Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors
Not Available
Connelly, Stephen↗
SEARCH · Engineering Papers
Results for “Identifiability”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors
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99 GENERAL AND MISCELLANEOUS↗
Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1
Abstract not provided
Morgan, Cynthia A.↗
Biochemical, structural, and computational analyses of two new clinically identified missense mutations of ALDH7A1
Not provided.
Biochemistry & Molecular Biology↗
High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia
Aging is associated with tissue-level changesin cellular composition that are correlated withincreased susceptibility to disease. Aging humanmammary tissue shows skewed progenitor cell po-tency, resulting in diminished tumor-suppressivecelltypes and the accumulation ofdefective epithelialprogenitors. Quantitative characterization of theseage-emergent human cell subpopulations is lacking,impeding our understanding of the relationship be-tween age and cancer susceptibility. We conductedsingle-cell resolution proteomic phenotyping ofhealthy breast epithelia from 57 women, aged 16–91years, using mass cytometry. Remarkable hetero-geneity was quantified within the two mammaryepithelial lineages. Population partitioning identifiedasubsetofaberrantbasal-likeluminalcellsthataccu-mulate with age and originate from age-alteredprogenitors. Quantification of age-emergent pheno-types enabled robust classification of breast tissuesby age in healthy women. This high-resolution map-ping highlighted specific epithelial subpopulationsthat change with age in a manner consistent withincreased susceptibility to breast cancer.
60 APPLIED LIFE SCIENCES↗
Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome
Abstract not provided
Rao, Suman↗
VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA
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99 GENERAL AND MISCELLANEOUS↗
Conducting a metering assessment to identify submetering needs at a manufacturing facility
Not Available
Rao, Prakash↗
Positive follow-up blood cultures identify high mortality risk among patients with Gram-negative bacteraemia
Not Available
Maskarinec, S. A.↗
Methods identifying cost reduction potential for water electrolysis systems
The electrochemical reduction of water to form hydrogen is an emerging alternative for energy storage, where hydrogen can be used as a transportation fuel, combusted to generate electricity, utilized in a fuel cell, or used as a feedstock for chemical synthesis. Techno-economic analysis (TEA) is a valuable tool for understanding how to inform research directions that could make hydrogen from electrolysis cost competitive with that produced by conventional means like steam methane reforming. The current state of knowledge on TEA of electrolysis systems suggests cost reductions are likely to result from advances in system design and materials, scale-up of manufacturing processes, and learning by doing effects as electrolysis deployment increases. Future directions and opportunities for TEA of electrolysis systems include dispatchable operation in wholesale power markets, optimization of capital cost and system durability, and analysis of pathways for hydrogen to support economy-wide decarbonization.
08 HYDROGEN↗
An MINLP formulation to identify thermodynamically-efficient distillation configurations
Not provided.
Computer Science↗
A workflow for identifying metabolically active chemicals to complement in vitro toxicity screening
Not Available
Leonard, Jeremy A.↗
Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods
Metabolomics continues to make rapid progress through the development of new and better methods and their applications to gain insight into the metabolism of a wide range of different biological systems from a systems biology perspective. Customization of NMR databases and search tools allows the faster and more accurate identification of known metabolites, whereas the identification of unknowns, without a need for extensive purification, requires new strategies to integrate NMR with mass spectrometry, cheminformatics, and computational methods. For some applications, the use of covalent and non-covalent attachments in the form of labeled tags or nanoparticles can significantly reduce the complexity of these tasks.
Bingol, Kerem↗