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At least 1,207 records · Page 67

The anemia of primary autonomic failure and its reversal with recombinant erythropoietin

OBJECTIVE: To determine if chronic sympathetic deprivation is associated with anemia and a low erythropoietin response. DESIGN: Survey of the prevalence and characteristics of anemia in patients with severe primary autonomic failure. SETTING: A referral service for autonomic failure in a tertiary teaching hospital. PATIENTS: 84 patients with primary autonomic failure who had symptomatic orthostatic hypotension. INTERVENTION: Open-label trial with human recombinant erythropoietin. RESULTS: Anemia was present in 32 of 84 patients (38%; 95% Cl, 27% to 50%). Plasma norepinephrine levels, measured in patients standing upright, were lower in the patient group with lower hemoglobin levels. Mean values in 22 patients with a hemoglobin level of less than 120 g/L were as follows: hemoglobin, 108 g/L (range, 87 to 118 g/L); hematocrit, 0.33; corrected reticulocyte counts, 0.008; mean corpuscular volume, 89 fL (89 microns 3); serum iron, 16.5 mumol/L (92 micrograms/dL); total iron binding capacity, 43.3 mumol/L (242 micrograms/dL); ferritin, 184 micrograms/L; serum vitamin B12, 410 pmol/L (556 pg/mL); and serum folate, 22.7 nmol/L (10 ng/mL). No relation was found between serum erythropoietin and blood hemoglobin levels. In seven of nine patients with autonomic failure who had hemoglobin levels less than 120 g/L, serum erythropoietin levels decreased below the 95% confidence interval corresponding to patients with iron deficiency anemia. Therapy with recombinant erythropoietin improved mean hemoglobin levels (from 108 to 133 g/L) in all patients treated (n = 5) at relatively low doses (25 to 50 units/kg body weight, subcutaneously, three times a week). CONCLUSIONS: Our data support the hypothesis that the sympathetic nervous system stimulates erythropoiesis in humans because anemia is a frequent occurrence in patients with severe autonomic failure and is associated with a blunted erythropoietin response.

Clinical Trial↗

A New Global Regression Analysis Method for the Prediction of Wind Tunnel Model Weight Corrections

A new global regression analysis method is discussed that predicts wind tunnel model weight corrections for strain-gage balance loads during a wind tunnel test. The method determines corrections by combining "wind-on" model attitude measurements with least squares estimates of the model weight and center of gravity coordinates that are obtained from "wind-off" data points. The method treats the least squares fit of the model weight separate from the fit of the center of gravity coordinates. Therefore, it performs two fits of "wind- off" data points and uses the least squares estimator of the model weight as an input for the fit of the center of gravity coordinates. Explicit equations for the least squares estimators of the weight and center of gravity coordinates are derived that simplify the implementation of the method in the data system software of a wind tunnel. In addition, recommendations for sets of "wind-off" data points are made that take typical model support system constraints into account. Explicit equations of the confidence intervals on the model weight and center of gravity coordinates and two different error analyses of the model weight prediction are also discussed in the appendices of the paper.

strain-gage balance↗

Increasing Activity in T CrB Suggests Nova Eruption Is Impending

Estimates of the accretion rate in symbiotic recurrent novae (RNe) often fall short of theoretical expectations by orders of magnitude. This apparent discrepancy can be resolved if the accumulation of mass by the white dwarf(WD)is highly sporadic, and most observations are performed during low states. Here we use a re-analysis of archival data from the Digital Access to a Sky Century @Harvard survey to argue that the most recent nova eruption in symbiotic RN T CrB, in 1946, occurred during—and was therefore triggered by—a transient accretion high state. Based on similarities in the optical light curve around 1946 and the time of the prior eruption, in 1866,we suggest that the WD in T CrB accumulates most of the fuel needed to ignite the thermonuclear runaways (TNRs) during accretion high states. A natural origin for such states is dwarf-nova like accretion-disk instabilities, which are expected in the presumably large disks in symbiotic binaries. The timing of the TNRs in symbiotic RNe could thus be set by the stability properties of their accretion disks. T CrB is in the midst of an accretion high state like the ones we posit led to the past two nova eruptions. Combined with the approach of the time at which a TNR would be expected based on the 80 yr interval between the prior two novae (2026 ± 3), the current accretion high state increases the likelihood of a TNR occurring in T CrB in the next few years.

Gerardo J M Luna↗

Multi-resolution processing for fractal analysis of airborne remotely sensed data

Fractal geometry is increasingly becoming a useful tool for modeling natural phenomenon. As an alternative to Euclidean concepts, fractals allow for a more accurate representation of the nature of complexity in natural boundaries and surfaces. Since they are characterized by self-similarity, an ideal fractal surface is scale-independent; i.e. at different scales a fractal surface looks the same. This is not exactly true for natural surfaces. When viewed at different spatial resolutions parts of natural surfaces look alike in a statistical manner and only for a limited range of scales. Images acquired by NASA's Thermal Infrared Multispectral Scanner are used to compute the fractal dimension as a function of spatial resolution. Three methods are used to determine the fractal dimension - Schelberg's line-divider method, the variogram method, and the triangular prism method. A description of these methods and the results of applying these methods to a remotely-sensed image is also presented. Five flights were flown in succession at altitudes of 2 km (low), 6 km (mid), 12 km (high), and then back again at 6 km and 2 km. The area selected was the Ross Barnett reservoir near Jackson, Mississippi. The mission was flown during the predawn hours of 1 Feb. 1992. Radiosonde data was collected for that duration to profile the characteristics of the atmosphere. This corresponds to 3 different pixel sizes - 5m, 15m, and 30m. After, simulating different spatial sampling intervals within the same image for each of the 3 image sets, the results are cross-correlated to compare the extent of detail and complexity that is obtained when data is taken at lower spatial intervals.

Jaggi, S.↗

Determining structure in molecular clouds

We descibe an automatic, objective routine for analyzing the clumpy structure in a spectral line position-position-velocity data cube. The algorithm works by first contouring the data at a multiple of the rms noise of the observations, then searches for peaks of emission which locate the clumps, and then follows them down to lower intensities. No a proiri clump profile is assumed. By creating simulated data, we test the performance of the algorithm and show that a contour map most accurately depicts internal structure at a contouring interval equal to twice the rms noise of the map. Blending of clump emission leads to small errors in mass and size determinations and in severe cases can result in a number of clumps being misidentified as a single unit, flattening the measured clump mass spectrum. The algorithm is applied to two real data sets as an example of its use. The Rosette molecular cloud is a 'typical' star-forming cloud, but in the Maddalena molecular cloud high-mass star formation is completely absent. Comparison of the two clump lists generated by the algorithm show that on a one-to-one basis the clumps in the star-forming cloud have higher peak temperatures, higher average densities, and are more gravitationally bound than in the non-star-forming cloud. Collective properties of the clumps, such as temperature-size-line-width-mass relations appear very similar, however. Contrary to the initial results reported in a previous paper (Williams & Blitz 1993), we find that the current, more thoroughly tes ted analysis finds no significant difference in the clump mass spectrum of the two clouds.

Williams, Jonathan P.↗

The Meteoritic Component in Impact Deposits

This proposal requested support for a broad-based research program designed to understand the chemical and mineralogical record of accretion of extraterrestrial matter to the Earth. The primary goal of this research is to study the accretion history of the Earth, to understand how this accretion history reflects the long-term flux of comets, asteroids, and dust in the inner solar system and how this flux is related to the geological and biological history of the Earth. This goal is approached by seeking out the most significant projects that can be attacked utilizing the expertise of the PI and potential collaborators. The greatest expertise of the PI is the analysis of meteoritic components in terrestrial sediments. This proposal identifies three primary areas of research, involving impact events in the early Archean (3.2 Ga), the late Eocene (35 Ma) and the late Pliocene (2 Ma). In the early Archean we investigate sediments that contain the oldest recorded impacts on Earth. These are thick spherule beds, three of which were deposited within 20 m.y. If these are impact deposits the flux of objects to Earth at this time was much greater than predicted by current models. Earlier work used Cr isotopes to prove that one of these contain extraterrestrial matter, from a projectile with Cr isotopes similar to CV chondrites. We planned to expand this work to other spherule beds and to search for additional evidence of other impact events. With samples from D. Lowe (Stanford Univ.) the PI proposed to screen samples for high Ir and Cr so that appropriate samples can be provided to A. Shukolyukov for Cr-isotopic analyses. This work was expected to provide evidence that at least one interval in the early Archean was a period of intense bombardment and to characterize the composition of objects accreted. The late Eocene is also a period of intense bombardment with multiple spherule deposits and two large craters. Farley et al. (1998) demonstrated an increased (3)He flux to marine sediments that was attributed to an increase in interplanetary dust due to a shower of comets invading the inner solar system. We planned to detect a change in the Cr-isotopic composition in the flux of fine-grained extraterrestrial matter to ocean sediments. This would provide evidence for the comet shower hypothesis. We planned attempt to locate late Eocene impact deposits in a new high resolution, hi-latitude site that had the potential for excellent preservation and new information of the sources and effects of these impacts. Although most impacts on Earth occur in deep-ocean basins, only one such event is known - the late Pliocene impact of the Eltanin asteroid. The ejecta from this impact includes Ir- rich impact melt, spherules, and actual meteorites from the km-sized mesosiderite asteroid. Through a study of the ejecta, we can learn about the formation, distribution, alteration and preservation of Ir-rich deposits. We can also learn about meteorite survival during hypervelocity impacts and we can study pieces of a km-sized object to learn more about the mesosiderite parent body. Analyses of sediment cores and geophysical exploration of the impact site can further our understanding of the processes involved in deep-ocean impacts and potential effects on the terrestrial climate and biosphere. We planned analyses of this ejecta, a search for ejecta 5000 km distant from the impact area, and a new oceanographic expedition to study and sample the impact site. In addition to these three specific areas of research, the PI planned to remain flexible and available to exploit new opportunities presented by new discoveries, and to engage in new collaborations if other researchers require his expertise to develop new projects that fit within the objectives of the overall research program.

Kyte, Frank T.↗

Broad-Band Measurements of Cen X-3 With XTE and CGRO

Centaurus X-3 has played a key role in the development of our understanding of galactic x-ray binary sources. Timing analysis of the UHURU x-ray observations for the luminous Cen X-3 source (L approximately 10(exp 38) erg/s) revealed the first evidence for coherent x-ray pulsations from an object in a binary system (Giaconni 1971; Schreier 1972). It was quickly understood that the luminous pulsed x-ray emission could be generated by the accretion of matter from a companion star onto a rotating neutron star and led to the adoption of binary star models as the fundamental model for galactic x-ray sources (e.g. Pringle and Rees 1972; Lamb 1973). Based on modeling and refined observations since the original measurements, we now believe that Cen X-3 is a high mass x-ray binary system that contains a disk-fed pulsar with a period of 4.84 seconds that is in a 2.087 day orbit around an O-star companion. Since the pulsar discovery, its period has been intermittently monitored and those studies show a long term spin-up of the pulsar punctuated by short intervals of spin-down (e.g. Finger 1994). The implied torques are thought to originate from the interaction of an accretion disk with the magnetic field of a neutron star (Ghosh and Lamb 1979).

Vestrand, W. Thomas↗

The 2004 Hyperflare from SGR 1806-20: Further Evidence for Global Torsional Vibrations

We report an analysis of the archival Rossi X-ray Timing Explorer (RXTE) data from the December 2004 hyperflare from SGR 1806-20. In addition to the approx. equal to 90 Hz QPO first discovered by Israel et al., we report the detection of higher frequency oscillations at approx. equal to 150, 625, and 1,835 Hz. In addition to these frequencies there are indications of oscillations at approx. equal to 720, and 2,384 Hz, but with lower significances. The 150 Hz QPO has a width (FWHM) of about 17 Hz, an average amplitude (rms) of 6.5%, and is detected in average power spectra centered on the rotational phase of the strongest peak in the pulse profile. This is approximately half a rotational cycle from the phase at which the 90 Hz QPO is strongly detected. The 625 Hz oscillation was first detected in an average power spectrum from nine successive cycles beginning approximately 180 s after the initial hard spike. It has a width (FWHM) of approx. equal to 2 Hz and an average amplitude (rms) during this interval of 9%. We find a strong detection of the 625 Hz oscillation in a pair of successive rotation cycles beginning about 230 s after the start of the flare. In these cycles we also detect the 1,835 Hz QPO with the 625 Hz oscillation. The rotational phase in which the 625 Hz &PO is detected is similar to that for the 90 Hz QPO, indeed, this feature is seen in the same average power spectrum. During the time the 625 Hz QPO is detected we also confirm the simultaneous presence of 30 and 92 Hz QPOs, first reported by Israel et al. The centroid frequency of the 625 Hz QPO detected with RXTE is within 1 Hz of the M 626 Hz oscillation recently found in RHESSI data from this hyperflare by Watts & Strohmayer, however, the two detections were made in different phase and energy intervals. Nevertheless, we argue that the two results likely represent detections of the same oscillation frequency intrinsic to the source, but we comment on some of the difficulties in making direct comparisons between the RXTE and RHESSI measurements

Strohmayer, Tod E.↗

Status of the NASA GMAO Observing System Simulation Experiment

An Observing System Simulation Experiment (OSSE) is a pure modeling study used when actual observations are too expensive or difficult to obtain. OSSEs are valuable tools for determining the potential impact of new observing systems on numerical weather forecasts and for evaluation of data assimilation systems (DAS). An OSSE has been developed at the NASA Global Modeling and Assimilation Office (GMAO, Errico et al 2013). The GMAO OSSE uses a 13-month integration of the European Centre for Medium- Range Weather Forecasts 2005 operational model at T511/L91 resolution for the Nature Run (NR). Synthetic observations have been updated so that they are based on real observations during the summer of 2013. The emulated observation types include AMSU-A, MHS, IASI, AIRS, and HIRS4 radiance data, GPS-RO, and conventional types including aircraft, rawinsonde, profiler, surface, and satellite winds. The synthetic satellite wind observations are colocated with the NR cloud fields, and the rawinsondes are advected during ascent using the NR wind fields. Data counts for the synthetic observations are matched as closely as possible to real data counts, as shown in Figure 2. Errors are added to the synthetic observations to emulate representativeness and instrument errors. The synthetic errors are calibrated so that the statistics of observation innovation and analysis increments in the OSSE are similar to the same statistics for assimilation of real observations, in an iterative method described by Errico et al (2013). The standard deviations of observation minus forecast (xo-H(xb)) are compared for the OSSE and real data in Figure 3. The synthetic errors include both random, uncorrelated errors, and an additional correlated error component for some observational types. Vertically correlated errors are included for conventional sounding data and GPS-RO, and channel correlated errors are introduced to AIRS and IASI (Figure 4). HIRS, AMSU-A, and MHS have a component of horizontally correlated error. The forecast model used by the GMAO OSSE is the Goddard Earth Observing System Model, Version 5 (GEOS-5) with Gridpoint Statistical Interpolation (GSI) DAS. The model version has been updated to v. 5.13.3, corresponding to the current operational model. Forecasts are run on a cube-sphere grid with 180 points along each edge of the cube (approximately 0.5 degree horizontal resolution) with 72 vertical levels. The DAS is cycled at 6-hour intervals, with 240 hour forecasts launched daily at 0000 UTC. Evaluation of the forecasting skill for July and August is currently underway. Prior versions of the GMAO OSSE have been found to have greater forecasting skill than real world forecasts. It is anticipated that similar forecast skill will be found in the updated OSSE.

OSSE↗

Prototype development and test results of a continuous ambient air monitoring system for hydrazine at the 10 ppb level

A Hydrazine Vapor Area Monitor (HVAM) system is currently being field tested as a detector for the presence of hydrazine in ambient air. The MDA/Polymetron Hydrazine Analyzer has been incorporated within the HVAM system as the core detector. This analyzer is a three-electrode liquid analyzer typically used in boiler feed water applications. The HVAM system incorporates a dual-phase sample collection/transport method which simultaneously pulls ambient air samples containing hydrazine and a very dilute sulfuric acid solution (0.0001 M) down a length of 1/4 inch outside diameter (OD) tubing from a remote site to the analyzer. The hydrazine-laden dilute acid stream is separated from the air and the pH is adjusted by addition of a dilute caustic solution to a pH greater than 10.2 prior to analysis. Both the dilute acid and caustic used by the HVAM are continuously generated during system operation on an "as needed" basis by mixing a metered amount of concentrated acid/base with dilution water. All of the waste water generated by the analyzer is purified for reuse by Barnstead ion-exchange cartridges so that the entire system minimizes the generation of waste materials. The pumping of all liquid streams and mixing of the caustic solution and dilution water with the incoming sample are done by a single pump motor fitted with the appropriate mix of peristaltic pump heads. The signal to noise (S/N) ratio of the analyzer has been enhanced by adding a stirrer in the MDA liquid cell to provide mixing normally generated by the high liquid flow rate designed by the manufacturer. An onboard microprocessor continuously monitors liquid levels, sample vacuum, and liquid leak sensors, as well as handles communications and other system functions (such as shut down should system malfunctions or errors occur). The overall system response of the HVAM can be automatically checked at regular intervals by measuring the analyzer response to a metered amount of calibration standard injected into the dilute acid stream. The HVAM system provides two measurement ranges (threshold limit value (TLV): 10 to 1000 parts per billion (ppb)/LEAK: 100 ppb to 10 parts per million (ppm)). The LEAK range is created by dilution of the sulfuric acid/hydrazine liquid sample with pure water. This dual range capability permits the analyzer to quantify ambient air samples whose hydrazine concentrations range from 10 ppb to as high as 10 ppm. The laboratory and field prototypes have demonstrated total system response times on the order of 10 to 12 minutes for samples ranging from 10 to 900 ppb in the lLV mode and is greater than 2 minutes for samples ranging from 100 to 1300 ppb in the LEAK mode. Service intervals of over 3 months have been demonstrated for continuous 24 hour/day, 7 day/week usage. The HVAM is made up of a purged cabinet that contains power supplies, RS422 signal transmission capabilities, a UPS, an on-site warning system, and a Line Replaceable Unit (LRU). The LRU includes all of the liquid flow system, the analyzer, the control/data system microprocessor and assorted flow and liquid-level sensors. The LRU is mounted on a track slide system so it can be serviced inplace or totally removed and quickly exchanged with another calibrated unit, thus minimizing analyzer downtime. Once an LRU is removed from an analyzer enclosure, it can be brought to a laboratory facility for complete calibration and periodic maintenance.

Meneghelli, Barry↗

The TRMM Multi-satellite Precipitation Analysis (TMPA): Quasi-Global Precipitation Estimates at Fine Scales

The TRMM Multi-satellite Precipitation Analysis (TMPA) provides a calibration-based sequential scheme for combining multiple precipitation estimates from satellites, as well as gauge analyses where feasible, at fine scales (0.25 degrees x 0.25 degrees and 3-hourly). It is available both after and in real time, based on calibration by the TRMM Combined Instrument and TRMM Microwave Imager precipitation products, respectively. Only the after-real-time product incorporates gauge data at the present. The data set covers the latitude band 50 degrees N-S for the period 1998 to the delayed present. Early validation results are as follows: The TMPA provides reasonable performance at monthly scales, although it is shown to have precipitation rate dependent low bias due to lack of sensitivity to low precipitation rates in one of the input products (based on AMSU-B). At finer scales the TMPA is successful at approximately reproducing the surface-observation-based histogram of precipitation, as well as reasonably detecting large daily events. The TMPA, however, has lower skill in correctly specifying moderate and light event amounts on short time intervals, in common with other fine-scale estimators. Examples are provided of a flood event and diurnal cycle determination.

Huffman, George J.↗

Optical studies in the holographic ground station

The Holographic Group System (HGS) Facility in rooms 22 & 123, Building 4708 has been developed to provide for ground based research in determining pre-flight parameters and analyzing the results from space experiments. The University of Alabama, Huntsville (UAH) has researched the analysis aspects of the HGS and reports their findings here. Some of the results presented here also occur in the Facility Operating Procedure (FOP), which contains instructions for power up, operation, and powerdown of the Fluid Experiment System (FES) Holographic Ground System (HGS) Test Facility for the purpose of optically recording fluid and/or crystal behavior in a test article during ground based testing through the construction of holograms and recording of videotape. The alignment of the optical bench components, holographic reconstruction and and microscopy alignment sections were also included in the document for continuity even though they are not used until after optical recording of the test article) setup of support subsystems and the Automated Holography System (AHS) computer. The HGS provides optical recording and monitoring during GCEL runs or development testing of potential FES flight hardware or software. This recording/monitoring can be via 70mm holographic film, standard videotape, or digitized images on computer disk. All optical bench functions necessary to construct holograms will be under the control of the AHS personal computer (PC). These include type of exposure, time intervals between exposures, exposure length, film frame identification, film advancement, film platen evacuation and repressurization, light source diffuser introduction, and control of realtime video monitoring. The completed sequence of hologram types (single exposure, diffuse double exposure, etc.) and their time of occurrence can be displayed, printed, or stored on floppy disk posttest for the user.

Workman, Gary L.↗

Probability Bounds Analysis Applied to Multi-Purpose Crew Vehicle Nonlinearity

The Multi-Purpose Crew Vehicle (MPCV) Program Orion vehicle finite element model (FEM) was updated based on a modal test performed by Lockheed Martin. Due to nonlinearity observed in the test results, linear low force level (LL) and high force level (HL) FEMs were developed for use during various Space Launch System (SLS) flight regimes depending on expected forcing levels. Uncertainty models were derived for the combined MPCV and MPCV Stage Adaptor LL and HL Hurty/Craig-Bampton (HCB) components based on the MPCV structural test article Configuration 4 modal test-analysis correlation results. Subsequently, system-level uncertainty quantification analyses were performed using both models for various SLS flight configurations to determine the impact of the nonlinearity on important system metrics. The system metrics included both transfer functions associated with attitude control and dynamic loads associated with aerodynamic buffeting during ascent. In each case, an independent Monte Carlo (MC) analysis was performed, and no attempt was made to combine the results. The Hybrid Parametric Variation (HPV) method was used to develop the LL and HL MPCV HCB uncertainty models. The HPV method provides both parametric and non-parametric components of uncertainty. The non-parametric uncertainty accounts for the difference in model-form between the linearized analytical model and the corresponding linearized component test results in the form of mode shapes and frequencies at that force level. This linear model-form uncertainty is implemented in the HPV method using random matrix theory. However, the HPV uncertainty models developed for the linear LL and HL MPCV components do not account for the nonlinearity in the MPCV. With respect to the linearized models, this nonlinearity is also an uncertainty in model form, but in this case, it must be treated independently as an epistemic uncertainty. It represents a lack of knowledge, in contrast to an aleatory uncertainty due to the randomness of a variable. In the case of an epistemic variable, the true value is unknown, only the interval within which it lies is known. Epistemic uncertainty can be reduced with increased knowledge, while in general, aleatory uncertainty cannot. This work combines the epistemic uncertainty due to the MPCV nonlinearity with the parametric and non-parametric uncertainty within the HPV method using a second order propagation approach. The LL and HL test data is augmented with surrogate test data derived from a nonlinear MPCV representation. The impact of the MPCV nonlinearity on system response statistics is determined using a series of cumulative distribution functions in the form of a horsetail plot, or p-box. This results in an interval of probabilities for a specific response value, or an interval of response values at a specific probability.

Daniel C Kammer↗

Performance characteristics of wind profiling radars

Doppler radars used to measure winds in the troposphere and lower stratosphere for weather analysis and forecasting are lower-sensitivity versions of mesosphere-stratosphere-troposphere radars widely used for research. The term wind profiler is used to denote these radars because measurements of vertical profiles of horizontal and vertical wind are their primary function. It is clear that wind profilers will be in widespread use within five years: procurement of a network of 30 wind profilers is underway. The Wave Propagation Laboratory (WPL) has operated a small research network of radar wind profilers in Colorado for about two and one-half years. The transmitted power and antenna aperture for these radars is given. Data archiving procedures have been in place for about one year, and this data base is used to evaluate the performance of the radars. One of the prime concerns of potential wind profilers users is how often and how long wind measurements are lacking at a given height. Since these outages constitute an important part of the performance of the wind profilers, they are calculated at three radar frequencies, 50-, 405-, and 915-MHz, (wavelengths of 6-, 0.74-, and 0.33-m) at monthly intervals to determine both the number of outages at each frequency and annual variations in outages.

Strauch, R. G.↗

Recent History of Large-Scale Ecosystem Disturbances in North America Derived from the AVHRR Satellite Record

Ecosystem structure and function are strongly impacted by disturbance events, many of which in North America are associated with seasonal temperature extremes, wildfires, and tropical storms. This study was conducted to evaluate patterns in a 19-year record of global satellite observations of vegetation phenology from the Advanced Very High Resolution Radiometer (AVHRR) as a means to characterize major ecosystem disturbance events and regimes. The fraction absorbed of photosynthetically active radiation (FPAR) by vegetation canopies worldwide has been computed at a monthly time interval from 1982 to 2000 and gridded at a spatial resolution of 8-km globally. Potential disturbance events were identified in the FPAR time series by locating anomalously low values (FPAR-LO) that lasted longer than 12 consecutive months at any 8-km pixel. We can find verifiable evidence of numerous disturbance types across North America, including major regional patterns of cold and heat waves, forest fires, tropical storms, and large-scale forest logging. Summed over 19 years, areas potentially influenced by major ecosystem disturbances (one FPAR-LO event over the period 1982-2000) total to more than 766,000 km2. The periods of highest detection frequency were 1987-1989, 1995-1997, and 1999. Sub- continental regions of Alaska and Central Canada had the highest proportion (greater than 90%) of FPAR-LO pixels detected in forests, tundra shrublands, and wetland areas. The Great Lakes region showed the highest proportion (39%) of FPAR-LO pixels detected in cropland areas, whereas the western United States showed the highest proportion (16%) of FPAR-LO pixels detected in grassland areas. Based on this analysis, an historical picture is emerging of periodic droughts and heat waves, possibly coupled with herbivorous insect outbreaks, as among the most important causes of ecosystem disturbance in North America.

Potter, Christopher↗

Application of Modern Design of Experiments to CARS Thermometry in a Model Scramjet Engine

We have applied formal experiment design and analysis to optimize the measurement of temperature in a supersonic combustor at NASA Langley Research Center. We used the coherent anti-Stokes Raman spectroscopy (CARS) technique to map the temperature distribution in the flowfield downstream of an 1160 K, Mach 2 freestream into which supersonic hydrogen fuel is injected at an angle of 30 degrees. CARS thermometry is inherently a single-point measurement technique; it was used to map thc flow by translating the measurement volume through the flowfield. The method known as "Modern Design of Experiments" (MDOE) was used to estimate the data volume required, design the test matrix, perform the experiment and analyze the resulting data. MDOE allowed us to match the volume of data acquired to the precision requirements of the customer. Furthermore, one aspect of MDOE, known as response surface methodology, allowed us to develop precise maps of the flowfield temperature, allowing interpolation between measurement points. An analytic function in two spatial variables was fit to the data from a single measurement plane. Fitting with a Cosine Series Bivariate Function allowed the mean temperature to be mapped with 95% confidence interval half-widths of +/- 30 Kelvin, comfortably meeting the confidence of +/- 50 Kelvin specified prior to performing the experiments. We estimate that applying MDOE to the present experiment saved a factor of 5 in data volume acquired, compared to experiments executed in the traditional manner. Furthermore, the precision requirements could have been met with less than half the data acquired.

Danehy, P. M.↗

Assessment of Precipitation Anomalies in California Using TRMM and MERRA Data

After more than a decade of moderate seasonal deviations from the expected climate, it is easy to forget that California is actually prone to instabilities in precipitation patterns that occur on various scales. Using modern satellite and reanalysis data we reassess certain aspects of the precipitation climate in California from the past three decades. California has a well-pronounced rain season that peaks in December-February. However, the 95% confidence interval around the climatological precipitation during these months imply that deviations on the order of 60% of the expected amounts are very likely during the most important period of the rain season. While these positive and negative anomalies alternate almost every year and tend to cancel each other, severe multi-year declines of precipitation in California seem to appear on decadal scales. The 1986-1994 decline of precipitation was similar to the current one that started in 2011, and is apparent in the reanalysis data. In terms of accumulated deficits of precipitation, that episode was no less severe than the current one. While El Niño (the warm phase of the El Niño Southern Oscillation, ENSO) is frequently cited as the natural forcing expected to bring a relief, our assessment is that ENSO has been driving at best only 6% of precipitation variability in California in the past three decades. It means El Niño needs to be stronger and longer, in order to have a higher likelihood of a positive impact, and the current one does not match these criteria. Using fractional risk analysis of precipitation populations during normal and dry periods, we show that the likelihood of losing the most intensive precipitation events drastically increases during the multi-year drying events. Since storms delivering up to 50% of precipitation in California are driven by atmospheric rivers making landfall, thus the importance of their suppression and blockage by persistent ridges of atmospheric pressure in the northeast Pacific.

Savtchenko, Andrey K.↗

IVGEN Post Flight Analysis

The Intravenous Fluid Generation (IVGEN) Experiment was a technology demonstration experiment that purified ISS potable water, mixed it with salt, and transferred it through a sterilizing filter. On-orbit performance was verified as appropriate and two 1.5 l bags of normal saline solution were returned to earth for post-flight testing by a FDA certified laboratory for compliance with United States Pharmacopiea (USP) standards. Salt concentration deviated from required values and an analysis identified probable causes. Current efforts are focused on Total Organic Content (TOC) testing, and shelf life.The Intravenous Fluid Generation (IVGEN) Experiment demonstrated the purification of ISS potable water, the mixing of the purified water with sodium chloride, and sterilization of the solution via membrane filtration. On-orbit performance was monitored where feasible and two 1.5-liter bags of normal saline solution were returned to earth for post-flight testing by a FDA-registered laboratory for compliance with United States Pharmacopeia (USP)standards [1]. Current efforts have been focused on challenge testing with identified [2] impurities (total organic-carbon), and shelf life testing. The challenge testing flowed known concentrations of contaminants through the IVGEN deionizing cartridge and membrane filters to test their effectiveness. One finding was that the filters and DI-resin themselves contribute to the contaminant load during initial startup, suggesting that the first 100 ml of fluid be discarded. Shelf life testing is ongoing and involves periodic testing of stored DI cartridges and membrane filters that are capped and sealed in hermetic packages. The testing is conducted at six month intervals measuring conductivity and endotoxins in the effluent. Currently, the packaging technique has been successfully demonstrated for one year of storage testing. The USP standards specifies that the TOC be conducted at point of generation as opposed to point of consumption. Samples were generated and shipped to an FDA facility however, testing determined that the samples failed the TOC specification with most likely due to leaching from the sample container. Shelf life testing is examining packaging techniques and periodic testing of samples of DI cartridges that are capped and sealed in hermetic packages. Periodic testing of the purified water output will be conducted at six month intervals.

microgravity applications↗