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At least 1,189 records · Page 66

2013 Immune Risk Standing Review Panel Evidence Review for: The Risk of Crew Adverse Health Event Due to Altered Immune Response

The 2013 Immune Risk Standing Review Panel (from here on referred to as the SRP) met for a site visit in Houston, TX on February 3-4, 2014. The SRP reviewed the new Evidence Report for the Risk of Crew Adverse Health Event Due to Altered Immune Response (from here on referred to as the 2013 Immune Evidence Report), as well as the Research Plan for this Risk that is in the current version of the Human Research Program’s (HRP) Integrated Research Plan (IRP).

Steinberg, Susan↗

Managing Research in a Risk World

The Office of Chief Medical Officer (OCHMO) owns all human health and performance risks managed by the Human System Risk Board (HSRB). While the HSRB manages the risks, the Human Research Program (HRP) manages the research portion of the overall risk mitigation strategy for these risks. The HSRB manages risks according to a process that identifies and analyzes risks, plans risk mitigation and tracks and reviews the implementation of these strategies according to its decisions pertaining to the OCHMO risk posture. HRP manages risk research work using an architecture that describes evidence-based risks, gaps in our knowledge about characterizing or mitigating the risk, and the tasks needed to produce deliverables to fill the gaps and reduce the risk. A planning schedule reflecting expected research milestones is developed, and as deliverables and new evidence are generated, research progress is tracked via the Path to Risk Reduction (PRR) that reflects a risk's research plan for a design reference mission. HRP's risk research process closely interfaces with the HSRB risk management process. As research progresses, new deliverables and evidence are used by the HSRB in conjunction with other operational and non-research evidence to inform decisions pertaining to the likelihood and consequence of the risk and risk posture. Those decisions in turn guide forward work for research as it contributes to overall risk mitigation strategies. As HRP tracks its research work, it aligns its priorities by assessing the effectiveness of its contributions and maintaining specific core competencies that would be invaluable for future work for exploration missions.

Anton, W.↗

Development of a Heterogeneous sUAS High-Accuracy Positional Flight Data Acquisition System

Recently, a heterogeneous FDAS, consisting of a diverse range of instruments was developed to support acoustic flight research programs at NASA Langley Research Center. In addition to a conventional GPS to measure latitude, longitude and altitude, the FDAS also utilizes a small, light-weight, low-cost DGPS system to obtain centimeter accuracy to measure the distance traveled by sound from a sUAS vehicle to a microphone on the ground. Acoustic flight testing using the FDAS installed on several different sUAS platforms has been conducted in support of the NASA CAS DELIVER and ERA ITD projects (Reference 1). The first FDAS prototype was assembled and implemented in the acoustic/flight measurement system in December 2014 to support DELIVER acoustic flight tests. Evaluation of the system performance and results from the data analyses were used to further test, develop and enhance the FDAS over a six-month period to support acoustic flight research for the ERA.

McSwain, Robert G.↗

Experimental Design for Pre-Clinical Animal Model Study in Microgravity

The Rodent Research program at NASAs Ames Research Center (ARC) has pioneered a new research capability on the International Space Station in less than four years and has progressed toward translating research to the ISS utilizing commercial rockets, collaborating with academia and science industry, and training crew for research purposes on-orbit. Animal models are the foundation of pre-clinical research to understand human diseases and evaluate new therapeutics. Advancement in alleviating ground diseases such as muscle atrophy and osteoporosis can come from the study of similar conditions that are known to occur as a result of exposure to the spaceflight environment. During the completion of the flight phase of two missions, our practices, hardware and operations evolved from tested to developed standards, which successfully translated the studies from ground to space. Results from these studies contribute to the science community via both the primary investigation and banked samples that are shared in publicly available data repository such as GeneLab. Every completed mission sets a foundation to build and design greater complexity into future research and answer questions about common human diseases on ground and in space. Here, we present methods developed for the translation of a rodent experiment to the ISS including a description of hardware and kits available for investigators and a discussion of operational constraints.

Rodent Research↗

Analysis of CDC Bioreactor Internal Thermal Measurements and Sample Coupon Temperatures

The CDC Biofilm Reactor is an integral laboratory tool for the Environmental Control and Life Support Systems (ECLSS) biofilm formation and growth research program. Critical to this research is the need to adjust and maintain various surface temperatures of the coupons housed within the CDC Biofilm Reactor. The purpose of this study was to provide quantitative temperature gradient information when the CDC Biofilm Reactor was operating according to several process scenarios. Two primary process parameters were evaluated. For the first set of test parameters, the liquid level was maintained at 350 mL, with an inlet flowrate of 0.1 mL/min, 1 mL/min, 10 mL/min. The liquid was allowed to gravity drain out of the outlet spout. For the second set of test parameters, the liquid level within the reactor was maintained at 550 mL, with an inlet flow of 0.1 mL/min, 1 mL/min, 10 mL/min and draining intermittently controlled to 0.8 mL/min to maintain the 550 mL level. Due to the placement of the thermocouple in the reactor, a difference in temperature occurred between the coupon surfaces and target biofilm reactor temperature when operated according to the first set of test parameters. When the reactor was operated according to the second set of parameters, which resulted in the thermocouple being submerged, the temperature gradient was eliminated. The results demonstrated minimal temperature gradient between the top and bottom coupon surfaces for coupons placed in a single rod within the CDC Biofilm Reactor for both sets of test parameters evaluated. The collection of this information helped to explain previous ECLSS biofilm formation test runs, along with providing guidance on best operating practices for future ECLSS experiments. The placement of the thermocouple also helps to explain the challenge of achieving and maintaining bulk liquid temperatures when biofilm is grown according to the standardized test methods.

CDC Bioreactor↗

Analysis of CDC Bioreactor Internal Thermal Measurements and Sample Coupon Temperatures

The Center for Disease Control and Prevention (CDC) bioreactor is an integral laboratory tool for the Environmental Control and Life Support Systems (ECLSS) biofilm formation and growth research program. Critical to this research is the need to adjust and maintain various surface temperatures of the coupons housed within the CDC Bioreactor. The purpose of this study was to provide quantitative temperature gradient information when the CDC Bioreactor was operating according to several process scenarios. Two primary process parameters were evaluated. For the first set of test parameters, the liquid level was maintained at 350 mL, with an inlet flowrate of 0.1 mL/min, 1 mL/min, 10 mL/min. The liquid was allowed to gravity drain out of the outlet spout. For the second set of test parameters, the liquid level within the reactor was maintained at 550 mL, with an inlet flow of 0.1 mL/min, 1 mL/min, 10 mL/min and draining intermittently controlled to 0.8 mL/min to maintain the 550 mL level. Due to the placement of the thermocouple in the reactor, a difference in temperature occurred between the coupon surfaces and target Bioreactor temperature when operated according to the first set of test parameters. When the reactor was operated according to the second set of parameters, which resulted in the thermocouple being submerged, the temperature gradient was eliminated. The results demonstrated minimal temperature gradient between the top and bottom coupon surfaces for coupons placed in a single rod within the CDC Bioreactor for both sets of test parameters evaluated. The collection of this information helped to explain previous ECLSS biofilm formation test runs, along with providing guidance on best operating practices for future ECLSS experiments. The placement of the thermocouple also helps to explain the challenge of achieving and maintaining bulk liquid temperatures when biofilm is grown according to the standardized test methods.

CDC Bioreactor↗

Studies to Improve the Sensitivity to Low Energy Interactions in Dual-Phase Xenon Dark Matter Detectors. Department of Energy Office of Science Graduate Student Research (SCGSR) Program, Final project report

Noble liquid time projection chambers (TPCs) are some of the most sensitive particle detectors ever developed. They see use in searches for new physics with neutrinos, or for new particles like dark matter. They work by sensing light and charge signals left behind by particle interactions in a volume of liquified xenon or argon. TPCs are so sensitive that even a single electron liberated in an interaction can be readily detected. However this sensitivity to signals comes with a sensitivity to background noise, with one example being single electrons that arrive long after the signals from a true particle interaction. This type of noise has been the subject of multiple studies, which have concluded that single electron backgrounds are well correlated with prior events in the TPC, as well as impurities in the detection medium. At Lawrence Livermore National Laboratory (LLNL), the XeNu TPC is a testbed for a novel study of these backgrounds by generating data with new components made of aluminum and Shapal--the latter being an exotic ceramic which can be machined using standard tools. These materials were selected to replace plastic components which introduce impurities in the TPC during operation. Without plastic, the hope is that electron backgrounds will be reduced, leaving new opportunities for studying their origins and dependence on impurities. The SCGSR fellowship served as a springboard to help meet these objectives. Over the course of a year, the new components were designed, fabricated, and installed in XeNu. Following their installation, data was taken for use in a future study that will enable the electron background contributions from plastic components to be studied directly. In the interim, preliminary analysis results indicate that electron backgrounds with the new components are roughly 50% lower. This has established the efficacy of Shapal as a low-background replacement for plastic components where electrical and thermal stability are needed

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Long-term performance of engineered barriers for high-level waste repositories - 15358

The evolution of the engineered barrier system (EBS) of geological repositories for high-level radioactive waste (HLW) and spent fuel (SF) has been the subject of many national and international research programs during recent years. The emphasis of the research activities was on the elaboration of a detailed understanding of the complex coupled thermo-hydro-mechanical and -chemical (THM-C) processes, which are expected to evolve in the early post-closure period in the near field. From the perspective of radiological long-term safety, an in-depth understanding of these coupled processes is of great significance, because the evolution of the EBS during the early post-closure phase may have a non-negligible impact on the safety functions at later stages of the repository's lifetime. Process interactions during the re-saturation phase (heat pulse, gas generation, non-uniform water uptake from the host rock) could impair the homogeneity of the safety-relevant properties in the EBS (e.g. swelling pressure, hydraulic conductivity, diffusivity). The 7. Framework EURATOM PEBS project (long-term Performance of Engineered Barrier Systems) was initiated in 2010 and completed in March 2014. The project aimed at evaluating the sealing and barrier performance of clay-based EBS over time. The project approach included experiments, model development and consideration of the potential impact on long-term safety functions. The specific project aims were to: -deepen the understanding of the THM and THM-C evolution of the EBS system with time, - provide an enhanced quantitative basis for relating the evolutionary behavior to the safety functions, - clarify further the significance of residual uncertainties for long-term performance assessment. It can be concluded that uncertainties in process understanding occurring in the re-saturation period have been better constrained through PEBS studies, thus the uncertainties in the long-term performance of bentonite barriers have been reduced in some areas. Improvements are in the areas of evolution of materials properties and model development and testing at various scales. On-going in-situ experiments in underground research laboratories may play an important role in further confirming bentonite performance over periods of 10 - 20 years. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Laboratory for Nuclear Science. High Energy Physics Program

High energy and nuclear physics research at MIT is conducted within the Laboratory for Nuclear Science (LNS). Almost half of the faculty in the MIT Physics Department carry out research in LNS at the theoretical and experimental frontiers of subatomic physics. Since 2004, the U.S. Department of Energy has funded the high energy physics research program through grant DE-FG02-05ER41360 (other grants and cooperative agreements provided decades of support prior to 2004). The Director of LNS serves as PI. The grant supports the research of four groups within LNS as “tasks” within the umbrella grant. Brief descriptions of each group are given here. A more detailed report from each task follows in later sections. Although grant DE-FG02-05ER41360 has ended, DOE continues to fund LNS high energy physics research through five separate grants (a research grant for each of the four groups, as well as a grant for AMS Operations). We are pleased to continue this longstanding partnership.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

The 1982 NASA/ASEE Summer Faculty Fellowship Program

A NASA/ASEE Summer Faculty Fellowship Research Program was conducted to further the professional knowledge of qualified engineering and science faculty members, to stimulate an exchange of ideas between participants and NASA, to enrich and refresh the research and teaching activities of participants' institutions, and to contribute to the research objectives of the NASA Centers.

Barfield, B. F.↗

NASA Microgravity Combustion Science Research Plans for the ISS

A peer-reviewed research program in Microgravity Combustion Science has been chartered by the Physical Sciences Research Division of the NASA Office of Biological and Physical Research. The scope of these investigations address both fundamental combustion phenomena and applied combustion research topics of interest to NASA. From this pool of research, flight investigations are selected which benefit from access to a microgravity environment. Fundamental research provides insights to develop accurate simulations of complex combustion processes and allows developers to improve the efficiency of combustion devices, to reduce the production of harmful emissions, and to reduce the incidence of accidental uncontrolled combustion (fires, explosions). Through its spacecraft fire safety program, applied research is conducted to decrease risks to humans living and working in space. The Microgravity Combustion Science program implements a structured flight research process utilizing the International Space Station (ISS) and two of its premier facilities- the Combustion Integrated Rack of the Fluids and Combustion Facility and the Microgravity Science Glovebox - to conduct space-based research investigations. This paper reviews the current plans for Microgravity Combustion Science research on the International Space Station from 2003 through 2012.

Sutliff, Thomas J.↗

Nacelle-wing integration

The Aerodynamics Division at NASA ARC is participating in the propulsion airframe integration phase of the High Speed Research Program. The two areas of research being pursued include an experimental program and analysis using computational fluid dynamics. The applied Aerodynamics Branch is conducting the experimental program, which will involve a nacelle airframe model that was tested in the Ames 11- by 11-Foot Transonic Wind Tunnel in 1973. This branch will also assess various Euler codes in predicting nacelle airframe interference effects. The goal is to provide the industry with the necessary data and tools to design a high speed civil transport with favorable propulsion airframe interference.

Cappuccio, Gelsomina↗

The 1995 NASA guide to graduate support

The future of the United States is in the classrooms of America and tomorrow's scientific and technological capabilities are derived from today's investments in research. In 1980, NASA initiated the Graduate Student Researchers Program (GSRP) to cultivate additional research ties to the academic community and to support promising students pursuing advanced degrees in science and engineering. Since then, approximately 1300 students have completed the program's requirements. In 1987, the program was expanded to include the Underrepresented Minority and Disabled Focus (UMDF) Component. This program was designed to increase participation of underrepresented groups in graduate study and research and, ultimately, in space science and aerospace technology careers. Approximately 270 minority students have completed the program's requirements while making significant contributions to the nation's aerospace efforts. Continuing to expand fellowship opportunities, NASA announced the Graduate Student Fellowships in Global Change Research in 1990. Designed to support the rapid growth in the study of earth as a system, more than 250 fellowships have been awarded. And, in 1992, NASA announced opportunities in the multiagency High Performance Computing and Communications (HPCC) Program designed to accelerate the development and application of massively parallel processing. Approximately five new fellowships will be awarded yearly. This booklet will guide you in your efforts to participate in programs for graduate student support.

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