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NASA NTRSDate not supplied

Designing for Advanced Aerial Mobility: Human-Autonomy Teaming and In-Time System-Wide Safety Assurance

The continued growth of aviation shall require new innovative technologies and operational concepts to meet the ever-increasing demands on air transportation. The NASA Advanced Air Mobility (AAM) project focuses on emerging aviation markets, such as Urban Air Mobility (UAM). UAM is defined as “...a safe and efficient system for air passenger and cargo transportation within an urban area. It is inclusive of small package delivery and other urban unmanned aerial system services and supports a mix of onboard/ground-piloted and increasingly autonomous operations” ([1]). The AAM project emphasizes technology development and validating system-level concepts and solutions in coordination with other NASA Aeronautics Research Mission Directorate (ARMD) projects to enable UAM metro- and micro-plex vertiport and airspace concepts of operations. The NASA AAM research portfolio includes the concepts of Remote Supervisor-in-Command (RSC) and Fleet and Airspace Manager (FAM) as possible human roles for consumer fleet providers. NASA research in RSC is focused on development of guidelines and standards for remote pilots/operators passively and actively controlling a large fleet of autonomous aircraft. For FAM, flight and ground system concepts and technologies to enable high density homogeneous operations at increased scale from vertiport(s), and coordination with other humans in the systems (e.g., UAM urban airspace manager, Air Traffic Control) are key research areas. The envisioned UAM operations are posited to require autonomous systems to enable functions ranging from fleet and resource management to vehicle control. Although automation has become increasingly sophisticated and ubiquitous in civil aviation, autonomy represents a significant evolution in automation, which has generally been limited in functional scope and capability. As autonomy takes on increasing responsibilities, humans and machines will be required to work together in new and different ways [2], rather than traditional design approaches focused on how machines (i.e., autonomy) can do the work of people. The emerging field of human-autonomy teaming (HAT) represents a comprehensive and prioritized research-driven approach to enable the success of future emerging aviation market applications through capabilities and principles that facilitate humans and machine working and thinking better together. The NASA Transformational Tools and Technologies (TTT) Autonomous System (AS) Sub-project was created to assist with the transition into higher levels of autonomy to enable new modes of air transportation, such as UAM. TTT-AS has identified HAT as a key research need to enable UAM while maintaining today’s ultra-safe aviation system safety levels. The latter challenge has been taken up by the NASA System-Wide Safety (SWS) Project, which recognizes that aviation safety, as it evolves, shall require new ways of thinking about safety to include integration of a wide-range of existing and new safety systems and practices, enhanced tools and technologies, increased access to data and data fusion, improved data analysis capabilities, enhanced in-time risk monitoring and detection, hazard prioritization and mitigation, safety assurance decision-support, and in-time integrated system analytics [3].The operational concept of UAM represents a variety of work that has been termed, “work-as-imagined” to characterize the idea that how people think that work is done and how work is actually done are often not the same [4]. To ensure design success and system safety, looking at “work-as-done” provides a comparative approach toward UAM concept and technology design through examination of corresponding analogs found today in aviation (e.g., on-demand operations) and other transportation domains (e.g., port operations). The paper shall discuss various alternative applications with specific focus on airline operation center (AOC) operations, and unmanned aerial system (UAS) command-and-control to inform scaled-versions of FAM and RSC, respectively, and with consideration of the national airspace system contextual environment. The tenets and principles of the HAT field and current NASA research efforts under the TTT-AS sub-project shall also be described. Finally, the SWS sub-project efforts to develop In-Time System-Wide Safety Assurance (ISSA) and In-Time Safety Management Systems (IASMS) are discussed in terms of how “in-time” safety assurance may be conceptualized for the on-demand mobility air taxi “work-as-imagined” operational concept [5]. As part of this effort, concepts from the emerging field of resilience engineering, are being studied. Traditional approaches to aviation safety have focused on what can go wrong and how to prevent it. Another approach to thinking about system safety should reflect not only “avoiding things that go wrong” (protective safety) but also “ensuring that things go right” (productive safety), that enables a system to exhibit the resilient performance [6] necessary for the success of the future aviation system emerging concepts of operations. The paper shall describe efforts focused on how productive safety and resilience may enable a more complete approach to system safety thinking and design of ISSA and IASMS for UAM. Future directions and research needs shall also be discussed.

resilience↗

NASA NTRS2020

Development and Comparison of an Artificial Gravity Concept for Human Spaceflight

Artificial Gravity (AG) for a long-duration space journey has been theorized since the dawn of human spaceflight. The purpose of this project is to begin bringing those concepts into real-life. The goal and primary study for this project is to research and understand the physics behind making a rotating centrifuge and the human limitations that may contribute to the design. The research first started with finding the physics equations we can use to calculate the rotational speed required for a certain gravity or the required radius for the centrifuge structure, this equation is a(sub c) = v2/r = w(sub c)2 r, where v is linear velocity, r is the radius of the structure, and is the rotational speed. Next, it is important to understand AG may be worthwhile because of the negative health effects of microgravity. The research then leads to finding human limitations in a rotating structure. The main limitation of a human living in this habitat is the Coriolis effect, which causes discomfort and motion sickness in the subject inside the structure, this causes the three semicircular fluid canals in your head that sense balance and motion. Finally, we use that knowledge to best hypothesize and propose the radius size for the structure that would negate the Coriolis effect, and using that we can calculate the appropriate rotational speed to get the desired gravity level, for example: 1 g or 9.81 m/s2 of acceleration. Overall this research can encourage increase knowledge in understanding AG, the physics and human limitation in a rotating centrifuge on future NASA long-duration Missions and Goals. This research can be a reference to future design proposals for long-duration exploration missions and colonization of planets or moons.

Cody L Beard↗

NASA NTRSDate not supplied

When the Eyes Don't Have It: Autonomous Control of Deep Space Vehicles for Human Spaceflight

NASA has been charged with expanding human presence into the solar system. The next phase of exploration will focus on learning how to develop and sustain habitats on the moon for eventual missions to Mars. The Gateway Lunar Orbiting Platform (G-LOP) is a modular spacecraft being built for cis-lunar orbit and offers a true deep space environment for gaining experience for human missions to Mars. The mission concept for Gateway involves long uncrewed periods between missions; therefore, Gateway requires increased self-reliance to separate the spacecraft from Earth-bound control and oversight. This complicates the human-in-the-loop (HITL) concept and requires major adjustments to the traditional automation human-computer interaction paradigm. This paper discusses the design, development, and verification of complex human-computer interactions with the autonomous systems managers which will control the Gateway spacecraft.

Julia M. Badger↗

NASA NTRSDate not supplied

Neurovascular Outcomes of Space Radiation in Human Blood-Brain Barrier Models

One of the main health risks in human deep space exploration is central nervous system (CNS) damage by ionizing radiation due to exposure to galactic cosmic rays (GCRs). In animal models, irradiation with simulated GCRs or their components has been shown to cause neurodegeneration and neuroinflammation associated with cognitive and behavioral dysfunction. The extent of CNS damage is partially mediated by the blood-brain barrier (BBB), which regulates the interaction between CNS and systemic responses to stressors in the rest of the body. The main cellular regulators of BBB permeability are astrocytes, which also modulate neuronal death, neuroinflammation and oxidative stress. However, studies on BBB and astrocyte functions in regulating CNS responses to ionizing radiation have been limited, especially in human tissue/organ analogs. Therefore, we developed a high-throughput 3D organ-on-a-chip system to study human CNS and BBB impairments caused by deep space radiation. We investigated both immediate and delayed CNS responses to major GCR components: 0.15-0.5Gy 250MeV/n 4He and 0.3-0.8Gy 600MeV/n 56Fe; as well as to 0.5-1Gy X-rays. We observed ionizing radiation-mediated increases in BBB permeability that was exacerbated by astrocyte presence and accompanied by damage to endothelial cells and tight junctions, altered cytokine expression including TNFalpha upregulation, and increased oxidative stress. In particular, 600MeV/n 56Fe particle irradiation selectively induced astrocyte damage and increased blood-brain barrier permeability only in models that contained astrocytes in addition to endothelial cells, indicating astrocytes as a particularly radiosensitive component of the CNS that could therefore be a suitable a target for neuroprotection. Future studies will compare human and mouse CNS model responses to simulated GCRs and evaluate the induction of an anti-inflammatory phenotype in astrocytes as a potential countermeasure. Ultimately, we aim to expand upon these results to uncover novel cellular and mechanistic targets for countermeasure development to mitigate human CNS damage in deep space exploration.

centrat nervous system↗

NASA NTRSDate not supplied

Neurovascular Outcomes of Ionizing Radiation in Human Blood-Brain Barrier Models

One of the main health risks in human deep space exploration is central nervous system (CNS) damage by ionizing radiation due to exposure to galactic cosmic rays (GCRs). In animal models, irradiation with simulated GCRs or their components has been shown to cause neurodegeneration and neuroinflammation associated with cognitive and behavioral dysfunction. The extent of CNS damage is partially mediated by the blood-brain barrier (BBB), which regulates the interaction between CNS and systemic responses to stressors in the rest of the body. The main cellular regulators of BBB permeability are astrocytes, which also modulate neuronal death, neuroinflammation and oxidative stress. However, studies on BBB and astrocyte functions in regulating CNS responses to ionizing radiation have been limited, especially in human tissue/organ analogs. Therefore, we developed a high-throughput 3D organ-on-a-chip system to study human CNS and BBB impairments caused by deep space radiation. We investigated both immediate and delayed CNS responses to major GCR components: 0.15-0.5Gy 250MeV/n 4He and 0.3-0.8Gy 600MeV/n 56Fe; as well as to 0.5-1Gy X-rays. We observed ionizing radiation-mediated increases in BBB permeability that was exacerbated by astrocyte presence and accompanied by damage to endothelial cells and tight junctions, altered cytokine expression including TNFalpha upregulation, and increased oxidative stress. In particular, 600MeV/n 56Fe particle irradiation selectively induced astrocyte damage and blood-brain barrier permeability only in models that contained astrocytes in addition to endothelial cells, indicating astrocytes as a particularly radiosensitive component of the CNS that could therefore be a suitable a target for neuroprotection. Future studies will compare human and mouse CNS model responses to simulated GCRs and evaluate the induction of an anti-inflammatory phenotype in astrocytes as a potential countermeasure. Ultimately, we aim to expand upon these results to uncover novel cellular and mechanistic targets for countermeasure development to mitigate human CNS damage in deep space exploration.

space radiation↗

NASA NTRSDate not supplied

Using Systems Engineering to Develop an Integrated Crew Health and Performance System to Mitigate Risk for Human Exploration Missions

New space exploration missions are currently being designed to take humanity beyond Low EarthOrbit (LEO) to cis-lunar space, the lunar surface, and eventually to Mars. These missions carryincreased risks due to a number of factors, including distance from Earth, exposure to deep spacehazards, reduced capacity and ability to resupply and evacuate, and increased communication delays.As distance from Earth grows and mission length increases, a growing proportion of overall missionrisk can be attributed to the “human system.” Almost twenty years ago, the Institute of Medicine in theUnited States recommended the early and complete integration of the human system into thespacecraft and mission design process to mitigate this increased risk inherent in exploration missions.Exploration missions will require increasing levels of crew self-sufficiency that will challenge thecurrent operational paradigms established in LEO. Enabling progressive Earth independence requiresmanagement of the increasingly complex interactions among spacecraft systems and integration of allthe data and functions that affect human health and performance into one coordinated system – theCrew Health and Performance (CHP) system. This system is a critical spacecraft system that isanalogous to other systems such as propulsion, guidance and navigation, or avionics. Design andintegration of the CHP system requires the evidence-based merger of typically disparate disciplinessuch as medicine, human factors, and physiological support system design, using systems engineering(SE) practices. The approach described here enables spacecraft and mission designers to align thescope of a CHP system with mission specific requirements, decrease risk to the crew, and increase theprobability of mission success.

Kerry Mcguire↗

NASA NTRSDate not supplied

Human System Risk Changes in 2021

The Human System Risk Board (HSRB) has the overall responsibility for tracking the evolution of the top ~30 human system risks that it has identified to be associated with human spaceflight. As part of this process, the Board is charged with maintaining a consistent, integrated process to mitigate those risks, and developing evidence-based risk posture recommendations. Risks are re-evaluated in a Continuous Risk Management (CRM) process. This session will summarize the risk posture changes that have occurred in the last year and what high level research, performance, and epidemiologic data have informed those changes. Human System Risks updated in 2021 include: Dynamic Loads, Sensorimotor, EVA, Crew Egress, Behavioral Medicine, Electrical Shock, Human System Integration Architecture (HSIA), Toxic Exposure, Bone Fracture, Cardiovascular, Medical Conditions, Renal Stone, CO2 Exposure, and Pharmacology.

Mary Van Baalen↗

NASA NTRSDate not supplied

High Value Risk Targets in Human System Risk

The Human System Risk Board (HSRB) has the overall responsibility for tracking the evolution of the top ~30 human system risks that it has identified to be associated with human spaceflight. The Board is also charged with maintaining a consistent, integrated process to mitigate those risks, and developing evidence-based risk posture recommendations. Each Risk Custodian Team (RCT) identifies High Value Risk Mitigation Targets (HVRMT) that have the highest likelihood or greatest impact in reducing their risk. These typically include areas where there are major gaps in knowledge or capability; or other targets that promise to yield returns worthy of investments in time, money and other resources by stakeholders interested in reducing Human System Risk. As part of the review of each risk the Board members consider and discuss the HVRMT statements, which are then approved by the Board Chair. High Value Risk Mitigation Targets can include research activities funded by the Human Research Program, but often involve recommending standards, monitoring, or other operational goals to reduce risk. This presentation will discuss common themes and highlights of the approved HVRTs to inform IWS attendees and the wider research community.

D M Buckland↗

NASA NTRS2022

NASA Utilization of Space Nuclear Systems for Robotic and Human Exploration Missions: Response to EO 13972: Promoting Small Nuclear Reactors for National Defense and Space Exploration

Space Nuclear Systems (SNS) technology development offers a wide range of capabilities to support NASA’s current and future missions. Executive Order (EO) 13972, “Promoting Small Modular Reactors for National Defense and Space Exploration” [1], issued 5 January 2021, directs NASA to define requirements for NASA utilization of nuclear energy systems for human and robotic exploration missions through 2040 and analyze the costs and benefits of such requirements.” Although it is premature to define requirements and cost for future exploration missions that have not yet been formulated, this report describes planned objectives and missions by 2040 that are enabled or enhanced by nuclear systems while taking into account a number of unique considerations for nuclear energy in the space environment. Nuclear energy systems are enabling for space missions and critical capabilities where conventional forms of energy production are impractical or impossible due to mass constraints, mission duration, or distance from the Sun. Space nuclear technologies available or in development for use by 2040 utilize radioisotope decay or nuclear fission and fall into three categories: heat, power, and propulsion. Current applications utilize radioisotope power systems that provide consistent and reliable performance in the sub-kilowatt power range. More advanced SNS can enable new mission objectives where high energy density solutions are critical, or where access to solar solutions is prohibitive. Higher power radioisotope and fission systems are under development within NASA for a wide variety of human exploration and science mission applications. Planned missions designed to use radioisotope systems include Dragonfly, a rotorcraft that will explore the surface of Titan, and Persephone, a mission concept for a Pluto orbiter. Nuclear fission systems have the key advantage of providing significantly higher power, lower mass solutions from tens to even thousands of kilowatts. Fission power is enabling to a sustained human presence on the Moon and developing a robust lunar economy. Fission propulsion is enabling for missions within and beyond cis-lunar space. This report examines NASA-envisioned mission applications and associated performance needs for SNS over the next twenty years leading to 2040 along with the unique technical considerations posed by space nuclear technology development. This includes engineering and operational logistics for ground handling, thermal management, survival of the space environment, operational safety, power requirements, and service longevity. Safety to the public, the NASA work force, and agency assets remains a top priority for NASA and particular attention is given to this aspect in the design, hardware assembly, ground operation, launch, and mission operation of an SNS. NASA relies on the Department of Energy as nuclear authority and its legacy of rigorous safety procedures as standards for ground development, test, transportation, and launch site operation. The principal concern is preventing unintended radiological release to the public or environment. Radioisotope system experience has established processes, including ground operation, transportation, and launch, that are considered directly applicable to emerging fission systems; however, fission systems have unique design needs that impact the safety and performance requirements. High efficiency power conversion from both fission and radioisotope systems requires high operating temperatures necessitating both passive and active thermal management to maintain safe and nominal operating conditions. Effective cooling and waste heat rejection have special considerations for space applications, whether in zero-g or reduced gravity. Fluid and heat transfer within the reactor system is not anticipated to be impacted by reduced or zero-g environments. Cryogenic working fluids and propellant supplies utilized in some space nuclear applications will need low mass, high capacity cryocoolers to meet the long-term storage and near zero-boiloff needs. Integrated, high power density SNS capable of being packaged in a single vehicle is a key consideration for NASA. Due to concerns for complexity and reliability, in space reactor assembly and reactor refueling are not current design considerations. Expanding into a new era for space exploration depends on mass-efficient, high-energy solutions to power deep-space vehicles, operate in harsh environments, and increase mission flexibility. NASA nuclear technology investments are targeting power for surface operations and propulsion for fast-transit, deep-space missions, all with the ability to reliably operate without the need for repair or refueling. NASA’s goals, enabled by nuclear technologies, provide for exciting advances in scientific objectives and human exploration, ushering in a new space age that enables a human presence on bodies beyond our Earth.

nuclear↗

NASA NTRSDate not supplied

NASA’s Human Landing System: Enabling the Next Generation of Lunar Science

The Human Landing System (HLS) is the mode of transportation that will take astronauts to the lunar surface as part of NASA's Artemis exploration program. HLS also serves as a research platform both on the surface and in lunar orbit, enabling critical scientific investigations on and of the Moon. With support at NASA centers around the country, the HLS program, based at Marshall Space Flight Center in Huntsville, Alabama, is working closely with its commercial partners throughout the development process to design and build innovative and technically advanced lunar landers – new vehicles designed for the modern era of space travel – leveraging decades of human spaceflight experience and the speed of the commercial sector. In 2019, NASA asked U.S. industry for proposals to design and develop a human lander for the first human mission to the lunar surface under Artemis. Initial contracts were awarded to Blue Origin Federation, Dynetics, and SpaceX to advance their designs. Following the execution of the ten-month Base Period, NASA announced in April 2021 that the agency selected SpaceX to move forward with its human landing system [1] and land the first two astronauts on the lunar surface during the Artemis III mission. Following two protest periods, NASA awarded the contract, known as Option A, to SpaceX in July 2021 and resumed work in November 2021 (Fig. 1). In parallel, the HLS program has been preparing for the acquisition that will procure regular crewed transportation to the lunar surface following Artemis III. NASA released a request for information (RFI) in July 2021 asking U.S. industry for feedback to help inform the future solicitation, known as Lunar Exploration Transportation Services (LETS) [2]. Also in July 2021, NASA released the NextSTEP-2 Appendix N broad agency announcement soliciting new work from U.S. industry to mature their HLS designs and perform risk reduction activities in advance of the LETS procurement [3]. NASA selected Blue Origin Federation, Dynetics, Lockheed Martin, Northrop Grumman, and SpaceX to participate [4]. This work will also help better inform the LETS procurement and prepare industry to propose. NASA hopes to release a draft request for proposals (RFP) in Spring 2022.

R C Weber↗

NASA NTRSDate not supplied

Human Interfaces and Management of Information (HIMI) Challenges for “In-time” Aviation Safety Management Systems (IASMS)

The envisioned transformation of the National Airspace System to integrate an In-time Aviation Safety Management System(IASMS)to assure safety in Advanced Air Mobility(AAM)brings unprecedented challenges to the design of human interfaces and management of safety information. Safety in design and operational safety assurance are critical factors for how humans will interact with increasingly autonomous systems. The IASMS Concept of Operations builds from traditional commercial operator safety management and scales in complexity to AAM. The transformative changes in future aviation systems pose potential new critical safety risks with novel types of aircraft and other vehicles having different performance capabilities, flying in increasingly complex airspace, and using adaptive contingencies to manage normal and non-normal operations. These changes compel development of new and emerging capabilities that enable innovative ways for humans to interact with data and manage information. In-creasing complexity of AAM corresponds with use of predictive modeling, data analytics, machine learning, and artificial intelligence to effectively address known hazards and emergent risks. The roles of humans will dynamically evolve in increments with this technological and operational evolution. The interfaces for how humans will interact with increasingly complex and assured systems designed to operate autonomously and how information will need to be presented are important challenges to be resolved.

Lawrence J Prinzel↗

NASA NTRSDate not supplied

Genomic and Phenotypic Predictors of Human Ex Vivo Sensitivity to Simulated Deep Space Radiation

High-linear energy transfer (LET) ionizing radiation is a major health hazard for astronauts who will be exposed to galactic cosmic rays during upcoming lunar and Mars missions. Predicting and mitigating this risk requires understanding the factors underlying individual radiation sensitivity. We started to address this challenge by identifying the genomic and phenotypic associations with sensitivity to low and high-LET ionizing radiation ex vivo in over 750 healthy human donors. We exposed primary human blood mononuclear cells to simulated galactic cosmic ray components: 350 MeV/n 28Si, 350 MeV/n 40Ar and 600 MeV/n 56Fe particles, at 1.1 and 3 particles/100 sq.m fluences, as well as 0.1 Gy and 1 Gy doses of gamma rays, and analyzed the outcomes at 4 and 24 hours post-irradiation. We quantified DNA damage and repair responses based on 53BP1+ radiation-induced foci formation, together with oxidative stress and changes in secreted factors including immune cytokines and exosomes. We also analyzed phenotypic associations with spontaneous DNA repair foci at baseline prior to irradiation. We identified an increase in spontaneous DNA repair associated with age and latent viral infection, and observed that human spontaneous DNA repair foci at baseline can serve as a negative predictor of DNA repair and immunoregulatory cytokine production after irradiation. Furthermore, we observed a wide variability of subject- and LET-dependent radiation responses, with radiation-induced DNA repair foci increasing by dose and LET, and high-LET particle radiation resulting in more residual DNA damage compared to low-LET particles and gamma rays. We have developed multiple metrics to quantify human radiosensitivity across the spectrum of conditions. Here we present their dependence on radiation quality and phenotypic variables, including an age-dependent decrease in DNA repair after irradiation, and genomic associations with radiosensitivity based on low-coverage whole genome sequencing. We anticipate that our work will pave the way for understanding the spectrum of human radiosensitivity and identifying targets for countermeasure development to reduce DNA and cellular damage and radiation carcinogenesis during deep space exploration.

GWAS↗

NASA NTRSDate not supplied

Implementation of Human Systems Integration Technical and Management Process for the Lunar Gateway Program

NASA recognizes Human Systems Integration (HSI) as part of the overall systems engineering and acquisition strategy for space systems. The Lunar Gateway Program is implementing HSI technical and management process across the lifecycle of the mission, as required by NPR 7123.1C NASA Systems Engineering Processes and Requirements, and led by the Gateway HSI team as required by NPR 8705.2C Human-Rating Requirements for Space Systems, now HEOMD-003 Crewed Deep Space Systems Human Rating Certification Requirements and Standards for NASA Missions. NASA has been using HSI principles for many years and has applied them to many of its previous human spaceflight Programs. As NASA returns to the Moon in a more sustainable manner, the Gateway Program is maturing the application of HSI by implementing it more visibly as part of Artemis, with guidance from the NASA/SP-20210010952 NASA HSI Handbook. This paper discusses how HSI is being implemented in the Gateway Program, challenges faced with its implementation during the development phase, and strategies/approaches used to overcome those. The paper also covers HSI implementation for flight systems, vehicle processing, and interfaces across the six identified NASA HSI Domains: human factors engineering, operations, safety, training, maintainability and supportability, habitability and environment. The goal is to provide an overview of the implementation process of HSI in the Gateway Program as an example for other Programs/Projects/Missionsthat are looking to implement HSI.

Jackelynne Silva-Martinez↗

NASA NTRSDate not supplied

Genomic and phenotypic predictors of human ex vivo sensitivity to simulated deep space radiation

High-linear energy transfer (LET) ionizing radiation is a major health hazard for astronauts who will be exposed to galactic cosmic rays during upcoming lunar and Mars missions. Predicting and mitigating this risk requires understanding the factors underlying individual radiation sensitivity. We started to address this challenge by identifying the genomic and phenotypic associations with sensitivity to low and high-LET ionizing radiation ex vivo in over 750 healthy human donors. We exposed primary human blood mononuclear cells to simulated galactic cosmic ray components: 350MeV/n (28)Si, 350MeV/n (40)Ar and 600MeV/n (56)Fe particles, at 1.1 and 3 particles/100µm^(2) fluences, as well as 0.1 Gy and 1 Gy doses of gamma rays, and analyzed the outcomes at 4 and 24 hours post-irradiation. We quantified DNA damage and repair responses based on 53BP1^(+) radiation-induced foci formation, together with oxidative stress and changes in secreted factors including immune cytokines and exosomes. We also analyzed phenotypic associations with spontaneous DNA repair foci at baseline prior to irradiation. We identified an increase in spontaneous DNA repair associated with age and latent viral infection, and observed that human spontaneous DNA repair foci at baseline can serve as a negative predictor of DNA repair and immunoregulatory cytokine production after irradiation. Furthermore, we observed a wide variability of subject- and LET-dependent radiation responses, with radiation-induced DNA repair foci increasing by dose and LET, and high-LET particle radiation resulting in more residual DNA damage compared to low-LET particles and gamma rays. We have developed multiple metrics to quantify human radiosensitivity across the spectrum of conditions. Here we present their dependence on radiation quality and phenotypic variables, including an age-dependent decrease in DNA repair after irradiation, and genomic associations with radiosensitivity based on low-coverage whole genome sequencing. We anticipate that our work will pave the way for understanding the spectrum of human radiosensitivity and identifying targets for countermeasure development to reduce DNA and cellular damage and radiation carcinogenesis during deep space exploration.

GWAS↗

NASA NTRS2023

Identifying and Closing Medical Capability Gaps for Human Spaceflight Missions Beyond Low Earth Orbit

BACKGROUND: Features of human space missions beyond low Earth orbit such as increasing distance from Earth, lack of real-time communication, and limited or no evacuation or resupply capability are expected to drive an increase in medical risk and require crews to operate in an increasingly autonomous fashion. A diverse set of stakeholders at NASA are seeking to fund the development of concepts of operations, medical requirements, and medical capabilities for such missions. However, a systematic approach to identification of current medical capability gaps and a strategic framework to gap closure is needed. OVERVIEW: The Exploration Medical Integrated Product Team (XMIPT) has developed a list of nine high-level medical capability gaps and associated activities required for gap closure. The list was derived based on inputs from subject matter experts at NASA including flight surgeons, other clinical providers, as well as operational and research communities regarding medical capabilities required to support human missions to the Moon and the Mars surface. Responses were reviewed and distilled to identify common themes across capabilities. To ensure alignment with established human system risks, the gap list was further refined based on inputs from NASA’s Human System Risk Board. Relevant medical gap closure activities outside of those funded by the XMIPT were identified through solicitation of inputs from Elements of NASA’s Human Research Program (particularly Exploration Medical Capability), the broader medical operations community, and other stakeholders. This medical capability gap list is reviewed and updated regularly as new information becomes available or new stakeholders are identified. DISCUSSION: The medical capability gap list has matured to include a large group of NASA stakeholders and development activities. This has enabled articulation of priorities to funding entities and programmatic stakeholders, while serving as an accessible resource summarizing gap closure activities, relevant programmatic infusion points, and opportunities for collaboration between stakeholders. This presentation will provide an overview of the nine NASA medical capability gaps and their associated gap closure activities.

Moriah Thompson↗

NASA NTRSDate not supplied

Immersive Technologies for Human-in-the-Loop Lunar Surface Simulations

NASA, the National Aeronautics and Space Administration, continually seeks innovative solutions to enhance its operations, particularly in the realms of testing, evaluation, and training for future missions. Immersive technologies, such as virtual, augmented, and mixed reality have proven to be powerful tools for realistic, interactive, and engaging environments. This paper explores how the Simulation and Graphics Branch at NASA’s Johnson Space Center (JSC) leverages immersive technology, modern commercial rendering engines, and physics-based systems simulations to develop human-in-the-loop systems for humanity’s return to the Moon through the Artemis program. When NASA returns to the Moon, astronauts will travel to the Moon’s South Pole where lighting conditions will cause a more complex operational environment. Human-in-the-loop testing plays a crucial role in NASA's mission planning, spacecraft and space systems development, and evaluation of operational scenarios. The development of immersive environments such as a lunar rover mockup at a video wall enables engineers and astronauts to simulate and experience mission scenarios, integrated spacecraft systems, and operational procedures in a relevant environment before deployment. By integrating realistic virtual environments, immersive technology allows for the visualization and interaction with virtual spacecraft models, mission landscapes, and complex operational tasks. This approach helps identify potential design flaws, operational challenges, and safety considerations. It also provides valuable insights for risk reduction and helps improve mission efficiency and effectiveness. With advanced motion tracking systems and custom virtual environments data can be gathered and evaluated to help NASA refine training protocols, develop specialized training procedures and optimize human-robotic interactions for future space missions. Furthermore, immersive technology offers opportunities for future training initiatives at NASA. The Virtual Reality Laboratory at JSC has pioneered training with Virtual Reality (VR) since the Hubble Space Telescope repair missions in the early 1990’s. Extended Reality (XR) simulations enable astronauts to rehearse complex spacewalks, spacecraft maneuvers, and extravehicular activities in a safe and controlled environment. By replicating the physical and cognitive challenges of space missions, immersive training experiences enhance astronauts' situational awareness, decision-making abilities, and adaptability to unexpected scenarios. Additionally, immersive technology facilitates collaborative training, allowing geographically dispersed crew and mission control personnel to engage in synchronized simulations, fostering teamwork and effective communication. The adoption of immersive technology in NASA's testing, evaluation, and future training programs has yielded significant benefits. By incorporating human-in-the-loop testing for studies involving Extra Vehicular Activities (EVA), surface mobility and landing systems, NASA can identify and mitigate risks, optimize operational procedures, and enhance mission success. Ultimately, immersive training experiences can empower astronauts to better navigate the complexities of space missions, ensuring their safety, productivity, and success in the dynamic and challenging environments they will experience at the Lunar South Pole.

Simulation Modeling Virtual Reality Immersive Tech↗

NASA NTRSDate not supplied

The Gateway Program as Part of NASA’s Plans for Human Exploration Beyond Low Earth Orbit

This paper provides an overview and status of Gateway, humanity’s first space station in lunar orbit as a vital component of the NASA-led Artemis missions to return humans to the Moon as preparation for the first human missions to Mars. Gateway is an aggregation point in deep space for a variety of spacecraft, including the crewed Orion vehicle, the Human Landing System that will ferry astronauts to and from the lunar surface, logistics supply craft, and vehicles transiting further into deep space beyond the Earth-Moon system, such as to Mars. NASA is building on decades of partnership with space agencies on three continents and multiple commercial partners to design, build, and launch Gateway’s core elements to near-rectilinear halo orbit (NRHO) around the Moon, where it will operate for a minimum of 15 years. Gateway is humanity’s next in-space science utilization platform, and its first in deep space, with three science payloads already selected to study solar and cosmic radiation. This paper will provide an overview of the Gateway space station’s major components in various stages of development, including the Power and Propulsion Element (PPE), Habitation and Logistics Outpost (HALO), the International Habitation (I-Hab) module, ESPRIT Refueling Module (ERM), the planned airlock, advanced external robotics systems, Deep Space Logistics supply craft, and next-generation autonomous Vehicle System Manager software. It will also provide an overview of how Gateway will be utilized for science, and highlight the space station’s multilateral governance structure and international agreements.

Emma Lehnhardt↗

NASA NTRSDate not supplied

Long Term Human Presence in Space Requires Artificial Gravity and Radiation Shielding

Astronauts who spend many months in microgravity suffer serious health problems including muscle atrophy, cardiovascular deconditioning, bone calcium loss, impaired vision, and immune system changes. Exercise countermeasures have been insufficient to maintain normal human performance. Similar problems can be expected in the partial gravity of the Moon and Mars. Achieving the long-term presence of healthy humans in space requires providing artificial Earth level gravity. This can be done on the Moon and Mars by using horizontally rotating habitats with angled floors, but it is easier in space habitats. Astronauts travelling beyond the protection of the Earth’s magnetic field can suffer harm from cosmic background radiation and occasional strong solar flares. Supporting healthy long-term human lives will require radiation shielding on the Moon and Mars as well as in space. Human space settlement will probably begin with artificial rotating space habitats in Low Earth Orbit (LEO) where they will be shielded from radiation. The earlier anticipated human communities in pressurized domes on the Moon or Mars appear unrealistic because of the now known problems of partial gravity and radiation.

Astronauts↗