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At least 1,153 records · Page 64

Efficacy and Delivery of Novel FAST Agents for Coronaviruses

We proposed to test and develop advanced delivery for novel agents from our collaborators Facile Accelerated Specific Therapeutics (FAST) platform to reduce coronavirus replication. Sachi Bioworks Inc., Prof. Anushree Chatterjee, and Prof. Prashant Nagpal at the University of Colorado Boulder have developed a bioinformatics and synthesis pipeline to produce sequence specific theranostic agents (agents that can be therapies and/or diagnostics) that are inherently transported into the cytoplasm of mammalian host cells and sequence-specifically interfere in nucleic acid replication. The agent comprises a small nanoparticle (2-5 nm) chosen for ideal cellular transport and/or imaging conjugated to a short, synthetic DNA analog oligomer designed for binding to one or more target viral sequences. The sequence specific binding of the FAST agent to its target prevents nucleic acid replication due to its high affinity binding. While the small nanoparticle facilitates delivery in vitro, we plan to package the FAST agents into a larger nanoparticle (80-300 nm) for future in vivo delivery applications. Our team at Sandia has expertise encapsulating biomolecules including protein, DNA, and RNA into solid lipid nanoparticles (LNP) and lipid coated mesoporous silica nanoparticles (LC-MSN) and shown successful delivery in mouse models to multiple tissues. Our team focused on formulation parameters for FAST agents into lipid nanoparticles (LNP) and lipid coated mesoporous silica nanoparticles (LC-MSN) for enhanced delivery and/or efficacy and in vivo translation. We used lipid formulas that have been shown in literature to facility in vitro and more importantly, in vivo delivery. In our work discussed below, we successfully demonstrate loading and release of FAST agents on silica core and stable LC-MSN in a reasonable size range for in vivo testing.

59 BASIC BIOLOGICAL SCIENCES↗

"Experimental Research at the Energy Frontier in High Energy Physics" (Final Technical Report)

Recent developments in particle physics and cosmology raise the exciting prospect that we are on the threshold of a major step forward in our understanding of the universe. This proposal describes a research program at the University of Illinois in experimental high-energy physics on the ATLAS experiment at CERN’s Large Hadron Collider (LHC). Our group actively collaborates with the Theory Group and other experimental efforts within the Office of Science frontiers (energy, intensity, and cosmic) to search broadly in the ATLAS data to maximize our potential for scientifc discovery. The thrust of this proposal is to search for new physics using ATLAS data. Emphasis is placed on novel use of the Higgs boson as a tool to search for new particles and interactions and development of fast particle tracking systems for use in triggering. We propose to continue our strong role in FTK commissioning and operations. To maximize the impact and vitality of the proposed physics program through the HL-LHC running, we will lead firmware efforts in the HWTT Phase-II TDAQ upgrade, leveraging our expertise acquired through development of fast tracking hardware and firmware for the FTK system.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

University of Missouri Research Reactor (MURR) LEU Fuel Fluid-Structure Interaction Analysis

The University of Missouri Research Reactor (MURR ® ) is one of five U.S. high performance research reactors (USHPRR), plus one critical facility, that are actively collaborating with the National Nuclear Security Administration (NNSA) Material Management and Minimization (M 3 ) Reactor Conversion Program to convert from highly enriched uranium (HEU, ≥ 20 wt.% U-235) to low-enriched uranium (LEU, < 20 wt.% U-235) fuel. A new type of LEU fuel with very high density, based on an alloy of uranium and 10 weight percent molybdenum (U-10Mo), is expected to allow the conversion to LEU of USHPRR that have been found unable to be converted with previously qualified uranium silicide-aluminum (U 3 Si 2 -Al) dispersion fuel. MURR has been working with the USHPRR Reactor Conversion (RC) Pillar at Argonne National Laboratory to perform fuel element design and fuel cycle performance analyses, steady-state thermal hydraulics safety analyses, and accident safety analyses in preparation for the conversion of MURR and to support a preliminary Safety Analysis Report (SAR) for conversion to LEU fuel. In this work, Fluid-structure interaction (FSI) analysis at the fuel element level, as compared to the fuel plate level of the previous work. is performed which models all components of the MURR LEU fuel element, including fuel plates and the supporting structures e.g., side plates, end fittings, and combs. Therefore, the effect of supporting structures on the coolant flow distribution, the fuel plate deflection, and the resulting coolant channel gap reduction can be evaluated. In addition to the nominal element geometry and flow rate, the tolerances in the geometry dimensions of coolant channel and plate thickness, the effect of a comb on plate deflection, and the uncertainty of the flow rate per element are considered in this work. The effect of comb on plate displacement is quantified through two bounding cases: the case assuming a perfect bond between the comb and plates and the case neglecting the comb effect. Note that in this analysis, the FSI has been decoupled from the other structural effects caused by irradiation (e.g., swelling and irradiation creep). Assessment of combined effects is planned for a later stage of this project.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Advanced CO 2 Capture Solvent Systems for Dynamic Power Generation

RTI International, in collaboration with Pacific Northwest National Laboratory (PNNL), Carbon Capture Simulation for Industry Impact (CCSI 2 ), Electricity Power Research Institute (EPRI), and West Virginia University (WVU), successfully completed a joint research effort in developing a cost-effective, resilient, load-following advanced CO 2 capture technology for natural gas power plants. The project’s objective was to develop a CO 2 capture process that maximizes the net present value (NPV) of the electricity sale by minimizing the levelized cost of electricity (LCOE) under dynamic plant loads and high renewable penetration environments. The two key innovations developed in this project were the use of (i) advanced water-lean solvents (WLSs) and (ii) process intensification equipment, such as a rotating packed bed (RPB) absorber and dual-stage flash regeneration. The process’s low CO 2 capture cost is realized through WLSs’ low energy required for solvent regeneration, which lowers the operating cost while RPBs intensify the absorption process and reduces the power plant capital cost. A suite of advanced computational and simulation packages was implemented to guide the process design, validate the dynamic response of the capture plant, evaluate system-wide performance, and maximize the power plant’s profit. The project also engaged with power producers and other stakeholders to ensure its technical relevance and techno-economic viability. The development of this highly disruptive CO 2 capture technology could accelerate the industry adoption and thereby lower the greenhouse gas emissions of the U.S. power sector. Deployment of this technology can increase the reliability and decrease the cost of electricity generation in the U.S. by enabling the use of low-carbon fossil fuels to balance fluctuations of renewable energy availability.

03 NATURAL GAS↗

Operational Forecasting of Induced Seismicity (CRADA Final Report)

This was a collaborative effort between Lawrence Livermore National Security, LLC ("LLNS"), as manager and operator of Lawrence Livermore National Laboratory ("LLNL"), The Regents of the University of California, as manager and operator of Lawrence Berkeley National Laboratory (Collectively, Contractors) and Nanometrics, Inc. ("Participant"), to develop a toolkit called "Operational Forecasting of Induced Seismicity (ORION)" that includes a decision tree method for operational forecasting of induced seismicity rates related to fluid disposal operations.

58 GEOSCIENCES↗

Human Dimensions of Deforestation and Regrowth in the Brazilian Amazon: Integrating Data from Satellites, Demographic Censuses, and Field Surveys

This report summarizes research activities and products from a collaborative project on the "Human Dimensions of Deforestation and Regrowth in the Brazilian Amazon," awarded to Charles H. Wood (PI; Department of Sociology, University of Texas at Austin, now in the Center for Latin American Studies, University of Florida), Steven E. Sanderson (Co-PI; Department of Political Science, University of Florida, now Dean of Emory College, Emory University) and David L. Skole (Co-PI; Institute for Earth, Oceans and Space, University of New Hampshire, now in the Department of Geography and Basic Science Remote Sensing Initiative, Michigan State University).

Wood, Charles H.↗

Satellite Test of the Equivalence Principle, Overview and Progress

An overview of STEP, the Satellite test of the Equivalence Principle will be presented. This space-based experiment will test the Universality of free fall and is designed to advance the present state of knowledge by over 5 orders of magnitude. The international STEP collaboration is pursuing a development plan to improve and verify the technology readiness of key systems. We will discuss recent advances with an emphasis on accelerometer fabrication and test. The transfer of critical technologies successfully demonstrated in flight by the Gravity Probe B mission will be described.

Kolodziejczak, Jeffery↗

A Framework for Managing Inter-Site Storage Area Networks using Grid Technologies

The NASA Goddard Space Flight Center and the University of Maryland Institute for Advanced Computer Studies are studying mechanisms for installing and managing Storage Area Networks (SANs) that span multiple independent collaborating institutions using Storage Area Network Routers (SAN Routers). We present a framework for managing inter-site distributed SANs that uses Grid Technologies to balance the competing needs to control local resources, share information, delegate administrative access, and manage the complex trust relationships between the participating sites.

Kobler, Ben↗

A Framework for Managing Inter-Site Storage Area Networks using Grid Technologies

The NASA Goddard Space Flight Center and the University of Maryland Institute for Advanced Computer Studies are studying mechanisms for installing and managing Storage Area Networks (SANs) that span multiple independent collaborating institutions using Storage Area Network Routers (SAN Routers). We present a framework for managing inter-site distributed SANs that uses Grid Technologies to balance the competing needs to control local resources, share information, delegate administrative access, and manage the complex trust relationships between the participating sites.

McCall, Fritz↗

Sonic Booms in Atmospheric Turbulence (SonicBAT): The Influence of Turbulence on Shaped Sonic Booms

The objectives of the Sonic Booms in Atmospheric Turbulence (SonicBAT) Program were to develop and validate, via research flight experiments under a range of realistic atmospheric conditions, one numeric turbulence model research code and one classic turbulence model research code using traditional N-wave booms in the presence of atmospheric turbulence, and to apply these models to assess the effects of turbulence on the levels of shaped sonic booms predicted from low boom aircraft designs. The SonicBAT program has successfully investigated sonic boom turbulence effects through the execution of flight experiments at two NASA centers, Armstrong Flight Research Center (AFRC) and Kennedy Space Center (KSC), collecting a comprehensive set of acoustic and atmospheric turbulence data that were used to validate the numeric and classic turbulence models developed. The validated codes were incorporated into the PCBoom sonic boom prediction software and used to estimate the effect of turbulence on the levels of shaped sonic booms associated with several low boom aircraft designs. The SonicBAT program was a four year effort that consisted of turbulence model development and refinement throughout the entire period as well as extensive flight test planning that culminated with the two research flight tests being conducted in the second and third years of the program. The SonicBAT team, led by Wyle, includes partners from the Pennsylvania State University, Lockheed Martin, Gulfstream Aerospace, Boeing, Eagle Aeronautics, Technical & Business Systems, and the Laboratory of Fluid Mechanics and Acoustics (France). A number of collaborators, including the Japan Aerospace Exploration Agency, also participated by supporting the experiments with human and equipment resources at their own expense. Three NASA centers, AFRC, Langley Research Center (LaRC), and KSC were essential to the planning and conduct of the experiments. The experiments involved precision flight of either an F-18A or F-18B executing steady, level passes at supersonic airspeeds in a turbulent atmosphere to create sonic boom signatures that had been distorted by turbulence. The flights spanned a range of atmospheric turbulence conditions at NASA Armstrong and Kennedy in order to provide a variety of conditions for code validations. The SonicBAT experiments at both sites were designed to capture simultaneous F-18A or F-18B onboard flight instrumentation data, high fidelity ground based and airborne acoustic data, surface and upper air meteorological data, and additional meteorological data from ultrasonic anemometers and SODARs to determine the local atmospheric turbulence and boundary layer height.

Bradley, Kevin A.↗

Collaborative Research: Louis Stokes Regional Center of Excellence: Louis Stokes Midwest Regional Center of Excellence (LSMRCE) for Broadening Participation in STEM

The Louis Stokes Midwest Regional Center of Excellence (LSMRCE) for Broadening Participation in STEM, a partnership of Chicago State University (CSU), aimed to increase the number of underrepresented minority (URM) students graduating with science, technology, engineering, and math (STEM) degrees and matriculating into graduate STEM programs. As a member institution of the LSMRCE, Fermi Research Alliance, LLC, (Fermilab) looked to support its continued mission of increasing URM student participation in its Summer Internship in Science and Technology (SIST) internship program. The program provided URMs with access to research skills development, mentoring and professionalization activities via paid, summer research internships at Fermilab. Students received instruction and mentoring while gaining exposure to a global laboratory workforce and community with diverse academic and professional expertise. In addition, students established professional relationships and networked with senior researchers, early career scientists, technical professionals, post-docs and other undergraduate interns to help forge collaboration, innovation and mentoring opportunities at Fermilab and LSMRCE partner institutions

99 GENERAL AND MISCELLANEOUS↗

Overview: Small Aircraft Transportation System Airborne Remote Sensing Fuel Droplet Evaporation

The NASA Nebraska Preparation Grant was designed to solidify relationships, intensify communication, and launch collaborative initiatives among Nebraska researchers and key contacts at NASA research centers and enterprises. In doing so, Nebraska was successful in laying the groundwork for the foundation for numerous long-term, mutually beneficial collaborations that were subsequently proposed and awarded in the NASA EPSCoR 2000 competition. The NASA Nebraska EPSCoR Preparation Grant was managed by the same administrative team that oversees Nebraska's NASA Space Grant and EPSCoR programs. An advisory board (later Technical Advisory Committee) made up of voting representatives from all affiliate and partner organizations regularly reviewed grant progress and direction. The University of Nebraska at Omaha's Aviation Institute, the host institution for all three programs, provided additional administrative oversight and program evaluation through established review mechanisms. This structure has served NASA well and has been cited as a model program. The second year of preparation grant funding served as a significant opportunity for Nebraska to lay the groundwork for the continued elevation and success of its NASA EPSCoR program. In anticipation of the NASA EPSCoR 2000 grant competition, Year 2 funding enabled funded researchers to further broaden and enhance the quality and quantity of collaborations with NASA Field Centers, Codes, and Enterprises. The plan set the stage for long-term research and outreach endeavors that have contributed significantly to the achievement of NASA's strategic objectives; the state of Nebraska's economic and aerospace development efforts; and have advanced Nebraska s aeronautics research efforts to a national leadership level. The overarching goal of the NASA Nebraska EPSCoR Preparation grant was met by facilitating research endeavors among Nebraska faculty that addressed research and technology priorities of the NASA Field Centers, Codes, and Strategic Enterprises. During the first year of funding, Nebraska established open and frequent lines of communication with university affairs officers and other key personnel at all NASA Centers and Enterprises, and facilitated the development of collaborations between and among junior faculty in the state and NASA researchers. As a result, Nebraska initiated a major research cluster, the Small Aircraft Transportation System Nebraska Implementation Template.

Bowen, Brent↗

Abstract for CRADA among the National Energy Technology Laboratory, National Technology & Engineering Solutions of Sandia, The Regents of the University of California, and Tri-State Generation and Transmission Association, Inc. (AGMT-0855)

The objective of this CRADA is to facilitate cooperation among Tri-State Generation and Transmission Association, Inc. and collaborators of the Institute for the Design of Advanced Energy Systems (IDAES), including the National Energy Technology Laboratory, Sandia National Laboratories, and Lawrence Berkeley National Laboratory. The goal is to develop steady-state and dynamic optimization models of power plants. Tri-State will provide data related to the design and operation of power plants, which will be used to validate the IDAES team’s models and tools. These models will provide insight into potential improvements which could improve heat rate, reduce operations and maintenance costs, and/or improve reliability of the existing fleet of coal plants in the United States.

20 FOSSIL-FUELED POWER PLANTS↗

2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study

# 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study The 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge (CIVIC) Study provided insight into the travel patterns and associated energy consumption of participants. Study results helped researchers identify opportunities for the development of shared mobility strategies—such as collaborative ride-sharing programs—that could address the mobility needs of rural communities in Puerto Rico. The Civic Innovation Challenge is a multiagency, federal government research and action competition that funds ready-to-implement, research-based pilot projects that have the potential for scalable, sustainable, and transferable impact on community-identified priorities. ## Data Collection Agency The University of Puerto Rico at Mayagüez conducted the study. ## Survey Methodology The study was conducted in Spanish. Data collection was enabled via the open-source [NREL OpenPATH platform](https://www.nrel.gov/transportation/openpath). The resulting dataset consists of partially automated travel diaries—combining sensed and surveyed data reflecting patterns of multimodal, end-to-end, individual human mobility—as well as demographic and socioeconomic information from the 31 participants. ## Survey Records, Data, and Documentation Survey records include 31 participants. The total number of trips was 1,373 and the total non-air-miles traveled was approximately 8,260.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study

# 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study The 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge (CIVIC) Study provided insight into the travel patterns and associated energy consumption of participants. Study results helped researchers identify opportunities for the development of shared mobility strategies—such as collaborative ride-sharing programs—that could address the mobility needs of rural communities in Puerto Rico. The Civic Innovation Challenge is a multiagency, federal government research and action competition that funds ready-to-implement, research-based pilot projects that have the potential for scalable, sustainable, and transferable impact on community-identified priorities. ## Data Collection Agency The University of Puerto Rico at Mayagüez conducted the study. ## Survey Methodology The study was conducted in Spanish. Data collection was enabled via the open-source [NREL OpenPATH platform](https://www.nrel.gov/transportation/openpath). The resulting dataset consists of partially automated travel diaries—combining sensed and surveyed data reflecting patterns of multimodal, end-to-end, individual human mobility—as well as demographic and socioeconomic information from the 31 participants. ## Survey Records, Data, and Documentation Survey records include 31 participants. The total number of trips was 1,373 and the total non-air-miles traveled was approximately 8,260.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study

# 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study The 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge (CIVIC) Study provided insight into the travel patterns and associated energy consumption of participants. Study results helped researchers identify opportunities for the development of shared mobility strategies—such as collaborative ride-sharing programs—that could address the mobility needs of rural communities in Puerto Rico. The Civic Innovation Challenge is a multiagency, federal government research and action competition that funds ready-to-implement, research-based pilot projects that have the potential for scalable, sustainable, and transferable impact on community-identified priorities. ## Data Collection Agency The University of Puerto Rico at Mayagüez conducted the study. ## Survey Methodology The study was conducted in Spanish. Data collection was enabled via the open-source [NREL OpenPATH platform](https://www.nrel.gov/transportation/openpath). The resulting dataset consists of partially automated travel diaries—combining sensed and surveyed data reflecting patterns of multimodal, end-to-end, individual human mobility—as well as demographic and socioeconomic information from the 31 participants. ## Survey Records, Data, and Documentation Survey records include 31 participants. The total number of trips was 1,373 and the total non-air-miles traveled was approximately 8,260.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study

# 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study The 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge (CIVIC) Study provided insight into the travel patterns and associated energy consumption of participants. Study results helped researchers identify opportunities for the development of shared mobility strategies—such as collaborative ride-sharing programs—that could address the mobility needs of rural communities in Puerto Rico. The Civic Innovation Challenge is a multiagency, federal government research and action competition that funds ready-to-implement, research-based pilot projects that have the potential for scalable, sustainable, and transferable impact on community-identified priorities. ## Data Collection Agency The University of Puerto Rico at Mayagüez conducted the study. ## Survey Methodology The study was conducted in Spanish. Data collection was enabled via the open-source [NREL OpenPATH platform](https://www.nrel.gov/transportation/openpath). The resulting dataset consists of partially automated travel diaries—combining sensed and surveyed data reflecting patterns of multimodal, end-to-end, individual human mobility—as well as demographic and socioeconomic information from the 31 participants. ## Survey Records, Data, and Documentation Survey records include 31 participants. The total number of trips was 1,373 and the total non-air-miles traveled was approximately 8,260.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study

# 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge Study The 2024 University of Puerto Rico at Mayagüez Civic Innovation Challenge (CIVIC) Study provided insight into the travel patterns and associated energy consumption of participants. Study results helped researchers identify opportunities for the development of shared mobility strategies—such as collaborative ride-sharing programs—that could address the mobility needs of rural communities in Puerto Rico. The Civic Innovation Challenge is a multiagency, federal government research and action competition that funds ready-to-implement, research-based pilot projects that have the potential for scalable, sustainable, and transferable impact on community-identified priorities. ## Data Collection Agency The University of Puerto Rico at Mayagüez conducted the study. ## Survey Methodology The study was conducted in Spanish. Data collection was enabled via the open-source [NREL OpenPATH platform](https://www.nrel.gov/transportation/openpath). The resulting dataset consists of partially automated travel diaries—combining sensed and surveyed data reflecting patterns of multimodal, end-to-end, individual human mobility—as well as demographic and socioeconomic information from the 31 participants. ## Survey Records, Data, and Documentation Survey records include 31 participants. The total number of trips was 1,373 and the total non-air-miles traveled was approximately 8,260.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗