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NASA NTRS2001

Global Failure Modes in Composite Structures

Composite materials provide well-known advantages for space and aeronautical applications in terms of strength and rigidity to weight ratios and other mechanical properties. As a consequence, their use has experienced a constant increase in the past decades and it is anticipated that this trend will be maintained in the near future. At the same time, being these materials relatively new compared to metals, and having failure characteristics completely different from them, their damage growth and their failure mechanisms are not as well understood in a predictive sense. For example, while in metals fracture produces "clean" cracks with their well defined analytically stress fields at the crack tip, composite fracture is a more complex phenomenon. Instead of a crack, we confront a "damage zone" that may include fiber breakage, fiber microbuckling, fiber pullout, matrix cracking, delamination, debonding or any combination of all these different mechanisms. These phenomena are prevalent in any failure process through an aircraft structure, whether one addresses a global failure such as the ripping of a fuselage or wing section, or whether one is concerned with the failure initiation near a thickness change at stringers or other reinforcement. Thus the topic that has been under consideration has wide application in any real structure and is considered an essential contribution to the predictive failure analysis capability for aircraft containing composite components. The heterogeneity and the anisotropy of composites are not only advantageous but essential characteristics, yet these same features provide complex stress fields, especially in the presence of geometrical discontinuities such as notches, holes or cutouts or structural elements such as stiffeners, stringers, etc. To properly address the interaction between a damage/crack front and a hole with a stringer it is imperative that the stress and deformation fields of the former be (sufficiently well) characterized. The question of "scaling" is an essential concern in any structural materials investigation. For example, experiments in the past have shown that the "strength" of a composite depends on hole size. As a consequence the validity of traditional fracture mechanics concepts applied to composite materials failure must be questioned. The size of the fibers, the dimensions of the laminae, etc. together with the fact that, because of the layered anisotropy, the stress field is no longer two-dimensional, prevent the otherwise obviously confident use of "similarity concepts". Therefore, the question needs to be raised of whether in composites "size matters or not", i.e., whether the results obtained in a laboratory using small coupons are truly representative of the situation involving a full scale component.

Knauss, W. G.↗

NASA NTRS2000

Solar Spicules: A Review of Recent Models and Targets for Future Observations

Since their discovery over 100 years ago, there have been many suggestions for the origin and development of solar spicules. Because the velocities of spicules are comparable to the sound and Alfven speeds of the low chromosphere, linear theory cannot fully describe them. Consequently, detailed tests of theoretical ideas had to await the development of computing power that only became available during the 1970s. This work reviews theories for spicules and spicule-like features over approximately the past 25 years, with an emphasis an the models based on nonlinear numerical simulations. These models have given us physical insight into wave propagation in the solar atmosphere and have helped elucidate how such waves, and associated shock waves, may be capable of creating motions and structures on magnetic flux tubes in the lower solar atmosphere. So far, however, it has been difficult to reproduce the most commonly quoted parameters for spicules with these models, using what appears to be the most suitable input parameters. A key impediment to developing satisfactory models has been the lack of reliable observational information, which is a consequence of the small angular size and transient lifetime of spicules. I close with a list of key observational questions to be addressed with space-based satellites, such as the currently operating Transition Region and Coronal Explorer (TRACE) satellite, and especially the upcoming Solar-B mission. Answers to these questions will help determine which, if any, of the current models correctly explains spicules.

Sterling, Alphonse C.↗

NASA NTRS1995

The Nature of Procedural Interrupts in Ground Operations in Aerospace Systems

This study proposes a methodology for characterizing the causal context and consequences of procedural interrupts in ground operations tasks. Behavioral science researchers observed 26 tasks at NASA's Kennedy Space Center. From these tasks, 81 procedural interrupts were identified and coded for the following information: source of the interrupt, circumstances surrounding the interrupt, and consequences of the interrupt. We found that more interrupts were equipment or personnel-related than procedure-related. More interrupts were due to unavailable resources or resources being incorrect than resources being inaccessible, and most interrupts resulted in some action being taken. Variation in duration of procedural interrupts across causal categories was also examined. The characterization process helps to identify those interrupts that are disruptive, those that cannot be avoided, and those that may have been prevented through better planning or scheduling of resources. Implications for the use of the methodology and suggestions for further research are discussed.

Irwin, Cheryl M.↗

NASA NTRS1996

Cross-Cultural Barriers to Effective Communication in Aviation

Communication is essential to safe flight, as evidenced by several accidents in which crew communicates was found to have contributed to the accidents. This chapter documents the essential role of explicit efficient communication to flight safety with a global context. It addresses communication between flight crews and air traffic controllers in regions a the world where pilots and controllers speak different native languages, as well as cases in which crew members within the flight deck represent different native languages and cultures. It also addresses problems associated with "exporting" crew resource management training programs to parts of the world which values and norms differ from those of the United States, where these programs were initially developed. This chapter is organized around several central questions: (1) What are various kinds of communication failures and what are their consequences; (2) What are the causes of communication failure; (3) What are features of effective crew communication; (4) What can be done to enhance communication success? To explore a wider range of communication failures than available from accident reports, we examined a set of incident reports from the Aviation Safety Reporting System. These could be classified into three major categories: those in which language actually interfered with transmission of a message; those in which transmission was adequate but the context was not expressed unambiguously and thus the message received was not the same as the message intended; and those in which the message was received as intended, but was not adequately understood or acted upon, mainly because of cultural factors. The consequences of failed communication can be flight errors (such as when a clearance is not received correctly), loss of situation awareness, or failure of crew members (or ATC and pilots) to build a shared understanding of a situation. Causes of misunderstanding can be traced to a number of sources, often grounded in faulty assumptions held by one or both parties to a conversation. Speakers and listeners often experience "illusionary understanding" in which they think they understand each other, but in fact do not. While this problem can exist within a single culture, it is much more serious across cultures. Training in effective explicit communication is a component of Crew Resource Management training programs developed in the U.S. These programs are being adopted by airlines around the world, with varying degrees of success. The level of success in part depends on how similar the conversational and social styles of those cultures are to those of the U.S. A factor that influences conversational style is a culture's relative positioned on two major dimensions that distinguish national cultural groups: individualism vs. collectivism and degree of power distance. The chapter concludes with a discussion of techniques for overcoming the various classes of communication failures and for effectively adapting training programs to fit the values and norms of cultures around the globe.

Fischer, U.↗

NASA NTRS2002

Observations of Closed Structures at the Magnetopause: A Case for Multiple Reconnections

We further analyze a case of Interball LLBL crossing on the dusk flank of geomagnetosphere under southward magnetosheath magnetic field, previously categorized as an interval of highly structured LLBL. These conditions of highly structured LLBL include reconnection signatures. Observed ion velocity distributions with LLBL are quite variable. D-shaped distributions that are associated with the open reconnected flux tube are observed at the boundaries of LLBL transients and sometimes within the LLBL transients. In most cases the ion velocity distributions consist of two magnetosheath-type components with different velocities parallel to the magnetic field, or of three components one of which has nearly zero Vpar. The shapes of ion velocity distributions and their evolution with decreasing number density in LLBL indicate that most of LLBL is located on closed magnetic field lines. These observations strongly favor multiple reconnections between magnetosheath and magnetosphereric flux tubes, creating long spiral flux tube islands at the magnetopause. We report evidence for the simultaneous occurrence of magnetic reconnection at multiple points across the magnetopause, as has been proposed and found to occur in magnetopause simulations. The evidence is in the form of highly structured distributions of ions in velocity parallel to the local magnetic field direction, within the magnetopause and low latitude boundary layer region, from the Interball-Tall spacecraft. We interpret these distributions as a natural consequence of the formation of spiral magnetic flux tubes consisting of a mixture of alternating segments originating from the magnetosheath or interplanetary plasma and from the low latitude boundary layer or magnetospheric plasma. We further analyze a case of Interball LLBL crossing on the dusk flank of geomagnetosphere under southward magnetosheath magnetic field, previously categorized as an interval of highly structured LLBL. These conditions of highly structured LLBL include reconnection signatures. Observed ion velocity distributions with LLBL are quite variable. D-shaped distributions that are associated with the open reconnected flux tube are observed at the boundaries of LLBL transients and sometimes within the LLBL transients. In most cases the ion velocity distributions consist of two magnetosheath-type components with different velocities parallel to the magnetic field, or of three components one of which has nearly zero Vpar. The shapes of ion velocity distributions and their evolution with decreasing number density in LLBL indicate that most of LLBL is located on closed magnetic field lines. These observations strongly favor multiple reconnection between magnetosheath and magnetospheric flux tubes, creating long spiral flux tube islands at the magnetopause. We report evidence for the simultaneous occurrence of magnetic reconnection at multiple points across the magnetopause, as has been proposed and found to occur in magnetopause simulations. The evidence is in the form of highly structured distributions of ions in velocity parallel to the local magnetic field direction, within the magnetopause and low latitude boundary layer region, from the Interball-Tail spacecraft. We interpret these distributions as a natural consequence of the formation of spiral. We further analyze a case of Interball LLBL crossing on the dusk flank of geomagnetosphere under southward magnetosheath magnetic field, previously categorized as an interval of highly structured LLBL. These conditions of highly structured LLBL include reconnection signatures. Observed ion velocity distributions with LLBL are quite variable. D-shaped distributions that are associated with the open reconnected flux tube are observed at the boundaries of LLBL transients and sometimes within the LLBL transients. In most cases the ion velocity distributions consist of two magnetosheath-type components with different velocities parallel to the magnetic field, or of three components one of which has nearly zero Vpar.

Vaisberg, O. L.↗

NASA NTRS2002

Defining the Relationship Between Human Error Classes and Technology Intervention Strategies

One of the main factors in all aviation accidents is human error. The NASA Aviation Safety Program (AvSP), therefore, has identified several human-factors safety technologies to address this issue. Some technologies directly address human error either by attempting to reduce the occurrence of errors or by mitigating the negative consequences of errors. However, new technologies and system changes may also introduce new error opportunities or even induce different types of errors. Consequently, a thorough understanding of the relationship between error classes and technology "fixes" is crucial for the evaluation of intervention strategies outlined in the AvSP, so that resources can be effectively directed to maximize the benefit to flight safety. The purpose of the present project, therefore, was to examine the repositories of human factors data to identify the possible relationship between different error class and technology intervention strategies. The first phase of the project, which is summarized here, involved the development of prototype data structures or matrices that map errors onto "fixes" (and vice versa), with the hope of facilitating the development of standards for evaluating safety products. Possible follow-on phases of this project are also discussed. These additional efforts include a thorough and detailed review of the literature to fill in the data matrix and the construction of a complete database and standards checklists.

Wiegmann, Douglas A.↗

NASA NTRS1997

Alternative Perspectives on Risk

The goal of the commercial air transport system is to provide air transportation to the flying public at an acceptable cost with minimal risk. in an ideal situation these three goals would support each other. In fact, it is sometimes the case that the goals conflict: getting passengers to their destinations on time may conflict with fixing a minor mechanical malfunction that may or may not impact safety; flying a route that will avoid turbulence, thereby providing passengers with a more comfortable ride, may consume more fuel; managing traffic density may mean aircraft are delayed or must use an approach that will result in a long taxi to their gates, costing time and fuel. Various players in the system--pilots, dispatchers, controllers, as well as managers in the airline carriers and traffic management system--make decisions every day that involve trade-offs of benefits and costs. The prospect of revisions in the air traffic management system, with shifts in responsibilities from controllers to users, including airline operations center personnel and pilots, means that individuals may be performing either new jobs or old jobs under new guidance. It will be essential to know how the various players (a) perceive the risks and benefits associated with the decisions they will make under the old and new control structures, and (b) how much risk they are willing to accept in making decisions. Risk is here defined as the probability and magnitude of negative events (after Slovic, 1987). Of primary interest are risks associated with traffic, weather, and operational factors such as schedule, fuel consumption, and passenger service. Previous research has documented differences between groups in perceptions of risks associated with both everyday and aviation related situations. Risk perception varies as a function of familiarity with the situation, degree to which one is potentially affected by the risk, the level of control one has over the situation, and one's level of experience and responsibility in the situation. In our presentation we will consider several factors that may influence differences in risk perception, risk tolerance and risk management among the three major categories of participants in the aviation system (pilots, dispatchers, and controllers). Primary factors that may affect risk attitudes (the collective term we will use for the three components of risk) include: expertise or job-specific knowledge or training, personal involvement or vulnerability to consequences, goals, time horizon (imminence of consequences), span of control and type of control, and information or technology support. These will be considered in the context of five different types of risk (physical threat, economic, social, legal, and ethical). A study designed to study differences between pilots and controllers in their perceptions and responses to traffic risks under the present and a user-preferred control situation will be described. Future studies involving dispatchers' risk perceptions regarding various types of risk will be discussed.

Davison, Jeannie↗

NASA NTRS2002

Space Weathering Processes on Mercury

Like the Moon, Mercury has no atmosphere to protect it from the harsh space environment and therefore it is expected that it will incur the effects of space weathering. These weathering processes are capable of both creating regolith and altering its optical properties. However, there are many important differences between the environments of Mercury and the Moon. These environmental differences will almost certainly affect the weathering processes as well as the products of those processes. It should be possible to observe the effects of these differences in Vis/NIR spectra of the type expected to be returned by MESSENGER. More importantly, understanding these weathering processes and their consequences is essential for evaluating the spectral data returned from MESSENGER and other missions in order to determine the mineralogy and the iron content of the Mercurian surface. Theoretical and experimental work has been undertaken in order to better understand these consequences.

Noble, S. K.↗

NASA NTRS2003

Tethers as Debris: Hydrocode Simulation of Impacts of Polymer Tether Fragments on Aluminum Plates

Tethers promise to find use in a variety of space applications. Despite being narrow objects, their great lengths result in them having large total areas. Consequently, tethers are very susceptible to being severed by orbital debris. Extensive work has been done designing tethers that resist severs by small debris objects, in order to lengthen their working lives. It is from this perspective that most recent work has considered the tether - debris question. The potential of intact tethers, or severed tether fragments, as debris, to pose a significant collision risk to other spacecraft has been less well studied. Understanding the consequences of such collisions is important in assessing the risks tethers pose to other spacecraft. This paper discusses the damage that polymer tethers may produce on aluminum plates, as revealed by hypervelocity impact simulations using the SPHC hydrodynamic code.

Evans, Steven W.↗

NASA NTRS2003

Impact Hydrothermal Alteration of Terrestrial Basalts: Explaining the Rock Component of the Martian Soil

The large energy in terrestrial impacts can create hydrothermal systems and consequently produce hydrothermal alteration materials. In this study we consider the chemistry of impact and volcanic hydrothermal alteration under relatively low water/rock ratios in basaltic or a somewhat more evolved protolith. Our work on the Lonar and Mistastin craters suggests that Fe-rich clays, including Fe-rich saponite can be produced. We postulate that similar alteration materials are produced on Mars and could be a component of the martian soil or regolith, contrary to some earlier studies. The martian regolith is a globally homogenized product of various weathering processes. The soil [1] is thought to consist of a rock component, with lesser amounts of mobile elements (Ca, Na, and K) than a presumed protolith, and a salt or mobile element component enriched in sulfur and chlorine [2, 3]. In this study we consider the contributions of impacts and consequent hydrothermal processes to the rock component of the martian soil.

Nelson, M. J.↗

NASA NTRS2003

Defining the Relationship Between Human Error Classes and Technology Intervention Strategies

The modus operandi in addressing human error in aviation systems is predominantly that of technological interventions or fixes. Such interventions exhibit considerable variability both in terms of sophistication and application. Some technological interventions address human error directly while others do so only indirectly. Some attempt to eliminate the occurrence of errors altogether whereas others look to reduce the negative consequences of these errors. In any case, technological interventions add to the complexity of the systems and may interact with other system components in unforeseeable ways and often create opportunities for novel human errors. Consequently, there is a need to develop standards for evaluating the potential safety benefit of each of these intervention products so that resources can be effectively invested to produce the biggest benefit to flight safety as well as to mitigate any adverse ramifications. The purpose of this project was to help define the relationship between human error and technological interventions, with the ultimate goal of developing a set of standards for evaluating or measuring the potential benefits of new human error fixes.

Wiegmann, Douglas A.↗

NASA NTRS2003

RGS Spectroscopy of the Cygnus Loop XA Knot

The observations were performed at the end of April 2002, and the data were received in July 2002. Unfortunately, the observations were badly compromised by high levels of background radiation; one the three observations lost entirely. Two replacement observations were scheduled for November 2002, and were only made available in January of 2003. Consequently, we have had little time to grapple with the unusual data analysis challenges. The search for a postdoctoral fellow has been successfully concluded, and Manami Sasaki began working for us in January 2003. She will be supported in part by these funds, and will be working to help understand these data. Examination of the RGS 'Orders' images indicate the presence of broad emission lines (as expected for the diffuse XA knot). However, examination of the 'Spatial' dispersion/cross-dispersion images indicate that the emission is also broad in the cross-dispersion direction. (As a crosscheck, some of the 'Lockman Hole' datasets were also examined as representative 'sky background' datasets; in these, both types of images are relatively flat (outside the calibration source regions). The quicklook plots of the spectra show the expected O VII and O VIII lines, in addition to a complex around 35 Angstroms; the approx. 35 Angstrom line is likely the C V He-beta line at 34.97 Angstrom, but identifying the additional line(s) will require a more careful reduction of the data. Consequently, there is valuable information to be extracted from these data, but it is complicated by diffuse nature of the emission. Because the angular scale is large, we will have to make use of sky background datasets in order to do the background fitting. A color composite image of OM data in the three UV bands was presented at the 'How does the Galaxy Work?' meeting, and compared to optical and X-ray imaging data. Quantitative analysis will require obtaining the effective bandpasses of the UV filters so that the predominant line and continuum contributions can be identified using plasma shock emission models. In view of the facts that the data were only obtained relatively recently, and the complexity of the data analysis, we request a one year no-cost extension on the grant.

Gaetz, Terrance J.↗

NASA NTRS2003

IMAGE Observations of Plasmasphere/Ring Current Interactions

Evidence has been found in IMAGE observations that overlap of the plasmasphere and the ring current may lead to enhanced loss of plasma into the ionosphere. It has long been anticipated that this mixing of plasma leads to coupling and resulting consequences on both populations. Wave generation, pitch angle scattering, and heating are some of the consequences that are anticipated. IMAGE plasmasphere ring current, and auroral observations will be presented and used to explore these interactions and their effects.

Gallagher, D. L.↗

NASA NTRS2004

Evidence of Nebula Processes from Primitive Meteorites

Astronomical observations of T Tauri stars provide information about the masses, sizes, temperatures, and lifetimes of the solar-nebula-like disks surrounding these stars. Theoretical interpretations of these observations can be used to construct models of the evolution of the solar nebula, and to derive implications for the properties of meteoritic material. The consequences of nebular thermal history might have been retained in patterns of elemental fractionation, presolar grains abundances, and oxygen isotopes, among other meteorite properties. Thus, such data may be used in conjunction with models to constrain the parameters that describe the overall evolution of the solar nebula. On the other hand, major meteoritic components such as chondrules and CAIs apparently reflect localized processes that are not readily related to global thermal evolution. In several cases, the theoretical tools required for the evaluation of proposals for their mode of formation exist, but have yet to be applied. Proposals that meteoritic material was thermally and radiatively processed very close to the young Sun, based on the emerging picture of the interactions between young stars and their disks, have radical consequences for the distribution of solid material in the solar system and the formation of chondritic meteorites. Tests of these models may be provided by their predictions for irradiated material and the physical characteristics of primitive meteorites.

Cassen, Patrick↗

NASA NTRS2004

Spatially Complete Surface Albedo Data Sets: Value-Added Products Derived from Terra MODIS Land Products

Spectral land surface albedo is an important parameter for describing the radiative properties of the Earth. Accordingly it reflects the consequences of natural and human interactions, such as anthropogenic, meteorological, and phenological effects, on global and local climatological trends. Consequently, albedos are integral parts in a variety of research areas, such as general circulation models (GCMs), energy balance studies, modeling of land use and land use change, and biophysical, oceanographic, and meteorological studies. The availability of global albedo data over a large range of spectral channels and at high spatial resolution has dramatically improved with the launch of the Moderate Resolution Imaging Spectroradiometer (MODIS) instrument aboard NASA s Earth Observing System (EOS) Terra spacecraft in December 1999. However, lack of spatial and temporal coverage due to cloud and snow effects can preclude utilization of official products in production and research studies. We report on a technique used to fill incomplete MOD43 albedo data sets with the intention of providing complete value-added maps. The technique is influenced by the phenological concept that within a certain area, a pixel s ecosystem class should exhibit similar growth cycle events over the same time period. The shape of an area s phenological temporal curve can be imposed upon existing pixel-level data to fill missing temporal points. The methodology will be reviewed by showcasing 2001 global and regional results of complete albedo and NDVl data sets.

Moody, E. G.↗

NASA NTRS2003

The impact of the new biology on radiation risks in space

Radiation is considered to be one of three or four major hazards for personnel in space and has emerged as the most critical issue to be resolved for long-term missions, both orbital and interplanetary. Space habitats are stressful and dangerous environments. Health and medical consequences arising from microgravity, stress, and trauma include weakened immune systems, increased viral activity, and loss of bone mass. The greatest risks from radiation are generally assumed to be cancers and possibly damage to the central nervous system. Synergistic effects arising from the other environmental hazards along with abscopal and exogenic factors are likely. Space programs represent an exceptional opportunity for examining the biological consequences of low-dose exposures of humans to radiation at every level of progression. Although astronauts are a relatively small population, they are healthy, physically active volunteers who undergo extensive testing and medical examinations before, during, and after protracted exposures with periodic follow-up examinations. The radiation environments along with other hazards are likewise monitored and documented. Extensive international research programs are in progress. Seven years ago the U.S. National Aeronautics and Space Administration established the National Space Biomedical Research Institute through a cooperative agreement with a consortium of research and academic institutions in order to address radiation issues through a concerted, programmatic effort. Advanced technologies are rapidly being incorporated into these programs to determine the significance of new biological data and to evaluate the interplay among the different medical hazards. Programmatic in vivo and in vitro studies of the processes leading to carcinogenesis are in progress. Drugs and dietary supplements are being examined at the cellular and in vivo levels to assess their potential as dose-modifying agents. The infrastructure of this new approach, recent results, and research in progress are reviewed and discussed.

NASA Discipline Radiation Health↗

NASA NTRS2003

The evolution of transcriptional regulation in eukaryotes

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is an important component of the genetic basis for evolutionary change in diverse aspects of phenotype. However, the evolution of transcriptional regulation remains understudied and poorly understood. Here we review the evolutionary dynamics of promoter, or cis-regulatory, sequences and the evolutionary mechanisms that shape them. Existing evidence indicates that populations harbor extensive genetic variation in promoter sequences, that a substantial fraction of this variation has consequences for both biochemical and organismal phenotype, and that some of this functional variation is sorted by selection. As with protein-coding sequences, rates and patterns of promoter sequence evolution differ considerably among loci and among clades for reasons that are not well understood. Studying the evolution of transcriptional regulation poses empirical and conceptual challenges beyond those typically encountered in analyses of coding sequence evolution: promoter organization is much less regular than that of coding sequences, and sequences required for the transcription of each locus reside at multiple other loci in the genome. Because of the strong context-dependence of transcriptional regulation, sequence inspection alone provides limited information about promoter function. Understanding the functional consequences of sequence differences among promoters generally requires biochemical and in vivo functional assays. Despite these challenges, important insights have already been gained into the evolution of transcriptional regulation, and the pace of discovery is accelerating.

Review, Academic↗

NASA NTRS2002

Total-body irradiation with high-LET particles: acute and chronic effects on the immune system

Although the immune system is highly susceptible to radiation-induced damage, consequences of high linear energy transfer (LET) radiation remain unclear. This study evaluated the effects of 0.1 gray (Gy), 0.5 Gy, and 2.0 Gy iron ion (56Fe(26)) radiation on lymphoid cells and organs of C57BL/6 mice on days 4 and 113 after whole body exposure; a group irradiated with 2.0 Gy silicon ions (28Si) was euthanized on day 113. On day 4 after 56Fe irradiation, dose-dependent decreases were noted in spleen and thymus masses and all major leukocyte populations in blood and spleen. The CD19(+) B lymphocytes were most radiosensitive and NK1.1(+) natural killer (NK) cells were most resistant. CD3(+) T cells were moderately radiosensitive and a greater loss of CD3(+)/CD8(+) T(C) cells than CD3(+)/CD4(+) T(H) cells was noted. Basal DNA synthesis was elevated on day 4, but response to mitogens and secretion of interleukin-2 and tumor necrosis factor-alpha were unaffected. Signs of anemia were noted. By day 113, high B cell numbers and low T(C) cell and monocyte percents were found in the 2.0 Gy 56Fe group; the 2.0 Gy 2)Si mice had low NK cells, decreased basal DNA synthesis, and a somewhat increased response to two mitogens. Collectively, the data show that lymphoid cells and tissues are markedly affected by high linear energy transfer (LET) radiation at relatively low doses, that some aberrations persist long after exposure, and that different consequences may be induced by various densely ionizing particles. Thus simultaneous exposure to multiple radiation sources could lead to a broader spectrum of immune dysfunction than currently anticipated.

NASA Discipline Radiation Health↗