizing instrument performance and updating calibration parameters. Products will be generated that include the spectral bands from both instruments, terrain corrected and registered to the geoid. Also, like Landsat-7, data products will be distributed at no charge to the user. The current status and plans of the space and ground segments of the LDCM project will be presented along with performance predictions as available. More detailed information on the two instruments is intended to be presented in separate papers.

Markham, Brian↗

NASA NTRS2005

Inflatable Aeroponic System

Aeroponics Internationals (AI) innovation is a self-contained, self-supporting, flexible low mass aeroponic crop production unit with integral environmental systems for the control and delivery of a nutrient mist to the roots. This FLEX Aeroponic System model was developed for commercialization as a result of the NASA SBIR Phase I contract for the research and development of a low-mass, Inflatable Aeroponic System (IAS) for producing pesticide-free lettuces, grains, peppers, tomatoes and other vegetables. The innovation addresses the needs of water and nutrient delivery systems technologies for food production in space. The inflatable nature of the innovation makes it lightweight, allowing it to be deflated so it takes up less volume during transportation and storage. It improves upon AI's current aeroponic system design that uses more rigid structures and takes advantage of vertical inclines to increase bio-mass production by over 600%.

Pelt, Jennifer Van↗

NASA NTRS2012

A Concept for Airborne Precision Spacing for Dependent Parallel Approaches

The Airborne Precision Spacing concept of operations has been previously developed to support the precise delivery of aircraft landing successively on the same runway. The high-precision and consistent delivery of inter-aircraft spacing allows for increased runway throughput and the use of energy-efficient arrivals routes such as Continuous Descent Arrivals and Optimized Profile Descents. This paper describes an extension to the Airborne Precision Spacing concept to enable dependent parallel approach operations where the spacing aircraft must manage their in-trail spacing from a leading aircraft on approach to the same runway and spacing from an aircraft on approach to a parallel runway. Functionality for supporting automation is discussed as well as procedures for pilots and controllers. An analysis is performed to identify the required information and a new ADS-B report is proposed to support these information needs. Finally, several scenarios are described in detail.

Barmore, Bryan E.↗

NASA NTRS2011

Method for Impeding Degradation of Porous Silicon Structures

This invention relates to surface modification of porosified silicon (pSi) structures with poly(alkylene) glycols for the purpose of controlled degradation of the silicon matrix and tailored release of encapsulated substances for biomedical applications. The pSi structures are currently used in diverse biomedical applications including bio-molecular screening, optical bio-sensoring, and drug delivery by means of injectable/orally administered carriers and implantable devices. The size of the pores and the surface chemistry of the pSi structure can be controlled during the microfabrication process and thereafter. A fine regulation of the degradation kinetics of mesoporous silicon structures is of fundamental importance. Polyethylene glycols (PEGs) represent the major category of surface modifying agents used in classical drug delivery systems and in pharmaceutical dosage forms. PEGylation enables avoidance of RES uptake, thus prolonging circulation time of intravenously injectable nanovectors. PEG molecules demonstrate little toxicity and immunogenicity, and are cleared from the body through the urine (molecular weight, MW less than 30 kDa) or in the feces (MW greater than 30kDa). The invention focuses on the possibility of finely tuning the degradation kinetics of the pSi nanovectors and other structures through surface conjugation of PEGs with various backbone lengths/MWs. To prove the concept, pSi nanovectors were covalently conjugated to seven PEGs with MW from 245 to 5,000 Da and their degradation kinetics in physiologically relevant media (phosphate buffer saline, PBS pH7.4, and fetal bovine serum) was assessed by the elemental analysis of the Si using inductive coupled plasma atomic emission spectroscopy (ICP-AES). The conjugation of the PEG with lowest MW to the nanovectors surface did not induce any change in the degradation kinetics in serum, but inhibited degradation and consequently the release of orthosilicic acid into buffer. When PEGs with the longer chains were evaluated, Si mass loss from the nanovectors was slowed down, and the PEGylated structures were almost fully degraded within 18 24 hours in serum and within 48 hours in PBS. The most dramatic effect was observed for high MW PEGs 3,400 and 5,000 Da, which prominently inhibited the degradation of the systems, with complete degradation achieved only after four days. For these PEGs, during the early stages of the degradation, there was a lag period of little or no Si mass loss from the nanovector. The obtained profiles were in agreement with the erosion of the nanovector surface as observed by scanning electron microscopy.

Vilentchouk, Biana Godin↗

NASA NTRS2011

Microfabrication of a High-Throughput Nanochannel Delivery/Filtration System

A microfabrication process is proposed to produce a nanopore membrane for continuous passive drug release to maintain constant drug concentrations in the patient s blood throughout the delivery period. Based on silicon microfabrication technology, the dimensions of the nanochannel area, as well as microchannel area, can be precisely controlled, thus providing a steady, constant drug release rate within an extended time period. The multilayered nanochannel structures extend the limit of release rate range of a single-layer nanochannel system, and allow a wide range of pre-defined porosity to achieve any arbitrary drug release rate using any preferred nanochannel size. This membrane system could also be applied to molecular filtration or isolation. In this case, the nanochannel length can be reduced to the nanofabrication limit, i.e., 10s of nm. The nanochannel delivery system membrane is composed of a sandwich of a thin top layer, the horizontal nanochannels, and a thicker bottom wafer. The thin top layer houses an array of microchannels that offers the inlet port for diffusing molecules. It also works as a lid for the nanochannels by providing the channels a top surface. The nanochannels are fabricated by a sacrificial layer technique that obtains smooth surfaces and precisely controlled dimensions. The structure of this nanopore membrane is optimized to yield high mechanical strength and high throughput.

Ferrari, Mauro↗

NASA NTRS2012

Amino Acids in Asteroids and Comets: Implications for the Origin of Life on Earth and Possibly Elsewhere

Meteorites provide a record of the chemical processes that occurred in the early solar system before life began on Earth. The delivery of organic matter by asteroids, comets, and their fragments to the Earth and other planetary bodies in our solar system could have been an important source of the prebiotic organic inventory needed for the emergence of life. Amino acids are essential components of proteins and enzymes in life on Earth and these prebiotic organic compounds have been detected in a wide variety of carbon-rich meteorites, the majority of which have been determined to be extraterrestrial in origin. In addition, many amino acids are structurally chiral (they possess handedness) and with a few very rare exceptions, only left handed (L) amino acids are found in biology, while all known abiotic syntheses of amino acids result in equal mixtures of left and right handed (L~D) amino acids. The discovery of a significant left handed amino acid imbalance of up to 20% in several different carbonaceous meteorites, could point toward a possible prebiotic contribution to the origin of biological homochirality by the exogenous delivery of extraterrestrial organic material to the early Earth. In this talk, I will focus on recent state-of-the-art measurements of the distribution, chirality, and isotopic composition of amino acids in meteorites and cometary samples carried out at the Goddard Astrobiology Analytical Laboratory. Results from the analyses of a variety of Antarctic meteorites, samples from comet Wild 2 returned by the STARDUST mission, and meteorite fragments of asteroid 2008 TC3 called Almahata Sitta recovered from northern Sudan will be discussed

Glavin, Daniel↗