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At least 1,135 records · Page 63

Rapid susceptibility testing of mycobacterium avium complex and mycobacterium tuberculosis isolated from AIDS patients

In ominous projections issued by both U.S. Public Health Service and the World Health Organization, the epidemic of the Human Immunodeficiency Virus (HIV) infection will continue to rise more rapidly worldwide than predicted earlier. The Acquired Immunodeficiency Syndrome (AIDS) patients are susceptible to diseases called opportunistic infections of which tuberculosis and M. avium Complex (MAC) infection are most common. This has created an urgent need to uncover new drugs for the treatment of these infections. In the seventies, NASA scientists at Goddard Space Flight Center, Greenbelt, Maryland, had adopted a biochemical indicator, adenosine triphosphate (ATP), to detect presence of life in extraterrestrial space. Therefore, we proposed to develop ATP assay technique to determine sensitivity of antibacterial compounds against MAC and M. tuberculosis. The work was initiated in June 1992. In the last report, we described our efforts in developing ATP assay method using MAC. Studies were continued further, and during the period of this report, we established the relationship between colony forming units and ATP levels of these organisms during the growth cycle. Also, we evaluated the effects of standard antimycobacterial drugs using ATP assay technique and compared the results with those obtained with conventional tube dilution proportional method.

Dhople, Arvind M.↗

A composite structured/unstructured-mesh Euler method for complex airfoil shapes

A general two-dimensional Euler zonal method has been developed for computing flows about complex airfoil geometries such as multielement and iced airfoils. The method utilizes a composite structured and unstructured grid generated using conformal mapping and Delaunay triangulation, respectively. The finite-volume Euler method is then modified to couple solutions in the zones with structured and unstructured grids. Solutions about an iced airfoil and a multielement airfoil are given as examples of applications of the scheme.

Hefazi, H.↗

Multiscale Morphological Filtering for Analysis of Noisy and Complex Images

Images acquired with passive sensing techniques suffer from illumination variations and poor local contrasts that create major difficulties in interpretation and identification tasks. On the other hand, images acquired with active sensing techniques based on monochromatic illumination are degraded with speckle noise. Mathematical morphology offers elegant techniques to handle a wide range of image degradation problems. Unlike linear filters, morphological filters do not blur the edges and hence maintain higher image resolution. Their rich mathematical framework facilitates the design and analysis of these filters as well as their hardware implementation. Morphological filters are easier to implement and are more cost effective and efficient than several conventional linear filters. Morphological filters to remove speckle noise while maintaining high resolution and preserving thin image regions that are particularly vulnerable to speckle noise were developed and applied to SAR imagery. These filters used combination of linear (one-dimensional) structuring elements in different (typically four) orientations. Although this approach preserves more details than the simple morphological filters using two-dimensional structuring elements, the limited orientations of one-dimensional elements approximate the fine details of the region boundaries. A more robust filter designed recently overcomes the limitation of the fixed orientations. This filter uses a combination of concave and convex structuring elements. Morphological operators are also useful in extracting features from visible and infrared imagery. A multiresolution image pyramid obtained with successive filtering and a subsampling process aids in the removal of the illumination variations and enhances local contrasts. A morphology-based interpolation scheme was also introduced to reduce intensity discontinuities created in any morphological filtering task. The generality of morphological filtering techniques in extracting information from a wide variety of images obtained with active and passive sensing techniques is discussed. Such techniques are particularly useful in obtaining more information from fusion of complex images by different sensors such as SAR, visible, and infrared.

Kher, A.↗

Search for evidence of a clock related to the solar 154 day complex of periodicities

Evidence indicates that the 154-day periodicity in solar activity may be part of a complex of periodicities that are approximate multiples of 25.8 d, which suggests that the sun contains a 'clock' with frequency in the range 440-463 nHz. To search for evidence of this clock, the daily Greenwich sunspot areas and daily Zurich sunspot numbers have been Fourier-analyzed. The Zurich data show a strong peak that may clearly be identified with the fundamental frequency, while the Greenwich data show a peak that may be the harmonic of the fundamental frequency. A model is discussed which provides a kinematical interpretation of the sunspot spectrum.

Sturrock, P. A.↗

On the molecular complexity of the hot cores in Orion A - Grain surface chemistry as 'The last refuge of the scoundrel'

We have modeled the gas phase chemistry of warm molecular material around protostars that is seeded with evaporating grain mantles. We show that the release of simple molecules into the gas drives ion-molecule and neutral chemistries which can account for many of the complex O-bearing and N-bearing molecules observed in hot cores. Initial grain mantle components and secondary product molecules are identified, and the observational consequences are discussed.

Charnley, S. B.↗

Aerodynamic optimization of an HSCT configuration using variable-complexity modeling

An approach to aerodynamic configuration optimization is presented for the high-speed civil transport (HSCT). A method to parameterize the wing shape, fuselage shape and nacelle placement is described. Variable-complexity design strategies are used to combine conceptual and preliminary-level design approaches, both to preserve interdisciplinary design influences and to reduce computational expense. Conceptual-design-level (approximate) methods are used to estimate aircraft weight, supersonic wave drag and drag due to lift, and landing angle of attack. The drag due to lift, wave drag and landing angle of attack are also evaluated using more detailed, preliminary-design-level techniques. New, approximate methods for estimating supersonic wave drag and drag due to lift are described. The methodology is applied to the minimization of the gross weight of an HSCT that flies at Mach 2.4 with a range of 5500 n.mi. Results are presented for wing planform shape optimization and for combined wing and fuselage optimization with nacelle placement. Case studies include both all-metal wings and advanced composite wings.

Hutchison, M. G.↗

Variable-complexity aerodynamic-structural design of a high-speed civil transport wing

A variable-complexity strategy of combining simple and detailed analysis methods is presented for the design optimization of a high-speed civil transport (HSCT) wing. Two sets of results are shown: the aerodynamic design of the wing using algebraic weight equations for structural considerations, and optimization results of the internal wing structure for a fixed wing configuration. We show example results indicating that using simple analysis methods alone for the calculation of a critical constraint can allow an optimizer to exploit weaknesses in the analysis. The structural optimization results provide a valuable check for the weight equations used in the aerodynamic design. In addition, these results confirm the need for using simple, algebraic models in conjunction with more detailed analysis methods. A strategy of interlaced aerodynanic-structural design is proposed.

Hutchison, M. G.↗

Direct detection of C4H2 photochemical products - Possible routes to complex hydrocarbons in planetary atmospheres

The photochemistry of diacetylene (C4H2), the largest hydrocarbon to be unambiguously identified in planetary atmospheres, is of considerable importance to understanding the mechanisms by which complex molecules are formed in the solar system. In this work, the primary products of C4H2's ultraviolet photochemistry were determined in a two-laser pump-probe scheme in which the products of C4H2 photoexcitation are detected by vacuum ultraviolet photoionization in a time-of-flight mass spectrometer. Three larger hydrocarbon primary products were observed with good yield in the C4H2 + C4H2 reaction: C6H2, C8H2, and C8H3. Neither C6H2 or C8H3 is anticipated by current photochemical models of the atmospheres of Titan, Uranus, Neptune, Pluto, and Triton. The free hydrogen atoms that are released during the formation of the C8H3 and C8H2 products also may partially offset the role of C4H2 in catalyzing the recombination of free hydrogen atoms in the planetary atmospheres.

Bandy, Ralph E.↗

A gridless Euler/Navier-Stokes solution algorithm for complex-aircraft applications

The development of a gridless computational fluid dynamics (CFD) method for the solution of the two- and three-dimensional Euler and Navier-Stokes equations is described. The method uses only clouds of points and does not require that the points be connected to form a grid as a necessary in conventional CFD algorithms. The gridless CFD approach appears to resolve the inefficiencies encountered with structured or unstructured grid methods, and consequently offers great potential for accurately and efficiently solving viscous flows about complex aircraft configurations. The method is described in detail and calculations are presented for standard Euler and Navier-Stokes cases to assess the accuracy and efficiency of the capability.

Batina, John T.↗

The complex structured singular value

A tutorial introduction to the complex structured singular value (mu) is presented, with an emphasis on the mathematical aspects of mu. The mu-based methods discussed here have been useful for analyzing the performance and robustness properties of linear feedback systems. Several tests for robust stability and performance with computable bounds for transfer functions and their state space realizations are compared, and a simple synthesis problem is studied. Uncertain systems are represented using linear fractional transformations which naturally unify the frequency-domain and state space methods.

Packard, A.↗

Display format and highlight validity effects on search performance using complex visual displays

Display format and highlight validity were shown to affect visual display search performance; however, these studies were conducted on small, artificial displays of alphanumeric stimuli. A study manipulating these variables was conducted using realistic, complex Space Shuttle information displays. A 2x2x3 within-subjects analysis of variance found that search times were faster for items in reformatted displays than for current displays. The significant format by highlight validity interaction showed that there was little difference in response time to both current and reformatted displays when the highlight validity was applied; however, under the non or invalid highlight conditions, search times were faster with reformatted displays. Benefits of highlighting and reformatting displays to enhance search and the necessity to consider highlight validity and format characteristics in tandem for predicting search performance are discussed.

Donner, Kimberly A.↗

Adaptive fuzzy leader clustering of complex data sets in pattern recognition

A modular, unsupervised neural network architecture for clustering and classification of complex data sets is presented. The adaptive fuzzy leader clustering (AFLC) architecture is a hybrid neural-fuzzy system that learns on-line in a stable and efficient manner. The initial classification is performed in two stages: a simple competitive stage and a distance metric comparison stage. The cluster prototypes are then incrementally updated by relocating the centroid positions from fuzzy C-means system equations for the centroids and the membership values. The AFLC algorithm is applied to the Anderson Iris data and laser-luminescent fingerprint image data. It is concluded that the AFLC algorithm successfully classifies features extracted from real data, discrete or continuous.

Newton, Scott C.↗

Interactive flare sites within an active region complex

We examine here a set of images of an active region complex, acquired on June 24-25, 1980, by the Hard X-ray Imaging Spectrometer on SMM, with the purpose of establishing whether there was any interplay between the frequent activity observed at different sites in the activity center and, in such a case, how the interaction was established. By analyzing both quiet and active orbits we show that, as a rule, activity originating in one region triggers the other region's activity. However, we find little unambiguous evidence for the presence of large-scale interconnecting loops. A comparison of X-ray images with magnetic field observations suggested that we interpret the active region behavior in terms of the interaction between different loop systems, in a scenario quite analogous to the interacting bipole representation of individual flares. We conclude that active region interplay provides an easily observable case to study the time-dependent topology and the mechanisms for the spreading of activity in transient events over all energy scales.

Poletto, G.↗

On the Bur Gheluai H5 chondrite and other meteorites with complex exposure histories

Isotopic concentrations and track densities measured in 13 samples of the Bur Gheluai meteorite fall are presented. Experimental methods are described and results are presented for isotopic ratios of noble gases and cosmogenic radionuclide contents. Evidence for complex irradiation is discussed and a model for two-stage exposure histories is presented. The duration of each irradiation stage and possible effects on isotope production rates are considered. Explanations are suggested for the discrepant Ne production rates.

Vogt, S. K.↗

Defect-mediated spatial complexity and chaos in a phase-conjugate resonator

We have studied the spatiotemporal dynamics of a phase-conjugate resonator. The cavity Fresnel number is used to vary the degree of transverse confinement of the system. The generation and subsequent motion of the phase defects in the wave front are seen to mediate the system's dynamics. The number of defects and the complexity of their motion increases as the confinement is relaxed, leading the system through a sequence of bifurcations and eventually to chaos.

Indebetouw, Guy↗

Aluminum acceptor four particle bound exciton complex in 4H, 6H, and 3C SiC

Evidence is presented for a four particle acceptor complex in 3C, 6H, and 4H SiC, obtained in low-temperature photoluminescence and cathodoluminescence experiments. The new lines were observed in p-type films lightly doped with aluminum, of 6H, 4H, and 3C SiC grown on the silicon (0001) face of 6H SiC under special conditions. The lines increase in intensity as more aluminum is added during growth. The multiplicity of observed lines is consistent with symmetry-based models similar to those which have been proposed to describe 4A centers in p-type zincblende semiconductors.

Clemen, L. L.↗

Analysis and representation of complex structures in separated flows

We discuss our recent work on extraction and visualization of topological information in separated fluid flow data sets. As with scene analysis, an abstract representation of a large data set can greatly facilitate the understanding of complex, high-level structures. When studying flow topology, such a representation can be produced by locating and characterizing critical points in the velocity field and generating the associated stream surfaces. In 3D flows, the surface topology serves as the starting point. The 2D tangential velocity field near the surface of the body is examined for critical points. The tangential velocity field is integrated out along the principal directions of certain classes of critical points to produce curves depicting the topology of the flow near the body. The points and curves are linked to form a skeleton representing the 2D vector field topology. This skeleton provides a basis for analyzing the 3D structures associated with the flow separation. The points along the separation curves in the skeleton are used to start tangent curve integrations. Integration origins are successively refined to produce stream surfaces. The map of the global topology is completed by generating those stream surfaces associated with 3D critical points.

Helman, James↗

Hidden supernova remnants in the Large Magellanic Cloud H II complex N44

We have obtained ROSAT PSPC observations of N44, one of the largest H II complexes in the Large Magellanic Cloud. The X-ray emission mostly fails within the ionized shell structures in N44. We find that one faint shell is a classical supernova remnant overlooked by previous surveys. If we model the two largest shells as pressure-driven superbubbles, the predicted X-ray luminosity falls far below the observed value. Instead, we show that off-center supernova remnants hitting superbubble shells can explain the excess X-ray emission.

Chu, You-Hua↗