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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,225 records · Page 68
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of these proteins, Acidic Mammalian Chitinase (AMCase), is an enzyme known for its ability to function under acidic conditions in the stomach but is also active in tissues with more neutral pHs, such as the lung. Here, we used a combination of biochemical, structural, and computational modeling approaches to examine how the mouse homolog (mAMCase) can act in both acidic and neutral environments. We measured kinetic properties of mAMCase activity across a broad pH range, quantifying its unusual dual activity optima at pH 2 and 7. We also solved high-resolution crystal structures of mAMCase in complex with oligomeric GlcNAcn, the building block of chitin, where we identified extensive conformational ligand heterogeneity. Leveraging these data, we conducted molecular dynamics simulations that suggest how a key catalytic residue could be protonated via distinct mechanisms in each of the two environmental pH ranges. These results integrate structural, biochemical, and computational approaches to deliver a more complete understanding of the catalytic mechanism governing mAMCase activity at different pH. Engineering proteins with tunable pH optima may provide new opportunities to develop improved enzyme variants, including AMCase, for therapeutic purposes in chitin degradation.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1966

Function generator eliminates necessity of series summation

Diode generator using four building-block circuits produces complex waveforms without the necessity of series summation. This highly specialized method of producing complex waveforms requires less power than present methods and uses simpler circuitry.

Callan, J. D.↗
NASA NTRS1971

Data sampling system for monitor and control station

System design is based on development of standardized, interchangeable modules that minimize power dissipation, interconnecting cables and size. Maximum flexibility is achieved by using building block approach where all data modules are identical and are connected at any remote location and addressed in random fashion from central unit.

Source record↗
NASA NTRS1972

Formulation of an effective safety design review for the Skylab Program.

The Skylab Program is presenting a unique set of requirements by extending the capabilities of both men and equipment to withstand extended periods of time in space. The progression of space programs which preceded Skylab have provided a set of building blocks of knowledge and experience coupled with an extensive ground test program which makes it possible to plan its flight program without earlier, unmanned test flights. This approach, however, makes it mandatory that to the maximum extent possible, we factor into the design review process all the 'lessons learned' which are applicable. It is this conscious review of the Skylab design, based on checklists prepared from design criteria, gleaned from a variety of sources and experiences, which is the subject of this paper. A brief description of the Skylab Program, its objectives, and the missions planned for it are presented briefly to better understand the degree of extrapolation of hardware development from previous programs.

Cohen, H.↗
NASA NTRS1972

A translator and simulator for the Burroughs D machine

The D Machine is described as a small user microprogrammable computer designed to be a versatile building block for such diverse functions as: disk file controllers, I/O controllers, and emulators. TRANSLANG is an ALGOL-like language, which allows D Machine users to write microprograms in an English-like format as opposed to creating binary bit pattern maps. The TRANSLANG translator parses TRANSLANG programs into D Machine microinstruction bit patterns which can be executed on the D Machine simulator. In addition to simulation and translation, the two programs also offer several debugging tools, such as: a full set of diagnostic error messages, register dumps, simulated memory dumps, traces on instructions and groups of instructions, and breakpoints.

Roberts, J.↗
NASA NTRS1972

Earth resources data analysis system

The Earth Resources Laboratory Data Analysis System provides a valuable research tool in the evaluation of multispectral, radiometric, photographic, and passive microwave imagery data. The system has been in operational use for several months and has performed quite well. Emphasis on versatility of both the hardware and software design facilitates system expansion to many specialized data analysis tasks. The many independent software handlers provide building blocks for major processing programs.

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NASA NTRS1972

Concept for a high voltage solar array with integral power conditioning.

Description of a general case solution that synthesizes a high voltage solar array system from a switchable building block concept which makes possible system optimization for specific load requirements. A specific optimized solution is demonstrated, with performance estimates relating array area, weight, and power. Significant technology problems peculiar to a high-voltage switchable solar array design are discussed, along with special requirements anticipated during a hardware development effort.

Wiener, P.↗
NASA NTRS1972

Solar array cost reductions.

There is great interest in reducing the cost of solar arrays, which will continue to be the prime power source for unmanned spacecraft for some time. The cost of solar power systems over the last decade, and means by which cost reductions may be achieved in the future are discussed. It is shown that the total system cost index is a function of solar array area, and that cost decreases as production of solar arrays goes up. This effect can be exploited more than has been done in the past by making common building blocks from which a variety of arrays can be assembled.

Bernatowicz, D. T.↗
NASA NTRS1973

Spacecraft systems design trade-offs for the Earth Resources Technology Satellite.

The Earth Resources Technology Satellite Program's use of flight proven hardware in the design of a satellite for earth sensor payload support and data handling is discussed. The use of an existing satellite as the building block around which additional support systems such as the orbit adjust system, the redundant wideband telemetry systems, the second regulated power system, and the quad redundant command system is analyzed. System performance seen in orbit vs design objectives are discussed to point up the success of the design approach chosen. Also discussed are the schedule and cost benefits derived from the use of previously developed hardware with additional subsystems as required to meet program requirements.

Branchflower, G. A.↗
NASA NTRS1973

A review of the technology of noncontacting systems

Advanced components are the fundamental building blocks of advanced systems and spacecraft. Non-contacting elements, including magnetic bearings, brushless and ironless armature motors, rotary transformers and encoders, are discussed. Most of the information presented in this paper has been generated from a continuing program of component development. The aim of this paper is to identify some of the important design features and provide a perspective on the state of development reached to date.

Studer, P. A.↗
NASA NTRS1974

Updated optical read/write memory system components

A survey of the building blocks of the electro-optic read/write system was made. Critical areas and alternate paths are discussed. The latest PLZT block data composer is analyzed. Stricter controls in the production and fabrication of PLZT are implied by the performance of the BDC. A reverse charge before erase has eliminated several problems observed in the parallel plane charging process for photoconductor-thermoplastic hologram storage.

Source record↗
NASA NTRS1974

FEP-Teflon covered solar cell array advancements

Progress is reported on the design and development of lightweight, flexible, FEP encapsulated solar cell modules. Such modules are intended to form standardized building blocks for larger roll-up or fold-up solar cell blankets having specific performance in the order of 100 W/sq m and 80 W/kg in space near earth. Modules are constructed by heat-laminating interconnected 200-micron thick single crystal silicon solar cells with solderless front and back contacts between two layers of clear FEP. The outer FEP layer is 125 microns thick and serves as the solar cell cover material. The inner layer is 50 microns thick and serves as the adhesive between the solar cells and a 25-micron thick loadbearing Kapton substrate sheet.

Rauschenbach, H. S.↗
NASA NTRS1974

A strapdown laser gyro navigator

A broad spectrum of commercial and military vehicles employ some form of inertial measurement equipment. In general this equipment has a special purpose in that it was tailored for each specific application thereby resulting in high installation and maintenance costs. Recently the emphasis has been directed toward developing low cost building blocks from which the desired inertial functions can be derived. This paper describes a National Aeronautics and Space Administration (NASA) program that combines inertial system sensor and computational advances into a flight demonstration configuration. Specifically, an inertial navigation system employing strapdown laser gyro angular rate sensors and a miniature, modular digital flight computer is described. The objective of this program is to demonstrate, via flight test evaluation, the capabilities of the advanced sensor and computer as they apply to future low cost, high reliability inertial system applications.

Garret, H.↗
NASA NTRS1974

Life on Jupiter

The possibilities of life on Jupiter are discussed from the point view of life as known on earth. That is, it is assumed that any life on Jupiter would not involve new principles foreign to us. Proteins would be a constituent as would fats and the other building blocks of living organisms on earth. This leads to a set of limiting parameters, such as pressure. Studies in the laboratory have shown that proteins and other essential molecules are denatured by pressures of 4000 atm and higher. Thus, life cannot be expected to exist in the great depths of the Jovian atmosphere. It could exist only at depths of several hundred kilometers in the atmosphere. Since no solid surface could possibly exist at such altitudes, any organisms present must be small enough to be buoyed up by the turbulent atmospheric currents or must fly or both. Such possibilities, however, seem to be real. The necessary nutrients to preserve life and foster growth could be furnished by the Miller-Urey type reactions of ionizing radiation on the reducing atmosphere undoubtedly present.

Libby, W. F.↗
NASA NTRS1959

Preliminary Study of Capsule Recovery for the First Series of Project Mercury Orbital Flights

This report contains the results of a preliminary study of the search and. recovery operations required. for the safe and. expeditious return of the Mercury Recovery Capsule in the first series of orbital flights. The study is concerned primarily with the high-probability impact areas in the Atlantic Ocean. Emphasis is placed on safe recovery within reasonable time at least cost. A preliminary study of this nature is not able to provide final answers to all of the problems; the report instead constitutes a "first look" at the overall operation. Much of the report is therefore devoted to basic data, the building blocks from which recovery systems can be assembled and evaluated. These include the performance characteristics, reliability, and cost of the vehicles and equipment which may be used, and their compatibility with one another, with the capsule, and with the expected environment. The availability of vehicles and equipment has also been considered., although it is appreciated. that this may change from week to week where the forces are drawn from the military services. consideration of alternative vehicles, equipments, and systems, and their evaluation from the standpoint of effectiveness and. cost. While the equipment considered. is generally expected to be operational throughout 1960, consideration is also given to more advanced schemes which might effect reductions in recovery time, cost, or dependence upon the military forces.

Source record↗
NASA NTRS1974

Unmanned solar systems exploration - An arena for international cooperation

Mission profiles for a Mars Surface Sample Return (MSSR) mission are considered. A profile using separate launches for a lander/ascent module and an orbiter/return system could use present technology and is appropriate for international cooperation. The achievement of clean interfaces between major building blocks and ease of controlling back contamination are advantages offered by the concept. A spatially distributed surface sample could be obtained by using multiple landers delivering samples to a common orbiter. The Pioneer Venus program, originally planned as a cooperative NASA-ESRO project, resulted in development of a standardized spacecraft bus yielding benefits at minimized cost. The first joint US-European planetary mission now planned is the launch of a Pioneer class orbiter to Jupiter in 1980. Feasibility studies are being conducted.

Herman, D. H.↗