SEARCH · Engineering Papers

Results for “Proliferation”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

SourceResearch connectionFrom yearThrough year

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,243 records · Page 69

All sources NASA NTRS DOE OSTI

NASA NTRS2018

Design and Development of Modules to Support Live Microscopic Imaging on Ground-Based Microgravity Simulators

In space, astronauts are exposed to environmental stressors that often result in physiological changes. One prominent stressor in spaceflight is microgravity, and research has shown that long term microgravity exposure causes muscle atrophy, bone loss, cardiovascular concerns, and vision impairment. It is critical to understand how altered gravity affects physiology on the cellular, molecular, and gene level in order to accurately assess health risks and to develop effective countermeasures. Ground-based microgravity simulators such as random positioning machines (RPMs) are used to produce some of the biological effects of altered gravity on different cell types and organisms. Real-time imaging during simulations are of particular interest as we can study how basic cell functions such as cell division, cell migration, and proliferation progress under microgravity conditions. However, design limitations of present microgravity simulators such as susceptibility to parasitic vibration and displacement of the sample from the center of rotation challenge the accuracy of experiment results and live images. We have developed a cell culture sample holder module suitable for live microscopic imaging on an RPM. CAD modeling and 3D printing technology were used to implement modifications to the sample holder and to install a digital microscope to perform live bright-field and fluorescent imaging. Vibration damping materials were also investigated to allow for stable imaging while the microgravity simulator was within a cell culture incubator. Novel methods and hardware modifications for improving live cell imaging on ground-based microgravity simulators were proposed and discussed.

3D printing↗

NASA NTRS2016

Leveraging Technology in Invasive Species Mapping

Kenya has had several invasions of alien species that have had negative impacts on biodiversity, agriculture and human development. For instance, prickly pear out-competes native plants, precludes grazing and browsing near it, and inhibits the proliferation of indigenous species. The Northern Kenya Rangelands in the recent decades has experienced increased infestation by invasive plant species shrinking forage space available for both livestock and wildlife. An Invasive Species App has been co-developed and is currently being used in tracking locations and sightings of invasive species of trees or shrubs and the extensiveness of their effects. The App is customized to include any list of local invasive plants present in an area, take photos of the invasive species and is also able to work offline in cases of no internet connection in the remote areas.

remote sensing↗

NASA NTRS2016

Bayesian Methods for Longitudinal Trending in Probabilities of Collision

Satellites have become an integral part of modern life, supporting phone communication, television and radio broadcasting, internet access, and military activities. Indeed, it is difficult to imagine modern society without many of these technologies, especially in an age when the world is increasingly interconnected via long-distance communications. As of 2013, there were over one thousand operational satellites in orbit about Earth. About half of these active satellites are in Low-Earth Orbit (LEO, meaning an orbital period less than 225 minutes), which is where the International Space Station (ISS) conducts operations, along with other commercial missions such as earth observation and satellite telephone communications. An increasing amount of attention is being placed on protecting satellites in LEO, as the frequency of object launches and satellite fragmentation events has contributed to the proliferation of space debris, resulting in increased congestion.

Conjunction↗

NASA NTRS2018

Stem Cell-Based Regenerative Health in Microgravity

The research of Dr. Almeida's Lab at NASA Ames focuses on the effects of microgravity mechanical unloading on stem-cell-based tissue regeneration. The research focuses on testing the broad hypothesis that mechanical load from gravity at 1 g is required for normal adult stem cell proliferation and differentiation during tissue regeneration. Research from the lab has provides evidence supporting the hypothesis in various biological models, including newt tail regeneration, mouse bone and bone marrow in whole animals, and mouse embryonic stem cells all exposed to microgravity during spaceflight. Using these models, the lab has identified overexpression of the cell cycle inhibitor p21/CDKN1a as a candidate molecular mediator mechanism of bone marrow mesenchymal and hematopoietic lineage tissue regenerative arrest in microgravity. The labis currently focused on using p21/CDKN1a null mouse and cell culture approaches in microgravity to test the gravity tissue regeneration hypothesis.

stem cells microgravity regeneration↗

NASA NTRS2018

Management of Leshmaniases in the Era of Climate Change in Morocco

The proliferation of vector-borne diseases are predicted to increase in a changing climate and Leishmaniases, as a vector-borne diseases, are re-emerging diseases in several regions of the world. In Morocco, during the last decade, a sharp increase in cutaneous leishmaniases cases has been reported. Nevertheless, in Morocco, leishmaniases are a major public health problem, and little interest was given to climate change impacts on the distribution and spread of these diseases. As insect-borne diseases, the incidence and distribution of leishmaniases are influenced by environmental changes, but also by several socio-economic and cultural factors. From a biological point of view, environmental variables have effects on the survival of insect vectors and mammalian reservoirs, which, in turn, affects transmission. Here, we highlight the effects of climate change in Morocco and discuss its consequences on the epidemiology of leishmaniases to identify challenges and define targeted recommendations to fight this disease.

climate change↗

NASA NTRS2017

Renin-Angiotensin System (RAS) in Hematopoietic Stem/Progenitor Cells (HS/PC) Predicts Vaso-Reparative Dysfunction and Progression of Diabetic Retinopathy (DR)

Purpose: We tested the hypothesis that loss of angiotensin converting enzyme 2 (ACE2) within diabetic HS/PCs (Hematopoietic Stem/Progenitor Cells) would be detrimental to HS/PC reparative function, and alter their ability to contribute to vascular remodeling in human subjects and rodent models of DR (Diabetic Retinopathy). Methods: Subjects (n52) were recruited as controls (n13) or diabetics (n39) with either no DR, mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR or proliferative DR (PDR). Fluorescein angiograms were analyzed using Vessel Generation Analysis (VESGEN) software in a cohort of subjects. CD34+ HS/PCs were isolated from peripheral blood. RAS (Renin-Angiotensin System) gene expression and migration was measured. Diabetic ACE2 knockout (KO)C57BL6-Ins2 (Akita) mice at 3, 6 and 9 months of diabetes were compared to age-matched controls. Bone marrow HS/PC populations were analyzed by flow cytometry and migration and proliferation studies performed. Results: ACE2 gene expression in human CD34+ cells from diabetics without DR was increased compared to controls (p0.0437). Mas receptor mRNA was also increased in diabetics without DR, but reduced with the onset of NPDR (p0.0002), suggesting a loss of compensation. DR was associated with CD34+ cell migratory dysfunction. By VESGEN analysis, vessel density measured by several confirming parameters in early NPDR (n3) was greater than in normal retina (n6) in both arteries and veins, which suggests active retinal remodeling. ACE2KO-Akita and Akita cohorts showed reduced retinal thickness by OCT (Optical Coherence Tomography) at 9 months of diabetes. Absence of ACE2 in 9-month Akita mice led to an accelerated increase in acellular capillaries compared to diabetic alone. Electroretinogram (ERG) in ACE2KO-Akita mice resulted in persistent deterioration of the neural retina. Reparative function studies showed that ACE2KO exacerbated diabetes-induced impairment of LK (Low Potassium) cell migration and proliferative functions as early as 3-month of diabetes (p0.0019). Conclusions: Retinopathy and adverse vascular remodeling in subjects with diabetes was associated with a loss of the protective arm of RAS in HS/PCs. Loss of ACE2 exacerbated vascular dysfunction in diabetic mice.

retina↗

NASA NTRS2018

Future of Big Earth Data Analytics

The state of the art of Big Earth Data Analytics can be expected to evolve rapidly in the coming years. The forces driving evolution come from both growth in the data and advancement in the field of data analytics. In the data area, advances in sensor instrumentation and platform miniaturization are increasing both data resolution and coverage, resulting in enormous growth in data Volume. Increases in temporal resolution in particular also generate demands for higher data Velocity. At the same time, the proliferation of instruments and the platforms on which they reside is increasing the Variety of datasets. The Variety increase in turn leads to questions about the Veracity of the data. In the algorithm area, powerful machine learning methods are coming to the fore, particularly Deep Neural Networks. These are powerful at detecting interesting features in the data, integrating many different measurements (i.e., data fusion), and classification problems. However, they are still challenging when seeking explanations of how natural or socio-economic phenomena work using Earth Observations. Thus, classical analysis techniques will remain relevant when the emphasis is on forming or testing explanations, as well as to support interactive data exploration.

Lynnes, Christopher↗

NASA NTRS2015

Unmitigated ACES Simulation Supporting Draft DAA MOPS Alerting

alerting↗

NASA NTRS2019

Discrete Lattice Material Vacuum Airship

Vacuum airships fueled by renewable energy would reduce reliance on fossil fuel-based modes of transport, lessen the need for limited and non-renewable lifting gases, and can be achieved using novel manufacturing techniques for ultra-light, discrete lattice material systems.The Discrete Lattice Material Vacuum Airships (DLMVA) system combines novel material science and manufacturing technologies for new modes of mass transportation, resulting in a disruptive approach to reduce national resource consumption and emissions. Through the use of high performance building block elements, modular, scalable and extensible aircraft can be rapidly assembled into positive net-buoyancy systems utilizing a vacuum instead of a lifting gas. By using architected lattice material principles, show that lattice materials can overcome stability limitations of previous vacuum balloon designs. Additionally, we show that lattice vacuum balloons are strength limited, rather than stability limited. As a result,airborne infrastructure can be developed to support the proliferation of modern systems such as e-commerce and distributed communications, while simultaneously reducing dependence on finite, non-renewable, emission-heavy resources.

Jenett, Benjamin E.↗

NASA NTRS2018

Approaches to Difficult Aerospace Telecommunications Links

With the proliferation of local wireless and 4G cellular networks, it is often presumed that reliable and fast wireless links are commonplace. However, there are still systems that must leverage very constrained, lagged, and lossy communication links. This discussion explores aerospace systems that utilize these problematic links, the challenges of using modern protocols over these links, and how potential solutions can negatively impact the performance of the entire system.

IP↗

NASA NTRS2018

Wildfire-driven Thunderstorms Cause a Volcano-Like Stratospheric Injection of Smoke

Intense heating by wildfires can generate deep, smoke-infused thunderstorms, known as pyrocumulonimbus (pyroCb), which can release a large quantity of smoke particles above jet aircraft cruising altitudes. Injections of pyroCb smoke into the lower stratosphere have gained increasing attention over the past 15 years due to the rapid proliferation of satellite remote sensing tools. Impacts from volcanic eruptions and other troposphere-to-stratosphere exchange processes on stratospheric radiative and chemical equilibrium are well recognized and monitored. However, the role of pyroCb smoke in the climate system has yet to be acknowledged. Here, we show that the mass of smoke aerosol particles injected into the lower stratosphere from five near-simultaneous intense pyroCbs occurring in western North America on 12 August 2017 was comparable to that of a moderate volcanic eruption, and an order of magnitude larger than previous benchmarks for extreme pyroCb activity. The resulting stratospheric plume encircled the Northern Hemisphere over several months. By characterizing this event, we conclude that pyroCb activity, considered as either large singular events, or a full fire season inventory, significantly perturb the lower stratosphere in a manner comparable with infrequent volcanic intrusions.

Pyrocumulonimbus (pyroCb)↗

NASA NTRS2017

The Effects of CDKN1a/p21 on Oxidative Stress and Mitochondrial Function During Long Duration Spaceflight

Spaceflight factors, such as microgravity and space radiation, are known to put astronauts at risk for negative effects to their tissue regeneration and degenerative conditions. On our previous spaceflight research, we found that long duration spaceflight produced increased oxidative stress and activation of the inflammatory response as a major contributor to physiological changes, including alterations to the cardiovascular and musculoskeletal systems, metabolism, and the liver. Proliferation, apoptosis, and ion-channel remodeling of vascular smooth muscle cells, as well as endothelial inflammation, and nitric oxide synthase-nitric oxide system regulation have been shown by spaceflight and simulated spaceflight projects. CDKN1ap21 is a regulatory gene for tissue regeneration and also plays an important role in upregulating oxidative stress caused by radiation. In further research, we have also determined CDKN1ap21 to be overexpressed during spaceflight. When knocked out in mice, however, it protects against unloading-induced changes to the morphology and physiology of carotid arteries. In this proposal, we seek to test a potential dietary countermeasure to down-regulate CDKN1ap21 in the mice and protect against oxidative stress in the rodents. Specifically, we will expose both Wildtype and CDKN1ap21-null mice to hydrogen peroxide to induce oxidative stress and observe the molecular mechanisms in which a dietary supplement protects vascular smooth muscle cells against the consequences of the apoptotic environment within Wildtype mice versus the, hypothetically, sound physiology of CDKN1ap21-null mice. The successful completion of this experiment will conclusively determine accuracy of a dietary supplement as a CDKN1ap21 suppressor. This will provide a new perspective on the problem of increased oxidative stress developing into cardiovascular disease as a result of long-term space flight. This research will address the Human Research Plan Roadmaps Risk of Cardiac Rhythm Problems including CV-8, the Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure including Degen-6 and Degen-7, and the Risk of Adverse Health Event from Radiation Exposure including IM-8. Additionally, this research will address Space Biology Research Plans questions SBP CMB-1, SBP CMB-3, and SB AN-2.

Oxidative Stress↗

NASA NTRS2019

Vortex Radiometry: Enabling Frequency Agile Communications

Exponential proliferation of UAVs and CubeSats puts NASA's high priority communication systems at risk. UAVs and CubeSats are easy to acquire, modify and build, making it extremely likely that some will be used in unauthorized ways. While these systems provide several benefits to society, their increased use also increases the probability of unintentional signal interference, and even deliberate jamming of NASA's communication systems.This paper presents an algorithm to determine 1) when an interference induced fade will occur, 2) how long the fade will persist for and 3) how intense the fade will be. The algorithm requires data collected from Vortex Radiometers (VRs), which probe the RF environment using annular antenna beam patterns. A set of numerical simulations show that a multi-beam VR system can instruct a cognitive antenna to switch between Ka- and X-Band communications, in order to avert interference from small diameter noise sources. Analysis of the simulation results indicate that practical VR systems will require several concentric annular beam patterns, in order to mitigate fades from noise sources of various sizes. The paper concludes by identifying technology challenges that need to be overcome to achieve these capabilities.

Orbital Angular Momentum↗

NASA NTRS2016

Architecture and CONOPS of Next-Generation Ground Network for Communications and Tracking of Interplanetary SmallSats

As small spacecraft venture out of Earth orbit, they will encounter challenges not experienced or addressed by the numerous low Earth orbit (LEO) CubeSat and Smallsat missions staged to date. The LEO CubeSats typically use low-cost, proven CubeSat radios, antennas, and university ground stations with small apertures. As more ambitious yet cost-constrained space mission concepts to the Moon and beyond are being developed, CubeSats and smallsats have the potential to provide a more affordable platform for exploring deep space and performing the associated science. Some of the challenges that have, so far, slowed the proliferation of small interplanetary spacecraft are those of communications and navigation.

Cheung, Kar-ming↗

NASA NTRS2014

ACES Study of DAA-Mitigated UAS Operations SC-228 Requirements Sub Group

Realization of the expected proliferation of Unmanned Aircraft System (UAS) operations in the National Airspace System (NAS) depends on the development and validation of performance standards for UAS Detect and Avoid (DAA) Systems. The RTCA Special Committee 228 is charged with leading the development of draft Minimum Operational Performance Standards (MOPS) for UAS DAA Systems. NASA, as a participating member of RTCA SC-228 is committed to supporting the development and validation of draft requirements as well as the safety substantiation and end-to-end assessment of DAA system performance. A recent study conducted using NASA's ACES (Airspace Concept Evaluation System) simulation capability begins to address questions surrounding the development of draft MOPS for DAA systems by assessing DAA performance in a NAS-wide context. ACES analyses were conducted to determine the impact of varying elements of UAS pilot performance and uncertainty mitigations on DAA system performance. Simulations were conducted with recorded cooperative and non-cooperative VFR (Visual Flight Rules) traffic to accurately model UAS encounters with other NAS traffic (ATC (Air Traffic Control) being responsible for separation with other IFR (Instrument Flight Rules) aircraft) and with roughly 25, 000 simulated UAS operations The number of Loss of Well Clear (LoWC) events were recorded across the range of independent variables: pilot response time, horizontal LoWC prediction buffer and horizontal LoWC resolution buffer. The number of LoWC events was compared to the unmitigated case (without the benefit of a DAA system) to determine the resultant risk-ratio for each of 8 simulation conditions. The parameter trades presented by the resultant DAA system performance (risk ratio) will be used by SC 228 to inform decisions about future requirements development and validation efforts.

Detect-and-Avoid↗

NASA NTRS2019

Planetary Science with Small Satellites: Opportunities and Challenges

Small satellites aren't anything particularly new. Earth orbiting small satellites go back 30 years or more. What is new is the proliferation and access to small satellite technologies and flight opportunities. This has been in large part due to the advent of the "cubesat" model, initially a means to develop student's engineering skills, but has since evolved into an industry and accepted method within government space agencies. Until very recently these smallsats were limited to Earth orbiting missions, but with the successful flight of the MarCO spacecraft and the upcoming launch of EM-1 cubesats, the Moon, Mars and beyond are now within reach. While all this is good news, we still have a ways to go before smallsats become true planetary science tools. One could argue that Deep Space 2 was the first planetary smallsat, launched in 1999 and having a mass of 2.3 kg (each probe) it hoped to demonstrate that "real" science could be done with a small (and less expensive) package. The DS2 failure shelved the idea of smallsats (even chilling some to "Class D" planetary missions in general) for nearly two decades. NASA has slowly come back around to smallsats for planetary missions, going so far as to support a range of mission studies (the Planetary Science Deep Space SmallSat Studies, or PSDS3, Program) and the creation of a new Program (SIMPLEx) to developed such missions for opportunistic flights. The MarCO success was hugely important in maintaining (and building) this forward momentum. However, we still have yet to demonstrate "real" science from a planetary smallsat and there are some fundamental disconnects between expectation and reality. This talk will discuss some of the opportunities and challenges that reside with planetary smallsats, focusing on two examples: LunaH-Map (the first SIMPLEx cubesat) and Aeolus (a Mars PSDS3 smallsat concept).

Colaprete, Anthony↗

NASA NTRS2015

Airspace Safety Threshold Study: NAS-Wide Encounter Rate Evaluation Using Historical Radar Data and ACES

Realization of the expected proliferation of Unmanned Aircraft System (UAS) operations in the National Airspace System (NAS) depends on the development and validation of performance standards for UAS Detect and Avoid (DAA) Systems. The RTCA Special Committee 228 (SC-228) is charged with leading the development of draft Minimum Operational Performance Standards (MOPS) for UAS DAA Systems. NASA, as a participating member of RTCA SC-228 is committed to supporting the development and validation of draft requirements as well as the safety substantiation and end-to-end assessment of DAA system performance. With regard to the safety aspect being studied by the SC-228 DAA Safety sub-group, NASA has conducted a study using the ACES (Airspace Concept Evaluation System) simulation capability to determine: 1) the rate at which IFR aircraft encounter other IFR and VFR aircraft, and 2) the rate at which UAS aircraft encounter VFR aircraft as well as the corresponding encounter geometries. Five different separation thresholds were used (two for encounter and one each for well-clear, near mid-air collision, and closest point of approach). The results will be used by the SC-228 DAA Safety sub-group to inform decisions about the safety aspect of UAS DAA systems and future requirements development and validation efforts.

encounter geometry↗

NASA NTRS2014

Airspace Safety Threshold Study: Status Update to SC-228 DAA Safety Sub-Group

Risk ratio↗