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Towards a more healthy conservation paradigm: integrating disease and molecular ecology to aid biological conservation†
Not provided.
Ischemia and inflammation on chronic kidney disease
No abstract prepared.
Do we need diagnostic strategies enhanced with genetic information for ischemic heart disease?
No abstract prepared.
Coronary circulation: Pressure/flow parameters for assessment of ischemic heart disease
Both invasive and non-invasive parameters have been reported for assessment of the physiological status of the coronary circulation. Fractional flow reserve and coronary (or myocardial) flow reserve may be obtained by invasive or non-invasive means. These metrics of coronary stenosis severity have achieved wide clinical acceptance for guiding revascularization decisions and risk stratification. Other indices are obtained invasively (e.g., instantaneous wave-free ratio, iFR; hyperemic stenosis resistance) or non-invasively (e.g., PET absolute myocardial blood flow (mL/min/g)) and have been used for the same purposes. Both iFR, and whole-cycle distal coronary to aortic mean pressure (Pd/Pa) are measured under basal condition and used for assessment of hemodynamic stenosis severity as is index of basal stenosis resistance (BSR). These metrics typically are dichotomized at an empirically derived cut point into “normal” and “abnormal” categories for purposes of clinical decision making and data analysis. Once dichotomized the indices do not always point in the same direction and so confusion may arise. This review, therefore, will present basic principles relevant to understanding commonly employed metrics of the physiological status of the coronary circulation, potential strengths and weaknesses, and hopefully an improved appreciation of the clinical information provided by each.
Correction to: ACC/AATS/AHA/ASE/ASNC/SCAI/SCCT/STS 2017 Appropriate Use Criteria for Coronary Revascularization in Patients With Stable Ischemic Heart Disease
To more clearly reflect the relationship between iFR (instantaneous wave-free ratio) and FFR (fractional flow reserve), this Correction document highlights the following changes to the original document published in the Journal of Nuclear Cardiology; the version available at JACC [1] has been updated to reflect the changes, with JACC’s Correction document available at [2].
CME instructions: Coronary circulation: Pressure/flow parameters for assessment of ischemic heart disease
No abstract prepared.
Fragment Screening of Infectious Disease Targets in a Structural Genomics Environment
Abstract not provided
The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease
Not Available
A Whole-Genome Analysis Framework for Effective Identification of Pathogenic Regulatory Variants in Mendelian Disease
Not Available
Incident Diabetes Mellitus, Hypertension, and Cardiovascular Disease Risk in Exercising Hypercholesterolemic Patients
Not Available
Risk Prediction Tool for Assessing the Probability of Death or Myocardial Infarction in Patients With Stable Coronary Artery Disease
Not Available
Comparison of Characteristics and Outcomes of Veterans With Stable Ischemic Heart Disease Enrolled in the COURAGE Trial Versus the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program
Not Available
Comparing methods of measuring geographic patterns in temporal trends: an application to county-level heart disease mortality in the United States, 1973 to 2010
Not Available
Optimization of Bangladesh and Malaysian genotype recombinant reporter Nipah viruses for in vitro antiviral screening and in vivo disease modeling
Not Available
Analysis of a shrimp farming network during an outbreak of white spot disease in Rayong Province, Thailand
Not Available