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At least 1,171 records · Page 65

All sources NASA NTRS DOE OSTI

DOE OSTI2024

Entropy Analysis of FPGA Interconnect and Switch Matrices for Physical Unclonable Functions

Random variations in microelectronic circuit structures represent the source of entropy for physical unclonable functions (PUFs). In this paper, we investigate delay variations that occur through the routing network and switch matrices of a field-programmable gate array (FPGA). The delay variations are isolated from other components of the programmable logic, e.g., look-up tables (LUTs), flip-flops (FFs), etc., using a feature of Xilinx FPGAs called dynamic partial reconfiguration (DPR). A set of partial designs is created to fix the placement of a time-to-digital converter (TDC) and supporting infrastructure to enable the path delays through the target interconnect and switch matrices to be extracted by subtracting out common-mode delay components. Delay variations are analyzed in the different levels of routing resources available within FPGAs, i.e., local routing and across-chip routing. Data are collected from a set of Xilinx Zynq 7010 devices, and a statistical analysis of within-die variations in delay through a set of the randomly-generated and hand-crafted interconnects is presented.

97 MATHEMATICS AND COMPUTING↗

DOE OSTI2016

Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines

Polymer-based interpenetrating networks (IPNs) with controllable and programmable degradation and release kinetics enable unique opportunities for physisorption and controlled release of therapeutic proteins or vaccines while their chemical and structural integrities are conserved. This paper presents materials, a simple preparation method, and release kinetics of a series of long-term programmable, biocompatible, and biodegradable polymer-based IPN controlled release platforms. Release kinetics of the gp41 protein was controlled over a 30-day period via tuning and altering the chemical structure of the IPN platforms. Post-release analysis confirmed structural conservation of the gp41 protein throughout the process. Cell viability assay confirmed biocompatibility and non-cytotoxicity of the IPNs.

Materials Science↗

DOE OSTI2020

Dynamically Reconfigurable Data Readout of Pixel Detectors for Automatic Synchronization with Data Acquisition Systems

Reconfigurable detectors with dynamically selectable sensing and readout modes are highly desirable for implementing edge computing as well as enabling advanced imaging techniques such as foveation. The concept of a camera system capable of simultaneous passive imaging and dynamic ranging in different regions of the detector is presented. Such an adaptive-autonomous detector with both spatial and temporal control requires programmable window of exposure (time frames), ability to switch between readout modes such as full-frame imaging and zero-suppressed data, modification of the number of pixel data bits and independent programmability for distinct detector regions. In this work, a method is presented for seamlessly changing time frames and readout modes without data corruption while still ensuring that the data acquisition system (DAQ) does not need to stop and resynchronize at each change of setting, thus avoiding significant dead time. Data throughput is maximized by using a minimum unique data format, rather than lengthy frame headers, to differentiate between consecutive frames. A data control and transmitter (DCT) synchronizes data transfer from the pixel to the periphery, reconfigures the data to transmit it serially off-chip, while providing optimized decision support based on a DAQ definable mode. Measurements on a test structure demonstrate that the DCT can operate at 1 GHz in a 65 nm LP CMOS process.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

DOE OSTI2024

A Modular 512-Channel Neural Signal Acquisition ASIC for High-Density 4096 Channel Electrophysiology

The complexity of information processing in the brain requires the development of technologies that can provide spatial and temporal resolution by means of dense electrode arrays paired with high-channel-count signal acquisition electronics. In this work, we present an ultra-low noise modular 512-channel neural recording circuit that is scalable to up to 4096 simultaneously recording channels. The neural readout application-specific integrated circuit (ASIC) uses a dense 8.2 mm × 6.8 mm 2D layout to enable high-channel count, creating an ultra-light 350 mg flexible module. The module can be deployed on headstages for small animals like rodents and songbirds, and it can be integrated with a variety of electrode arrays. The chip was fabricated in a TSMC 0.18 µm 1.8 V CMOS technology and dissipates a total of 125 mW. Each DC-coupled channel features a gain and bandwidth programmable analog front-end along with 14 b analog-to-digital conversion at speeds up to 30 kS/s. Additionally, each front-end includes programmable electrode plating and electrode impedance measurement capability. We present both standalone and in vivo measurements results, demonstrating the readout of spikes and field potentials that are modulated by a sensory input.

47 OTHER INSTRUMENTATION↗

DOE OSTI2025

The Linear Collider Facility (LCF) at CERN

In this paper we outline a proposal for a Linear Collider Facility as the next flagship project for CERN. It offers the opportunity for a timely, cost-effective and staged construction of a new collider that will be able to comprehensively map the Higgs boson's properties, including the Higgs field potential, thanks to a large span in centre-of-mass energies and polarised beams. A comprehensive programme to study the Higgs boson and its closest relatives with high precision requires data at centre-of-mass energies from the Z pole to at least 1 TeV. It should include measurements of the Higgs boson in both major production mechanisms, ee -> ZH and ee -> vvH, precision measurements of gauge boson interactions as well as of the W boson, Higgs boson and top-quark masses, measurement of the top-quark Yukawa coupling through ee ->ttH, measurement of the Higgs boson self-coupling through HH production, and precision measurements of the electroweak couplings of the top quark. In addition, ee collisions offer discovery potential for new particles complementary to HL-LHC.

43 PARTICLE ACCELERATORS↗

DOE OSTI2026

Quantum science with arrays of metastable helium-3 atoms

The motion of atoms in programmable optical tweezer arrays offers many new opportunities for neutral atom quantum science. These include inter- and intra-site atom motion for resource-efficient implementations of fermionic and bosonic modes, respectively, as well as tweezer transport for efficient compilation of arbitrary circuits. However, the exploitation of atomic motion for all three purposes and others is limited by the inertia of the atoms. We present a comprehensive architectural blueprint for the use of fermionic metastable helium-3 (He) atoms -- the lightest trappable atomic species -- in programmable optical tweezer arrays. This includes a concrete analysis of atomic structure considerations as well as Rydberg-mediated interactions. We show that inter-tweezer hopping of He atoms can be faster than previous demonstrations with lithium-6. We also demonstrate a new toolbox for encoding and manipulating qubits directly in the tweezer trap potential, uniquely enabled by the light mass of He. Finally, we provide several examples of new opportunities for fermionic quantum simulation and computation that leverage the transport and inter-tweezer hopping of He atom arrays. These tools present new methods to improve the resource efficiency of neutral atom quantum science that may also enable quantum simulations of lattice gauge theories and quantum chemistry outside the Born-Oppenheimer approximation

Li, Zheyuan↗

DOE OSTI2016

Russia's black carbon emissions: focus on diesel sources

Black carbon (BC) is a significant climate forcer with a particularly pronounced forcing effect in polar regions such as the Russian Arctic. Diesel combustion is a major global source of BC emissions, accounting for 25–30 % of all BC emissions. While the demand for diesel is growing in Russia, the country's diesel emissions are poorly understood. This paper presents a detailed inventory of Russian BC emissions from diesel sources. Drawing on a complete Russian vehicle registry with detailed information about vehicle types and emission standards, this paper analyzes BC emissions from diesel on-road vehicles. We use the COPERT emission model (COmputer Programme to calculate Emissions from Road Transport) with Russia-specific emission factors for all types of on-road vehicles. On-road diesel vehicles emitted 21 Gg of BC in 2014: heavy-duty trucks account for 60% of the on-road BC emissions, while cars represent only 5% (light commercial vehicles and buses account for the remainder). Using Russian activity data and fuel-based emission factors, the paper also presents BC emissions from diesel locomotives and ships, off-road engines in industry, construction and agriculture, and generators. The study also factors in the role of superemitters in BC emissions from diesel on-road vehicles and off-road sources. The total emissions from diesel sources in Russia are estimated to be 49 Gg of BC and 17 Gg of organic carbon (OC) in 2014. Off-road diesel sources emitted 58% of all diesel BC in Russia.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2018

RNA-dependent RNA targeting by CRISPR-Cas9

Double-stranded DNA (dsDNA) binding and cleavage by Cas9 is a hallmark of type II CRISPR-Cas bacterial adaptive immunity. All known Cas9 enzymes are thought to recognize DNA exclusively as a natural substrate, providing protection against DNA phage and plasmids. Here, we show that Cas9 enzymes from both subtypes II-A and II-C can recognize and cleave single-stranded RNA (ssRNA) by an RNA-guided mechanism that is independent of a protospacer-adjacent motif (PAM) sequence in the target RNA. RNA-guided RNA cleavage is programmable and site-specific, and we find that this activity can be exploited to reduce infection by single-stranded RNA phage in vivo. We also demonstrate that Cas9 can direct PAM-independent repression of gene expression in bacteria. These results indicate that a subset of Cas9 enzymes have the ability to act on both DNA and RNA target sequences, and suggest the potential for use in programmable RNA targeting applications.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2022

Molecular mechanism of active Cas7-11 in processing CRISPR RNA and interfering target RNA

Cas7-11 is a Type III-E CRISPR Cas effector that confers programmable RNA cleavage and has potential applications in RNA interference. Cas7-11 encodes a single polypeptide containing four Cas7- and one Cas11-like segments that obscures the distinction between the multi-subunit Class 1 and the single-subunit Class-2 CRISPR Cas systems. We report a cryo-EM (cryo-electron microscopy) structure of the active Cas7-11 from Desulfonema ishimotonii (DiCas7-11) that reveals the molecular basis for RNA processing and interference activities. DiCas7-11 arranges its Cas7- and Cas11-like domains in an extended form that resembles the backbone made up by four Cas7 and one Cas11 subunits in the multi-subunit enzymes. Unlike the multi-subunit enzymes, however, the backbone of DiCas7-11 contains evolutionarily different Cas7 and Cas11 domains, giving rise to their unique functionality. The first Cas7-like domain nearly engulfs the last 15 direct repeat nucleotides in processing and recognition of the CRISPR RNA, and its free-standing fragment retains most of the activity. Both the second and the third Cas7-like domains mediate target RNA cleavage in a metal-dependent manner. The structure and mutational data indicate that the long variable insertion to the fourth Cas7 domain has little impact on RNA processing or targeting, suggesting the possibility for engineering a compact and programmable RNA interference tool.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1972

Interactive graphics system for IBM 1800 computer

A FORTRAN compatible software system that has been developed to provide an interactive graphics capability for the IBM 1800 computer is described. The interactive graphics hardware consists of a Hewlett-Packard 1300A cathode ray tube, Sanders photopen, digital to analog converters, pulse counter, and necessary interface. The hardware is available from IBM as several related RPQ's. The software developed permits the application programmer to use IBM 1800 FORTRAN to develop a display on the cathode ray tube which consists of one or more independent units called pictures. The software permits a great deal of flexibility in the manipulation of these pictures and allows the programmer to use the photopen to interact with the displayed data and make decisions based on information returned by the photopen.

Carleton, T. P.↗

NASA NTRS1970

Syntax-directed documentation for PL360

PL360 is a phrase-structured programming language which provides the facilities of a symbolic machine language for the IBM 360 computers. An automatic process, syntax-directed documentation, is described which acquires programming documentation through the syntactical analysis of a program, followed by the interrogation of the originating programmer. This documentation can be dispensed through reports of file query replies when other programmers later need to know the program structure and its details. A key principle of the programming documentation process is that it is managed solely on the basis of the syntax of programs.

Mills, H. D.↗

NASA NTRS1973

Software approach to automatic patching of analog computer

The Automatic Patching Verification program (APV) is described which provides the hybrid computer programmer with a convenient method of performing a static check of the analog portion of his study. The static check insures that the program is patched as specified, and that the computing components being used are operating correctly. The APV language the programmer uses to specify his conditions and interconnections is similar to the FORTRAN language in syntax. The APV control program reads APV source program statements from an assigned input device. Each source program statement is processed immediately after it is read. A statement may select an analog console, set an analog mode, set a potentiometer or DAC, or read from the analog console and perform a test. Statements are read and processed sequentially. If an error condition is detected, an output occurs on an assigned output device. When an end statement is read, the test is terminated.

Source record↗

NASA NTRS1975

Evaluation of several navigation algorithms for application to general aviation

Using data obtained in flight, three position determining algorithms for use by general aviation aircraft were evaluated representing increasing software requirements. These were a DME only, DME/air data and blended DME/air data. Although each step represented additional software with resultant increase in position accuracy, all could be performed on a programmable electronic desk calculator. Results from the computation of aircraft position using the three algorithms are presented. The algorithms employed can be extended to accept VOR, TACAN bearing, ADF, or other NAVAID Data. To obtain the flight data an experimental system was configured and flown on a general aviation aircraft. Principal hardware elements (all with low-cost potential) were a programmable calculator, a single DME receiver (multiplexed for multiple DME use) and a low-cost air speed sensor (shed-vortex principle). The flight test demonstrated satisfactory performance of these principal elements.

Conrad, B.↗

NASA NTRS1976

Hardware additions to microprocessor architecture aid software development

An address trap (breakpoint) mechanism and last-in-first-out (LIFO) address stack are suggested as two additions to the basic microprocessor architecture whose functions are solely to aid the programmer. These devices provide the programmer with the ability to specify address breakpoints and to trace program execution back through N instructions, where N is the depth of the stack. Both devices, plus interface logic and buffering, have been designed for an INTEL 8080-based system using approximately 25 integrated-circuit packages.

Sievers, M. W.↗

NASA NTRS1977

Ergometer

The bicycle ergometer was designed for use in experiments M171 and M093 and for use in optional exercise by the crewmen. The ergometer allows a crewman to exercise in zero-gravity using either his hands or his feet. It provides a precisely calibrated and, if needed, a programmable standard of work rate for the crewman. The ergometer operates in any of three selectable modes. The set heart rate mode varies the ergometer work rate, as necessary, to achieve and maintain a preselected heart rate. The sequenced heart rate mode is similar to the set heart rate mode except that the heart rate is programmable through five preset levels with a period of time for each level. The set work rate mode delivers a preset work load to the subject.

Lem, J. D.↗

NASA NTRS1978

A cycle timer for testing electric vehicles

A cycle timer was developed to assist the driver of an electric vehicle in more accurately following and repeating SAE driving schedules. These schedules require operating an electric vehicle in a selected stop-and-go driving cycle and repeating this cycle pattern until the vehicle ceases to meet the requirements of the cycle. The heart of the system is a programmable read-only memory (PROM) that has the required test profiles permanently recorded on plug-in cards, one card for each different driving schedule. The PROM generates a direct current analog signal that drives a speedometer displayed on one scale of a dual movement meter. The second scale of the dual movement meter displays the actual speed of the vehicle as recorded by the fifth wheel. The vehicle operator controls vehicle speed to match the desired profile speed. The PROM controls the recycle start time as well as the buzzer activation. The cycle programmer is powered by the test vehicle's 12-volt accessory battery, through a 5-volt regulator and a 12-volt dc-to-dc converter.

Soltis, R. F.↗

NASA NTRS1978

Operational manual for two-dimensional transonic code TSFOIL

This code solves the two-dimensional, transonic, small-disturbance equations for flow past lifting airfoils in both free air and various wind-tunnel environments by using a variant of the finite-difference method. A description of the theoretical and numerical basis of the code is provided, together with complete operating instructions and sample cases for the general user. In addition, a programmer's manual is also presented to assist the user interested in modifying the code. Included in the programmer's manual are a dictionary of subroutine variables in common and a detailed description of each subroutine.

Stahara, S. S.↗

NASA NTRS1978

Improvements of the gravity field from satellite techniques as proposed to the European Space Agency

A summary of the European Earth Sciences Space Programme and the requirements for each gravity field mapping resulting from this programme are given. Three satellite experiments for gravity field improvement proposed to the European Space Agency in the last years are shortly characterized. One of these experiments, the low-low-SST-SLALOM experiment, based on laser interferometry for a "two target-one Spacelab telescope" configuration, is discussed in more detail. Reasons for the low-low concept selection are given and some mission aspects and a possible system concept for a compact ranging, acquisition and tracking system are presented.

Reigber, C.↗