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A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site
Abstract not provided
Crystal Structures of Ternary Complexes of MEF2 and NKX2?5 Bound to DNA Reveal a Disease Related Pro
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The discriminative capacity of CSF β-amyloid 42 and Tau in neurodegenerative diseases in the Chinese population
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Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification
Abstract not provided
A theoretical framework to identify invariant thresholds in infectious disease epidemiology
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Assessing the spread of foot and mouth disease in mainland China by dynamical switching model
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Sexual transmission and the probability of an end of the Ebola virus disease epidemic
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Treatment approach, delivery, and follow-up evaluation for cardiac rhythm disease management patients receiving radiation therapy: Retrospective physician surveys including chart reviews at numerous centers
In a 2-part study, we first examined the results of 71 surveyed physicians who provided responses on how they address the management of patients who maintained either a pacemaker or a defibrillator during radiation treatment. Second, a case review study is presented involving 112 medical records reviewed at 18 institutions to determine whether there was a change in the radiation prescription for the treatment of the target cancer, the method of radiation delivery, or the method of radiation image acquisition. Statistics are provided to illustrate the level of administrative policy; the level of communication between radiation oncologists and heart specialists; American Joint Committee on Cancer (AJCC) staging and classification; National Comprehensive Cancer Network (NCCN) guidelines; tumor site; patient's sex; patient's age; device type; manufacturer; live monitoring; and the reported decisions for planning, delivery, and imaging. This survey revealed that 37% of patient treatments were considered for some sort of change in this regard, whereas 59% of patients were treated without regard to these alternatives when available. Only 3% of all patients were identified with an observable change in the functionality of the device or patient status in comparison with 96% of patients with normal behavior and operating devices. Documented changes in the patient's medical record included 1 device exhibiting failure at 0.3-Gy dose, 1 device exhibiting increased sensor rate during dose delivery, 1 patient having an irregular heartbeat leading to device reprogramming, and 1 patient complained of twinging in the chest wall that resulted in a respiratory arrest. Although policies and procedures should directly involve the qualified medical physicist for technical supervision, their sufficient involvement was typically not requested by most respondents. No treatment options were denied to any patient based on AJCC staging, classification, or NCCN practice standards.
Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models
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A deep learning approach for Maize Lethal Necrosis and Maize Streak Virus disease detection
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Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease
Abstract not provided