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At least 1,135 records · Page 63

SU-F-T-142: An Analytical Model to Correct the Aperture Scattered Dose in Clinical Proton Beams

Purpose: Apertures or collimators are used to laterally shape proton beams in double scattering (DS) delivery and to sharpen the penumbra in pencil beam (PB) delivery. However, aperture-scattered dose is not included in the current dose calculations of treatment planning system (TPS). The purpose of this study is to provide a method to correct the aperture-scattered dose based on an analytical model. Methods: A DS beam with a non-divergent aperture was delivered using a single-room proton machine. Dose profiles were measured with an ion-chamber scanning in water and a 2-D ion chamber matrix with solid-water buildup at various depths. The measured doses were considered as the sum of the non-contaminated dose and the aperture-scattered dose. The non-contaminated dose was calculated by TPS and subtracted from the measured dose. Aperture scattered-dose was modeled as a 1D Gaussian distribution. For 2-D fields, to calculate the scatter-dose from all the edges of aperture, a sum of weighted distance was used in the model based on the distance from calculation point to aperture edge. The gamma index was calculated between the measured and calculated dose with and without scatter correction. Results: For a beam with range of 23 cm and aperture size of 20 cm, the contribution of the scatter horn was ∼8% of the total dose at 4 cm depth and diminished to 0 at 15 cm depth. The amplitude of scatter-dose decreased linearly with the depth increase. The 1D gamma index (2%/2 mm) between the calculated and measured profiles increased from 63% to 98% for 4 cm depth and from 83% to 98% at 13 cm depth. The 2D gamma index (2%/2 mm) at 4 cm depth has improved from 78% to 94%. Conclusion: Using the simple analytical method the discrepancy between the measured and calculated dose has significantly improved.

60 APPLIED LIFE SCIENCES↗

SU-F-T-572: Small Fields Output Factors Measurement and Correction Factor Determination for Several Active and Passive Detectors

Purpose: To measure the output factor (OF) and output correction factors (OCF) of small circular cones using various active and passive detectors. Methods: The OF of BrainLab circular cones of 4, 6, 7.5, 10, 12.5 and 15mm diameter were measured isocentrically at 15mm depth for 6 MV X-rays at 1000 MU/min from Novalis-Tx Linac using high resolution diodes (SFD, Edge, PTW60008), plastic scintillator (ExtradinW1), small ionization chamber (CC01), EBT3 film and Al2O3:C OSLDs (nanoDot). OCF was calculated as a ratio of the OF of each detector relative to EBT3. Long term overall measurement uncertainty were estimated from the 15 repeat measurement performed for each detector over a period of 1year Results: The mean OF measured using various detectors are shown in the figure. In comparison to EDR3 measurement, nanoDot, CC01 and ExtradinW1 showed consistently lower OF upto −25.7% (nanoDot) which gradually improves with cone size (Table). The variation in OF measure with CC01 and ExtradinW1 for cone size >10mm is within −1.4% and −1.9%. Whereas, Edge and PTW60008 measured consistently larger OF except for 4mm cone. All diodes showed better agreement with EDR3 with maximum variation within ±1.7% (SFD), 2.5% (Edge) and 4.4% (PTW60008). The OCF was largest for nanoDot (range 1.04–1.35) and least for the diodes (range 0.97–1.04). The estimated overall long term standard uncertainty (k=2, 95% confidence) were highest for nanoDot at 3% followed by 2.43% for EDR3, 1% for SFD, 0.49% for ExtradinW1, 0.42% for CC01 and PTW60008, 0.16% for edge. Conclusion: Largest OF for the smallest cone was observed from EDR3. Although correction factor needed for all diodes were very similar, Edge showed most consistent result. nanoDot in its present form is not suitable for OF measurement from small fields. ExtradinW1 with its stem oriented perpendicular to beam axis underestimate OF for field size ≤10mm and need further investigation.

60 APPLIED LIFE SCIENCES↗

SU-G-201-02: Application of RayStretch in Clinical Cases: A Calculation for Heterogeneity Corrections in LDR Permanent I-125 Prostate Brachytherapy

Purpose: Tissue heterogeneities and calcifications have significant impact on the dosimetry of low energy brachytherapy (BT). RayStretch is an analytical algorithm developed in our institution to incorporate heterogeneity corrections in LDR prostate brachytherapy. The aim of this work is to study its application in clinical cases by comparing its predictions with the results obtained with TG-43 and Monte Carlo (MC) simulations. Methods: A clinical implant (71 I-125 seeds, 15 needles) from a real patient was considered. On this patient, different volumes with calcifications were considered. Its properties were evaluated in three ways by i) the Treatment planning system (TPS) (TG-43), ii) a MC study using the Penelope2009 code, and iii) RayStretch. To analyse the performance of RayStretch, calcifications located in the prostate lobules covering 11% of the total prostate volume and larger calcifications located in the lobules and underneath the urethra for a total occupied volume of 30% were considered. Three mass densities (1.05, 1.20, and 1.35 g/cm3) were explored for the calcifications. Therefore, 6 different scenarios ranging from small low density calcifications to large high density ones have been discussed. Results: DVH and D90 results given by RayStretch agree within 1% with the full MC simulations. Although no effort has been done to improve RayStretch numerical performance, its present implementation is able to evaluate a clinical implant in a few seconds to the same level of accuracy as a detailed MC calculation. Conclusion: RayStretch is a robust method for heterogeneity corrections in prostate BT supported on TG-43 data. Its compatibility with commercial TPSs and its high calculation speed makes it feasible for use in clinical settings for improving treatment quality. It will allow in a second phase of this project, its use during intraoperative ultrasound planning. This study was partly supported by a fellowship grant from the Spanish Ministry of Education, by the Generalitat Valenciana under Project PROMETEOII/2013/010, by the Spanish Government under Project No. FIS2013-42156 and by the European Commission within the SeventhFramework Program through ENTERVISION (grant agreement number 264552).

60 APPLIED LIFE SCIENCES↗

SU-G-TeP1-03: Beam Quality Correction Factors for Linear Accelerator with and Without Flattening Filter

Purpose: The impact of removing the flattening filter on absolute dosimetry based on IAEA’s TPR-398 and AAPM’s TG-51 was investigated in this study using Monte Carlo simulations. Methods: The EGSnrc software package was used for all Monte Carlo simulations performed in this work. Five different ionization chambers and nine linear accelerator heads have been modeled according to technical drawings. To generate a flattening filter free radiation field the flattening filter was replaced by a 2 mm thick aluminum layer. Dose calculation in a water phantom were performed to calculate the beam quality correction factor k{sub Q} as a function of the beam quality specifiers %dd(10){sub x}, TPR{sub 20,10} and mean photon and electron energies at the point of measurement in photon fields with (WFF) and without flattening filter (FFF). Results: The beam quality correction factor as a function of %dd(10){sub x} differs systematically between FFF and WFF beams for all investigated ionization chambers. The largest difference of 1.8% was observed for the largest investigated Farmer-type ionization chamber with a sensitive volume of 0.69 cm{sup 3}. For ionization chambers with a smaller nominal sensitive volume (0.015 – 0.3 cm{sup 3}) the deviation was less than 0.4% between WFF and FFF beams for %dd(10){sub x} > 62%. The specifier TPR{sub 20,10} revealed only a good correlation between WFF and FFF beams (< 0.3%) for low energies. Conclusion: The results confirm that %dd(10){sub x} is a suitable beam quality specifier for FFF beams with an acceptable bias. The deviation depends on the volume of the ionization chamber. Using %dd(10){sub x} to predict k{sub Q} for a large volume chamber in a FFF photon field may lead to not acceptable errors according to the results of this study. This bias may be caused by the volume effect due to the inhomogeneous photon fields of FFF linear accelerators.

60 APPLIED LIFE SCIENCES↗

WE-AB-BRA-08: Correction of Patient Motion in C-Arm Cone-Beam CT Using 3D-2D Registration

Purpose: Intraoperative C-arm cone-beam CT (CBCT) is subject to artifacts arising from patient motion during the fairly long (∼5–20 s) scan times. We present a fiducial free method to mitigate motion artifacts using 3D-2D image registration that simultaneously corrects residual errors in geometric calibration. Methods: A 3D-2D registration process was used to register each projection to DRRs computed from the 3D image by maximizing gradient orientation (GO) using the CMA-ES optimizer. The resulting rigid 6 DOF transforms were applied to the system projection matrices, and a 3D image was reconstructed via model-based image reconstruction (MBIR, which accommodates the resulting noncircular orbit). Experiments were conducted using a Zeego robotic C-arm (20 s, 200°, 496 projections) to image a head phantom undergoing various types of motion: 1) 5° lateral motion; 2) 15° lateral motion; and 3) 5° lateral motion with 10 mm periodic inferior-superior motion. Images were reconstructed using a penalized likelihood (PL) objective function, and structural similarity (SSIM) was measured for axial slices of the reconstructed images. A motion-free image was acquired using the same protocol for comparison. Results: There was significant improvement (p < 0.001) in the SSIM of the motion-corrected (MC) images compared to uncorrected images. The SSIM in MC-PL images was >0.99, indicating near identity to the motion-free reference. The point spread function (PSF) measured from a wire in the phantom was restored to that of the reference in each case. Conclusion: The 3D-2D registration method provides a robust framework for mitigation of motion artifacts and is expected to hold for applications in the head, pelvis, and extremities with reasonably constrained operative setup. Further improvement can be achieved by incorporating multiple rigid components and non-rigid deformation within the framework. The method is highly parallelizable and could in principle be run with every acquisition. Research supported by National Institutes of Health Grant No. R01-EB-017226 and academic-industry partnership with Siemens Healthcare (AX Division, Forcheim, Germany).

60 APPLIED LIFE SCIENCES↗

WE-DE-207B-10: Library-Based X-Ray Scatter Correction for Dedicated Cone-Beam Breast CT: Clinical Validation

Purpose: Scatter contamination is detrimental to image quality in dedicated cone-beam breast CT (CBBCT), resulting in cupping artifacts and loss of contrast in reconstructed images. Such effects impede visualization of breast lesions and the quantitative accuracy. Previously, we proposed a library-based software approach to suppress scatter on CBBCT images. In this work, we quantify the efficacy and stability of this approach using datasets from 15 human subjects. Methods: A pre-computed scatter library is generated using Monte Carlo simulations for semi-ellipsoid breast models and homogeneous fibroglandular/adipose tissue mixture encompassing the range reported in literature. Projection datasets from 15 human subjects that cover 95 percentile of breast dimensions and fibroglandular volume fraction were included in the analysis. Our investigations indicate that it is sufficient to consider the breast dimensions alone and variation in fibroglandular fraction does not significantly affect the scatter-to-primary ratio. The breast diameter is measured from a first-pass reconstruction; the appropriate scatter distribution is selected from the library; and, deformed by considering the discrepancy in total projection intensity between the clinical dataset and the simulated semi-ellipsoidal breast. The deformed scatter-distribution is subtracted from the measured projections for scatter correction. Spatial non-uniformity (SNU) and contrast-to-noise ratio (CNR) were used as quantitative metrics to evaluate the results. Results: On the 15 patient cases, our method reduced the overall image spatial non-uniformity (SNU) from 7.14%±2.94% (mean ± standard deviation) to 2.47%±0.68% in coronal view and from 10.14%±4.1% to 3.02% ±1.26% in sagittal view. The average contrast to noise ratio (CNR) improved by a factor of 1.49±0.40 in coronal view and by 2.12±1.54 in sagittal view. Conclusion: We demonstrate the robustness and effectiveness of a library-based scatter correction method using patient datasets with large variability in breast dimensions and composition. The high computational efficiency and simplicity in implementation make this attractive for clinical implementation. Supported partly by NIH R21EB019597, R21CA134128 and R01CA195512.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

60 APPLIED LIFE SCIENCES↗

TH-EF-207A-01: Respiratory Motion Correction in 4D-Multi Pinhole Small Animal SPECT

Purpose: Respiration causes lesion smearing, image blurring and quality degradation, affecting lesion contrast and the ability to define correct lesion size. The spatial resolution of current multi pinhole SPECT (MPHS) scanners is sub-millimeter. Therefore, the effect of motion is more noticeable in comparison to conventional SPECT scanner. Gated imaging aims to reduce motion artifacts. A major issue in gating is the lack of statistics and individual reconstructed frames are noisy. The increased noise in each frame, deteriorates the quantitative accuracy of the MPHS Images. The objective of this work, is to enhance the image quality in 4D-MPHS imaging, by 4D image reconstruction. Methods: The new algorithm requires deformation vector fields (DVFs) that are calculated by non-rigid Demons registration. The algorithm is based on the motion-incorporated version of ordered subset expectation maximization (OSEM) algorithm. This iterative algorithm is capable to make full use of all projections to reconstruct each individual frame. To evaluate the performance of the proposed algorithm a simulation study was conducted. A fast ray tracing method was used to generate MPHS projections of a 4D digital mouse phantom with a small tumor in liver in eight different respiratory phases. To evaluate the 4D-OSEM algorithm potential, tumor to liver activity ratio was compared with other image reconstruction methods including 3D-MPHS and post reconstruction registered with Demons-derived DVFs. Results: Image quality of 4D-MPHS is greatly improved by the 4D-OSEM algorithm. When all projections are used to reconstruct a 3D-MPHS, motion blurring artifacts are present, leading to overestimation of the tumor size and 24% tumor contrast underestimation. This error reduced to 16% and 10% for post reconstruction registration methods and 4D-OSEM respectively. Conclusion: 4D-OSEM method can be used for motion correction in 4D-MPHS. The statistics and quantification are improved since all projection data are combined together to update the image.

60 APPLIED LIFE SCIENCES↗

Bremsstrahlung radiation from slow electrons in a Coulomb field: Classical limit and quantum correction

Compact analytic expressions have been derived by a direct expansion in ħ → 0 for the nonrelativistic amplitude of Coulomb bremsstrahlung radiation (BR), the differential (in frequency and angles of the scattered electron) BR cross section, and the triply differential BR cross section that takes into account the bremsstrahlung photon direction and polarization and the scattered electron direction. They contain the classical limit and a quantum correction of the order of ħ at an arbitrary BR frequency ω. An explicit expression has been found for the quantum correction of the order of ħ to the classical BR spectrum.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Decoy States and Low-Density Parity-Check Error-Correcting Codes in Quantum Cryptography with Phase–Time Coding

The cryptographic robustness of quantum key distribution (QKD) with phase–time coding against a photon number splitting (PNS) attack is analyzed. The line length up to which a secret key distribution is guaranteed is determined both by the protocol itself and by the efficiency of error correction in raw keys. The effect of different parameters of avalanche single-photon detectors on the length of the secret key distribution line is investigated. To correct errors, various versions of low-density parity-check (LDPC) codes are considered whose efficiency today is the closest to the Shannon theoretical limit.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Precision of approximate Kramers formulas for the nuclear-fission rate in the presence of shell corrections

The precision of approximate Kramers formulas for the nuclear-fission rate in the presence of shell corrections in a quasistationary state is studied. The rates in question obtained analytically are compared with their numerical counterparts resulting from a dynamical simulation based on the Smoluchowski equation. It is shown that the integral Kramers formula is applicable even in the presence of shell corrections. As the excitation energy of the nucleus being considered decreases, the inaccuracy of this formula decreases monotonically, reaching 2% (inaccuracy of the dynamical simulation) in which case the dimensionless controlling parameter (entropy barrier) becomes greater than four. At small and intermediate values of this parameter, the accuracy of the integral Kramers formula is higher than the accuracy of the approximate Kramers formula obtained from it.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Analysis of approximations used in calculations of radiative corrections to electron-proton scattering cross section

An analysis of approximations used in calculations of radiative corrections to electron-proton scattering cross section is presented. We investigate the difference between the relatively recent Maximon and Tjon result and the Mo and Tsai result, which was used in the analysis of experimental data. We also discuss the proton form factors ratio dependence on the way we take into account radiative corrections.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Effects of first-order correction to eikonal approximation in the analysis of {sup 9}Be({sup 15}C,{sup 14}C + n){sup 9}Be stripping reaction

We have studied the effects of the first-order correction to the eikonal approximation for {sup 9}Be({sup 15}C,{sup 14}C + n){sup 9}Be stripping reactions at 54A MeV incident energy and have found that the correction term slightly changes the tail of the longitudinal momentum distribution of the core fragment.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Statistics-Based Correction to Measurements of Hardness of Rough Surfaces by Instrumented Indentation

Abstract—A procedure for correcting hardness data measured on rough surfaces using instrumented indentation is presented. The correction procedure relies on the knowledge of surface topography, which can be obtained by atomic force microscopy or other appropriate instrumental technique. The analyzed surface is characterized by the standard deviation of height distribution and an autocorrelation function. The latter is proposed to be modeled with an exponential function with either a quadratic or linear exponent.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Radiative corrections beyond the ultra relativistic limit in unpolarized ep elastic and Møller scatterings for the PRad Experiment at Jefferson Laboratory

The clear 7σ discrepancy between measurements of the proton charge radius from muonic hydrogen Lamb shifts and those from hydrogen Lamb shift and electron scattering lead to both intense theoretical and experimental efforts to understand and explain this difference. In this regard, a new experiment (PRad) based on unpolarized ep elastic scattering cross section measurements normalized to Møller scattering is underway at Jefferson Laboratory to extract the proton charge radius based on new proton electric form factor down to values of momentum transfer squared Q 2 , as low as 10 -4 GeV/c) -2 . Reaching the precision of the experiment in such a small Q 2 region requires reliable knowledge of radiative corrections. In this paper, we present a complete calculation of radiative corrections for unpolarized elastic ep and Møller scatterings performed within a covariant formalism resulting in the set of explicit formulas beyond the ultra relativistic approximation (m e 2 &NestedLessLess; Q 2 ), and numerical results for the kinematics of the PRad experiment.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Aberration correction in photoemission microscopy and applications in photonics and plasmonics

We report on the design, assembly, operation and application of an aberration-corrected photoemission electron microscope. The instrument used novel hyperbolic mirror-correctors with two and three electrodes that allowed simultaneous correction of spherical and chromatic aberrations. A spatial resolution of 5.4nm was obtained with this instrument in 2009, and 4.7nm in subsequent years. New imaging methodology was introduced involving interferometric imaging of light diffraction. This methodology was applied in nano-photonics and in the characterization of surface-plasmon polaritons. Photonic crystals and waveguides, optical antennas and new plasmonic devices such as routers, localizers and filters were designed and demonstrated using the new capabilities offered by the microscope.

36 MATERIALS SCIENCE↗

Model Evaluation Report for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nye County, Nevada (Revision 1)

This Model Evaluation Report (MER) has been prepared for Corrective Action Unit (CAU) 97, Yucca Flat/Climax Mine (YF/CM), Nevada National Security Site (NNSS), Nevada. The YF/CM CAU is located in the northeastern portion of the NNSS and comprises 720 corrective action sites. A total of 747 underground nuclear detonations took place within this CAU between 1957 and 1992 and resulted in the release of radionuclides (RNs) in the subsurface in the vicinity of the detonation cavities.

54 ENVIRONMENTAL SCIENCES↗

Underground Test Area (UGTA) Sampling Plan for Corrective Action Units 101 and 102: Central and Western Pahute Mesa, Nevada National Security Site, Nevada, Revision 2

The purpose of this groundwater sampling plan (referred to herein as “the Plan”) is to describe the approach for collecting and analyzing groundwater samples to meet the objectives of the U.S. Department of Energy (DOE), Environmental Management (EM) Nevada Program’s Underground Test Area (UGTA) Activity. The Plan is focused on the Central and Western Pahute Mesa corrective action units (CAUs 101 and 102), which are currently in the Corrective Action Decision Document (CADD)/Corrective Action Plan (CAP) stage of the Federal Facility Agreement and Consent Order (FFACO) UGTA Strategy. The remaining UGTA CAUs are in the final stage of the UGTA strategy (Closure Report [CR] stage), and monitoring requirements for these CAUs are described in the Federal Facility Agreement and Consent Order Nevada National Security Site Use Restriction Management Plan (DOE/EMNV, 2024a). The Plan supersedes the Nevada National Security Site Integrated Groundwater Sampling Plan and its ensuing Record of Technical Change (ROTC) (DOE/EMNV, 2019b).

54 ENVIRONMENTAL SCIENCES↗

Non-Resource Conservation and Recovery Act Corrective Action Unit (CAU) Post-Closure Inspection Report, Nevada National Security Site, Nevada For Calendar Year 2025

This report includes visual inspection results, descriptions of maintenance and repair activities, and recommendations for CY 2025 for use restrictions (URs) at corrective action sites (CASs) located on the Nevada National Security Site and on the Nevada Test and Training Range (NTTR) that are accessed through the NNSS Main Gate. This document is arranged by project activity (i.e., Industrial Sites, Soils, and Defense Threat Reduction Agency [DTRA]); then by corrective action unit (CAU); and then by CAS. Post-closure UR inspections are performed on an annual basis, unless as noted in text. Post-closure UR inspections verify the condition of physical controls required by each UR, which may include the following activities: • Visual verification of the legibility of signs • Visual inspection of fencing, signs, monuments, and/or markers for indications of wear • Visual inspection of soil covers for indications of subsidence, erosion, or unauthorized use Deficiencies in UR requirements that were identified during CY 2024 inspections and not addressed in the CY 2024 report are addressed in this CY 2025 report.

54 ENVIRONMENTAL SCIENCES↗