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At least 1,135 records · Page 63

The Shadow Knows: Using Shadows to Investigate the Structure of the Pretransitional Disk of HD 100453

We present Gemini Planet Imager polarized intensity imagery of HD 100453 in Y, J, and K1 bands that reveals an inner gap (9-18 au), an outer disk (18-39 au) with two prominent spiral arms, and two azimuthally localized dark features that are also present in Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) total intensity images. Spectral energy distribution fitting further suggests that the radial gap extends to 1 au. The narrow, wedge-like shape of the dark features appears similar to predictions of shadows cast by an inner disk that is misaligned with respect to the outer disk. Using the Monte Carlo radiative transfer code HOCHUNCK3D, we construct a model of the disk that allows us to determine its physical properties in more detail. From the angular separation of the features, we measure the difference in inclination between the disks (45deg) and their major axes, PA = 140deg east of north for the outer disk, and 100deg for the inner disk. We find an outer-disk inclination of 25deg +/- 10deg from face-on, in broad agreement with the Wagner et al. measurement of 34deg. SPHERE data in J and H bands indicate a reddish disk, which indicates that HD 100453 is evolving into a young debris disk.

Spectro-Polarimetric High-contrast Exoplanet REsea↗

Infrared Free Space Communication - The Autonomous Testing of Free Space Infrared Communication

Fiber optics has been a winning player in the game of high-speed communication and data transfer in cable connections. Yet, in free space RF has been the repeated choice of communication medium of the space industry. Investigating the benefits of free space optical communication over radio frequency is worthwhile. An increase in science data rate return capabilities could occur if optical communication is implemented. Optical communication systems also provide efficiencies in power, mass, and volume over RF systems1. Optical communication systems have been demonstrated from a satellite in orbit with the moon to earth, and resulted in the highest data rates ever seen through space (622Mbps)2. Because of these benefits, optical communication is far superior to RF. The HiDRA (High Data Rate Architecture) project is researching Passive Misalignment Mitigation of Dynamic Free Apace Optical Communication Links. The goal of this effort is to enable gigabit per second transmission of data in short range dynamic links (less than 100 meters). In practice this would enhance data rates between sites on the International Space Station with minimal size, weight, and power requirements. This paper will focus on an autonomous code and a hardware setup that will be used to fulfill the next step in the research being conducted. The free space optical communications pointing downfalls will be investigated. This was achieved by creating 5 python programs and a top-level code to automate this test.

Heldman, Christopher↗

Oculomotor Behavior Metrics Change According to Circadian Phase and Time Awake

There is a need for non-invasive, objective measures to forecast performance impairment arising from sleep loss and circadian misalignment, particularly in safety-sensitive occupations. Eye-tracking devices have been used in some operational scenarios, but such devices typically focus on eyelid closures and slow rolling eye movements and are susceptible to the intrusion of head movement artifacts. We hypothesized that an expanded suite of oculomotor behavior metrics, collected during a visual tracking task, would change according to circadian phase and time awake, and could be used as a marker of performance impairment.

sleep deprivation↗

Sleeping on Mars: A Hidden Challenge for Human Space Exploration

The purpose of this talk is to provide a general public audience with basic information about what it is like to sleep in space. Dr. Flynn-Evans will begin by highlighting how sleep is different in movies and science fiction compared to real life. She will next cover basic information about sleep and circadian rhythms, including how sleep works on earth. She will explain how people have circadian rhythms of different lengths and how the circadian clock has to be re-set each day. She will also describe how jet-lag works as an example of what happens during circadian misalignment. Dr. Flynn-Evans will also describe how sleep is different in space and will highlight the challenges that astronauts face in low-earth orbit. She will discuss how astronauts have a shorter sleep duration in space relative to on the ground and how their schedules can shift due to operational constraints. She will also describe how these issues affect alertness and performance. She will then discuss how sleep and scheduling may be different on a long-duration mission to Mars. She will discuss the differences in light and day length on earth and mars and illustrate how those differences pose significant challenges to sleep and circadian rhythms.

Flynn-Evans, Erin↗

Hemispherical Optical Dome for Underwater Communication

For many years, acoustic systems have been used as the primary method for underwater communication; however, the data transfer rate of such systems is low because sound propagates slowly through the water. A higher throughput can be achieved using visible light to transmit data underwater. The first issue with using this approach is that there is generally a large loss of the light signal due to scattering and absorption in water even though there is an optimal wavelength for transmission in the blue or green wavelengths of the visible spectrum. The second issue is that a simple system consisting only of a highly directional source/transmitter and small optical detector/receiver has a very narrow field of view. The goal of this project is to improve an optical, underwater communication system by increasing the effective field of view of the receiving optics. To this end, we make two changes to the simple system: (1) An optical dome was added near the receiver. An array of lenses is placed radially on the surface of the dome, reminiscent of the compound eye of an insect. The lenses make the source and detector planes conjugate, and each lens adds a new region of the source plane to the instrument's total field of view. (2) The receiver was expanded to include multiple photodiodes. With these two changes, the receiver has much more tolerance to misalignments (in position and angle) of the transmitter.Two versions of the optical dome (with 6 and 8 diameters) were designed using the CREO CAD software and modeled using the CODE V optical design software. A series of these transparent hemispherical domes, with both design diameters, were manufactured using a 5-axis mill. The prototype was then retrofitted with lenses and compared with the computer-generated model to demonstrate the effectiveness of this solution. This work shows the dome design improves the optical field of view of the underwater communication system considerably. Furthermore, with the experimental test results, a geometric optimization model was derived providing insights to the design performance limits.

Underwater↗

Sleeping in Space: An Unexpected Challenge for Future Mars Explorers

This talk will serve as the keynote address for a research symposium being held at Washington State University. The purpose of the talk is to provide researchers and students at WSU with an overview about what it is like to sleep in space. Dr. Flynn-Evans will begin by highlighting how sleep is different in movies and science fiction compared to real life. She will next cover basic information about sleep and circadian rhythms, including how sleep works on earth. She will explain how people have circadian rhythms of different lengths and how the circadian clock has to be re-set each day. She will also describe how jet-lag works as an example of what happens during circadian misalignment. Dr. Flynn-Evans will also describe how sleep is different in space and will highlight the challenges that astronauts face in low-earth orbit. She will discuss how astronauts have a shorter sleep duration in space relative to on the ground and how their schedules can shift due to operational constraints. She will also describe how these issues affect alertness and performance. She will then discuss how sleep and scheduling may be different on a long-duration mission to Mars. She will discuss the differences in light and day length on earth and mars and illustrate how those differences pose significant challenges to sleep and circadian rhythms.

Flynn-Evans, Erin↗

Suomi NPP VIIRS Solar Diffuser Screen Transmittance Model and Its Applications

The visible infrared imaging radiometer suite on the Suomi National Polar-orbiting Partnership satellite calibrates its reflective solar bands through observations of a sunlit solar diffuser (SD) panel. Sunlight passes through a perforated plate, referred to as the SD screen, before reaching the SD. It is critical to know whether the SD screen transmittance measured prelaunch is accurate. Several factors such as misalignments of the SD panel and the measurement apparatus could lead to errors in the measured transmittance and thus adversely impact on-orbit calibration quality through the SD. We develop a mathematical model to describe the transmittance as a function of the angles that incident light makes with the SD screen, and apply the model to fit the prelaunch measured transmittance. The results reveal that the model does not reproduce the measured transmittance unless the size of the apertures in the SD screen is quite different from the design value. We attribute the difference to the orientation alignment errors for the SD panel and the measurement apparatus. We model the alignment errors and apply our transmittance model to fit the prelaunch transmittance to retrieve the "true" transmittance. To use this model correctly, we also examine the finite source size effect on the transmittance. Furthermore, we compare the product of the retrieved "true" transmittance and the prelaunch SD bidirectional reflectance distribution function (BRDF) value to the value derived from on-orbit data to determine whether the prelaunch SD BRDF value is relatively accurate. The model is significant in that it can evaluate whether the SD screen transmittance measured prelaunch is accurate and help retrieve the true transmittance from the transmittance with measurement errors, consequently resulting in a more accurate sensor data product by the same amount.

sensors↗

On-Ground Calibration and Optical Alignment for the Orion Optical Navigation Camera

The Orion Multi-Purpose Crew Vehicle on-board Navigation System will utilize the Optical Navigation measurements of the Moon and Earth during cis-lunar operations. Misalignment or an un-calibrated optical navigation camera may cause large measurement residuals in any on-board attitude determination and navigation system. Therefore, a novel estimation technique to calibrate the internal camera parameters, and a high accuracy optical alignment procedure to estimate the external camera alignment are introduced in this paper. The intrinsic camera parameters such as the focal length, the principle point offsets, and the camera lens distortion parameters will be estimated and evaluated using images of star fields. This calibration estimation technique can be used either on-ground or in flight. The proposed technique in this paper is using the discrepancy between imaged star vectors attained from the OpNav camera, and the matched star vectors from the star catalog to determine the changes in internal camera parameters. This gave rise to the two basic types of calibration the attitude dependent and attitude independent methods. The former utilizes the errors in imaged and cataloged vectors themselves, and the latter using the discrepancy in angles between pairs of vectors from the camera and catalog. The alignment procedure is carried out using Theodolite autocollimator measurements taken off alignment cubes mounted on the Orion frame and also the measurements from the OpNav focal plane. It is assumed that the alignment cubes and OpNav camera are rigidly mounted to the frame so that flexing effects do not significantly alter the orientation of the cubes relative to the OpNav camera.

Samaan, Malak↗

Better Performance on the Psychomotor Vigilance Task Is Associated with Longer Sleep Duration and Lower Self-Reported Sleep Need in the Real World

The psychomotor vigilance task (PVT) is sensitive measure of performance impairment arising from sleep loss and circadian misalignment. Some individuals are able to maintain stable, good performance during laboratory-imposed sleep restriction. It is unclear whether such individuals need less sleep or whether they are more resilient to the effects of sleep loss. We aimed to characterize the relationship between sleep duration and perceived sleep need with PVT performance under real-world conditions.

sleep↗

System and Method of Optical Axis Alignment Monitor and Feedback Control for a Spectrometer

The present invention relates to an apparatus and method of a real-time, monitoring and control feedback system for a 2-D spectrometer application, to correct for active optical axis pointing misalignments or jitter (i.e., tip, tilt), that result in degraded scientific image integrity, unwanted spatial crosstalk and image blurring artifacts which severely limit the applications for high resolution spectrometer image data. The present invention provides a unique system architecture which ensures the most direct optical axis motion detection and control capability that will enable sub-pixel image motion monitoring and boresight control stability, thus, maximizing the science image quality.

Marx, Catherine↗

Method for Approximating the Vacuum Motions of Spinning Symmetrical Bodies with Nonconstant Spin Rates

The analysis includes non-constant spin rates and inertias and considers the effects of time-varying thrust misalignments, mass unbalance, and jet damping. The method was developed for bodies having small trans verse angular velocities. Results are presented in the form of equations for space-referenced Euler angles, flight-path angles, body-referenced attitude rates, and earth-referenced vehicle-trajectory coordinates. Also, equations for maximum wobble have been derived for certain input conditions. Comparisons with numerical solutions are included for two sample problems.

Martz, C. William↗

On the 2018 Outburst of the Accreting Millisecond X-Ray Pulsar Swift J1756.9-2508 As Seen with NICER

We report on the coherent timing analysis of the 182 Hz accreting millisecond X-ray pulsar SwiftJ1756.92508during its 2018 outburst as observed with the Neutron Star Interior Composition Explorer (NICER). Combiningour NICER observations with Rossi X-ray Timing Explorer observations of the 2007 and 2009 outbursts, we alsostudied the long-term spin and orbital evolution of this source. We find that the binary system is well describedby a constant orbital period model, with an upper limit on the orbital period derivative of Pb < 7.4 ´ 10-13 ss1.Additionally, we improve upon the source coordinates through astrometric analysis of the pulse arrival times,finding R.A.=17h56m57 18±0 08 and decl.=25°0627 8±3 5, while simultaneously measuring thelong-term spin frequency derivative as n = -7.3 ´ 10-16 Hzs1. We briefly discuss the implications of thesemeasurements in the context of the wider population of accreting millisecond pulsars. We reported on the coherent timing analysis of the 2018 outburst of Swift J1756 as observed with NICER. Consistent with analyses of the previous outbursts (Krimm et al. 2007b; Patruno et al. 2010), we find that the X-ray pulsations have energy dependent amplitudes; the fractional amplitude of the fundamental increases with energy, whereas the fractional amplitude of the harmonic shows a slight decline with energy. This energy dependent behavior is not unusual in AMXPs (Patruno & Watts 2012) and can be interpreted in terms of the thermal emission from the stellar hotspot and reprocessing in the accretion column (e.g., Gierliński et al. 2002; Ibragimov & Poutanen 2009). The pulse arrival times of the 2018 outburst are well described by a timing model consisting of a circular orbit with a constant spin frequency. The pulse phases with respect to this model do not show spurious residuals with time or orbital phase, and no evidence is found that the pulse arrival times exhibit an additional delay associated with passing through the gravitational well of the companion star (Shapiro delay). We note, however, that the expected Shapiro delay is given as (Shapiro et al. 1971) Equation (5) where Φ is the orbital phase, G is the gravitational constant, c is the speed of light, and i is the inclination. Even for the maximum allowed companion mass, ${M}_{C}=0.030\,{M}_{\odot }$ (Krimm et al. 2007b, but see Section 4.2 for more details) and an inclination of 90°, the largest delay we can expect is only 4 μs. As this time-delay is smaller than the uncertainty on our phase residuals by nearly two orders of magnitude (see Figure 1), we are not sensitive to Shapiro delays in Swift J1756. Comparing our measurements for the 2018 outburst with those of the 2007 and 2009 outbursts as observed with RXTE, we analyzed the long-term evolution of this source. We found that the binary system is consistent with having a constant orbital period and that the pulsar shows a spin frequency derivative of $\dot{\nu }=-7.3\times {10}^{-16}\,\mathrm{Hz}\,{{\rm{s}}}^{-1}$. 4.1. Spin-down Evolution The long-term spin frequency derivative measured in Swift J1756 is of the same order as the spin frequency derivatives measured in other AMXPs (Hartman et al. 2008; Patruno 2010; Riggio et al. 2011). This frequency change is most likely driven by the neutron star's loss of rotational energy. If so, then the spin-down luminosity is given as Equation (6) where I represents the neutron star moment of inertia. The long-term spin-down of a neutron star is usually assumed to be dominated by the braking torque associated with a spinning magnetic field. Assuming this mechanism is responsible for the observed spin-down in Swift J1756, we can compute the magnetic dipole moment as (Spitkovsky 2006) Equation (7) where α is the misalignment angle between the rotational and magnetic poles. Considering α = 0°–90°, we then find a magnetic field strength of $B\simeq (4\mbox{--}6)\times {10}^{8}$ G at the stellar magnetic poles. This magnetic field strength estimate is in line with those obtained for other accreting millisecond pulsars (see Mukherjee et al. 2015 and references therein). 4.2. Orbit Evolution The observed long-term binary evolution of Swift J1756 is consistent with this source having a constant orbital period and a lower limit on the evolutionary timescale of Equation (8) Binary evolution theory predicts that systems of this type evolve due to angular momentum loss through gravitational radiation (Kraft et al. 1962; Rappaport et al. 1982; Verbunt 1993). For conservative mass transfer, the binary period derivative is given by di Salvo et al. (2008), Equation (9) where MNS is the neutron star mass, $q={M}_{C}/{M}_{\mathrm{NS}}$ is the binary mass ratio, and −1/3 < n < 1 is the mass–radius index of the companion star. Depending on the source inclination, Krimm et al. (2007b) derived a companion mass of ${M}_{C}\,=0.007\mbox{--}0.022\,{M}_{\odot }$ for a neutron star mass of 1.4 ${M}_{\odot }$. For a neutron star mass of 2.2 ${M}_{\odot }$, the allowed range increased to ${M}_{C}=0.009\mbox{--}0.030\,{M}_{\odot }$. In both cases, they assumed an upper limit on the inclination of i < 85°, motivated by the fact that Swift J1756 does not show eclipses in its light curve. Accounting for the extreme cases of stellar masses and n, the binary may either be contracting or expanding. In either case, however, the rate of change is limited to $| {\dot{P}}_{b}| \lesssim 7\times {10}^{-14}$ s s−1, which is well below the upper limit obtained in this work. Although the binary evolution timescale we obtain for Swift J1756 is consistent with theory, it is worth noting that this is not generally true for low-mass X-ray binaries (see Patruno et al. 2017, for a comprehensive discussion). The AMXP SAX J1808.4–3658, in particular, has been found to evolve on a much shorter timescale, with a first derivative on the orbital period of $3.5\times {10}^{-12}$ s s−1 (Hartman et al. 2008; Patruno et al. 2012; Sanna et al. 2017a). Two models have been proposed to explain this discrepancy: highly nonconservative mass transfer due to irradiation of the companion star by the pulsar (di Salvo et al. 2008; Burderi et al. 2009), and spin–orbit coupling in the companion star (Hartman et al. 2008, 2009). While the latter depends on the companion star, and may vary from source to source, the former should operate in all AMXPs (see also Patruno 2017; Sanna et al. 2017c), including Swift J1756. The spin-down luminosity impinging on the companion star can be estimated as Equation (10) where ${\dot{E}}_{\mathrm{abl}}$ is the ablation luminosity, RL2 is the Roche lobe radius of the companion (Eggleton 1983), and a the binary separation. The irradiation fraction is $f={\dot{E}}_{\mathrm{abl}}/{\dot{E}}_{\mathrm{sd}}$, which, accounting for the range of allowed neutron star and companion masses, evaluates to f = 0.15%–0.35%. The associated mass loss for the companion is given by Equation (11) such that, assuming an efficiency of η = 100%, ${\dot{M}}_{C}\,\sim -3\times {10}^{-10}\,{M}_{\odot }$ yr−1. The effect of this mass loss on the orbital period follows through the relation (Frank et al. 2002) Equation (12) giving a period derivative due to mass loss of ${\dot{P}}_{b,\mathrm{ML}}\,=5\times {10}^{-12}$ s s−1. This value is well above our limit on the period derivative. Hence, in order for this mechanism to be consistent with our observations of Swift J1756, the efficiency at which the companion star converts the incident luminosity into mass loss must be η < 15%. This value is very different from the 40% required in SAX J1808.4–3658 (Patruno et al. 2016) and is instead in line with the <5% efficiency determined for IGR J00291+5934 (Patruno 2017). This work was supported by NASA through the NICER mission and the Astrophysics Explorers Program, and made use of data and software provided by the High Energy Astrophysics Science Archive Research Center (HEASARC). P.B. was supported by an NPP fellowship at NASA Goddard Space Flight Center. D.A. acknowledges support from the Royal Society.

Bult, Peter↗

Focal Plane Geometry Characterization of the Kepler Mission

The Kepler Mission focal plane contains 42 charge-coupled device (CCD) photodetectors. Each CCD is composed of 2.2 million square pixels, 27 micrometers on a side, arranged in a grid of 2,200 columns by 1,044 rows. The science goals of the Kepler Mission require that the position of each CCD be determined with an accuracy of 0.1 pixels, corresponding to 2.7 micrometers or 0.4 seconds of arc, a level which is not achievable through pre-flight metrology. We describe a technique for determining the CCD positioning using images of the Kepler field of view (FOV) obtained in flight. The technique uses the fitted centroid row and column positions of 400 pre-selected stars on each CCD to obtain empirical polynomials which relate sky coordinates (right ascension and declination) to chip coordinates (row and column). The polynomials are in turn evaluated to produce constraints for a nonlinear model fit which directly determines the model parameters describing the location and orientation of each CCD. The focal plane geometry characterization algorithm is itself embedded in an iterative process which determines the focal plane geometry and the Pixel Response Function for each CCD in a self-consistent manner. In addition to the fully automated calculation, a person-in-the-loop implementation was developed to allow an initial determination of the geometry in the event of large misalignments, achieving a much looser capture tolerance for more modest accuracy and reduced automation.

ccd↗

High-Contrast Polarimetry Observation of the T Tau Circumstellar Environment

We conducted high-contrast polarimetry observations of T Tau in the H-band, using the High Contrast Instrument for the Subaru Next Generation Adaptive Optics instrument mounted on the Subaru Telescope, revealing structures as near as 0farcs1 from the stars T Tau N and T Tau S. The whole T Tau system is found to be surrounded by nebula-like envelopes, and several outflow-related structures are detected in these envelopes. We analyzed the detailed polarization patterns of the circumstellar structures near each component of this triple young star system and determined constraints on the circumstellar disks and outflow structures. We suggest that the nearly face-on circumstellar disk of T Tau N is no larger than 0".8, or 117 au, in the northwest, based on the existence of a hole in this direction, and no larger than 0".27, or 40 au, in the south. A new structure, "N5," extends to about 0."42, or 59 au, southwest of the star, and is believed to be part of the disk. We suggest that T Tau S is surrounded by a highly inclined circumbinary disk with a radius of about 0."3, or 44 au, with a position angle of about 30°, that is misaligned with the orbit of the T Tau S binary. After analyzing the positions and polarization vector patterns of the outflow-related structures, we suggest that T Tau S should trigger the well-known E–W outflow, and is also likely to be responsible for a southwest precessing outflow "coil" and a possible south outflow.

Yang, Yi↗

On the Curious Pulsation Properties of the Accreting Millisecond Pulsar IGR J17379-3747

(NICER) monitoring campaign of the 468 Hz accreting millisecond X-ray pulsar IGR J17379–3747. From a detailed spectral and timing analysis of the coherent pulsations we find that they show a strong energy dependence, with soft thermal emission lagging about 640 μs behind the hard, Comptonized emission. Additionally, we observe uncommonly large pulse fractions, with measured amplitudes in excess of 20% sinusoidal fractional amplitude across the NICER passband and fluctuations of up to ∼70%. Based on a phase-resolved spectral analysis, we suggest that these extreme properties might be explained if the source has an unusually favorable viewing geometry with a large magnetic misalignment angle. Due to these large pulse fractions, we were able to detect pulsations down to quiescent luminosities (~5 x 10(exp 33) erg/s).

Bult, Peter↗

The Benefits of Napping for Safety & How Quickly Can the Brain Wake-Up from Sleep?

Fatigue is a hazard that must be managed within 24-hour safety-critical operations. Napping is the best known countermeasure to fatigue caused by sleep-loss and circadian misalignment. This presentation will: define fatigue; discuss ways to make the most of a nap opportunity; highlight the benefits of napping, including two case studies from workplace settings; outline the challenges in implementing napping in the workplace; and walk through examples to demonstrate that not all naps are equal when it comes to benefits to alertness and performance. The second half of the presentation will focus on sleep inertia, that is, the brief period of impaired alertness and performance experienced after waking from sleep. The factors contributing to and caused by sleep inertia will be discussed, along with countermeasures to reduce the impact of sleep inertia on alertness and performance.

Hilditch, Cassie J.↗

A Summary Of: Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Sleep loss and circadian misalignment contribute to a meaningful proportion of operational accidents and incidents. Countermeasures and work scheduling designs aimed at mitigating fatigue are typically evaluated in controlled laboratory environments, but the effectiveness of translating such strategies to operational environments can be challenging to assess. This manuscript summarizes an approach for collecting sleep, circadian, fatigue, and performance data in a complex operational environment. We studied 44 airline pilots over 34 days while they flew a fixed schedule, which included a baseline data collection with 5 days of mid-morning flights, four early flights, four high-workload mid-day flights, and four late flights that landed after midnight. Each work block was separated by 3-4 days of rest. To assess sleep, participants wore a wrist-worn research-validated activity monitor continuously and completed daily sleep diaries. To assess the circadian phase, pilots were asked to collect all urine produced in four or eight hourly bins during the 24 h after each duty block for the assessment of 6-sulfatoxymelatonin (aMT6s), which is a biomarker of the circadian rhythm. To assess subjective fatigue and objective performance, participants were provided with a touchscreen device used to complete the Samn-Perelli Fatigue Scale and Psychomotor Vigilance Task (PVT) during and after each flight, and at wake-time, mid-day, and bedtime. Using these methods, it was found that sleep duration was reduced during early starts and late finishes relative to baseline. Circadian phase shifted according to duty schedule, but there was a wide range in the aMT6s peak between individuals on each schedule. PVT performance was worse on the early, high-workload, and late schedules relative to baseline. Overall, the combination of these methods was practical and effective for assessing the influence of sleep loss and circadian phase on fatigue and performance in a complex operational environment.

Arsintescu, Lucica↗

Stress Induced Immune Dysregulation: A Continuum Spanning Antarctica Winterover, Spaceflight, and Terrestrial Patients

Spaceflight is a unique environment characterized by stress, microgravity, isolation, circadian misalignment, and radiation exposure and impacts immune health. Planned long duration missions to Mars are a top priority for NASA and mitigating the negative health consequences of spaceflight is particularly important. Terrestrial analogs are a vital aspect of spaceflight research since data from astronauts is limited and it is costly to receive samples from ISS. The most relevant ground analog would include station lifestyle, stress, disrupted circadian rhythms and isolation. This analysis compares various aspects of immune dysregulation in astronauts during long-duration orbital spaceflight to groundanalogs. Astronaut data were also compared to a clinical immunodeficiency population, shingles patients, to help interpret clinical risks during deep space missions. A comprehensive evaluation was performed across hypoxic interior Antarctica, normoxic coastal Antarctica, HERA, and astronauts which included plasma and mitogen stimulated cytokine profiles, T-cell function, and peripheral leukocyte distribution. A cross platform analysis was then performed to define in-flight immune alterations, determine analog appropriateness, and interpret clinical risk.

Krieger, Stephanie↗