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NASA NTRS2011

Visual Impairment/Increased Intracranial Pressure (VIIP): Layman's Summary

To date NASA has documented that seven long duration astronauts have experienced in-flight and post-flight changes in vision and eye anatomy including degraded distant vision, swelling of the back of the eye, and changes in the shape of the globe. We have also documented in a few of these astronauts post-flight, increases in the pressure of the fluid that surrounds the brain and spinal cord. This is referred to as increased intracranial pressure (ICP). The functional and anatomical changes have varied in severity and duration. In the post-flight time period, some individuals have experienced a return to a pre-flight level of visual function while others have experienced changes that remain significantly altered compared to pre-flight. In addition, the increased ICP also persists in the post-flight time period. Currently, the underlying cause or causes of these changes is/are unknown but the spaceflight community at NASA suspects that the shift of blood toward the head and the changes in physiology that accompany it, such as increased intracranial pressure, play a significant role.

Fogarty, Jennifer↗
NASA NTRS2011

Spectrally Tailored Pulsed Thulium Fiber Laser System for Broadband Lidar CO2 Sensing

Thulium doped pulsed fiber lasers are capable of meeting the spectral, temporal, efficiency, size and weight demands of defense and civil applications for pulsed lasers in the eye-safe spectral regime due to inherent mechanical stability, compact "all-fiber" master oscillator power amplifier (MOPA) architectures, high beam quality and efficiency. Thulium fiber's longer operating wavelength allows use of larger fiber cores without compromising beam quality, increasing potential single aperture pulse energies. Applications of these lasers include eye-safe laser ranging, frequency conversion to longer or shorter wavelengths for IR countermeasures and sensing applications with otherwise tough to achieve wavelengths and detection of atmospheric species including CO2 and water vapor. Performance of a portable thulium fiber laser system developed for CO2 sensing via a broadband lidar technique with an etalon based sensor will be discussed. The fielded laser operates with approximately 280 J pulse energy in 90-150ns pulses over a tunable 110nm spectral range and has a uniquely tailored broadband spectral output allowing the sensing of multiple CO2 lines simultaneously, simplifying future potentially space based CO2 sensing instruments by reducing the number and complexity of lasers required to carry out high precision sensing missions. Power scaling and future "all fiber" system configurations for a number of ranging, sensing, countermeasures and other yet to be defined applications by use of flexible spectral and temporal performance master oscillators will be discussed. The compact, low mass, robust, efficient and readily power scalable nature of "all-fiber" thulium lasers makes them ideal candidates for use in future space based sensing applications.

Heaps, William S.↗
NASA NTRS2010

Direct Relationship Between Perceptual and Motor Variability

The time that elapses between stimulus onset and the onset of a saccadic eye movement is longer and more variable than can be explained by neural transmission times and synaptic delays (Carpenter, 1981, in: Eye Movements: Cognition & Visual Perception, Earlbaum). In theory, noise underlying response-time (RT) variability could arise at any point along the sensorimotor cascade, from sensory noise arising Vvithin the early visual processing shared Vvith perception to noise in the motor criterion or commands necessary to trigger movements. These two loci for internal noise can be distinguished empirically; sensory internal noise predicts that response time Vvill correlate Vvith perceived stimulus magnitude whereas motor internal noise predicts no such correlation. Methods. We used the data described by Liston and Stone (2008, JNS 28:13866-13875), in which subjects performed a 2AFC saccadic brightness discrimination task and the perceived brightness of the chosen stimulus was then quantified in a second 21FC perceptual task. Results. We binned each subject's data into quartiles for both signal strength (from dimmest to brightest) and RT (from slowest to fastest) and analyzed the trends in perceived brightness. We found significant effects of both signal strength (as expected) and RT on normalized perceived brightness (both p less than 0.0001, 2-way ANOVA), without significant interaction (p = 0.95, 2-way ANOVA). A plot of normalized perceived brightness versus normalized RT show's that more than half of the variance was shared (r2 = 0.56, P less than 0.0001). To rule out any possibility that some signal-strength related artifact was generating this effect, we ran a control analysis on pairs of trials with repeated presentations of identical stimuli and found that stimuli are perceived to be brighter on trials with faster saccades (p less than 0.001, paired t-test across subjects). Conclusion. These data show that shared early visual internal noise jitters perceived brightness and the saccadic motor output in parallel. While the present correlation could theoretically result, either directly or indirectly, from some low-level brainstem or retinal mechanism (e.g., arousal, pupil size, photoreceptor noise) that influences both visual and oculomotor circuits, this is unlikely given the earlier fin ding that the variability in perceived motion direction and smooth-pursuit motor output is highly correlated (Stone and Krauzlis, 2003, JOV 3:725-736), suggesting that cortical circuits contribute to the shared internal noise.

Liston, Dorion B.↗
NASA NTRS2011

Increased Intracranial Pressure and Visual Impairment Associated with Long-Duration Spaceflight

Although humans have been flying in space since the 1960s, more recent missions have revealed a new suite of physiological adaptations and consequences of space flight. Notably, 60% of long-duration crewmembers (ISS/MIR) and >25% of short-duration (Shuttle) crewmembers have reported subjective degradation in vision (based on debrief comments) (Gibson 2011). Decreased near-visual acuity was demonstrated in 46% of ISS/Mir and 21% of Shuttle crewmembers, resulting in a shift of up to 1-2 diopters in their refractive correction. It is likely that the recently revealed ophthalmic changes have been present since the first days of human space flight, but have been overlooked or attributed to other causations. The reported changes in vision have occurred at various time points throughout missions, with ranging degrees of visual degradation. Although some cases resolved upon return to Earth, several astronauts have not regained preflight visual acuity, indicating that the damage may be permanent. While observing these changes over the years, without other overt symptomology and with the given age range of the flying population, this has largely been attributed to an expected hyperopic shift due to aging. However, the availability of onboard analysis techniques, including visual acuity assessments, retinal imagery, and ultrasounds of the eye and optic nerve tracts, along with more detailed post-flight techniques, has led to the recent recognition of a wider syndrome. Along with vision changes, findings include flattening of the globe, swelling of the optic disc (papilledema), choroidal folds in the retina, swelling of the optic nerve sheath, and visual field defects. It is widely hypothesized that this constellation of findings may be explained by an elevation of intracranial pressure (ICP). Out of the 60% of long-duration astronauts that have reported a subjective degradation in vision, a subset (currently 10 astronauts) have developed this syndrome. The National Aeronautics and Space Administration (NASA) has made it a high priority to understand this syndrome and provide mitigation techniques to protect crewmembers from visual impairment. While there are many possible factors that could contribute to intracranial hypertension associated with spaceflight, the relative contribution of these, as well as the processes by which eye damage occurs as a result of intracranial hypertension, are not fully understood. The observed pathophysiological phenomena are extremely complex and it is likely that multiple factors contribute to their incidence, rather than one simple mechanism. This paper will define and examine the findings in detail, and expound upon the potential contributing factors and their relative contribution to this syndrome.

Marshall-Bowman, Karina↗
NASA NTRS2010

Oscillation of Angiogenesis with Vascular Dropout in Diabetic Retinopathy by VESsel GENeration Analysis (VESGEN)

PURPOSE. Vascular dropout and angiogenesis are hallmarks of the progression of diabetic retinopathy (DR). However, current evaluation of DR relies on grading of secondary vascular effects, such as microaneurysms and hemorrhages, by clinical examination instead of by evaluation of actual vascular changes. The purpose of this study was to map and quantify vascular changes during progression of DR by VESsel GENeration Analysis (VESGEN). METHODS. In this prospective cross-sectional study, 15 eyes with DR were evaluated with fluorescein angiography (FA) and color fundus photography, and were graded using modified Early Treatment Diabetic Retinopathy Study criteria. FA images were separated by semiautomatic image processing into arterial and venous trees. Vessel length density (L(sub v)), number density (N(sub v)), and diameter (D(sub v)) were analyzed in a masked fashion with VESGEN software. Each vascular tree was automatically segmented into branching generations (G(sub 1)...G(sub 8) or G(sub 9)) by vessel diameter and branching. Vascular remodeling status (VRS) for N(sub v) and L(sub v) was graded 1 to 4 for increasing severity of vascular change. RESULTS. By N(sub v) and L(sub v), VRS correlated significantly with the independent clinical diagnosis of mild to proliferative DR (13/15 eyes). N(sub v) and L(sub v) of smaller vessels (G(sub >=6) increased from VRS1 to VRS2 by 2.4 X and 1.6 X, decreased from VRS2 to VRS3 by 0.4 X and 0.6X, and increased from VRS3 to VRS4 by 1.7 X and 1.5 X (P < 0.01). Throughout DR progression, the density of larger vessels (G(sub 1-5)) remained essentially unchanged, and D(sub v1-5) increased slightly. CONCLUSIONS. Vessel density oscillated with the progression of DR. Alternating phases of angiogenesis/neovascularization and vascular dropout were dominated first by remodeling of arteries and subsequently by veins.

Parsons-Wingerter, Patricia↗
NASA NTRS2011

Observations of Leonids 2009 by the Tajikistan Fireball Network

The fireball network in Tajikistan has operated since 2009. Five stations of the network covering the territory of near eleven thousands square kilometers are equipped with all-sky cameras with the Zeiss Distagon "fish-eye" objectives and by digital SLR cameras Nikon with the Nikkor "fish-eye" objectives. Observations of the Leonid activity in 2009 were carried out during November 13-21. In this period, 16 Leonid fireballs have been photographed. As a result of astrometric and photometric reductions, the precise data including atmospheric trajectories, velocities, orbits, light curves, photometric masses and densities were determined for 10 fireballs. The radiant positions during the maximum night suggest that the majority of the fireball activity was caused by the annual stream component with only minor contribution from the 1466 trail. According to the PE criterion, the majority of Leonid fireballs belonged to the most fragile and weak fireball group IIIB. However, one detected Leonid belonged to the fireball group I. This is the first detection of an anomalously strong Leonid individual.

Borovicka, J.↗
NASA NTRS2004

Curved-Focal-Plane Arrays Using Deformed-Membrane Photodetectors

A versatile and simple approach to the design and fabrication of curved-focal-plane arrays of silicon-based photodetectors is being developed. This approach is an alternative to the one described in "Curved Focal-Plane Arrays Using Back- Illuminated High-Purity Photodetectors" (NPO-30566), NASA Tech Briefs, Vol. 27, No. 10 (October 2003), page 10a. As in the cited prior article, the basic idea is to improve the performance of an imaging instrument and simplify the optics needed to obtain a given level of performance by making an image sensor (in this case, an array of photodetectors) conform to a curved focal surface, instead of designing the optics to project an image onto a flat focal surface. There is biological precedent for curved-focal-surface designs: retinas - the image sensors in eyes - conform to the naturally curved focal surfaces of eye lenses. The present approach is applicable to both front-side- and back-side-illuminated, membrane photodetector arrays and is being demonstrated on charge-coupled devices (CCDs). The very-large scale integrated (VLSI) circuitry of such a CCD or other array is fabricated on the front side of a silicon substrate, then the CCD substrate is attached temporarily to a second substrate for mechanical support, then material is removed from the back to obtain the CCD membrane, which typically has a thickness between 10 and 20 m. In the case of a CCD designed to operate in back-surface illumination, delta doping can be performed after thinning to enhance the sensitivity. This approach is independent of the design and method of fabrication of the front-side VLSI circuitry and does not involve any processing of a curved silicon substrate. In this approach, a third substrate would be prepared by polishing one of its surfaces to a required focal-surface curvature. A CCD membrane fabricated as described above would be pressed against, deformed into conformity with, and bonded to, the curved surface. The technique used to press and bond the CCD membrane would depend on the nature of the supporting material (see figure). For example, if the third substrate were made of quartz frit, the substrate would be prepared by suffusing it with epoxy. Then one would take advantage of the porosity of the frit by applying a partial vacuum to the opposite surface of the frit, causing atmospheric pressure to push the CCD membrane against the curved surface. The curing of the epoxy would bond the CCD membrane to the curved surface. Alternatively, if the third substrate were made of a nonporous material, the curved substrate surface would be prepared by coating it with a wax or an uncured epoxy. The CCD membrane would be pressed against the coated, curved surface by use of a suitably pressurized balloon. The CCD membrane would then become bonded to the curved surface by curing of the epoxy or freezing of the wax.

Nikzad, Shouleh↗
NASA NTRS2004

Development of Biomorphic Flyers

Biomorphic flyers have recently been demonstrated that utilize the approach described earlier in "Bio-Inspired Engineering of Exploration Systems" (NPO-21142), NASA Tech Briefs, Vol. 27, No. 5 (May 2003), page 54, to distill the principles found in successful, nature-tested mechanisms of flight control. Two types of flyers are being built, corresponding to the imaging and shepherding flyers for a biomorphic mission described earlier in "Cooperative Lander- Surface/Aerial Microflyer Missions for Mars Exploration" (NPO-30286), NASA Tech Briefs, Vol. 28, No. 5 (May 2004), page 36. The common features of these two types of flyers are that both are delta-wing airplanes incorporating bio-inspired capabilities of control, navigation, and visual search for exploration. The delta-wing design is robust to approx.40 G axial load and offers ease of stowing and packaging. The prototype that we have built recently is shown in the figure. Such levels of miniaturization and autonomous navigation are essential to enable biomorphic microflyers (<1 kg) that can be deployed in large numbers for distributed measurements and exploration of difficult terrain while avoiding hazards. Individual bio-inspired sensors that will be incorporated in a biomorphic flyer have been demonstrated recently. These sensors include a robust, lightweight (~6 g), and low-power (~40 mW) horizon sensor for flight stabilization. It integrates successfully the principles of the dragonfly ocelli. The ocelli are small eyes on the dorsal and forward regions of the heads of many insects. The ocelli are distinct from the compound eyes that are most commonly associated with insect vision. In many insects, the ocelli are little more than single-point detectors of short-wavelength light and behavioral responses to ocelli stimuli are hard to observe. The notable exception is found in dragonflies, where flight control is notably degraded by any interference with the ocellar system. Our team has discovered recently that the ocelli are a dedicated horizon sensor, with substantial optical processing and multiple spectral sensitivity. To our knowledge, this is the world s first demonstrated use of a "biomorphic ocellus" as a flight-stabilization system. The advantage of the ocelli over a similarly sized system of rate gyroscopes is that both attitude control and rate damping can be realized in one device. A full inertial unit and significant processing would otherwise be required to achieve the same effect. As a prelude to full autonomy, substantial stability augmentation is provided to the pilot at very low cost in terms of space, power, and mass. The sensor is about 40 times lighter than a comparable inertial attitude reference system. Other significant features of the biomorphic flyer shown in the figure include its ability to fly at high angles of attack ~30 and a deep wing chord which allows scaling to small size and low Reynold s number situations. Furthermore, the placement of the propulsion system near the center of gravity allows continued control authority at low speeds. These attributes make such biomorphic flyers uniquely suited to planetary and terrestrial exploration where small size and autonomous airborne operation are required.

Thakoor, Sarita↗
NASA NTRS2004

Transplanting Retinal Cells using Bucky Paper for Support

A novel treatment for retinal degenerative disorders involving transplantation of cells into the eye is currently under development at NASA Ames Research Center and Stanford University School of Medicine. The technique uses bucky paper as a support material for retinal pigment epithelial (RPE) cells, iris pigment epithelial (IPE) cells, and/or stem cells. This technology is envisioned as a treatment for age-related macular degeneration, which is the leading cause of blindness in persons over age 65 in Western nations. Additionally, patients with other retinal degenerative disorders, such as retinitis pigmentosa, may be treated by this strategy. Bucky paper is a mesh of carbon nanotubes (CNTs), as shown in Figure 1, that can be made from any of the commercial sources of CNTs. Bucky paper is biocompatible and capable of supporting the growth of biological cells. Because bucky paper is highly porous, nutrients, oxygen, carbon dioxide, and waste can readily diffuse through it. The thickness, density, and porosity of bucky paper can be tailored in manufacturing. For transplantation of cells into the retina, bucky paper serves simultaneously as a substrate for cell growth and as a barrier for new blood vessel formation, which can be a problem in the exudative type of macular degeneration. Bucky paper is easily handled during surgical implantation into the eye. Through appropriate choice of manufacturing processes, bucky paper can be made relatively rigid yet able to conform to the retina when the bucky paper is implanted. Bucky paper offers a distinct advantage over other materials that have been investigated for retinal cell transplantation - lens capsule and Descemet's membrane - which are difficult to handle during surgery because they are flimsy and do not stay flat.

Loftus, David J.↗
NASA NTRS2011

Straight Ahead in Microgravity

INTRODUCTION The subjective straight-ahead direction is a very basic perceptual reference for spatial orientation and locomotion. The perceived straight-ahead along the horizontal and vertical meridian is largely determined by both otolith and somatosensory inputs which are altered in microgravity. The Straight Ahead in Microgravity (SAM) experiment will be conducted on the International Space Station (ISS) to examine how this spatial processing changes as a function of spaceflight. METHODS Data will be collected before the flight, at one-month intervals during long-duration stay (180 days) on board ISS, and after return to Earth. Control studies will also be performed during parabolic flights. Three different protocols will be used in each test session: (1) Fixation: The subject will be asked to look at actual targets (normal vision) and then to imagine these same targets (occluded vision) in the straight-ahead direction. Targets will be located at near distance (arm s length, ~0.5m), medium distance (~1 m), and far distance (beyond 2 m). This task will be successively performed with subject s body aligned with the spacecraft interior, and with subject s body tilted forward and backward by an operator. (2) Saccades: The subject will be asked to make horizontal and vertical saccades, first relative to the spacecraft interior reference system, and then relative to the subject s head reference system. This task will be successively performed with subject s body aligned with the spacecraft interior, and with subject s body tilted in roll or in pitch by an operator. (3) Linear Vestibulo-Ocular Reflex (VOR): The subject will be asked to stare at actual visual targets (normal vision) at various distances (near, medium, far) in the straight-ahead direction. Vision will then be occluded, and the subject will be asked to continue staring at the same imagined targets while he/she is passively translated forward-backward, up-down, or side-to-side. The subject's body motion will be performed by the restrained operator while the subject is free-floating. EXPECTED RESULTS The coupling of downward gaze with vergence eye movements observed on Earth is expected to increase in microgravity. Saccadic eye movements made in darkness along perceived axes are expected to be more closely aligned with the body s longitudinal axis in 0g compared to 1g, as the reference system for spatial orientation moves from an allocentric (gravitational) to an egocentric (idiotropic) vector. Changes in the linear VOR will reflect adaptive changes in otolith-ocular reflex contributions to the perceived straight-ahead. DISCUSSION A change in an individual's egocentric reference might have negative consequences on evaluating the direction of an approaching object or on the accuracy of reaching movements or locomotion. Consequently, investigating how microgravity affects the egocenter is important for understanding the problems associated with long-term effects of microgravity on astronauts' and how they re-adapt to the return of gravitational forces on Earth or other planetary surfaces. This project therefore has theoretical, practical and even clinical implications for the sensorimotor research gap "What are the changes in sensorimotor function over the course of a mission?"

Clement, G.↗
NASA NTRS2012

Contribution of Spaceflight Environmental Factors to Vision Risks

The recognition of a risk of visual impairment and intracranial pressure increase as a result of spaceflight has directed our attention and research efforts to the eye. While the alterations observed in astronauts returning from long duration missions include reportable vision and neuroanatomical changes observed by non-invasive methods, other effects and subsequent tissue responses at the molecular and cellular level can only be studied by accessing the tissue itself. As a result of this need, several studies are currently taking place that use animal models for eye research within the HHC Element. The implementation of these studies represents a significant addition to the capabilities of the biomedical research laboratories within the SK3 branch at JSC.

Zanello, Susana↗
NASA NTRS2010

Coarse, Intermediate and High Resolution Numerical Simulations of the Transition of a Tropical Wave Critical Layer to a Tropical Storm

Recent work has hypothesized that tropical cyclones in the deep Atlantic and eastern Pacific basins develop from within the cyclonic Kelvin cat's eye of a tropical easterly wave critical layer located equatorward of the easterly jet axis. The cyclonic critical layer is thought to be important to tropical cyclogenesis because its cat's eye provides (i) a region of cyclonic vorticity and weak deformation by the resolved flow, (ii) containment of moisture entrained by the developing flow and/or lofted by deep convection therein, (iii) confinement of mesoscale vortex aggregation, (iv) a predominantly convective type of heating profile, and (v) maintenance or enhancement of the parent wave until the developing proto-vortex becomes a self-sustaining entity and emerges from the wave as a tropical depression. This genesis sequence and the overarching framework for describing how such hybrid wave-vortex structures become tropical depressions/storms is likened to the development of a marsupial infant in its mother's pouch, and for this reason has been dubbed the "marsupial paradigm". Here we conduct the first multi-scale test of the marsupial paradigm in an idealized setting by revisiting the Kurihara and Tuleya problem examining the transformation of an easterly wave-like disturbance into a tropical storm vortex using the WRF model. An analysis of the evolving winds, equivalent potential temperature, and relative vertical vorticity is presented from coarse (28 km), intermediate (9 km) and high resolution (3.1 km) simulations. The results are found to support key elements of the marsupial paradigm by demonstrating the existence of rotationally dominant region with minimal strain/shear deformation near the center of the critical layer pouch that contains strong cyclonic vorticity and high saturation fraction. This localized region within the pouch serves as the "attractor" for an upscale "bottom up" development process while the wave pouch and proto-vortex move together.

Montgomery, M. T.↗
NASA NTRS2012

Mechanical Stress and Antioxidant Protection in the Retina of Hindlimb Suspended Rats

It has been postulated that hindlimb suspension (HS) causes a cephalad fluid shift in quadrupeds similar to that occurring to humans in microgravity. Therefore, HS may provide a suitable animal model in which to recapitulate the ocular changes observed in the human Visual Impairment and Intracranial Pressure (VIIP) syndrome. This work reports preliminary results from a tissue sharing project using 34 week-old Brown Norway rats. Two different experiments compared normal posture controls and HS rats for 2 weeks and rats exposed to HS for 2 weeks but allowed to recover in normal posture for 2 additional weeks. The effects of two nutritional countermeasures, green tea extract (GT) and plant polyphenol resveratrol (Rv), were also evaluated. Green tea contains the antioxidant epigallocatechin gallate (EGCG). qPCR gene expression analysis of selected targets was performed on RNA from isolated retinas, and histologic analysis was done on one fixed eye per rat. The transcription factor early growth response protein 1 (Egr1) was upregulated almost 2-fold in HS retinas relative to controls (P = 0.059), and its expression returned to control levels after 2 weeks of recovery in normal posture (P = 0.023). HS-induced upregulation of Egr1 was attenuated (but not significantly) in retinas from rats fed an antioxidant rich (GT extract) diet. In rats fed the GT-enriched diet, antioxidant enzymes were induced, evidenced by the upregulation of the gene heme oxygenase 1 (Hmox1) (P = 0.042) and the gene superoxide dismutase 2 (Sod2) (P = 0.0001). Egr1 is a stretch-activated transcription factor, and the Egr1 mechanosensitive response to HS may have been caused by a change in the translaminal pressure and/or mechanical deformation of the eye globe. The observed histologic measurements of the various retinal layers in the HS rats were lower in value than those of the control animal (n = 1), however insufficient data were available for statistical analysis. Aquaporin 4, a water-selective channel involved in interstitial fluid homeostasis, showed an upregulated trend in HS retinas; however, these results are preliminary. Total retinal thickness increased significantly (P = 0.049) in HS rats fed a resveratrol enriched diet compared to HS rats on a normal diet. This change appeared to be reversed during the 2 weeks of recovery post HS, but no differences in retina thickness were observed between HS animals and HS recovered animals when both groups consumed a normal diet. The reversibility of the increase in retinal thickness induced by resveratrol during HS may therefore reflect an interaction between the stress provoked by HS and the cytoprotective mechanisms elicited by resveratrol

Glass, Aziza↗
NASA NTRS2012

Universal fieldable assay with unassisted visual detection

A universal detection system based on allosteric aptamers, signal amplification cascade, and eye-detectable phrase transition. A broadly applicable homogeneous detection system is provided. It utilizes components of the blood coagulation cascade in the presence of polystyrene microspheres (MS) as a signal amplifier. Russell's viper venom factor X activator (RVV-X) triggers the cascade, which results in an eye-visible phase transition--precipitation of MS bound to clotted fibrin. An allosteric RNA aptamer, RNA132, with affinity for RVV-X and human vascular endothelial growth factor (VEGF.sub.165) was created. RNA132 inhibits enzymatic activity of RVV-X. The effector molecule, VEGF.sub.165, reverses the inhibitory activity of RNA132 on RVV-X and restores its enzymatic activity, thus triggering the cascade and enabling the phase transition. Similar results were obtained for another allosteric aptamer modulated by a protein tyrosine phosphatase. The assay is instrumentation-free for both processing and readout.

Chelyapov, Nicolas↗
NASA NTRS2012

Hurricane Imaging Radiometer (HIRAD) Observations of Brightness Temperatures and Ocean Surface Wind Speed and Rain Rate During NASA's GRIP and HS3 Campaigns

HIRAD flew on high-altitude aircraft over Earl and Karl during NASA s GRIP (Genesis and Rapid Intensification Processes) campaign in August - September of 2010, and plans to fly over Atlantic tropical cyclones in September of 2012 as part of the Hurricane and Severe Storm Sentinel (HS3) mission. HIRAD is a new C-band radiometer using a synthetic thinned array radiometer (STAR) technology to obtain spatial resolution of approximately 2 km, out to roughly 30 km each side of nadir. By obtaining measurements of emissions at 4, 5, 6, and 6.6 GHz, observations of ocean surface wind speed and rain rate can be retrieved. The physical retrieval technique has been used for many years by precursor instruments, including the Stepped Frequency Microwave Radiometer (SFMR), which has been flying on the NOAA and USAF hurricane reconnaissance aircraft for several years to obtain observations within a single footprint at nadir angle. Results from the flights during the GRIP and HS3 campaigns will be shown, including images of brightness temperatures, wind speed, and rain rate. Comparisons will be made with observations from other instruments on the campaigns, for which HIRAD observations are either directly comparable or are complementary. Features such as storm eye and eye-wall, location of storm wind and rain maxima, and indications of dynamical features such as the merging of a weaker outer wind/rain maximum with the main vortex may be seen in the data. Potential impacts on operational ocean surface wind analyses and on numerical weather forecasts will also be discussed.

Miller, Timothy L.↗
NASA NTRS2013

Observations of C-Band Brightness Temperatures and Ocean Surface Wind Speed and Rain Rate from the Hurricane Imaging Radiometer (HIRAD) during GRIP and HS3

HIRAD flew on high-altitude aircraft over Earl and Karl during NASA s GRIP (Genesis and Rapid Intensification Processes) campaign in August - September of 2010, and at the time of this writing plans to fly over Atlantic tropical cyclones in September of 2012 as part of the Hurricane and Severe Storm Sentinel (HS3) mission. HIRAD is a new C-band radiometer using a synthetic thinned array radiometer (STAR) technology to obtain cross-track resolution of approximately 3 degrees, out to approximately 60 degrees to each side of nadir. By obtaining measurements of emissions at 4, 5, 6, and 6.6 GHz, observations of ocean surface wind speed and rain rate can be retrieved. This technique has been used for many years by precursor instruments, including the Stepped Frequency Microwave Radiometer (SFMR), which has been flying on the NOAA and USAF hurricane reconnaissance aircraft for several years to obtain observations within a single footprint at nadir angle. Results from the flights during the GRIP and HS3 campaigns will be shown, including images of brightness temperatures, wind speed, and rain rate. Comparisons will be made with observations from other instruments on the campaigns, for which HIRAD observations are either directly comparable or are complementary. Features such as storm eye and eye-wall, location of storm wind and rain maxima, and indications of dynamical features such as the merging of a weaker outer wind/rain maximum with the main vortex may be seen in the data. Potential impacts on operational ocean surface wind analyses and on numerical weather forecasts will also be discussed.

Miller, Timothy L.↗
NASA NTRS2013

Visible Contrast Energy Metrics for Detection and Discrimination

Contrast energy was proposed by Watson, Robson, & Barlow as a useful metric for representing luminance contrast target stimuli because it represents the detectability of the stimulus in photon noise for an ideal observer. Like the eye, the ear is a complex transducer system, but relatively simple sound level meters are used to characterize sounds. These meters provide a range of frequency sensitivity functions and integration times depending on the intended use. We propose here the use of a range of contrast energy measures with different spatial frequency contrast sensitivity weightings, eccentricity sensitivity weightings, and temporal integration times. When detection threshold are plotting using such measures, the results show what the eye sees best when these variables are taken into account in a standard way. The suggested weighting functions revise the Standard Spatial Observer for luminance contrast detection and extend it into the near periphery. Under the assumption that the detection is limited only by internal noise, discrimination performance can be predicted by metrics based on the visible energy of the difference images

Ahumada, Albert↗
NASA NTRS2014

Effects of Long Duration Spaceflight on Venous and Arterial Compliance

The visual impairment and intracranial pressure syndrome (VIIP) is a newly described space flight-associated medical condition made up of a constellation of symptoms affecting at least 34% of American astronauts who have flown International Space Station (ISS) missions. VIIP is defined primarily by visual acuity deficits and anatomical changes to eye structures, and is thought to be related to elevated intracranial pressure secondary to space flightinduced cephalad fluid shifts. Loss of visual acuity could be a significant threat to crew health and performance and may be suggestive of other adaptations with implications for years post-flight. Our primary objective is to determine whether vascular compliance is altered by space flight and whether such adaptations are related to the incidence of VIIP. In particular, we will measure ocular parameters and vascular compliance in vessels of the head and neck in astronauts who have no space flight experience, in astronauts before, during, and after space flight, and in bed rest subjects with conditions similar to space flight. Additionally, we will analyze astronaut data from the Lifetime Surveillance of Astronaut Health (LSAH) archive to determine which factors might be predictive of the development of VIIP. The project will be conducted in four separate but related parts. To understand the baseline condition of astronauts without any prior space flight experience, we will study 10 astronauts who have never flown in space by performing a comprehensive evaluation of the vasculature of the head, neck and eyes. Hemodynamic data (stroke volume and blood pressure), ocular (tonometry and ocular ultrasound), venous and arterial parameters will be acquired across a range of tilt angles (20, 10, 0, -10, -20 degrees). Vessels to be studied include the temporal, jugular, and vertebral veins and the cerebral, carotid and vertebral arteries. Ophthalmic data from the annual physical will be obtained through data sharing. To examine the relation between vascular compliance in the head and neck and the development of VIIP after a long duration space flight, we will study 10 astronauts before, during, and after long-duration ISS missions. Pre- and post-flight testing will be identical to that described above. During flight, images of the same vessels of interest will be obtained for later analysis. Ophthalmic data including VIIP scores will be obtained through data sharing from medically-required tests. To investigate the effects of age and elevated sodium intake, two potential contributors to VIIP, we will study 24 men (in two age groups: 25-35 and 45-55) during a 14 day 6deg head-down bed rest, a well-accepted analog of space flight. Standard NASA bed rest conditions will be maintained except for dietary sodium. Sodium intake will be similar to that of ISS astronauts, which is higher than consumed in previous bed rest studies. Pre- and post-bed rest testing procedures will be identical to the testing protocol described above for astronauts. Ophthalmic testing (optical coherence tomography, fundoscopy, and tonometry) will be conducted on the same day that vascular compliance measures are obtained. To identify parameters that may relate to an increase in an astronaut's susceptibility to developing VIIP, we will use data mining techniques to evaluate astronaut data obtained from the LSAH. Medical history, family history, space flight history and its related exposures, and history of high performance jet aircraft exposure will be examined for their potential relationship to ocular data. We hypothesize that the cephalad fluid shift induced by space flight will result in structural and functional adaptations in head and neck vessels leading to decreased vascular compliance and related to the development of VIIP symptoms. Further, although VIIP has not been observed in previous bed rest studies, we hypothesize that an elevated sodium intake will increase the incidence of VIIP symptoms in this space flight analog. Finally, we hypothesize that data mining analyses will reveal relationships between health history, previous exposures (including space flight and high performance aircraft), and the development of VIIP in the astronaut population.

Ribeiro, L. C.↗