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At least 1,135 records · Page 63

T Lymphocyte Activation Threshold is Increased in Reduced Gravity

There have been substantial advances in molecular and cellular biology that have provided new insight into the biochemical and genetic basis of lymphocyte recognition, activation and expression of distinct functional phenotypes. It has now become evident that for both T and B cells, stimuli delivered through their receptors can result in either clonal expansion or apoptosis. In the case of T cells, clonal expansion of helper cells is accompanied by differentiation into two major functional subsets which regulate the immune response. The pathways between the membrane and the nucleus and their molecular components are an area of very active investigation. This meeting will draw together scientists working on diverse aspects of this problem, including receptor ligand interactions, intracellular pathways that transmit receptor mediated signals and the effect of such signal transduction pathways on gene regulation. The aim of this meeting is to integrate the information from these various experimental approaches into a new synthesis and molecular explanation of T cell activation, differentiation and death.

Adams, Charley L.↗

In Situ Activation of Microcapsules

Disclosed are microcapsules comprising a polymer shell enclosing two or more immiscible liquid phases in which a drug, or a prodrug and a drug activator are partitioned into separate phases. or prevented from diffusing out of the microcapsule by a liquid phase in which the drug is poorly soluble. Also disclosed are methods of using the microcapsules for in situ activation of drugs where upon exposure to an appropriate energy source the internal phases mix and the drug is activated in situ.

Morrison, Dennis R.↗

Horizon: A Proposal for Large Aperture, Active Optics in Geosynchronous Orbit

In 1999, NASA's New Millennium Program called for proposals to validate new technology in high-earth orbit for the Earth Observing-3 (NMP EO3) mission to fly in 2003. In response, we proposed to test a large aperture, active optics telescope in geosynchronous orbit. This would flight-qualify new technologies for both Earth and Space science: 1) a future instrument with LANDSAT image resolution and radiometric quality watching continuously from geosynchronous station, and 2) the Next Generation Space Telescope (NGST) for deep space imaging. Six enabling technologies were to be flight-qualified: 1) a 3-meter, lightweight segmented primary mirror, 2) mirror actuators and mechanisms, 3) a deformable mirror, 4) coarse phasing techniques, 5) phase retrieval for wavefront control during stellar viewing, and 6) phase diversity for wavefront control during Earth viewing. Three enhancing technologies were to be flight- validated: 1) mirror deployment and latching mechanisms, 2) an advanced microcontroller, and 3) GPS at GEO. In particular, two wavefront sensing algorithms, phase retrieval by JPL and phase diversity by ERIM International, were to sense optical system alignment and focus errors, and to correct them using high-precision mirror mechanisms. Active corrections based on Earth scenes are challenging because phase diversity images must be collected from extended, dynamically changing scenes. In addition, an Earth-facing telescope in GEO orbit is subject to a powerful diurnal thermal and radiometric cycle not experienced by deep-space astronomy. The Horizon proposal was a bare-bones design for a lightweight large-aperture, active optical system that is a practical blend of science requirements, emerging technologies, budget constraints, launch vehicle considerations, orbital mechanics, optical hardware, phase-determination algorithms, communication strategy, computational burdens, and first-rate cooperation among earth and space scientists, engineers and managers. This manuscript presents excerpts from the Horizon proposal's sections that describe the Earth science requirements, the structural -thermal-optical design, the wavefront sensing and control, and the on-orbit validation.

Chesters, Dennis↗

Seismic Holography of Solar Activity

The basic goal of the project was to extend holographic seismic imaging techniques developed under a previous NASA contract, and to incorporate phase diagnostics. Phase-sensitive imaging gives us a powerful probe of local thermal and Doppler perturbations in active region subphotospheres, allowing us to map thermal structure and flows associated with "acoustic moats" and "acoustic glories". These remarkable features were discovered during our work, by applying simple acoustic power holography to active regions. Included in the original project statement was an effort to obtain the first seismic images of active regions on the Sun's far surface.

Lindsey, Charles↗

Warrego Valles and Other Candidate Sites of Local Hydrothermal Activity Within The Thaumasia Region, Mars

We have previously demonstrated for the Thaumasia region of Mars that: (1) valley formation peaked during the Noachian and declined substantially during the Hesperian and Amazonian Periods and (2) valleys, many of which form networking systems, largely occur near volcanoes, highly faulted terrains, and large impact craters of similar age, thus suggesting hydrothermal activity. In Tanaka et al, the various hypotheses for valley formation on Mars are presented, and a geologic explanation for valley erosion in the Thaumasia region is given that "best fits" the region's geographic and geologic datasets. That comprehensive GIS-based investigation suggests that hydrothermal and seismic activity were the primary causes of valley formation in the Thaumasia region; the data make widespread precipitation less likely as a major factor in valley formation, except perhaps during the Early Noachian, for which much of the geologic record has been destroyed. Based on the reconstruction of the stratigraphic, tectonic, volcanic, and erosional histories and the close association of valleys in time and space with Noachian to Early Hesperian volcanoes and rift systems and Hesperian to Early Amazonian impact craters less than 50 km in diameter, we propose 13 sites of hydrothermal activity within the Thaumasia region; these are the best examples of valleys associated with these geologic features, but there are other less pronounced correlations elsewhere in the region.

Dohm, J. M.↗

A Multiplicity Survey of Chromospherically Active and Inactive Stars

Surveys of the three samples of solar-type stars, segregated by chromospheric emission level, were made to determine their multiplicity fractions and to investigate the evolution of multiplicity with age. In total, 245 stars were searched for companions with DeltaV <= 3.0 and separations of 0.035" to 1.08" using optical speckle interferometry, By incorporating the visual micrometer survey for duplicity of the LamontHussey Observatory, the angular coverage was extended to 5.0" with no change in in the DeltaV limit. This magnitude difference allows mass ratios of 0.63 and larger to be detected throughout a search region of 2-127 AU for the stars observed. The 84 primaries observed in the chromospherically active sample are presumably part of a young population and are found to have a multiplicity fraction of 17.9% +/- 4.6%. The sample of 118 inactive, presumably older, primaries were selected and observed using identical methods and are found to have a multiplicity fraction of only 8.5% +/- 2.7%. Given the known link between chromospheric activity and age, these results tentatively imply a decreasing stellar multiplicity fraction from 1 to 4 Gyr, the approximate ages of the two samples. Finally, only two of the 14 very active primaries observed were found to have a companion meeting the survey detection parameters. In this case, many of the systems are either very young, or close, RS CVn type multiples that are unresolvable using techniques employed here.

Mason, Brian D.↗

Thermal Noise Reduction of Mechanical Oscillators by Actively Controlled External Dissipative Forces

We show that the thermal fluctuations of very soft mechanical oscillators, such as the cantilever in an atomic force microscope (AFM), can be reduced without changing the stiffness of the spring or having to lower the environment temperature. We derive a theoretical relationship between the thermal fluctuations of an oscillator and an actively external-dissipative force. This relationship is verified by experiments with an AFM cantilever where the external active force is coupled through a magnetic field. With simple instrumentation, we have reduced the thermal noise amplitude of the cantilever by a factor of 3.4, achieving an apparent temperature of 25 K with the environment at 295K. This active noise reduction approach can significantly improve the accuracy of static position or static force measurements in a number of practical applications.

Liang, Shoudan↗

Structural Dynamics Experimental Activities in Ultra-Lightweight and Inflatable Space Structures

This paper reports recently completed structural dynamics experimental activities with new ultralightweight and inflatable space structures (a.k.a., "Gossamer" spacecraft) at NASA Langley Research Center, NASA Marshall Space Flight Center, and NASA Goddard Space Flight Center. Nine aspects of this work are covered, as follows: 1) inflated, rigidized tubes, 2) active control experiments, 3) photogrammetry, 4) laser vibrometry, 5) modal tests of inflatable structures, 6) in-vacuum modal tests, 7) tensioned membranes, 8) deployment tests, and 9) flight experiment support. Structural dynamics will play a major role in the design and eventual in-space deployment and performance of Gossamer spacecraft, and experimental R&D work such as this is required now to validate new analytical prediction methods. The activities discussed in the paper are pathfinder accomplishments, conducted on unique components and prototypes of future spacecraft systems.

Pappa, Richard S.↗

Structural Dynamics Experimental Activities in Ultra-Lightweight and Inflatable Space Structures

This paper reports recently completed structural dynamics experimental activities with new ultra-lightweight and inflatable space structures (a.k.a., "Gossamer" spacecraft) at NASA Langley Research Center, NASA Marshall Space Flight Center, and NASA Goddard Space Flight Center. Nine aspects of this work are covered: 1) inflated, rigidized tubes, 2) active control experiments, 3) photogrammetry, 4) laser vibrometry, 5) modal tests of inflatable structures, 6) in-vacuum modal tests, 7) tensioned membranes, 8) deployment tests, and 9) flight experiment support. Structural dynamics will play a major role in the design and eventually in-space deployment and performance of Gossamer spacecraft. Experimental research and development such as this is required to validate new analysis methods. The activities discussed in the paper are pathfinder accomplishments. conducted on unique components and prototypes of future spacecraft systems.

Pappa, Richard S.↗

Method and Apparatus for Monitoring of Daily Activity in Terms of Ground Reaction Forces

A device to record and analyze habitual daily activity in terms of the history of gait-related musculoskeletal loading is disclosed. The device consists of a pressure-sensing insole placed into the shoe or embedded in a shoe sole, which detects contact of the foot with the ground. The sensor is coupled to a portable battery-powered digital data logger clipped to the shoe or worn around the ankle or waist. During the course of normal daily activity, the system maintains a record of time-of-occurrence of all non-spurious foot-down and lift-off events. Off line, these data are filtered and converted to a history of foot-ground contact times, from which measures of cumulative musculoskeletal loading, average walking- and running-specific gait speed, total time spent walking and running, total number of walking steps and running steps, and total gait-related energy expenditure are estimated from empirical regressions of various gait parameters to the contact time reciprocal. Data are available as cumulative values or as daily averages by menu selection. The data provided by this device are useful for assessment of musculoskeletal and cardiovascular health and risk factors associated with habitual patterns of daily activity.

Whalen, Robert T.↗

Advanced Technology Development for Active Acoustic Liners

Objectives include: (1) Develop electro-mechanical/acoustic models of a Helmholtz resonator possessing a compliant diaphragm coupled to a piezoelectric device; (2) Design and fabricate the energy reclamation module and active Helmholtz resonator; (3) Develop and build appropriate energy reclamation/storage circuit; (4) Develop and fabricate appropriate piezoelectric shunt circuit to tune the compliance of the active Helmholtz resonator via a variable capacitor; (5) Quantify energy reclamation module efficiency in a grazing-flow plane wave tube possessing known acoustic energy input; and (6) Quantify actively tuned Helmholtz resonator performance in grazing-flow plane wave tube for a white-noise input

Sheplak, Mark↗

H-alpha Proxies for EIT Crinkles: Further Evidence for Pre-Flare "Breakout"-Type Activity in an Ejective Solar Eruption

We present Halpha observations from Big Bear Solar Observatory of an eruptive flare in NOAA AR 8210, occurring near 22:30 UT on 1998 May 1. Previously, using the EUV Imaging Telescope (EIT) on the SOHO spacecraft, we found that a pattern of transient, localized brightenings, which we call "EIT crinkles," appears in the neighborhood of the eruption near the time of flare onset. These EIT crinkles occur at a location in the active region well separated from the sheared core magnetic fields, which is where the most intense features of the eruption are concentrated. We also previously found that high-cadence images from the Soft X-ray Telescope (SXT) on Yohkoh indicate that soft X-ray intensity enhancements in the core begin after the start of the EIT crinkles. With the Halpha data, we find remote flare brightening counterparts to the EIT crinkles. Lightcurves as functions of time of various areas of the active region show that several of the remote flare brightenings undergo intensity increases prior to onset of principle brightenings in the core region, consistent with our earlier findings from EIT and SXT data. These timing relationships are consistent with the eruption onset mechanism known as the breakout model, introduced by Antiochos and colleagues, which proposes that eruptions begin with reconnection at a magnetic null high above the core region. Our observations are also consistent with other proposed mechanisms which do not involve early reconnection in the core region. As a corollary, our observations are not consistent with the so-called tether cutting models, which say that the eruption begins with reconnection in the core. The Halpha data further show that a filament in the core region becomes activated near the time of EIT crinkle onset, but little if any of the filament actually erupts, despite the presence of a halo Coronal Mass Ejection (CME) associated with this event.

Sterling, Alphonse C.↗

The Magnetic Free Energy in Active Regions

The magnetic field permeating the solar atmosphere governs much of the structure, morphology, brightness, and dynamics observed on the Sun. The magnetic field, especially in active regions, is thought to provide the power for energetic events in the solar corona, such as solar flares and Coronal Mass Ejections (CME) and is believed to energize the hot coronal plasma seen in extreme ultraviolet or X-rays. The question remains what specific aspect of the magnetic flux governs the observed variability. To directly understand the role of the magnetic field in energizing the solar corona, it is necessary to measure the free magnetic energy available in active regions. The grant now expiring has demonstrated a new and valuable technique for observing the magnetic free energy in active regions as a function of time.

Metcalf, Thomas R.↗

Aeronautics and Space Report of the President: Fiscal Year 2000 Activities

The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 1999, through September 30, 2000.

Source record↗

Alumina Encapsulated Strain Gage Not Mechanically Attached To The Substrate, Used to Temperature Compensate an Active High Temperature Gage In A Half-Bridge Configuration

A temperature compensation element for a high-temperature strain gage and the method of fabricating the same. Preferably, the element is a "dummy" strain gage not mechanically attached to the substrate. The element is encapsulated in an insulative material and used to compensate an active high-temperature strain gage and wired in a half-bridge configuration. The temperature compensation element and high-temperature strain gage are fabricated using the method of the present invention. This method includes temporarily adhering the element to a heat sink, encapsulated in an insulative material and then removed from the heat sink. Next, the element is either stacked or placed near the active gage. Ideally, the element and the active gage have substantially similar heat transfer and electrical properties.

Anthony Piazza↗

Quantification of Cyclic Ground Reaction Force Histories During Daily Activity in Humans

Theoretical models and experimental studies of bone remodeling suggest that bone density and structure are influenced by local cyclic skeletal tissue stress and strain histories. Estimation of long-term loading histories in humans is usually achieved by assessment of physical activity level by questionnaires, logbooks, and pedometers, since the majority of lower limb cyclic loading occurs during walking and running. These methods provide some indication of the mechanical loading history, but fail to consider the true magnitude of the lower limb skeletal forces generated by various daily activities. These techniques cannot account for individual gait characteristics, gait speed, and unpredictable high loading events that may influence bone mass significantly. We have developed portable instrumentation to measure and record the vertical component of the ground reaction force (GRFz) during normal daily activity. This equipment allows long-term quantitative monitoring of musculoskeletal loads, which in conjunction with bone mineral density assessments, promises to elucidate the relationship between skeletal stresses and bone remodeling.

Breit, G. A.↗

An Overview of SIMBIOS Project Activities and Accomplishments During FY00

In FY00, the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project brought a number of activities to fruition and laid the groundwork for new initiatives in FY01 of particular importance was ensuring that the SIMBIOS program was renewed and a new science team selected in FY00. With Sea-Viewing Wide Field-of-view Sensor (SeaWiFS) continuing to perform well, the Terra platform and Moderate Resolution Imaging Spectroradiometer (MODIS) being launched in December 1999, and several other global missions scheduled for launch (e.g., the Aqua platform with a second MODIS (2001), the ENVISAT mission with the Medium Resolution Imaging Spectrometer (2001), and Advanced Earth Observing Satellite-2 with GLI and Polarization and Directionality of the Earth's Reflectances (POLDER)), the first real opportunities to merge global data sets can be pursued. NASA Headquarters did approve a three-year continuation of the science team under an NASA Research Announcement (NRA) and the Project Office. As it is taking some time for the MODIS team to work through the initial on-orbit processing issues, merger activities within the Project Office have been a low priority with most of the emphasis being on other program objectives which will provide a broader foundation and capabilities for working with multiple global data sets in the future. These activities and accomplishments are described.

Fargion, Giulietta S.↗

[Activities of Center for Nondestructive Evaluation, Iowa State University]

The final report of NASA funded activities at Iowa State University (ISU) for the period between 1/96 and 1/99 includes two main areas of activity. The first is the development and delivery of an x-ray simulation package suitable for evaluating the impact of parameters affects the inspectability of an assembly of parts. The second area was the development of images processing tools to remove reconstruction artifacts in x-ray laminagraphy images. The x-ray simulation portion of this work was done by J. Gray and the x-ray laminagraphy work was done by J. Basart. The report is divided into two sections covering the two activities respectively. In addition to this work reported the funding also covered NASA's membership in the NSF University/Industrial Cooperative Research Center.

Gray, Joe↗