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At least 1,135 records · Page 63

A framework to measure myocardial extracellular volume fraction using dual-phase low dose CT images

Purpose: Myocardial extracellular volume fraction (ECVF) is a surrogate imaging biomarker of diffuse myocardial fibrosis, a hallmark of pathologic ventricular remodeling. Low dose cardiac CT is emerging as a promising modality to detect diffuse interstitial myocardial fibrosis due to its fast acquisition and low radiation; however, the insufficient contrast in the low dose CT images poses great challenge to measure ECVF from the image. Methods: To deal with this difficulty, the authors present a complete ECVF measurement framework including a point-guided myocardial modeling, a deformable model-based myocardium segmentation, nonrigid registration of pre- and post-CT, and ECVF calculation. Results: The proposed method was evaluated on 20 patients by two observers. Compared to the manually delineated reference segmentations, the accuracy of our segmentation in terms of true positive volume fraction (TPVF), false positive volume fraction (FPVF), and average surface distance (ASD), were 92.18% ± 3.52%, 0.31% ± 0.10%, 0.69 ± 0.14 mm, respectively. The interobserver variability measured by concordance correlation coefficient regarding TPVF, FPVF, and ASD were 0.95, 0.90, 0.94, respectively, demonstrating excellent agreement. Bland-Altman method showed 95% limits of agreement between ECVF at CT and ECVF at MR. Conclusions: The proposed framework demonstrates its efficiency, accuracy, and noninvasiveness in ECVF measurement and dramatically advances the ECVF at cardiac CT toward its clinical use.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Development and evaluation of a prototype tracking system using the treatment couch

Purpose: Tumor motion increases safety margins around the clinical target volume and leads to an increased dose to the surrounding healthy tissue. The authors have developed and evaluated a one-dimensional treatment couch tracking system to counter steer respiratory tumor motion. Three different motion detection sensors with different lag times were evaluated. Methods: The couch tracking system consists of a motion detection sensor, which can be the topometrical system Topos (Cyber Technologies, Germany), the respiratory gating system RPM (Varian Medical Systems) or a laser triangulation system (Micro Epsilon), and the Protura treatment couch (Civco Medical Systems). The control of the treatment couch was implemented in the block diagram environment Simulink (MathWorks). To achieve real time performance, the Simulink models were executed on a real time engine, provided by Real-Time Windows Target (MathWorks). A proportional-integral control system was implemented. The lag time of the couch tracking system using the three different motion detection sensors was measured. The geometrical accuracy of the system was evaluated by measuring the mean absolute deviation from the reference (static position) during motion tracking. This deviation was compared to the mean absolute deviation without tracking and a reduction factor was defined. A hexapod system was moving according to seven respiration patterns previously acquired with the RPM system as well as according to a sin{sup 6} function with two different frequencies (0.33 and 0.17 Hz) and the treatment table compensated the motion. Results: A prototype system for treatment couch tracking of respiratory motion was developed. The laser based tracking system with a small lag time of 57 ms reduced the residual motion by a factor of 11.9 ± 5.5 (mean value ± standard deviation). An increase in delay time from 57 to 130 ms (RPM based system) resulted in a reduction by a factor of 4.7 ± 2.6. The Topos based tracking system with the largest lag time of 300 ms achieved a mean reduction by a factor of 3.4 ± 2.3. The increase in the penumbra of a profile (1 × 1 cm{sup 2}) for a motion of 6 mm was 1.4 mm. With tracking applied there was no increase in the penumbra. Conclusions: Couch tracking with the Protura treatment couch is achievable. To reliably track all possible respiration patterns without prediction filters a short lag time below 100 ms is needed. More scientific work is necessary to extend our prototype to tracking of internal motion.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

SU-E-J-24: Can Fiducial Marker-Based Setup Using ExacTrac Be An Alternative to Soft Tissue-Based Setup Using Cone-Beam CT for Prostate IMRT?

Purpose: To assess an accuracy of fiducial maker-based setup using ExacTrac (ExT-based setup) as compared with soft tissue-based setup using Cone-beam CT (CBCT-based setup) for patients with prostate cancer receiving intensity-modulated radiation therapy (IMRT) for the purpose of investigating whether ExT-based setup can be an alternative to CBCT-based setup. Methods: The setup accuracy was analyzed prospectively for 7 prostate cancer patients with implanted three fiducial markers received IMRT. All patients were treated after CBCT-based setup was performed and corresponding shifts were recorded. ExacTrac images were obtained before and after CBCT-based setup. The fiducial marker-based shifts were calculated based on those two images and recorded on the assumption that the setup correction was carried out by fiducial marker-based auto correction. Mean and standard deviation of absolute differences and the correlation between CBCT and ExT shifts were estimated. Results: A total of 178 image dataset were analyzed. On the differences between CBCT and ExT shifts, 133 (75%) of 178 image dataset resulted in smaller differences than 3 mm in all dimensions. Mean differences in the anterior-posterior (AP), superior-inferior (SI), and left-right (LR) dimensions were 1.8 ± 1.9 mm, 0.7 ± 1.9 mm, and 0.6 ± 0.8 mm, respectively. The percentages of shift agreements within ±3 mm were 76% for AP, 90% for SI, and 100% for LR. The Pearson coefficient of correlation for CBCT and ExT shifts were 0.80 for AP, 0.80 for SI, and 0.65 for LR. Conclusion: This work showed that the accuracy of ExT-based setup was correlated with that of CBCT-based setup, implying that ExT-based setup has a potential ability to be an alternative to CBCT-based setup. The further work is to specify the conditions that ExT-based setup can provide the accuracy comparable to CBCT-based setup.

60 APPLIED LIFE SCIENCES↗

Measurements of spin observables in pseudo-scalar meson photo-production using polarized neutrons in solid HD

A measurement of psuedo-scalar meson photo production from longitudinally polarized solid HD has been carried out with the CLAS at Thomas Jefferson National Accelerator Facility (Jlab) with circularly and linearly polarized photon beams. Its aim is to measure a complete set of spin observables for the neutron simultaneously from the same experiment. As a polarized neutron, deutron in HD was used. Preliminary asymmetries are shown for the π{sup −} channel.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Quantifying sampling noise and parametric uncertainty in atomistic-to-continuum simulations using surrogate models

We present a methodology to assess the predictive fidelity of multiscale simulations by incorporating uncertainty in the information exchanged between the components of an atomistic-to-continuum simulation. We account for both the uncertainty due to finite sampling in molecular dynamics (MD) simulations and the uncertainty in the physical parameters of the model. Using Bayesian inference, we represent the expensive atomistic component by a surrogate model that relates the long-term output of the atomistic simulation to its uncertain inputs. We then present algorithms to solve for the variables exchanged across the atomistic-continuum interface in terms of polynomial chaos expansions (PCEs). We also consider a simple Couette flow where velocities are exchanged between the atomistic and continuum components, while accounting for uncertainty in the atomistic model parameters and the continuum boundary conditions. Results show convergence of the coupling algorithm at a reasonable number of iterations. As a result, the uncertainty in the obtained variables significantly depends on the amount of data sampled from the MD simulations and on the width of the time averaging window used in the MD simulations.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Measurement of the tt¯ production cross-section using eμ events with b-tagged jets in pp collisions at √s = 7 and 8 TeV with the ATLAS detector

The inclusive top quark pair (tt¯) production cross-section σ tt¯ has been measured in proton–proton collisions at √s = 7 TeV √s = 8 TeV with the ATLAS experiment at the LHC, using tt¯ events with an opposite-charge eμ pair in the final state. Thus, the measurement was performed with the 2011 7 TeV dataset corresponding to an integrated luminosity of 4.6 fb –1 and the 2012 8 TeV dataset of 20.3 fb –1 . The numbers of events with exactly one and exactly two b-tagged jets were counted and used to simultaneously determine σ tt¯ and the efficiency to reconstruct and b-tag a jet from a top quark decay, thereby minimizing the associated systematic uncertainties.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Measurement of the muon reconstruction performance of the ATLAS detector using 2011 and 2012 LHC proton–proton collision data

This study presents the performance of the ATLAS muon reconstruction during the LHC run with pp collisions at √s = 7–8 TeV in 2011–2012, focusing mainly on data collected in 2012. Measurements of the reconstruction efficiency and of the momentum scale and resolution, based on large reference samples of J/ψ → μμ, Z → μμ and Υ → μμ decays, are presented and compared to Monte Carlo simulations. Corrections to the simulation, to be used in physics analysis, are provided. Over most of the covered phase space (muon |η| < 2.7 and 5 ≲ p T ≲ 100 GeV) the efficiency is above 99% and is measured with per-mille precision. The momentum resolution ranges from 1.7% at central rapidity and for transverse momentum p T ≃ 10 GeV, to 4% at large rapidity and p T ≃ 100 GeV. The momentum scale is known with an uncertainty of 0.05% to 0.2% depending on rapidity. A method for the recovery of final state radiation from the muons is also presented.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for heavy long-lived multi-charged particles in pp collisions at √s = 8 TeV using the ATLAS detector

A search for heavy long-lived multi-charged particles is performed using the ATLAS detector at the LHC. Data collected in 2012 at √s = 8 TeV from pp collisions corresponding to an integrated luminosity of 20.3 fb -1 are examined. Particles producing anomalously high ionisation, consistent with long-lived massive particles with electric charges from |q| = 2e to |q| = 6e are searched for. No signal candidate events are observed, and 95 % confidence level cross-section upper limits are interpreted as lower mass limits for a Drell–Yan production model. The mass limits range between 660 and 785 GeV.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Measurements of top-quark pair differential cross-sections in the lepton+jets channel in pp collisions at $\sqrt{s}=8\,~{\mathrm {TeV}}$ using the ATLAS detector

Measurements of normalized differential cross-sections of top-quark pair production are presented as a function of the top-quark, t$\bar{t}$ system and event-level kinematic observables in proton–proton collisions at a centre-of-mass energy of √s=8TeV. The observables have been chosen to emphasize the t$\bar{t}$ production process and to be sensitive to effects of initial- and final-state radiation, to the different parton distribution functions, and to non-resonant processes and higher-order corrections. The dataset corresponds to an integrated luminosity of 20.3 fb - 1 , recorded in 2012 with the ATLAS detector at the CERN Large Hadron Collider. Events are selected in the lepton+jets channel, requiring exactly one charged lepton and at least four jets with at least two of the jets tagged as originating from a b-quark. The measured spectra are corrected for detector effects and are compared to several Monte Carlo simulations. The results are in fair agreement with the predictions over a wide kinematic range. Nevertheless, most generators predict a harder top-quark transverse momentum distribution at high values than what is observed in the data. Predictions beyond NLO accuracy improve the agreement with data at high top-quark transverse momenta. Using the current settings and parton distribution functions, the rapidity distributions are not well modelled by any generator under consideration. However, the level of agreement is improved when more recent sets of parton distribution functions are used.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for new phenomena using the invariant mass distribution of same-flavour opposite-sign dilepton pairs in events with missing transverse momentum in $\sqrt{s}=13$ TeV pp collisions with the ATLAS detector

A search for new phenomena in final states containing an e + e - or μ + μ - pair, jets, and large missing transverse momentum is presented. This analysis makes use of proton–proton collision data with an integrated luminosity of 36.1 fb -1 , collected during 2015 and 2016 at a centre-of-mass energy s√=13 TeV with the ATLAS detector at the Large Hadron Collider. The search targets the pair production of supersymmetric coloured particles (squarks or gluinos) and their decays into final states containing an e + e - or μ + μ - pair and the lightest neutralino ($\sim\atop{χ}$ $0\atop{1}$) via one of two next-to-lightest neutralino ($\sim\atop{χ}$ $0\atop{2}$) decay mechanisms: $\sim\atop{χ}$ $0\atop{2}$→Z$\sim\atop{χ}$ $0\atop{1}$, where the Z boson decays leptonically leading to a peak in the dilepton invariant mass distribution around the Z boson mass; and $\sim\atop{χ}$ $0\atop{2}$→ℓ + ℓ - $\sim\atop{χ}$ $0\atop{1}$ with no intermediate ℓ + ℓ - resonance, yielding a kinematic endpoint in the dilepton invariant mass spectrum. The data are found to be consistent with the Standard Model expectation. Finally, results are interpreted using simplified models, and exclude gluinos and squarks with masses as large as 1.85 and 1.3 TeV at 95% confidence level, respectively.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Measurement of the photon identification efficiencies with the ATLAS detector using LHC Run 2 data collected in 2015 and 2016

The efficiency of the photon identification criteria in the ATLAS detector is measured using 36.1 fb 1 to 36.7 fb 1 of pp collision data at √s = 13 TeV collected in 2015 and 2016. The efficiencies are measured separately for converted and unconverted isolated photons, in four different pseudorapidity regions, for transverse momenta between 10 GeV and 1.5 TeV. The results from the combination of three data-driven techniques are compared with the predictions from simulation after correcting the variables describing the shape of electromagnetic showers in simulation for the average differences observed relative to data. Data-to-simulation efficiency ratios are determined to account for the small residual efficiency differences. These factors are measured with uncertainties between 0.5% and 5% depending on the photon transverse momentum and pseudorapidity. The impact of the isolation criteria on the photon identification efficiency, and that of additional soft pp interactions, are also discussed. The probability of reconstructing an electron as a photon candidate is measured in data, and compared with the predictions from simulation. In conclusion, the efficiency of the reconstruction of photon conversions is measured using a sample of photon candidates from Z → μμγ events, exploiting the properties of the ratio of the energies deposited in the first and second longitudinal layers of the ATLAS electromagnetic calorimeter.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

On-Sensor Data Filtering using Neuromorphic Computing for High Energy Physics Experiments

This work describes the investigation of neuromorphic computing-based spiking neural network (SNN) models used to filter data from sensor electronics in high energy physics experiments conducted at the High Luminosity Large Hadron Collider. We present our approach for developing a compact neuromorphic model that filters out the sensor data based on the particle's transverse momentum with the goal of reducing the amount of data being sent to the downstream electronics. The incoming charge waveforms are converted to streams of binary-valued events, which are then processed by the SNN. We present our insights on the various system design choices - from data encoding to optimal hyperparameters of the training algorithm - for an accurate and compact SNN optimized for hardware deployment. Our results show that an SNN trained with an evolutionary algorithm and an optimized set of hyperparameters obtains a signal efficiency of about 91% with nearly half as many parameters as a deep neural network.

R. Kulkarni, Shruti↗

Evaluating Entrainment–Mixing Characteristics through Direct Comparisons of Drop Size Distributions Using In Situ Observations from ACE-ENA

Abstract Constraining the impacts of entrainment and associated mixing (i.e., entrainment–mixing) on cloud properties continues to be difficult, partly due to observational uncertainties as well as a lacking consensus of which methodologies for diagnosing entrainment–mixing are most appropriate. This study introduces a novel method to evaluate the presence and degree of inhomogeneous and homogeneous mixing using ∼100 h of in situ observations from a research aircraft over the northeastern Atlantic. Specifically, drop size distributions are compared between regions containing negligible and significant entrainment for select flight legs, making a direct characterization of the degree of homogeneous and inhomogeneous mixing possible. A measure of drop concentration variance is used as a proxy variable to diagnose entrainment–mixing. Results correspond well with entrainment–mixing metrics, showing lower Damköhler numbers where drop size distributions shift toward smaller drop sizes (i.e., inhomogeneous mixing) and greater transition length scales where drop size distributions do not (i.e., homogeneous mixing). Inhomogeneous mixing occurs in most samples from Aerosol and Cloud Experiment in the Eastern North Atlantic (ACE-ENA) (regardless of homogeneous mixing frequencies increasing with increasing spatial resolution from ∼100 to ∼10 m) and is associated with decreased drop size relative dispersion and both greater aerosol and drop concentrations compared with homogeneous mixing. Precipitating clouds have a greater frequency of homogeneous mixing compared with nonprecipitating clouds. The proposed methodology is similarly applied to in situ observations of southeast Pacific stratocumulus, shallow convective clouds over central Oklahoma and low-level clouds over the Southern Ocean. All four locations are primarily dominated by inhomogeneous mixing with minimal variability among each region.

Clouds↗

Greenhouse gas policy influences climate via direct effects of land-use change

Proposed climate mitigation measures do not account for direct biophysical climate impacts of land-use change (LUC), nor do the stabilization targets modeled for the 5th Climate Model Intercomparison Project (CMIP5) Representative Concentration Pathways (RCPs). To examine the significance of such effects on global and regional patterns of climate change, a baseline and alternative scenario of future anthropogenic activity are simulated within the Integrated Earth System Model, which couples the Global Change Assessment Model, Global Land-use Model, and Community Earth System Model. The alternative scenario has high biofuel utilization and approximately 50% less global forest cover compared to the baseline, standard RCP4.5 scenario. Both scenarios stabilize radiative forcing from atmospheric constituents at 4.5 W/m2 by 2100. Thus, differences between their climate predictions quantify the biophysical effects of LUC. Offline radiative transfer and land model simulations are also utilized to identify forcing and feedback mechanisms driving the coupled response. Boreal deforestation is found to strongly influence climate due to increased albedo coupled with a regional-scale water vapor feedback. Globally, the alternative scenario yields a 21st century warming trend that is 0.5 °C cooler than baseline, driven by a 1 W/m2 mean decrease in radiative forcing that is distributed unevenly around the globe. Some regions are cooler in the alternative scenario than in 2005. These results demonstrate that neither climate change nor actual radiative forcing are uniquely related to atmospheric forcing targets such as those found in the RCP’s, but rather depend on particulars of the socioeconomic pathways followed to meet each target.

Jones, Andrew D.↗

3D Volumetric Analysis of Wind Turbine Wake Properties in the Atmosphere Using High-Resolution Doppler Lidar

Wind turbine wakes in the atmosphere are three-dimensional (3D) and time dependent. An important question is how best to measure atmospheric wake properties, both for characterizing these properties observationally and for verification of numerical, conceptual, and physical (e.g., wind tunnel) models of wakes. Here a scanning, pulsed, coherent Doppler lidar is used to sample a turbine wake using 3D volume scan patterns that envelop the wake and simultaneously measure the inflow profile. The volume data are analyzed for quantities of interest, such as peak velocity deficit, downwind variability of the deficit, and downwind extent of the wake, in a manner that preserves the measured data. For the case study presented here, in which the wake was well defined in the lidar data, peak deficits of up to 80% were measured 0.6-2 rotor diameters (D) downwind of the turbine, and the wakes extended more than 11D downwind. Temporal wake variability over periods of minutes and the effects of atmospheric gusts and lulls in the inflow are demonstrated in the analysis. Lidar scanning trade-offs important to ensuring that the wake quantities of interest are adequately sampled by the scan pattern, including scan coverage, number of scans per volume, data resolution, and scan-cycle repeat interval, are discussed.

17 WIND ENERGY↗

Unit cell determination of coexisting post-perovskite and H-phase in (Mg,Fe)SiO3 using multigrain XRD: compositional variation across a laser heating spot at 119 GPa

Multigrain X-ray diffraction (XRD) can be used to accurately calculate the unit cell parameters of individual mineral phases in a mineral assemblage contained in a diamond anvil cell (DAC). Coexisting post-perovskite (ppv) and H-phase were synthesized at 119 GPa and 2500 K from (Mg 0.85 Fe 0.15 )SiO 3 in a laser-heated DAC. The unit cell parameters of the ppv and coexisting H-phase were determined using multigrain XRD with a 5 μm spatial resolution, close to the size of the X-ray beam, to understand compositional variations across the center area (20–30 μm) in a laser-heated sample. The ppv phase was Fe-depleted and the unit cell volume of ppv decreased by only 0.16 % (corresponding to ~3 % variation of FeSiO 3 ) from the heating center to 10 μm off the center, while the sample pressure remained at 119 GPa in a Ne quasi-hydrostatic environment. The unit cell volume of the H-phase decreased by 0.54 % (~10 % variation of FeSiO 3 content) over the same 10 μm distance. Both phases were more Fe-enriched in the slightly hotter center. This observation suggests that thermal diffusion may not be the major driver for the compositional variations of ppv and H-phase in the center portion of a laser-heated sample. Instead, these variations could be caused by a temperature effect on the partitioning between the ppv and H-phase over the small gradient.

58 GEOSCIENCES↗