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At least 1,207 records · Page 67

Mind the Gap: Exploring the Underground of the NASA Space Cancer Risk Model

The REID quantifies the lifetime risk of death from radiation-induced cancer in an exposed astronaut. The NASA Space Cancer Risk (NSCR) 2012 mode incorporates elements from physics, biology, epidemiology, and statistics to generate the REID distribution. The current model quantifies the space radiation environment, radiation quality, and dose-rate effects to estimate a NASA-weighted dose. This weighted dose is mapped to the excess risk of radiation-induced cancer mortality from acute exposures to gamma rays and then transferred to an astronaut population. Finally, the REID is determined by integrating this risk over the individual's lifetime. The calculated upper 95% confidence limit of the REID is used to restrict an astronaut's permissible mission duration (PMD) for a proposed mission. As a statistical quantity characterized by broad, subjective uncertainties, REID estimates for space missions result in wide distributions. Currently, the upper 95% confidence level is over 350% larger than the mean REID value, which can severely limit an astronaut's PMD. The model incorporates inputs from multiple scientific disciplines in the risk estimation process. Physics and particle transport models calculate how radiation moves through space, penetrates spacecraft, and makes its way to the human beings onboard. Epidemiological studies of exposures from atomic bombings, medical treatments, and power plants are used to quantify health risks from acute and chronic low linear energy transfer (LET) ionizing radiation. Biological studies in cellular and animal models using radiation at various LETs and energies inform quality metrics for ions present in space radiation. Statistical methodologies unite these elements, controlling for mathematical and scientific uncertainty and variability. Despite current progress, these research platforms contain knowledge gaps contributing to the large uncertainties still present in the model. The NASA Space Radiation Program Element (SRPE) defines the knowledge gaps that impact our understanding of the cancer risks. These gaps are outlined in NASA's Human Research Roadmap [4], which identifies the research questions and actions recommended for reducing the uncertainty in the current NSCR model and for formulation of future models. The greatest contributors to uncertainty in the current model include radiation quality, dose rate effects, and the transfer of exposure-based risk from other populations to an astronaut population. Future formulations of the risk model may benefit from including other potential sources of uncertainty such as space dosimetry, errors in human epidemiology data, and the impact of microgravity and other spaceflight stressors. Here, we discuss the current capabilities of the NSCR-2012 model and several immediate research needs, highlighting areas expected to have an operational impact on the current model schema. The following subway-style route map outlines the NSCR-2012 model (Green Line), emphasizing the research gaps in the Human Research Roadmap for risk of radiation-induced carcinogenesis (Stops on Dashed Lines). The map diagrams how these research gaps feed specific portions of the model.

Chappell, L. J.↗

Modeling the Risk of U.S. Offshore Oil & Gas Exploration-Well Drilling, Commercial Nuclear Plants, and Human Spaceflight

Nuclear power, offshore oil & gas exploration, and human spaceflight all have high consequence potential if something goes wrong. Each has had at least one major incident that pointed to a need for improved risk assessment. Careful risk analysis is very important for technologies having complexity, uncertainty, and high consequence potential. All rely on multiple barriers/controls/redundancy to minimize risk. NRC (Nuclear Regulatory Commission) has moved towards risk informed regulation with Probabilistic Risk Assessment (PRA) as a major input.

PRA↗

Benchmarking and Exploring Parameter Space of the 2-Phase Bubble Tracking Model for Liquid Mercury Target Simulation

High intensity proton pulses strike the Spallation Neutron Source (SNS)’s mercury target to provide bright neutron beams. These strikes deposit extensive energy into the mercury and its steel vessel. Prediction of the resultant loading on the target is difficult when helium gas is intentionally injected into the mercury to reduce the loading and to mitigate the pitting damage on the vessel. A 2-phase material model that incorporates the Rayleigh-Plesset (R-P) model is expected to address this complex multi-physics dynamics problem by including the bubble dynamics in the liquid mercury. We present a study comparing the measured target strains in the SNS target station with the simulation results of the solid mechanics simulation framework. We investigate a wide range of various physical model parameters, including the number of bubble families, bubble size distribution, viscosity, surface tension, etc. to understand their impact on simulation accuracy. Our initial findings reveal that using 8-10 bubble families in the model renders a simulation strain envelope that covers the experimental ones. Further optimization studies are planned to predict the strain response more accurately.

Lin, Lianshan↗

Low- ν method with LHC neutrinos

The Forward Physics Facility (FPF) plans to use neutrinos produced at the Large Hadron Collider to make a variety of measurements at previously unexplored TeV energies. Its primary goals include precision measurements of the neutrino cross section and using the measured neutrino flux both to uncover information about far-forward hadron production and to search for various beyond standard model scenarios. However, these goals have the potential to conflict: Extracting information about the flux or cross section relies upon an assumption about the other. In this paper, we demonstrate that the FPF can use the low- ν method—a technique for constraining the flux shape by isolating neutrino interactions with low energy transfer to the nucleus—to break this degeneracy. We show that the low- ν method is effective for extracting the ν μ flux shape, in a model-independent way. We discuss its application for extracting the ν ¯ μ flux shape but find that this is significantly more model dependent. Finally, we explore the precision to which the ν μ flux shape could be constrained at the FPF for a variety of proposed detector options. We find that the precision would be sufficient to discriminate between various realistic flux models. Published by the American Physical Society 2024

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Microlensing and the structure of active galactic nucleus accretion disks

Rapid variability has been reported in two of the four gravitationally lensed images of Q2237 + 0305, and this is attributed to microlensing caused by the intervening stars. The associated constraints on the source size and properties are studied and compared with a variety of stationary accretion disk models. The reported microlensing variation in Q2237 + 0305 requires the disk size to be over 3 times smaller than a blackbody disk of similar luminosity, implying that the optical emission is either nonthermal or optically tin. An exploration of nonstationary disk models including orbiting, transient hot spots leads to a similar conclusion. Implications for models of active galactic nucleus optical continua are briefly discussed.

Rauch, Kevin P.↗

Advances in Scientific Balloon Thermal Modeling

The National Aeronautics and Space Administration's Balloon Program office has long acknowledged that the accurate modeling of balloon performance and flight prediction is dependant on how well the balloon is thermally modeled. This ongoing effort is focused on developing accurate balloon thermal models that can be used to quickly predict balloon temperatures and balloon performance. The ability to model parametric changes is also a driver for this effort. This paper will present the most recent advances made in this area. This research effort continues to utilize the "Thrmal Desktop" addition to AUTO CAD for the modeling. Recent advances have been made by using this analytical tool. A number of analyses have been completed to test the applicability of this tool to the problem with very positive results. Progressively detailed models have been developed to explore the capabilities of the tool as well as to provide guidance in model formulation. A number of parametric studies have been completed. These studies have varied the shape of the structure, material properties, environmental inputs, and model geometry. These studies have concentrated on spherical "proxy models" for the initial development stages and then to transition to the natural shaped zero pressure and super pressure balloons. An assessment of required model resolution has also been determined. Model solutions have been cross checked with known solutions via hand calculations. The comparison of these cases will also be presented. One goal is to develop analysis guidelines and an approach for modeling balloons for both simple first order estimates and detailed full models. This papa presents the step by step advances made as part of this effort, capabilities, limitations, and the lessons learned. Also presented are the plans for further thermal modeling work.

Bohaboj, T.↗

Twenty‐First Century Drought Projections in the CMIP6 Forcing Scenarios

There is strong evidence climate change will increase drought risk and severity, but these conclusions depend on the regions, seasons, and drought metrics being considered. We analyze changes in drought across the hydrologic cycle (precipitation, soil moisture, and runoff) in projections from Phase Six of the Coupled Model Intercomparison Project (CMIP6). The multi‐model ensemble shows robust drying in the mean state across many regions and metrics by the end of the 21st century, even following the more aggressive mitigation pathways (SSP1‐2.6 and SSP2‐4.5). Regional hotspots with strong drying include western North America, Central America, Europe and the Mediterranean, the Amazon, southern Africa, China, Southeast Asia, and Australia. Compared to SSP3‐7.0 and SSP5‐8.5, however, the severity of drying in the lower warming scenarios is substantially reduced and further precipitation declines in many regions are avoided. Along with drying in the mean state, the risk of the historically most extreme drought events also increases with warming, by 200–300% in some regions. Soil moisture and runoff drying in CMIP6 is more robust, spatially extensive, and severe than precipitation, indicating an important role for other temperature‐sensitive drought processes, including evapotranspiration and snow. Given the similarity in drought responses between CMIP5 and CMIP6, we speculate both generations of models are subject to similar uncertainties, including vegetation processes, model representations of precipitation, and the degree to which model responses to warming are consistent with observations. These topics should be further explored to evaluate whether CMIP6 models offer reasons to have increased confidence in drought projections.

drought↗

Gravothermal collapse and the diversity of galactic rotation curves

The rotation curves of spiral galaxies exhibit a great diversity that challenges our understanding of galaxy formation and the nature of dark matter. Previous studies showed that in self-interacting dark matter (SIDM) models with a cross section per unit mass of σ/m ≈ $\mathscr{O}$(1) cm 2 /g, the predicted dark matter central densities are a good match to the observed densities in galaxies. Here, in this work, we explore a regime with a larger cross section of σ/m ≈ 20−40 cm 2 /g in dwarf galactic halos. We will show that such strong dark matter self-interactions can further amplify the diversity of halo densities inherited from their assembly history. High concentration halos can enter the gravothermal collapse phase within 10 Gyr, resulting in a high density, while low concentration ones remain in the expansion phase and have a low density. We fit the rotation curves of 14 representative low surface brightness galaxies and demonstrate how the large range of observed central densities is naturally accommodated in the strong SIDM regime of σ/m ≈ 20 – 40 cm 2 /g. Galaxies that are outliers in the previous studies, due to their high halo central densities, are no longer outliers in this SIDM regime as their halos would be in the collapse phase. For galaxies with a low density, the SIDM fits are robust to the variation of the cross section. Our findings open up a new window for testing gravothermal collapse, the unique signature of strong dark matter self-interactions, and exploring a broader SIDM model space. As an example, we illustrate how the larger cross sections favored by our fits, together with upper limits from strong lensing observations in clusters, pick out the preferred SIDM model space for a dark matter particle coupled to a light gauge boson in the Born regime.

dark matter↗

UNNT: A novel Utility for comparing Neural Net and Tree-based models

The use of deep learning (DL) is steadily gaining traction in scientific challenges such as cancer research. Advances in enhanced data generation, machine learning algorithms, and compute infrastructure have led to an acceleration in the use of deep learning in various domains of cancer research such as drug response problems. In our study, we explored tree-based models to improve the accuracy of a single drug response model and demonstrate that tree-based models such as XGBoost (eXtreme Gradient Boosting) have advantages over deep learning models, such as a convolutional neural network (CNN), for single drug response problems. However, comparing models is not a trivial task. To make training and comparing CNNs and XGBoost more accessible to users, we developed an open-source library called UNNT (A novel Utility for comparing Neural Net and Tree-based models). The case studies, in this manuscript, focus on cancer drug response datasets however the application can be used on datasets from other domains, such as chemistry.

59 BASIC BIOLOGICAL SCIENCES↗

Higher Surface Ozone Concentrations Over the Chesapeake Bay than Over the Adjacent Land: Observations and Models from the DISCOVER-AQ and CBODAQ Campaigns

Air quality models, such as the Community Multiscale Air Quality (CMAQ) model, indicate decidedly higher ozone near the surface of large interior water bodies, such as the Great Lakes and Chesapeake Bay. In order to test the validity of the model output, we performed surface measurements of ozone (O3) and total reactive nitrogen (NOy) on the 26-m Delaware II NOAA Small Research Vessel experimental (SRVx), deployed in the Chesapeake Bay for 10 daytime cruises in July 2011 as part of NASA's GEO-CAPE CBODAQ oceanographic field campaign in conjunction with NASA's DISCOVER-AQ air quality field campaign. During this 10-day period, the EPA O3 regulatory standard of 75 ppbv averaged over an 8-h period was exceeded four times over water while ground stations in the area only exceeded the standard at most twice. This suggests that on days when the Baltimore/Washington region is in compliance with the EPA standard, air quality over the Chesapeake Bay might exceed the EPA standard. Ozone observations over the bay during the afternoon were consistently 10-20% higher than the closest upwind ground sites during the 10-day campaign; this pattern persisted during good and poor air quality days. A lower boundary layer, reduced cloud cover, slower dry deposition rates, and other lesser mechanisms, contribute to the local maximum of ozone over the Chesapeake Bay. Observations from this campaign were compared to a CMAQ simulation at 1.33 km resolution. The model is able to predict the regional maximum of ozone over the Chesapeake Bay accurately, but NOy concentrations are significantly overestimated. Explanations for the overestimation of NOy in the model simulations are also explored

boundary layer↗

The effects of earth model uncertainty on the inversion of seismic data for seismic source functions

SUMMARY We use Monte Carlo simulations to explore the effects of earth model uncertainty on the estimation of the seismic source time functions that correspond to the six independent components of the point source seismic moment tensor. Specifically, we invert synthetic data using Green’s functions estimated from a suite of earth models that contain stochastic density and seismic wave-speed heterogeneities. We find that the primary effect of earth model uncertainty on the data is that the amplitude of the first-arriving seismic energy is reduced, and that this amplitude reduction is proportional to the magnitude of the stochastic heterogeneities. Also, we find that the amplitude of the estimated seismic source functions can be under- or overestimated, depending on the stochastic earth model used to create the data. This effect is totally unpredictable, meaning that uncertainty in the earth model can lead to unpredictable biases in the amplitude of the estimated seismic source functions.

58 GEOSCIENCES↗

Evaluation of Joint Cyber/Safety Risk in Nuclear Power Systems

This report presents an analysis of the Emergency Core Cooling System (ECCS) for a generic Boiling Water Reactor (BWR)-4 NPP. The Electric Power Research Institute (EPRI) developed Hazards and Consequences Analysis for Digital Systems (HAZCADS) process is applied to the ECCS and its subsystems to identify unsafe control actions (UCAs) which act as possible cyber events of concern. The analysis is performed for two design basis events: Small-break Loss of Coolant Accident (SLOCA) and general transients (TRANS), such as unintended reactor trip. In previous work, HAZCADS UCAs were combined with other cyber-attack analysis to develop a risk-informed approach; however, this was for a single system. This report explores advanced systems engineering modeling approaches to model the interactions between digital assets across multiple systems which may be targeted by cyber adversaries. The complex and interdependent design of digital systems has the potential to introduce emergent cyber properties that are generally not covered by hazard analyses nor formal nuclear Probabilistic Risk Assessment (PRA). The R&D and supporting analysis presented here explores approaches to predict and manage how interdependent system properties effect risk. To show the potential impact of a successful cyber-attack to formal PRA event tree probabilities, HAZCADS analysis was also used. HAZCADS was also used to model the automatic depressurization system (ADS) automatic actuation. This analysis extended to an integrated system analysis for common-cause failure (CCF). In this aspect, the HAZCADS analysis continued by analyzing plant design details for system connectivity in support of critical plant functions. A dependency matrix was developed to depict the integrated functionality of the interconnected systems. Areas of potential CCF are indicated. Future work could include adversary attack development to show how CCF could be caused, resulting in PRA events. Across the multiple systems that comprise the ECCS, the analysis shows that the change in such probabilities was very different between systems. This indicates that some systems have a larger potential risk impact from successful cyber-attack or digital failure, which indicates a need for these systems to have a higher priority for design and defensive measures. Furthermore, we were able to establish that a risk analysis using any arbitrary threat model establishes an ordering of components with regard to cyber-risk. This ordering can be used to influence the overall system design with an eye to lowering risk, or as a way to understand real-time risk to operational systems based on a current threat landscape. Expert knowledge of both the analysis process and the system being analyzed is required to perform a HAZCADS analysis. The need for a tiered risk analysis is demonstrated by the results of this report.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Experimental Observations of the Topology of Convolutional Neural Network Activations

Topological data analysis (TDA) is a branch of computational mathematics, bridging algebraic topology and data science, that provides compact, noise-robust representations of complex structures. Deep neural networks (DNNs) learn millions of parameters associated with a series of transformations defined by the model architecture resulting in high-dimensional, difficult to interpret internal representations of input data. As DNNs become more ubiquitous across multiple sectors of our society, there is increasing recognition that mathematical methods are needed to aid analysts, researchers, and practitioners in understanding and interpreting how these models' internal representations relate to the final classification. In this paper we apply cutting edge techniques from TDA with the goal of gaining insight towards interpretability of convolutional neural networks used for image classification. We use two common TDA approaches to explore several methods for modeling hidden layer activations as high-dimensional point clouds, and provide experimental evidence that these point clouds capture valuable structural information about the model's process. First, we demonstrate that a distance metric based on persistent homology can be used to quantify meaningful differences between layers and discuss these distances in the broader context of existing representational similarity metrics for neural network interpretability. Second, we show that a mapper graph can provide semantic insight as to how these models organize hierarchical class knowledge at each layer. These observations demonstrate that TDA is a useful tool to help deep learning practitioners unlock the hidden structures of their models.

topological data analysis, deep learning↗

Teachers’ Use and Adaptation of A Model-Based Climate Curriculum: A Three-Year Longitudinal Study

Foregrounding climate education in formal science learning environments provides students with opportunities to develop critical climate-related knowledge and skills. However, research has shown many challenges to teaching and learning about Earth’s climate and global climate change (GCC). This longitudinal study aims to establish how secondary science teachers, over time, implement model-based climate curricula in support of students’ climate and GCC education by utilizing EzGCM. The model (EzGCM) is a data-driven, computer-based climate modeling tool use to explore global climate data. Multiple sources of data collection, including teacher interviews, classroom observations, and daily reflections, were employed to address the research question: “How did two teachers’ implementation strategies evolve over the three-year study while utilizing a model-based, climate-focused curriculum?” This study provides insight into how and why these resources [model-based climate education curricula] are utilized in science learning environments, thereby informing ongoing efforts to enhance climate education and, in doing so, preparing the next generation of climate-literate adults prepared to confront this most critical global challenge of our age. The findings showed while both teachers engaged in increasingly model-centric instructional practices, these changes were modest. Furthermore, both teacher’s observed classroom practices were less model-centric than the designed curriculum. Ultimately emphasizing the transition from existing practices to improved ones, rather than seeking the perfect approach, the study offers practical insights that can honestly assist secondary educators in real-world settings by highlighting state of climate education in secondary science classrooms.

Secondary science teaching↗