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All sourcesNASA NTRSDOE OSTI
NASA NTRS2025

Human Spaceflight Applications of Novel Miniature X-Ray Technologies

INTRODUCTION: Radiography (XR) has long been a cornerstone of terrestrial medical imaging, though it has not yet been used in the spaceflight environment. Medical systems for human spaceflight missions are constrained by mass, volume, and power, and until recently, XR systems have been considered too large and power-consuming for spaceflight diagnostic and therapeutic applications. However, the rise of commercial spaceflight and NASA’s refocused efforts on returning crews to the Moon for long-duration missions have introduced a higher degree of medical risk to human spaceflight and require a re-evaluation when optimizing medical system design. Over the last decade, XR devices have miniaturized while maintaining good diagnostic and therapeutic sensitivity and specificity, making new in-flight medical and non-medical XR applications a possibility. Initial research identified several medical conditions where miniature XR would be beneficial for the diagnosis and/or management of medical conditions arising in space, though a more in-depth analysis is required to identify whether XR may add value to the management of such conditions. With this presentation, we aim to introduce the potential utility of miniature XR, review prior work highlighting where XR may be beneficial, and evaluate how miniature XR may reduce medical risk in human spaceflight missions. METHODS: IMPACT (Informing Mission Planning via Analysis of Complex Tradespaces) is a risk assessment tool developed by NASA to advance exploration mission medical system design by quantitatively estimating mission medical risk. IMPACT v1.0 includes a novel evidence library baselined to exploration environments, an expanded list of 119 medical conditions, medical capabilities and resources critical for management of these medical conditions, and the ability for rapid and iterative analysis in the setting of modifiable design reference missions (DRMs). Our first analysis identified which of the 119 medical conditions XR had diagnostic or therapeutic utility for. Subject matter experts (SMEs) recorded which XR views would be performed under ideal terrestrial circumstances for diagnosis/management of each condition, as well as which views are pragmatic for spaceflight limitations. A second analysis utilized IMPACT to identify significant conditions that contribute greatest to medical risk during a notional long-duration Lunar orbit and Lunar surface DRM. Medical system risk estimates include loss of crew life (LOCL), need for return to definitive care (RTDC; medical evacuation), and an estimate of crew task time affected (TTA). Using a standardized semi-quantitative scoring methodology, a deeper evaluation of each of the most significant medical conditions was performed. Data from both of these separate analyses were used to hypothesize what ideal and pragmatic XR studies may impact clinical management of the most significant conditions predicted to lead to medical risk. RESULTS: Approximately 1/3 of the IMPACT conditions were identified as being more effectively or comprehensively assessed or treated with the addition of miniature XR technology. The resulting conditions benefitting diagnostically and therapeutically from XR are revealed, as well as the ideal and pragmatic XR views and medical procedures benefitting from XR. The conditions of clinical significance and those most contributing to risk are also displayed. Among the conditions that contribute greatest to LOCL, four conditions for which XR may improve the diagnosis and management of include: decompression sickness, traumatic shock, dental abscess, and respiratory failure. Among conditions that contributed to RTDC, the evaluation and management of wrist fracture is likely improved by XR. For conditions leading to crew TTA, evaluation and management of EVA shoulder injuries, upper and lower extremity strains, back strains, and EVA hand injuries are likely improved by XR. DISCUSSION: Miniature XR in spaceflight has the potential to improve the evaluation and management of a substantial portion of conditions that most contribute to medical risk. This presentation is an introduction to the possibilities miniature XR provides for future human spaceflight missions and subsequent presenters will expand on potential applications in more detail. LEARNING OBJECTIVES: 1) Understand the previous limitations of using radiography in the management of spaceflight medical conditions; 2) Evaluate the findings from the IMPACT tool analysis, which allows quantification of the benefit miniature XR could provide for managing high-risk medical conditions in long-duration lunar orbit and surface missions, focusing on improvements in crew health outcomes; 3) Analyze case studies where miniature XR technology could reduce the medical risks associated with spaceflight missions, specifically in diagnosing and managing conditions such as decompression sickness, traumatic shock, and EVA-related injuries.

A Anderson↗
NASA NTRS2004

ViDI: Virtual Diagnostics Interface: Unified File Format and Web Services as Applied to Seamless Data Transfer - Volume 2

The desire to revolutionize the aircraft design cycle from its currently lethargic pace to a fast turn-around operation enabling the optimization of non-traditional configurations is a critical challenge facing the aeronautics industry. In response, a large scale effort is underway to not only advance the state of the art in wind tunnel testing, computational modeling, and information technology, but to unify these often disparate elements into a cohesive design resource. This paper will address Seamless Data Transfer, the critical central nervous system that will enable a wide variety of varied components to work together.

Fleming, Gary A.↗
NASA NTRS2022

Advances in the prediction of MJO-Teleconnections in the S2S forecast systems

This study evaluates the ability of state-of-the-art subseasonal to seasonal (S2S) forecasting systems to represent and predict the teleconnections of the Madden Julian Oscillations and their effects on weather in terms of midlatitude weather patterns and North Atlantic tropical cyclones. This evaluation of forecast systems applies novel diagnostics developed to track teleconnections along their preferred pathways in the troposphere and stratosphere, and to measure the global and regional responses induced by teleconnections across both the Northern and Southern Hemispheres. Results of this study will help the modeling community understand to what extent the potential to predict the weather on S2S time scales is achieved by the current generation of forecasting systems, while informing where to focus further development efforts. The findings of this study will also provide impact modelers and decision makers with a better understanding of the potential of S2S predictions related to MJO teleconnections.

Forecasting↗
DOE OSTI2011

Clinical Outcomes and Patterns of Failure After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma

Purpose: To study and report the clinical outcomes and patterns of failure after intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). Methods and Materials: The treatment outcomes of NPC patients treated with IMRT at Pamela Youde Nethersole Eastern Hospital between 2005 and 2007 were reviewed. The location and extent of locoregional failures were transferred to the pretreatment planning computed tomography for dosimetry analysis. Statistical analyses were performed on dose coverage and locoregional failures. Results: A total of 193 NPC patients were analyzed; 93% had Stage III/IV disease. Median follow-up was 30 months. Overall disease failure (at any site) developed in 35 patients. Among these, there were 23 distant metastases, 16 local failures, and 9 regional failures. Four of the locoregional failures were marginal. Dose conformity with IMRT was excellent. Patients with at least 66.5 Gy to their target volumes had significantly less locoregional failure. The 2-year local progression-free, regional progression-free, distant metastasis-free, and overall survival rates were 95%, 96%, 90%, and 92%, respectively. Conclusions: Intensity-modulated radiotherapy provides excellent locoregional control for NPC. Distant metastasis remains the most difficult challenge, and more effective systemic agents should be explored for patients presenting with advanced locoregional diseases.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2010

THE TYPE Ia SUPERNOVA RATE IN REDSHIFT 0.5-0.9 GALAXY CLUSTERS

Supernova (SN) rates are potentially powerful diagnostics of metal enrichment and SN physics, particularly in galaxy clusters with their deep, metal-retaining potentials and relatively simple star formation histories. We have carried out a survey for SNe in galaxy clusters, at a redshift range of 0.5 < z < 0.9, using the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope. We reimaged a sample of 15 clusters that were previously imaged by ACS, thus obtaining two to three epochs per cluster in which we discovered five likely cluster SNe, six possible cluster Type Ia supernovae, two hostless SN candidates, and several background and foreground events. Keck spectra of the host galaxies were obtained to establish cluster membership. We conducted detailed efficiency simulations, and measured the stellar luminosities of the clusters using Subaru images. We derive a cluster SN rate of 0.35SNu {sub B} {sup +0.17} {sub -0.12}(statistical) {+-}0.13(classification) {+-}0.01(systematic) (where SNu {sub B} = SNe (100 yr 10{sup 10} L {sub B,sun}){sup -1}) and 0.112SNu {sub M} {sup +0.055} {sub -0.039}(statistical) {+-}0.042(classification) {+-}0.005(systematic) (where SNu {sub M} = SNe (100 yr 10{sup 10} M {sub sun}){sup -1}). As in previous measurements of cluster SN rates, the uncertainties are dominated by small-number statistics. The SN rate in this redshift bin is consistent with the SN rate in clusters at lower redshifts (to within the uncertainties), and shows that there is, at most, only a slight increase of cluster SN rate with increasing redshift. The low and fairly constant SN Ia rate out to z {approx} 1 implies that the bulk of the iron mass in clusters was already in place by z {approx} 1. The recently observed doubling of iron abundances in the intracluster medium between z = 1 and 0, if real, is likely to be the result of redistribution of existing iron, rather than new production of iron.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2023

HFTS-1 (Final Report)

Despite the long history of hydraulic fracturing, the optimal number of fracturing stages during multi-stage fracture stimulation in horizontal wells can be a complex subject. In addition to the increased expense of multistage fracturing in horizontal wells, increasing the number of fracturing stages does not always correlate with a commensurate increase in production. The problem is the application of a uniform fracture stimulation design to all stages with no consideration for geological variations along the wellbore. The result is an inefficient use and costly waste of energy and water. Optimization of the fracturing process requires an understanding of the cause-and-effect relationship between fracturing parameters and local geological properties at a given location along the wellbore. Realizing that the generalized rock mechanics theories and hypotheses are not truly applicable to fractured and laminated shales, quantifiable impacts of a shale’s geomechanical and depositional features are a prerequisite for design and implementation of optimized hydraulic fractures. The overarching goal of this project is to understand and define the relationships of shale geology and fracture dynamics using detailed field data that includes coring of the fracture domain. Finally, resource recovery from shale formations is estimated to be less than fifteen percent. Research proposed in this project will establish the foundations for investigating enhanced recovery techniques for increased resource recovery in existing fracture treated wells. Natural gas as an EOR fluid is in the initial stages of being used broadly in the oil and gas industry and as such, many aspects of the process need to be researched and addressed prior to widespread acceptance. In addition, re-fracturing techniques, particularly using cemented liners also need to be further investigated. This project explores several of these EOR techniques in greater detail, not just at the theoretical level, but through actual field test sites. This report delves into the research program, identified tasks, several studies, observations, results, and conclusions under the Hydraulic Fracturing Test Site (HFTS) project. This test project is subdivided into three distinct phases and each phase is discussed in detail under separate sections. The original test site for Phase 1 as well as the Phase 2 site are in Midland Basin in Texas and operated by Laredo Petroleum. In the first two phases, the program targeted the Wolfcamp formation in Midland Basin. Phase 3 of the study targeted the EagleFord play in South Texas with Devon Energy as the operator. Significant conclusions from this study include: 1) lateral and vertical fracture growth mapping as well as proppant transport behavior, 2) Use of field gas and its applicability for huff n puff EOR injection in the Midland Basin, 3) Development and validation of proppant log, both at core scale as well as in-fill well implementation by analyzing drilling mud return samples, 4) Applicability of liner refracturing including best practices for enhanced unit level productivity. This report will detail all these studies as well as technical results and conclusions from said studies. These include general subsurface characterization work, completion designs as implemented, studies looking at fracture geometry, high resolution microseismic study, advanced crosswell strain mapping studies including drainage characterization, core characterization results, proppant analysis (core and observation wells), geochemistry, etc. to name a few.

02 PETROLEUM↗
NASA NTRS1976

Cardiovascular and pulmonary dynamics by quantitative imaging

The accuracy and range of studies on cardiovascular and pulmonary functions can be greatly facilitated if the motions of the underlying organ systems throughout individual cycles can be directly visualized and readily measured with minimum or preferably no effect on these motions. Achievement of this objective requires development of techniques for quantitative noninvasive or minimally invasive dynamic and stop-action imaging of the organ systems. A review of advances in dynamic quantitative imaging of moving organs reveals that the revolutionary value of cross-sectional and three-dimensional images produced by various types of radiant energy such as X-rays and gamma rays, positrons, electrons, protons, light, and ultrasound for clinical diagnostic and biomedical research applications is just beginning to be realized. The fabrication of a clinically useful cross-section reconstruction device with sensing capabilities for both anatomical structural composition and chemical composition may be possible and awaits future development.

Wood, E. H.↗
NASA NTRS1990

Observing system simulations using synthetic radiances and atmospheric retrievals derived for the AMSU and HIRS in a mesoscale model

The paper addresses the concept of synthetic satellite imagery as a visualization and diagnostic tool for understanding satellite sensors of the future and to detail preliminary results on the quality of soundings from the current sensors. Preliminary results are presented on the quality of soundings from the combination of the High-Resolution Infrared Radiometer Sounder and the Advanced Microwave Sounding Unit. Results are also presented on the first Observing System Simulation Experiment using this data in a mesoscale numerical prediction model.

Diak, George R.↗
NASA NTRS2002

Active Wireless Temperature Sensors for Aerospace Thermal Protection Systems

Health diagnostics is an area where major improvements have been identified for potential implementation into the design of new reusable launch vehicles in order to reduce life-cycle costs, to increase safety margins, and to improve mission reliability. NASA Ames is leading the effort to advance inspection and health management technologies for thermal protection systems. This paper summarizes a joint project between NASA Ames and Korteks to develop active wireless sensors that can be embedded in the thermal protection system to monitor sub-surface temperature histories. These devices are thermocouples integrated with radio-frequency identification circuitry to enable acquisition and non-contact communication of temperature data through aerospace thermal protection materials. Two generations of prototype sensors are discussed. The advanced prototype collects data from three type-k thermocouples attached to a 2.54-cm square integrated circuit.

Milos, Frank S.↗
NASA NTRS2013

Radial Profiles of Plasma Electron Characteristics in a Low-Power Arcjet

Since 1960, the Arc Jet Complex at NASA Ames Research Center has been a source of long-duration, high-enthalpy flow for materials testing with application to the thermal protection of aerospace vehicle components. From their inception the facilities have played an integral role supporting many of NASA's space flight programs and numerous DoD projects. In recent years advancements in computational fluid dynamics (CFO) have made the resultant models a valuable tool for assessing and predicting performance, however, the inherent limitation of models to compensate for a dissociated, transitionally high temperature nonequilibrated flowfield have made further measurements necessary. The use of electrostatic probe diagnostics within similarly harsh plasma environments in previous studies have been met with much success. In this study, the use of a single Langmuir probe was implemented to characterize the plasma parameters of interest as they vary radially within a large volume of the plume. Classical Langmuir probe theory was applied to achieve first order estimates of the heavy particle temperature, the ratio T(sub i)/T(sub e), and the ionization fraction. As expected, both the electron temperature and electron density measurements show a dependence on radial distance from the plume centerline, with electron density profiles showing the largest dependence. This paper aims to validate and strengthen modeling work conducted at the NASA Ames Research Center by measuring the critical plasma parameters (electron temperature, electron density, and plasma potential) within the arc plume of a subscale arc jet. These parameters are intended to give physical insight into the flow characteristics while providing the necessary boundary conditions to validate full scale simulations.

Codron, Douglas↗
NASA NTRS1981

Preparation and evaluation of advanced electrocatalysts for phosphoric acid fuel cells

The highest performance fuel cell cathode electrocatalyst combination ever observed gives 755 mV vs hydrogen at 100 ASF on air at 180 C and shows a potential improvement to 775 mV vs hydrogen for better electrode structures. A pressurized fuel cell (UTC at 5 atm) would then give 805 mV at 320 ASF and 180 C. Another activity diagnostic is the performance of this electrocatalyst on oxygen at 900 mV vs hydrogen. The value for electrocatalyst is 44 mA per milligram of platinum and is projected to reach 60 mA per milligram of platinum with improved electrode structures. Since the electrocatalyst surface area and the electrode structure are not yet optimized there is considerable room for performance enhancement beyond these values, especially at higher temperatures.

Stonehart, P.↗
NASA NTRS2001

Accomplishments of the Advanced Reusable Technologies (ART) RBCC Project at NASA/Marshall Space Flight Center

The focus of the NASA / Marshall Space Flight Center (MSFC) Advanced Reusable Technologies (ART) project is to advance and develop Rocket-Based Combined-Cycle (RBCC) technologies. The ART project began in 1996 as part of the Advanced Space Transportation Program (ASTP). The project is composed of several activities including RBCC engine ground testing, tool development, vehicle / mission studies, and component testing / development. The major contractors involved in the ART project are Aerojet and Rocketdyne. A large database of RBCC ground test data was generated for the air-augmented rocket (AAR), ramjet, scramjet, and ascent rocket modes of operation for both the Aerojet and Rocketdyne concepts. Transition between consecutive modes was also demonstrated as well as trajectory simulation. The Rocketdyne freejet tests were conducted at GASL in the Flight Acceleration Simulation Test (FAST) facility. During a single test, the FAST facility is capable of simulating both the enthalpy and aerodynamic conditions over a range of Mach numbers in a flight trajectory. Aerojet performed freejet testing in the Pebble Bed facility at GASL as well as direct-connect testing at GASL. Aerojet also performed sea-level static (SLS) testing at the Aerojet A-Zone facility in Sacramento, CA. Several flight-type flowpath components were developed under the ART project. Aerojet designed and fabricated ceramic scramjet injectors. The structural design of the injectors will be tested in a simulated scramjet environment where thermal effects and performance will be assessed. Rocketdyne will be replacing the cooled combustor in the A5 rig with a flight-weight combustor that is near completion. Aerojet's formed duct panel is currently being fabricated and will be tested in the SLS rig in Aerojet's A-Zone facility. Aerojet has already successfully tested a cooled cowl panel in the same facility. In addition to MSFC, other NASA centers have contributed to the ART project as well. Inlet testing and parametrics were performed at NASA / Glenn Research Center (GRC) and NASA / Langley Research Center (LaRC) for both the Aerojet and Rocketdyne concepts. LaRC conducted an Air-Breathing Launch Vehicle (ABLV) study for several vehicle concepts with RBCC propulsion systems. LaRC is also performing a CFD analysis of the ramjet mode for both flowpaths based on GASL test conditions. A study was performed in 1999 to investigate the feasibility of performing an RBCC flight test on the NASA / Dryden Flight Research Center (DFRC) SR-71 aircraft. Academia involvement in the ART project includes parametric RBCC flowpath testing by Pennsylvania State University (PSU). In addition to thrust and wall static pressure measurements, PSU is also using laser diagnostics to analyze the flowfield in the test rig. MSFC is performing CFD analysis of the PSU rig at select test conditions for model baseline and validation. Also, Georgia Institute of Technology (GT) conducted a vision vehicle study using the Aerojet RBCC concept. Overall, the ART project has been very successful in advancing RBCC technology. Along the way, several major milestones were achieved and "firsts" accomplished. For example, under the ART project, the first dynamic trajectory simulation testing was performed and the Rocketdyne engine A5 logged over one hour of accumulated test time. The next logical step is to develop and demonstrate a flight-weight RBCC engine system.

Nelson, Karl W.↗
DOE OSTI2021

Initial conditions for simulations of beam physics in linear induction accelerators

Flash radiography of hydrodynamic experiments driven by high explosives is a well-known diagnostic technique in use at many laboratories. At Los Alamos, the DualAxis Radiographic Hydrodynamic Test (DARHT) facility two linear induction electron accelerators (LIAs) make the bremsstrahlung radiographic source spots for point projection radiographs from orthogonal views. A new LIA, called Scorpius, is presently under development to advance this technology. To better understand electron-beam physics in these LIAs, numerical simulations are frequently performed with the objective of improving the radiography. At Los Alamos we frequently use the TRAK ray-trace and LSP particle-in-cell (PIC) codes to simulate the injector, and the XTR and LAMDA envelope/centroid codes along with LSP to simulate transport of the accelerated beam through the LIAs. The LIA simulations need the injected beam parameters as initial conditions for calculating beam transport and stability. The determination of these initial conditions is the topic of this note.

43 PARTICLE ACCELERATORS↗
NASA NTRS1985

Position Paper: Workshop on Geologic Applications of Remote Sensing to the Study of Sedimentary Basins

The utility of LANDSAT Multispectral Scanner (MSS) and Thematic Mapper (TM) data for providing regional coverage has been demonstrated. Information derived from LANDSAT spectral data is varied, but has primarily been used for distinguishing materials in a scene. Because of the limited number and width of the MSS and TM bands, LANDSAT data has only limited utility for actual identification of materials. The new advanced sensors (currently airborne, but eventually shuttle-based) have more limited areal extent than LANDSAT, but greater spatial and spectral resolution. The Airborne Imaging Spectrometer (AIS) has spectral resolution of about .01 microns and, typically, has 10m/pixel spatial resolution. This improved spectral resolution means that diagnostic spectral features may now be identified, which in turn means that actual identification of mineral phases present can be addressed (of either monominerallic or composite materials). Another new sensor, the Thermal Infrared Multispectral Scanners (TMS), obtains data in the 8 to 12 micron range. The information from the various sensors (e.g., LANDSAT, AIS, and TIMS) is complementary, covering different wavelength regions and consequently sensitive to different materials or physical properties of materials. In addition, the new sensors also produce a higher volume of data, which must be cleverly and efficiently handled.

Blake, P. L.↗
DOE OSTI2017

Time-Resolved PIV/PTV Measurements on Interior Subchannels of a Wire-Wrapped 61-pin Hexagonal Fuel Bundle

Liquid metal fast reactor fuel bundles using sodium as a coolant typically utilize a tightly packed triangular lattice of fuel pins enclosed in a hexagonal duct. Often, the fuel pins are helically wrapped with a wire spacer. The primary function of the wire spacers is to maintain a gap between adjacent fuel pins. They also enhance sub-channel mixing to increase convective heat transfer and mitigate vortex-induced vibration. Texas A and M University has conducted isothermal flow experiments in a wire-wrapped 61-pin hexagonal fuel bundle to support the research on advanced nuclear fuel development sponsored by the Department of Energy (DOE). These tests produced high spatial and temporal resolution measurements of the velocity field and pressure at different locations in the fuel bundle. The experimental facility employs matched-index-of-refraction (MIR) techniques and laser diagnostic velocity measurement techniques such as particle image velocimetry (PIV), particle tracking velocimetry (PTV), and laser Doppler velocimetry (LDV). The result of this experimental activity will be an experimental database of pressure and velocity field measurements that will be suitable for validating computational fluid dynamics (CFD) methods, such as Reynolds-averaged Navier-Stokes (RANS) and highly resolved large eddy simulation (LES). PIV results on the set of edge subchannels near the hexagonal duct have been presented in another paper. This paper presents PIV results on two sets of interior subchannels, defined as Interior- 1 and Center-2, at a Reynolds number (Re) of 19,000 in the turbulent regime.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2011

Overview of KSTAR initial operation

Since the successful first plasma generation in the middle of 2008, three experimental campaigns were successfully made for the KSTAR device, accompanied with a necessary upgrade in the power supply, heating, wall-conditioning and diagnostic systems. KSTAR was operated with the toroidal magnetic field up to 3.6 T and the circular and shaped plasmas with current up to 700 kA and pulse length of 7 s, have been achieved with limited capacity of PF magnet power supplies. The mission of the KSTAR experimental program is to achieve steady-state operations with high performance plasmas relevant to ITER and future reactors. The first phase (2008-2012) of operation of KSTAR is dedicated to the development of operational capabilities for a super-conducting device with relatively short pulse. Development of start-up scenario for a super-conducting tokamak and the understanding of magnetic field errors on start-up are one of the important issues to be resolved. Some specific operation techniques for a super-conducting device are also developed and tested. The second harmonic pre-ionization with 84 and 110 GHz gyrotrons is an example. Various parameters have been scanned to optimize the pre-ionization. Another example is the ICRF wall conditioning (ICWC), which was routinely applied during the shot to shot interval. The plasma operation window has been extended in terms of plasma beta and stability boundary. The achievement of high confinement mode was made in the last campaign with the first neutral beam injector and good wall conditioning. Plasma control has been applied in shape and position control and now a preliminary kinetic control scheme is being applied including plasma current and density. Advanced control schemes will be developed and tested in future operations including active profiles, heating and current drives and control coil-driven magnetic perturbation.

Kwon, M↗
DOE OSTI2026

A non-intrusive framework using acoustic signals and deep learning for boiling diagnostics in visual-limited environments

Accurate monitoring of boiling heat transfer is critical for safeguarding high-power systems operating in environments where conventional optical diagnostics are hindered by radiation fields or restricted visual accessibility. This study presents a non-intrusive framework that integrates hydroacoustic sensing with deep learning to infer near-wall boiling characteristics and enable predictive thermal assessment without visual access. In a prototypical subcooled flow-boiling facility representative of the Isotope Production Facility (IPF) at Los Alamos, hydrophones capture boiling-induced acoustic emissions that are transformed into background-removed Short-Time Fourier Transform (STFT) spectrograms. A convolutional neural network (CNN) then regresses heat flux, wall superheat, and key bubble parameters directly from these spectrograms. The CNN achieved predictive accuracy under nominal conditions and demonstrated robustness and generalization under acoustic noise for Signal-to-Noise Ratios (SNRs) down to approximately 0 dB. When integrated into an ANSYS CFX wall-boiling model, the acoustically inferred parameters reproduced boiling curve and critical heat flux (CHF) values consistent with image-based benchmarks. Furthermore, the model retained reliable performance under moderate variations in bulk temperature, flow rate, and hydrophone placement, confirming its generalizability across practical boundary conditions. These results demonstrate the feasibility of hydroacoustic-based deep learning as a viable path toward real-time, radiation-tolerant boiling diagnostics and predictive thermal safety assessment in inaccessible systems such as the IPF.

42 ENGINEERING↗
DOE OSTI2025

Enhanced Laser-Induced Graphene Microfluidic Integrated Sensors (LIGMIS) for On-Site Biomedical and Environmental Monitoring

The convergence of microfluidic and electrochemical biosensor technologies offers significant potential for rapid, in-field diagnostics in biomedical and environmental applications. Traditional systems face challenges in cost, scalability, and operational complexity, especially in remote settings. Addressing these issues, laser-induced graphene microfluidic integrated sensors (LIGMIS) are presented as an innovative platform that integrates microfluidics and electrochemical sensors both comprised of laser-induced graphene. This study advances the LIGMIS concept by resolving issues of uneven fluid transport, increased hydrophobicity during storage, and sensor biofunctionalization challenges. Key innovations include Y-shaped reservoirs for consistent fluid flow, hydrophilic polyethyleneimine coatings to maintain wettability, and separable microfluidic and electrochemical components enabling isolated electrode nanoparticle metallization and biofunctionalization. Multiplexed electrochemical detection of the neonicotinoid imidacloprid and nitrate ions in environmental water samples yields detection limits of 707 nm and 10 -5.4 m with wide sensing ranges of 5–100 µm and 10 -5 –10 -1 m, respectively. Similarly, uric acid and calcium ions are detected in saliva, demonstrating detection limits of 217 nm and 10 -5.3 m with sensing ranges of 10–50 µm, and 10 -5 –10 -2.5 m, respectively. Overall, this biosensing demonstrates the capability of the LIGMIS platform for multiplexed detection in biologically complex solutions, with applications in environmental water quality monitoring and oral cancer screening.

environmental monitoring↗