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At least 1,135 records · Page 63
All sourcesNASA NTRSDOE OSTI
NASA NTRS1991

Applications of the Strategic Defense Initiative's compact accelerators

The Strategic Defense Initiative's (SDI) investment in particle accelerator technology for its directed energy weapons program has produced breakthroughs in the size and power of new accelerators. These accelerators, in turn, have produced spinoffs in several areas: the radio frequency quadrupole linear accelerator (RFQ linac) was recently incorporated into the design of a cancer therapy unit at the Loma Linda University Medical Center, an SDI-sponsored compact induction linear accelerator may replace Cobalt-60 radiation and hazardous ethylene-oxide as a method for sterilizing medical products, and other SDIO-funded accelerators may be used to produce the radioactive isotopes oxygen-15, nitrogen-13, carbon-11, and fluorine-18 for positron emission tomography (PET). Other applications of these accelerators include bomb detection, non-destructive inspection, decomposing toxic substances in contaminated ground water, and eliminating nuclear waste.

Montanarelli, Nick↗
NASA NTRS1992

Biological Contamination of Mars: Issues and Recommendations

The ad hoc Task Group on Planetary Protection formed by the Space Studies Board (SSB) of the National Research Council focused on making recommendations concerning the protection of Mars from forward contamination (i.e., Earth to Mars) during upcoming missions by both the United States and the former Soviet Union. In so doing, it distinguished between missions whose goals include reconnaissance and measurement and those that specifically include experiments to detect life. The task group also discussed what additional knowledge will be needed in order to assure that future recommendations regarding contamination of Earth from Mars might be made with a higher degree of certainty than is now possible. Following a short introduction to the rationale underlying planetary exploration (Chapter 1) is a brief summary of approved and contemplated missions to Mars (Chapter 2). Chapter 3 briefly reviews the state of knowledge in several areas pertinent to the problem of planetary protection, in the limits of life on Earth and the abilities of known terrestrial organisms to withstand extreme environment conditions, as well as new approaches to detecting life forms. Chapter 5 includes a review and comments (made in light of current knowledge)- on the recommendations made in 'Recommendations on Quarantine Policy for Mars, Jupiter, Saturn, Uranus, Neptune, and Titan'. Updates to the recommendations made in 1978 are also given in Chapter 5. Chapter 6 gives additional recommendations concerning collection of essential data, spacecraft sterilization and bioburden assessment, and future research, as well as legal and social issues and NASA's overall planetary protection program.

Source record↗
NASA NTRS1991

Determining the IV fluids required for a ten day medical emergency on Space Station Freedom - Comparison of packaged vs. on-orbit produced solutions

To aid planning for the storage of supplies onboard Space Station Freedom, an estimate was made of the amount of intravenous (IV) fluid required to support a patient who has suffered a medical emergency for a period of up to 10 days. Six different medical scenarios were evaluated, and the volume of IV fluids required for each scenario was estimated. Up to 220 liters of fluid would be required to support a patient for all of the scenarios. When optimizing the volumes to support any single scenario, a total of 123 liters is required. Use of a water polishing system to produce sterile water for injection from potable supplies and on-station formulation of IV fluids results in a smaller mass and volume requirement for the Fluid Therapy Subsystem than carrying prepackaged bags of fluid.

Creager, Gerald J.↗
NASA NTRS1993

Unit-Dose Bags For Formulating Intravenous Solutions

Smaller unit-dose flowthrough bags devised for use with large-volume parenteral (LVP) bags in preparing sterile intravenous solutions. Premeasured amount of solute stored in such unit-dose bag flushed by predetermined amount of water into LVP bag. Relatively small number of LVP bags used in conjunction with smaller unit-dose bags to formulate large number of LVP intravenous solutions in nonsterile environment.

Finley, Mike↗
NASA NTRS1993

The violent environment of the origin of life - Progress and uncertainties

Dating of terrestrial fossils and returned lunar samples reveals that the origin of life on Earth occurred not in a quiescent, peaceful environment, but rather in a violent, impact-ridden one. This realization has important consequences. On the one hand, sufficiently large and fast impactors can erode planetary atmospheres, and the very largest of these may have sterilized the surface of the Earth. In this regard, deep-sea hydrothermal vents become especially interesting for the history of early life, as they provide an environment protected against all but the greatest impact devastation. At the same time, impactors would have been delivering key biogenic elements (such as carbon and nitrogen) to Earth's surface, and (with much greater difficulty) intact organic molecules as well. Estimates of the various sources of prebiotic organics suggest that the heavy bombardment either produced or delivered quantities of organics comparable to those produced by other energy sources. However, substantial uncertainties exist. After reviewing the current understanding of the role of the heavy bombardment in the origins of life, a number of remaining key uncertainties are considered, and attempts are made to both quantify their magnitude and point to means of resolving them.

Chyba, Christopher F.↗
NASA NTRS1994

Composite redesign of obstetrical forceps

Due to the increase in the number of children being born recently, medical technology has struggled to keep pace in certain areas. In these areas, particular needs have arisen to which the subject of this paper is directed. In the area of obstetrics, the forceps design and function has remained relatively unchanged for a number of years. In an effort to advance the technology, NASA Marshall Space Flight Center has been asked by the obstetrical community to help in a redesign of the obstetric forceps. Traditionally the forceps design has been of tubular stainless steel, constructed in two halves which interlock and hinge to provide the gripping force necessary to aid in the delivery of an infant. The stainless steel material was used to provide for ease of cleaning and sterilization. However, one of the drawbacks of the non-flexible steel design is that excessive force can be placed upon an infants head which could result in damage or injury to the infant. The redesign of this particular obstetric tool involves applying NASA's knowledge of advanced materials and state of the art instrumentation to create a tool which can be used freely throughout the obstetrics community without the fear of injury to an infant being delivered.

Lawson, Seth W.↗
NASA NTRS1991

Perceptual and performance consequences of flight in virtual worlds

There are two primary purposes for head-mounted systems in aeronautical settings. One is for helmet-mounted sights and teleoperated (head-slaved) weapons systems. Bennett, Johnson, Perrone, and Phatak (1988) evaluated head tracking performance during passive and controlled flight. In that study, comparisons were also made of head tracking performance in sterile and relatively complex virtual worlds. That study confirmed the robustness of head tracking performance across a wide variety of visual scenes. A second use of virtual world displays is for aircraft control. Aircraft controllability using head-mounted, panel-mounted, or simulated out-the-window scenes has been systematically examined. Those studies reported the range of rotorcraft flight tasks in which head-mounted virtual worlds provided some advantages. Two studies will be reported that examine the perceptual/performance effects of virtual worlds. The first examines head tracking performance with roll-stabilized versus non-roll stabilized virtual worlds. The purpose of the study was to (1) examine display strategies used in current display systems and (2) study the adaptability of observers to estimated glide slope angles using head-slaved versus head-stabilized imagery. The purpose of this study was to examine the usefulness of wide field-of-regards during final approaches to a runway.

Bennett, C. Thomas↗
NASA NTRS1992

A surgical support system for Space Station Freedom

Surgical techniques in microgravity are being developed for the Health Maintenance Facility (HMF) on Space Station Freedom (SSF). This will be a presentation of the proposed surgical capabilities and ongoing hardware and procedural investigations. Methods: Procedures and prototype hardware, which include a medical restraint system, a surgical overhead isolation canopy, a suction device, and a regional laminar flow device were evaluated. This was accomplished by realistic sterile surgical simulations involving both mannequins and animals during KC-135 parabolic flight and in a high fidelity ground based HMF mockup. Results: Animal surgery in the environment of microgravity allowed the observation of unique arterial and venous bleeding characteristics for the first time. The ability to control bleeding and to prevent cabin atmosphere contamination was also demonstrated. Conclusions: The procedures and prototype hardware tested provided valuable information and should be investigated and developed further. The use of standard surgical techniques are possible in microgravity if the principles of personnel and supply restraint and operative field containment are adhered to.

Campbell, M. R.↗
NASA NTRS1994

Optimization of moisture content for wheat seedling germination in a cellulose acetate medium for a space flight experiment

The Porous Tube Plant Nutrient Delivery System (PTPNDS), a hydrophilic, microporous ceramic tube hydroponic system designed for microgravity, will be tested in a middeck locker of the Space Shuttle. The flight experiment will focus on hardware operation and assess its ability to support seed germination and early seedling growth in microgravity. The water controlling system of the PTPNDS hardware has been successfully tested during the parabolic flight of the KC-135. One challenge to the development of the spaceflight experiment was to devise a method of holding seeds to the cylindrical porous tube. The seed holder must provide water and air to the seed, absorb water from the porous tube, withstand sterilization, provide a clear path for shoots and roots to emerge, and be composed of flight qualified materials. In preparation for the flight experiment, a wheat seed-holder has been designed that utilizes a cellulose acetate plug to facilitate imbibition and to hold the wheat seeds in contact with the porous tube in the correct orientation during the vibration of launch and the microgravity environment of orbit. Germination and growth studies with wheat at a range of temperatures showed that optimal moisture was 78% (by weight) in the cellulose acetate seed holders. These and other design considerations are discussed.

Johnson, Corinne F.↗
NASA NTRS1994

Systems of artificial lighting at the Phytotron of Plant Breeding and Genetic Institute (Odessa)

At the Odessa Phytotron we have installed over 50 climatic chambers and cabinets made by various companies of the United States, Canada, Germany and U.S.S.R. They employ different light sources including Sylvania fluorescent lamps of various types, fluorescent lamps produced in the former Soviet Union with a special luminophore, ordinary tungsten lamps, xenon, mercury, mercury-iodide, sodium, etc. Our objective in lighting is that the intensity distribution over the wave lengths should be maximal in the photosynthetically active part of the spectrum and minimal in the IR part to avoid plant sterilization. Phytotrons are extremely energy consuming entities, and the large part of their energy consumption falls into the lighting category in our electric bills. Therefore, we are in a constant search of the processes to reduce energy. However, the main way to increase effectiveness would be the development of new types of light sources, which would come close to the threshold of 150 to 200 lumens per watt.

Chernozubov, Adolf↗
NASA NTRS1996

The Effects of Promethazine on Human Performance, Mood States, and Motion Sickness Tolerance

Intramuscular (IM) injections of promethazine in 25 mg or 50 mg dosages are commonly used to treat space motion sickness in astronauts. The present study examined the effects of IM injections of promethazine on neuropsy-chological performance, mood states, and motion sickness tolerance in humans. Twelve men, mean age 36 plus or minus 3.1 participated in one training (no injections) and three treatment conditions: a 25 mg injection of promethazine, a 50 mg injection of promethazine, and a placebo injection of sterile saline. Each condition, spaced at 7 day intervals, required an 8-10 hr session in which subjects were given four repetitions of 12 performance tasks, and one rotating chair motion sickness test. On the training day subjects were trained on each task to establish stability and proficiency. On treatment days, the order in which the drug or placebo was assigned to subjects was counter-balanced and a double-blind technique was used. Statistically significant decrements in performance were observed on 10 of 12 tasks when subjects were given 25 mg or 50 mg of promethazine as compared to the placebo. Performance decrements were associated with mean blood alcohol dose equivalency levels of 0.085% for 25 mg and 0. 1 37% for 50 mg dosages. The mood scale results showed significant changes in individual subjective experiences with maximum deterioration in the arousal state and fatigue level. When compared to placebo significant increases in motion sickness tolerance were found for both dosages of promethazine. These data suggest that effective dosages of promethazine currently used to counteract motion sickness in astronauts may significantly impair task components of their operational performance.

Cowings, Patricia S.↗
NASA NTRS1991

High-Moisture Diet for Laboratory Rats: Nutrient Analysis, Growth, and Organ Weights

A diet (KSC-25) to be sterilized by irradiation was formulated to contain 66% moisture and to provide the required nutrients for growing rats. Analyses of the irradiated dry diet provided data to evaluate its nutrient content. The diet was evaluated for its ability to supply all nutrients, including water, required by immature rats. Sixteen Sprague-Dawley rats were fed the high-moisture diet with or without access to a water bottle. Rats (n = 16) fed an irradiated purified diet in a meal form with access to a water bottle were the control animals. Feed efficiency, food and water consumption, and growth rate data were collected during the 28-day study. Organ weights were collected on day 28. The test diet met or exceeded the National Research Council (NRC) estimated nutritional requirements for immature laboratory rats. The 66% moisture KSC-25 diet provided all nutrients, including water, required by weanling male Sprague-Dawley rats for growth equivalent to the established purified diet.

Battles, August H.↗
NASA NTRS1997

Light and Gravity Effects on Circadian Rhythms of Rhesus Macaques

Temporal integration of a biological organism's physiological, behavioral and biochemical systems depends upon its circadian timing system. The endogenous period of this timing system is typically synchronized to the 24- hour day by environmental cues. The daily alternation of light and dark has long been known as one of the most potent environmental synchronizers influencing the circadian timing system. Alterations in the lighting environment (length or intensity of light exposure) can also affect the homeostatic state of the organism. A series of experiments was performed using rhesus monkeys with the objective of defining the fundamental properties of the circadian rhythm of body temperature. Three major experiments were performed in addition to several preliminary studies. These experiments explored 1.) the response of the rhesus body temperature rhythm to varying day length and light intensity; 2.) the response of the body temperature rhythm to light exposure as a function of time of day; and 3.) the characteristics of the metabolic heat production rhythm which is responsible for the daily cycle in body temperature. Results of these three completed experiments will be reported here. In addition, preliminary experiments were also performed in social entrainment of rhesus circadian rhythms and the properties of rhesus body temperature rhythms in constant conditions, where no external time cues were provided. Four adult male rhesus monkeys served as subjects in all experiments. All experiments were performed at the California Regional Primate Research Center. Each animal was implanted with a biotelemetry unit that measured deep body temperature. All surgeries were performed by a board certified veterinary surgeon under sterile conditions. The biotelemetry implants also provided an index of activity level in each animal. For metabolic heat production measurements, oxygen consumption and carbon dioxide production were measured and the caloric equivalent of these was calculated. Specific methodologies are described in detail.

Fuller, Charles↗
NASA NTRS1997

Studies of Cell-Mediated Immunity Against Immune Disorders Using Synthetic Peptides and Rotating Bioreactor System

Our proposed experiments included: (1) immunzing mice with synthetic peptides; (2) preparing spleen and lymph node cells; (3) growing them under conventional conditions as well as in the rotatory vessel in appropriate medium reconstituting with synthetic peptides and/or cytokines as needed; and (4) comparing at regular time intervals the specific CTL activity as well as helper T-cell activity (in terms of both proliferative responses and cytokine production) using established procedures in my laboratory. We further proposed that once we demonstrated the merit of rotatory vessel technology to achieve desired results, these studies would be expanded to include immune cells from non-human primates (rhesus monkeys and chimpanzees) and also humans. We conducted a number of experiments to determine CTL induction by the synthetic peptides corresponding to antigenic proteins in HIV and HPV in different mouse strains that express MHC haplotypes H-2b or H-2d. We immunized mice with 100 ug of the synthetic peptide, suspended in sterile water, and emulsified in CFA (1:1). The immune lymph node cells obtained after 7 days were restimulated by culturing in T25 flask, HARV-10, or STLV-50, in the presence of the peptide at 20 ug/ml. The results from the 5'Cr-release assay consistently revealed complete abrogation of CTL activity of cells grown in the bioreactors (both HARV and STLV), while significant antigen-specific CTL activity was observed with cells cultured in tissue culture flasks. Thus, overall the data we generated in this study proved the usefulness of the NASA-developed developed technology for understanding the known immune deficiency during space travel. Additionally, this ex vivo microgravity technology since it mimics effectively the in vivo situation, it is also useful in understanding immune disorders in general. Thus, our proposed studies in TMC-NASA contract round II application benefit from data generated in this TMC-NASA contract round I study.

Sastry, Jagannadha K.↗
NASA NTRS1996

From the Primitive Soup to Cyanobacteria: It May have Taken Less Than 10 Million Years

Most scientific discussions on the likelihood of extraterrestrial life have been constrained by the characteristics of life on our planet and the environmental conditions under which it may have emerged. Although it has been generally assumed that this process must have been extremely slow, involving hundreds of millions or even billions of years, a number of recent discoveries have led to a considerable compression of the time believed necessary for life to appear. It is now recognized that during its early history the Earth and other bodies of the inner Solar System went through a stage of intense collisions. Some of these impacts by large asteroids or comets may have raised the terrestrial surface to sterilizing temperatures and may have evaporated the oceans and killed off life as late as 3.8 x 10(exp 9) years ago. However, there is also ample paleontological evidence derived from the 3.5 x 10(exp 9) year old Warrawoona sediments showing that only 300 million years after the period of intense impacts ended, our planet was populated by phototactic, stromatolite-forming microorganisms. Although these discoveries are now generally interpreted to imply that the origin and early evolution of life were rapid, no attempts have been made to estimate the actual time required for these processes to occur.

Miller, Stanley L.↗
NASA NTRS1998

Workshop on the Issue Martian Meteorites: Where do we Stand and Where are we Going?

The presentations in this workshop discuss the composition of Martian meteorites. Many of the talks were on a specific meteorite, i.e., Allan Hills 84001 (ALH84001). The discovery earlier of carbonates in ALH84001 lead some researchers to suggest that there was evidence of martian life. Other possible explanations for this phenomena are given. Other papers discuss methods to sterilize martian samples, the existence of water on Mars, the facilities of the Meteorite Processing Laboratory at Johnson Space Center, comparative analyses of geologic processes and the gathering of meteorites.

Source record↗
NASA NTRS1999

Mars Sample Handling and Requirements Panel (MSHARP)

In anticipation of the return of samples from Mars toward the end of the first decade of the next century, NASA's Office of Space Sciences chartered a panel to examine how Mars samples should be handled. The panel was to make recommendations in three areas: (1) sample collection and transport back to Earth; (2) certification of the samples as nonhazardous; and (3) sample receiving, curation, and distribution. This report summarizes the findings of that panel. The samples should be treated as hazardous until proven otherwise. They are to be sealed within a canister on Mars, and the canister is not to be opened until within a Biosafety Hazard Level 4 (BSL-4) containment facility here on Earth. This facility must also meet or exceed the cleanliness requirements of the Johnson Space Center (JSC) facility for curation of extraterrestrial materials. A containment facility meeting both these requirements does not yet exist. Hazard assessment and life detection experiments are to be done at the containment facility, while geochemical characterization is being performed on a sterilized subset of the samples released to the science community. When and if the samples are proven harmless, they are to be transferred to a curation facility, such as that at JSC.

Carr, Michael H.↗
NASA NTRS1977

No Organic Compounds on Mars? Understanding the Structure of Spiral Galaxies

A prime goal of the Viking missions to Mars is to search for life on that planet. Each of the two landers incorporate three specific life-detection experiments, and all have operated successfully. However, as any newspaper reader knows, the results are ambiguous, in that some experiments suggest a highly active martian biology while others appear to indicate that the samples are sterile. It would be premature to conclude from the results of the biological experiments that martian life forms have definitely been detected. In addition, the picture is clouded by unexpected results from another Viking experiment, which is designed to detect organic and inorganic chemical compounds in the martian soil. In Science for 1 October 1976, K. Biemann of MIT and ten of his colleagues report the first results from the Viking 1 Gas-Chromatograph/Mass Spectrometer (GCMS) experiment.

Morrison, Nancy D.↗