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At least 1,171 records · Page 65

Study of Martian Polar Caps with GISS ROCKE-3D GCM

Martian polar caps consist of both H 2 O and CO 2 ice. While H 2 O ice is mainly passive on modern Mars, it may have not been the case in recent Martian history, when its obliquity was higher, or when it was changing rapidly. The distribution of ice species in the snowpack affects its physical and thermodynamic properties. In the upper layers, it determines its albedo and thermal emissivity. Thus understanding the mutual effect between these ices and their interaction with the atmosphere is crucial for understanding the evolution of Martian polar regions. In this study, we employ a newly-developed Exotic Ices snow model coupled to the NASA Goddard Institute for Space Studies (GISS) ROCKE-3D planetary General Circulation Model (GCM) [1] to study the behavior of Martian polar caps. ROCKE-3D is a planetary GCM developed at NASA GISS as an extension of its Earth climate model, modelE [2]. It has been extensively used to simulate climate of various planets, including Mars (e.g. [3,4]). The Exotic Ices snow model was specially developed for planetary applications which involve more than one condensable in the atmosphere, in which case snow can contain multiple species of ice (CO2 and H 2 O in the Mars case). For each species of ice, the model uses their proper physical properties and phase diagram, but otherwise it treats all species of ice on an equal footing. The combined effects on albedo, thermal inertia and mutual insulation are treated accordingly. The snowpack interacts with the atmospheric dust cycle, and can accumulate a prognostic amount of dust, though the effect of dust on snow properties is not currently treated explicitly, and is prescribed. In this study, we first validate our model against the modern Martial climate, for which we use mission results from Mars Climate Sounder (atmospheric temperature and dust optical depth), SPICAM on Mars Express (atmospheric water), and Viking 2 (surface pressure). We investigate the effect of snow radiative properties on CO 2 and water cycles and the ability of our model to accurately reproduce those with minimal model tuning. We then perform simulations for several obliquities from a recent Martian past, and investigate the behavior of the Martian polar caps in such conditions.

Mars↗

Sensitivity studies of nighttime top-of-atmosphere radiances from artificial light sources using a 3-D radiative transfer model for nighttime aerosol retrievals

By accounting for surface-based light source emissions and top-of-atmosphere (TOA) downward lunar fluxes, we adapted the spherical harmonics discrete ordinate method (SHDOM) 3-dimensional (3-D) radiative transfer model (RTM) to simulate nighttime 3-D TOA radiances as observed from the Visible Infrared Imaging Radiometer Suite (VIIRS) Day/Night Band (DNB) on board the Suomi-NPP satellite platform. Used previously for daytime 3-D applications, these new SHDOM enhancements allow for the study of the impacts of various observing conditions and aerosol properties on simulated VIIRS-DNB TOA radiances. Observations over Dakar, Senegal, selected for its bright city lights and a large range of aerosol optical depth (AOD), were investigated for potential applications and opportunities for using observed radiances containing VIIRS-DNB “bright pixels” from artificial light sources to conduct aerosol retrievals. We found that using the standard deviation (SD) of such bright pixels provided a more stable quantity for nighttime AOD retrievals than direct retrievals from TOA radiances. Further, both the mean TOA radiance and SD of TOA radiances over artificial sources are significantly impacted by satellite viewing angles. Light domes, the enhanced radiances adjacent to artificial light sources, are strong functions of aerosol properties and especially aerosol vertical distribution, which may be further utilized for retrieving aerosol layer height in future studies. Through inter-comparison with both day- and nighttime Aerosol Robotic Network (AERONET) data, the feasibility of retrieving nighttime AODs using 3-D RTM SHDOM over artificial light sources was demonstrated. Our study shows strong potential for using artificial light sources for nighttime AOD retrievals, while also highlighting larger uncertainties in quantifying surface light source emissions. This study underscores the need for surface light emission source characterizations as a key boundary condition, which is a complex task that requires enhanced input data and further research. We demonstrate how quality-controlled nighttime light data from NASA’s Black Marble product suite could serve as a primary input into estimations of surface light source emissions for nighttime aerosol retrievals.

Jianglong Zhang↗

Overview of an Exploratory, Real-Time, Multi-Pilot Simulation Study of Early eVTOL Operations at Non-Towered Vertiports

This paper provides a report out on an exploratory, multi-aircraft/multi-pilot, real-time simulation study conducted by NASA of early commercial powered-lift, Urban Air Mobility (UAM) operations at a non-towered vertiport. As used in this paper, vertiport refers to the primary ground and airspace elements facilitating the takeoff and landing of electric vertical takeoff and landing (eVTOL) aircraft with central emphasis on a vertipad, i.e. the physical touch-down and lift-off area and surrounding approach , departure, local pattern procedures. The study, known as the Piloted UML-2 ConOps Study (PUCS), had two high-level goals. The first goal was providing preliminary insights and observations relevant to the piloting and flight operations of early, commercial UAM operations aligned with the initial stage of the FAA’s Advanced Air Mobility (AAM) Implementation Plan and the second level NASA’s UAM Maturity Level (UML) scale. The second goal was evaluating a novel, medium-fidelity, extensible, many-pilot, real-time simulation capability known as the UAM Flyers developed by NASA. The Flyers are intended to allow rapid development, screening, evaluation, and demonstrations of potential Concepts of Operation (ConOps) for UAM flight operations and airspace management in a modular and low-cost, real-time, human-in-the-loop rapid simulation prototyping environment. For this study, ten Flyer cockpits were configured to evaluate flight operations through a non-towered vertiport with pilot interfaces and displays (external and in-cockpit) appropriate for operations under visual flight rules (VFR) and employing flight and communication procedures representative of current operations at non-towered airports. The presented results include an achieved operational tempo; durations of individual flight tasks for approaches and departures; off-nominal events and triggers; and pilot comments regarding potential procedural and technology improvements.

Urban Air Mobility↗

Space Based Solar Power Study

Space based solar power (SBSP) entails in-space collection of solar energy, transmission of that energy to one or more stations on Earth, conversion to electricity, and delivery to the grid or to batteries for storage. Experts in both the aerospace and energy sectors are debating the benefits of SBSP as more organizations globally begin SBSP technology development programs. We conducted a study to evaluate the potential benefits, challenges, and options for NASA to engage with growing global interest in SBSP. We performed a first order lifecycle study of two representative SBSP designs for 2 GW utility-scale power generation that, for the purposes of the study, are presumed to begin in 2050. We assumed baseline capabilities to develop, assemble, operate, maintain, and dispose of the SBSP systems are a mix of capabilities that are above, below, or comparable to capabilities demonstrated to date. We then compared the lifecycle cost of electricity and lifecycle GHG emission intensity of the SBSP designs to alternative terrestrial renewable electricity production technologies. Our findings indicate the SBSP designs may produce lifecycle GHG emissions per unit of electricity that are comparable to terrestrial alternatives, pending further studies of upper atmosphere responses to launch emissions. We find the SBSP designs are more expensive than terrestrial alternatives and may have lifecycle costs per unit of electricity that are 12-80 times higher. Though, we do find cost competitiveness may be achieved if a favorable combination of cost and capability improvements related to launch and manufacturing that are beyond the advancements assumed in the baseline assessment can be attained.

solar↗

Overview of an Exploratory, Multi-Pilot Simulation Study of Early eVTOL Operations at Non-Towered Vertiports

This paper provides a report out on an exploratory, multi-aircraft/multi-pilot, real-time simulation study conducted by NASA of early commercial powered-lift, Urban Air Mobility (UAM) operations at a non-towered vertiport. As used in this paper, vertiport refers to the primary ground and airspace elements facilitating the takeoff and landing of electric vertical takeoff and landing (eVTOL) aircraft with central emphasis on a vertipad, i.e. the physical touch-down and lift-off area and surrounding approach , departure, local pattern procedures. The study, known as the Piloted UML-2 ConOps Study (PUCS), had two high-level goals. The first goal was providing preliminary insights and observations relevant to the piloting and flight operations of early, commercial UAM operations aligned with the initial stage of the FAA’s Advanced Air Mobility (AAM) Implementation Plan and the second level NASA’s UAM Maturity Level (UML) scale. The second goal was evaluating a novel, medium-fidelity, extensible, many-pilot, real-time simulation capability known as the UAM Flyers developed by NASA. The Flyers are intended to allow rapid development, screening, evaluation, and demonstrations of potential Concepts of Operation (ConOps) for UAM flight operations and airspace management in a modular and low-cost, real-time, human-in-the-loop rapid simulation prototyping environment. For this study, ten Flyer cockpits were configured to evaluate flight operations through a non-towered vertiport with pilot interfaces and displays (external and in-cockpit) appropriate for operations under visual flight rules (VFR) and employing flight and communication procedures representative of current operations at non-towered airports. The presented results include an achieved operational tempo; durations of individual flight tasks for approaches and departures; off-nominal events and triggers; and pilot comments regarding potential procedural and technology improvements.

Urban Air Mobility↗

South Pole Lunar Lighting Studies for Driving Exploration on the Lunar Surface

NASA’s Artemis lunar missions will face new exploration challenges due to inherently low sun angles in the lunar south pole region. Whereas the Apollo missions were afforded sunlight for approximately 8 to 50-degrees above the horizon, sunlight for the next lunar missions will only be 1 to 2-degrees about the horizon. With this low angle, long shadows and high contrasts of light and dark areas will be faced by the crew and remote teleop operators while exploring the lunar surface. With this in mind, NASA developed an integrated virtual Lighting and Navigation Simulation to understand these challenges. Two studies have been conducted in this Lunar South Pole environment to evaluate the effects of natural and artificial lighting on driving and navigating a lunar rover across the surface. Early NASA studies, such as this, are used to aid in developing techniques and explore concepts of operations to promote mission success and crew safety. In the Phase One development evaluation, six astronauts were teleported to ten different lighting conditions. For each location, drivers were to drive to an imaginary target approximately 200-meters straight ahead and provide subjective feedback on their ability to drive under the given lighting conditions. Phase Two, a more operational study, four astronauts and a remote operator tested five different Artemis lunar mission scenarios. Results indicated sun direction at such low angles, especially when driving a high speed, can severely impact the crew’s ability to safely drive the rover. In the up-sun situation, with the sun directly in the driver’s eyes and compounded long shadows, the consistent preference among drivers was to initiate a tacking strategy of approximately +/- 20 to 30-degrees to improve visibility. This maneuver does require more time and rover energetics. Conversely, driving down-sun required the crew to tack as well to avoid the shadow of rover blocking the terrain. Less appreciated is how the surrounding landscape is lit. Traveling into shadowed areas, especially while facing a lit terrain beyond the shadowed area, drivers enter at their own risk due to pupil contraction making artificial lights useless. Additionally, the constant transitioning between dark and light areas are mentally taxing to the crew and natural navigational references such as the stars are invisible and therefore unusable. Slope and depth magnitude are very difficult hazards to judge when approaching a shadowed crater. This naturally leads to slower driving speeds than originally anticipated. As for observing scientifically interesting features, assessing them accurately varies greatly by the lighting condition. In most cases, the task can be completed, but the strategy is to use the sun to one’s advantage. Crew workload distribution in the cockpit for driving operations was split amongst crew. The driver primarily focused attention on visual terrain (80%) but referenced displays approximately 20% of the time, while the co-pilot/navigator generally provided directional cues to the driver. These natural lighting conditions present significant challenges for safe rover operations; however, early studies having given investigators a “first-look” into understanding of how operating on the South Lunar Pole can be accomplished.

LTv↗

Plant Watering in Low Gravity: The Study of the Fluid Dynamic Characteristics of Lunar Regolith Simulant for the Application of Crop Production Systems Using Scaled Capillary Devices

Bioregenerative life support is key to sustaining human life on the surface of other celestial bodies for missions beyond Low Earth Orbit (LEO). One example of such life support includes crop production systems capable of producing both plants and fungi for astronaut consumption. There have been numerous efforts to design and deploy such systems; however, there have been persistent fundamental issues with the water delivery systems. This study aims to understand and model the fluid dynamics of crop production systems to inform engineers about the key parameters needed for the design of such systems. The primary objective is to validate and expand upon NASA’s previous study, the Plant Water Management (PWM) experiments, to understand the fluid phenomena present in substrate-based systems. The model will then be expanded to include parameters for changing the test material of potential growth media as well as the varying water demands of the crop throughout its different stages in its life cycle. Specifically, this study is focused on the viability of using lunar regolith for agricultural purposes. Terrestrial-based scaled capillary models will be utilized to mimic the fluid phenomena occurring due to the low gravity environment seen on the lunar surface. Ultimately, the study will model the fluid flow present in the lunar regolith simulant and inform researchers on how to incorporate the material into crop production systems on the lunar surface.

gravity↗

Conclusions of a Cryogenic Motor Configuration Study for Aircraft Propulsion

Cryogenic electric machines are a promising technology for multi megawatt electric aircraft drivetrains. Superconducting stators that make use of low AC loss superconducting wires are considered to be a key component for these cryogenic machines. This paper shares the lessons learned from a design study that evaluated several configurations of a 5 MW cryogenic motor for this application. The lessons are drawn from a qualitative study of 16 configurations and a quantitative study of 8 down selected configurations. The quantitative study involved using analytical calculations (electromagnetic, thermofluid, mechanical, and motor sizing) to determine each configuration’s Pareto front of total efficiency and total specific power. The conclusions from a preliminary assessment of different stator conductors (superconductors and cryogenic metals) are also presented. One motor configuration is down selected for future detailed design and demonstration at the multi megawatt level.

Electrified aircraft propulsion↗

Lessons Learned From A Cryogenic Motor Configuration Study for Aircraft Propulsion

Cryogenic electric machines are a promising technology for multi megawatt electric aircraft drivetrains. Superconducting stators that make use of low AC loss superconducting wires are considered to be a key component for these cryogenic machines. NASA has undertaken 6-year technical challenge to address this need by designing a 5 MW superconducting motor and cryogenic drive and developing multi-MW prototypes. This poster shares the lessons learned from a completed design study that evaluated several configurations of a 5 MW cryogenic motor for this application. The lessons are drawn from a qualitative study of 16 configurations and a quantitative study of 8 down selected configurations. The quantitative study involved using a motor design code based on analytical calculations (electromagnetic, thermofluid, mechanical, and motor sizing) to determine each configuration’s Pareto front of total efficiency and total specific power. This poster builds upon preliminary results that were previously presented by (1) reporting final results based on a revised design code for each configuration, including a considerable increase in fidelity for a novel radial flux motor and (2) making a down selection of the configuration for future detailed design and demonstration and documenting the rationale for the selection.

Superconductors↗

Quantitative analysis of aortic regurgitation: real-time 3-dimensional and 2-dimensional color Doppler echocardiographic method--a clinical and a chronic animal study

BACKGROUND: For evaluating patients with aortic regurgitation (AR), regurgitant volumes, left ventricular (LV) stroke volumes (SV), and absolute LV volumes are valuable indices. AIM: The aim of this study was to validate the combination of real-time 3-dimensional echocardiography (3DE) and semiautomated digital color Doppler cardiac flow measurement (ACM) for quantifying absolute LV volumes, LVSV, and AR volumes using an animal model of chronic AR and to investigate its clinical applicability. METHODS: In 8 sheep, a total of 26 hemodynamic states were obtained pharmacologically 20 weeks after the aortic valve noncoronary (n = 4) or right coronary (n = 4) leaflet was incised to produce AR. Reference standard LVSV and AR volume were determined using the electromagnetic flow method (EM). Simultaneous epicardial real-time 3DE studies were performed to obtain LV end-diastolic volumes (LVEDV), end-systolic volumes (LVESV), and LVSV by subtracting LVESV from LVEDV. Simultaneous ACM was performed to obtain LVSV and transmitral flows; AR volume was calculated by subtracting transmitral flow volume from LVSV. In a total of 19 patients with AR, real-time 3DE and ACM were used to obtain LVSVs and these were compared with each other. RESULTS: A strong relationship was found between LVSV derived from EM and those from the real-time 3DE (r = 0.93, P <.001, mean difference (3D - EM) = -1.0 +/- 9.8 mL). A good relationship between LVSV and AR volumes derived from EM and those by ACM was found (r = 0.88, P <.001). A good relationship between LVSV derived from real-time 3DE and that from ACM was observed (r = 0.73, P <.01, mean difference = 2.5 +/- 7.9 mL). In patients, a good relationship between LVSV obtained by real-time 3DE and ACM was found (r = 0.90, P <.001, mean difference = 0.6 +/- 9.8 mL). CONCLUSION: The combination of ACM and real-time 3DE for quantifying LV volumes, LVSV, and AR volumes was validated by the chronic animal study and was shown to be clinically applicable.

Validation Studies↗

Gravitational-wave Mission Study

In November 2013, ESA selected the science theme, the "Gravitational Universe," for its third large mission opportunity, known as L3, under its Cosmic Vision Programme. The planned launch date is 2034. ESA is considering a 20% participation by an international partner, and NASA's Astrophysics Division has indicated an interest in participating. We have studied the design consequences of a NASA contribution, evaluated the science benefits and identified the technology requirements for hardware that could be delivered by NASA. The European community proposed a strawman mission concept, called eLISA, having two measurement arms, derived from the well studied LISA (Laser Interferometer Space Antenna) concept. The US community is promoting a mission concept known as SGO Mid (Space-based Gravitational-wave Observatory Mid-sized), a three arm LISA-like concept. If NASA were to partner with ESA, the eLISA concept could be transformed to SGO Mid by the addition of a third arm, augmenting science, reducing risk and reducing non-recurring engineering costs. The characteristics of the mission concepts and the relative science performance of eLISA, SGO Mid and LISA are described. Note that all results are based on models, methods and assumptions used in NASA studies

identified the technology requirements↗

Near-Earth Asteroid Retrieval Mission (ARM) Study

The Asteroid Redirect Mission (ARM) concept brings together the capabilities of the science, technology, and the human exploration communities on a grand challenge combining robotic and human space exploration beyond low Earth orbit. This paper addresses the key aspects of this concept and the options studied to assess its technical feasibility. Included are evaluations of the expected number of potential targets, their expected discovery rate, the necessity to adequately characterize candidate mission targets, the process to capture a non-cooperative asteroid in deep space, and the power and propulsion technology required for transportation back to the Earth-Moon system. Viable options for spacecraft and mission designs are developed. Orbits for storing the retrieved asteroid that are stable for more than a hundred years, yet allow for human exploration and commercial utilization of a redirected asteroid, are identified. The study concludes that the key aspects of finding, capturing and redirecting an entire small, near-Earth asteroid to the Earth-Moon system by the first half of the next decade are technically feasible. The study was conducted from January 2013 through March 2013 by the Jet Propulsion Laboratory (JPL) in collaboration with Glenn Research Center (GRC), Johnson Space Center (JSC), Langley Research Center (LaRC), and Marshall Space Flight Center (MSFC).

Solar Electric Propulsion (SEP)↗

The Large UV/Optical/Infrared Surveyor (LUVOIR): Decadal Mission Concept Study Update

In preparation for the 2020 Decadal Survey in Astronomy and Astrophysics, NASA commissioned the study of four large mission concepts: the Large UV/Optical/Infrared Surveyor (LUVOIR), the Habitable Exoplanet Imager (HabEx), the far-infrared surveyor Origins Space Telescope (OST), and the X-ray surveyor Lynx. The LUVOIR Science and Technology Definition Team (STDT) has identified a broad range of science objectives for LUVOIR that include the direct imaging and spectral characterization of habitable exoplanets around sun-like stars, the study of galaxy formation and evolution, the exchange of matter between galaxies, star and planet formation, and the remote sensing of Solar System objects. The LUVOIR Study Office, located at NASA's Goddard Space Flight Center (GSFC), is developing two mission concepts to achieve the science objectives. LUVOIR-A is a 15-meter segmented-aperture observatory that would be launched in an 8.4-m extended fairing on the Space Launch System (SLS) Block 2 configuration. LUVOIR-B is an 8-meter unobscured segmented aperture telescope that fits in a smaller, conventional 5-meter fairing, but still requires the lift capacity of the SLS Block 1B Cargo vehicle. Both concepts include a suite of serviceable instruments: the Extreme Coronagraph for Living Planetary Systems (ECLIPS), an optical/near-infrared coronagraph capable of delivering 10 (sup minus10) contrast at inner working angles as small as 2 lambda divided by D; the LUVOIR UV Multi-object Spectrograph (LUMOS), which will provide low- and medium-resolution UV (100-400 nanometer) multi-object imaging spectroscopy in addition to far-UV imaging; the High Definition Imager (HDI), a high-resolution wide-field-of-view NUV-Optical-NIR imager. LUVOIR-A also has a fourth instrument, Pollux, a high-resolution UV spectro-polarimeter being contributed by Centre National d'Etudes Spatiales (CNES). This paper provides an overview of the LUVIOR science objectives, design drivers, and mission concepts.

Decadal Study↗

The Large UV/Optical/Infrared Surveyor (LUVOIR): Decadal Mission Concept Study Update

In preparation for the 2020 Decadal Survey in Astronomy and Astrophysics, NASA commissioned the study of four large mission concepts: the Large UV/Optical/Infrared Surveyor (LUVOIR), the Habitable Exoplanet Imager (HabEx), the far-infrared surveyor Origins Space Telescope (OST), and the X-ray surveyor Lynx. The LUVOIR Science and Technology Definition Team (STDT) has identified a broad range of science objectives for LUVOIR that include the direct imaging and spectral characterization of habitable exoplanets around sun-like stars, the study of galaxy formation and evolution, the exchange of matter between galaxies, star and planet formation, and the remote sensing of Solar System objects. The LUVOIR Study Office, located at NASA's Goddard Space Flight Center (GSFC), is developing two mission concepts to achieve the science objectives. LUVOIR-A is a 15-meter segmented-aperture observatory that would be launched in an 8.4-meter extended fairing on the Space Launch System (SLS) Block 2 configuration. LUVOIR-B is an 8-meter unobscured segmented aperture telescope that fits in a smaller, conventional 5-meter fairing, but still requires the lift capacity of the SLS Block 1B Cargo vehicle. Both concepts include a suite of serviceable instruments: the Extreme Coronagraph for Living Planetary Systems (ECLIPS), an optical/near-infrared coronagraph capable of delivering 10 (sup minus 10) contrast at inner working angles as small as 2 lambda divided by D; the LUVOIR UV Multi-object Spectrograph (LUMOS), which will provide low- and medium-resolution UV (100-400 nanometer) multi-object imaging spectroscopy in addition to far-UV imaging; the High Definition Imager (HDI), a high-resolution wide-field-of-view NUV-Optical-NIR imager. LUVOIR-A also has a fourth instrument, Pollux, a high-resolution UV spectro-polarimeter being contributed by Centre National d'Etudes Spatiales (CNES). This paper provides an overview of the LUVIOR science objectives, design drivers, and mission concepts.

Decadal Study↗

Parametric-Based Heat Rejection Trade Study for Lunar and Martian Surface Operations

Establishing and maintaining a sustained presence on the lunar and/or Martian surfaces will require a diverse portfolio of surface elements (e.g., habitation, mobility, power generation, etc.). Many of these systems generate excess heat that must be rejected across a wide range of magnitudes, temperatures, and duty cycles and under variable environmental conditions. To identify the most promising heat rejection approaches for this diverse portfolio, a heat rejection trade study was conducted to evaluate the performance of different technology approaches across a spectrum of surface environments and heat-load requirements. The trade study consisted of three stages: (1) development of a parametric-based modeling framework, (2) creation of a database of heat rejection technologies, surface elements, and environmental conditions for the Moon and Mars, and (3) execution of a quantitative analysis of various heat rejection technologies across different operating conditions and surface elements. The modeling framework is developed in Python and Excel to prioritize small model size and hence low computational cost to enable large parametric sweeps while avoiding the reliance on proprietary software. Individual heat rejection processes are represented as simple Excel models, and a centralized Python script interfaces with the models to coordinate the parametric study. These simple sizing models were developed to take heat load requirements and environmental parameters as inputs and compute mass, power, and volume as outputs. Rather than assess each heat rejection technology separately for each surface element, a unified parametric space was developed to evaluate all technologies across all elements. This parametric space includes factors related to heat load (e.g., magnitude or temperature) and environment (e.g., surface temperature, sky temperature, solar flux). This effort generated a database containing information on over 60 heat rejection technologies and 30 surface elements. For each surface element, the expected heat rejection requirements were documented and analyzed to determine the most common needs shared across all elements. Environmental conditions at various lunar and Martian latitudes were also established for worst-case hot and worst-case cold scenarios. High-fidelity heat rejection models are currently under development. Preliminary trades between heat rejection technologies including radiators, venting technologies, convective coolers, and more have been conducted to identify promising options. This presentation will summarize the preliminary trade results and provide an overview and discussion of the expected heat loads and thermal environments for sustained surface operations on the Moon and Mars.

Heat Rejection↗

Usefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational study

OBJECTIVES: This study was designed to evaluate the ability of microvolt-level T-wave alternans (MTWA) to identify prospectively patients with idiopathic dilated cardiomyopathy (DCM) at risk of ventricular tachyarrhythmic events and to compare its predictive accuracy with that of conventional risk stratifiers. BACKGROUND: Patients with DCM are at increased risk of sudden death from ventricular tachyarrhythmias. At present, there are no established methods of assessing this risk. METHODS: A total of 137 patients with DCM underwent risk stratification through assessment of MTWA, left ventricular ejection fraction, baroreflex sensitivity (BRS), heart rate variability, presence of nonsustained ventricular tachycardia (VT), signal-averaged electrocardiogram, and presence of intraventricular conduction defect. The study end point was either sudden death, resuscitated ventricular fibrillation, or documented hemodynamically unstable VT. RESULTS: During an average follow-up of 14 +/- 6 months, MTWA and BRS were significant univariate predictors of ventricular tachyarrhythmic events (p < 0.035 and p < 0.015, respectively). Multivariate Cox regression analysis revealed that only MTWA was a significant predictor. CONCLUSIONS: Microvolt-level T-wave alternans is a powerful independent predictor of ventricular tachyarrhythmic events in patients with DCM.

Evaluation Studies↗

WRF Hindcasts of Cold Front Passages over the ARM Eastern North Atlantic Site: A Sensitivity Study

The present study explores the ability of the Weather Research and Forecasting (WRF) Model to accurately reproduce the passage of extratropical cold fronts at the DOE-ARM Eastern North Atlantic (ENA) observation site on the Azores Islands. An analysis of three case studies is performed in which the impact of the WRF domain size, position of the model boundary relative to the ENA site, grid spacing, and spectral nudging conditions are explored. The results from these case studies indicate that model biases in the timing and duration of cold front passages change with the distance between the model domain boundary and the ENA site. For these three cases, if the western model boundary is further than 1500 km from the site, the front becomes too meridional and fails to reach the site, making 1000 km or 1500 km the optimal distances. In contrast, integrations with small distances (e.g., 500 km) between the site and domain boundaries have inadequate spatial spin-up, i.e. the domain is too small for the model to properly stabilize. For all 3 cases, regardless of domain size, the model has biases in its upper-level circulation that impact the position and timing of the front. However, this issue is most serious for 4000 km2 domains and larger. For these domains, prolonged spectral nudging can correct cold front biases. As such, this analysis provides a framework to optimize the WRF model configuration necessary for a realistic hindcast of a cold front passage at a fixed location centered in a domain as large as computationally possible.

Faycal Lamraoui↗

Photosynthetic Gas Exchange in the Closed Ecosystem for Space. Phase II, Part II. Studies on the Growth of Thermophilic Chlorella 71105

Bench-scale studies with Chlorella pyrenoidosa 71105 were conducted in four- and eight-liter culture vessels, with and without recycling. It was established that the algal strain could be maintained for periods up to 72 days with supplemented re-cycled medium. In a factorial series of experiments, the highest yields were obtained with a 2.0% concentration of carbon dioxide, a 0.07 dilution factor (nutrient dilution rate/culture volume), and an 8.5 ft(exp -1) ratio of light surface to liquid culture volume. Optimum pH and concentrations of the constituents of the growth medium were determined in corollary test-tube studies. Other test-tube studies showed that the nutrient medium used for mass culture could be stored up to five weeks at 25 C or at refrigerator temperature (4 C) with little change in nitrogen-urea level. Algal suspensions stored at 4 C remained viable for periods of at least 12 weeks; growth resumed after a lag period when stored suspensions were cultured at 39 C. Streptomycin was found suitable for controlling a blue-green containment.

ALGAE↗