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At least 1,099 records · Page 61

Laser radiation of CdS{sub x}Se{sub 1-x} targets in a gas diode

Laser radiation of semiconductor targets of CdS{sub x}Se{sub 1-x} solid solutions excited by an electron beam in a gas-filled diode was investigated at constant and varying gas pressures. In the first case, lasing was excited by an electron beam with an energy of 170 keV and a duration of 100 ps in semiconductor targets with different x. The highest powers 125 and 96 kW were achieved at x ≈ 0.2 (λ ≈ 677 nm) and x ≈ 1 (λ ≈ 522 nm), respectively. The minimum power (26 kW) was observed in the yellow-green spectral region. The maximum slope efficiency in these experiments reached 9%. In the second case, the radiation power of CdS targets (x = 1) was studied as a function of the air pressure in the gas diode varying from 0.1 to 2.5 Torr. The experimental data well agree with the calculation results. The possibility of reducing the radiation divergence by using a conical optical fibre is demonstrated. At the lasing threshold of semiconductor targets exited by an electron beam or a streamer discharge, filamentary channels appear due to, probably, an anisotropy of the impact ionisation coefficient. (lasers)

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Negative pressure and spallation in graphite targets under nano- and picosecond laser irradiation

We present the results of experiments on the spallation phenomena in graphite targets under shock-wave nano- and picosecond irradiation, which have been performed on Kamerton-T (GPI, Moscow, Russia) and PHELIX (GSI, Darmstadt, Germany) laser facilities. In the range of the strain rates of 10{sup 6} – 10{sup 7} s{sup -1}, the data on the dynamic mechanical strength of the material at rapure (spallation) have been for the first time obtained. With a maximal strain rate of 1.4 × 10{sup 7} s{sup -1}, the spall strength of 2.1 GPa is obtained, which constitutes 64% of the theoretical ultimate tensile strength of graphite. The effect of spallation is observed not only on the rear side of the target, but also on its irradiated (front) surface. With the use of optical and scanning electron microscopes, the morphology of the front and rear surfaces of the targets is studied. By means of Raman scattering of light, the graphite structure both on the target front surface under laser exposure and on its rear side in the spall zone is investigated. A comparison of the dynamic strength of graphite and synthetic diamond is performed. (extreme light fields and their applications)

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells

Bcl-2 family proteins regulate apoptosis, and aberrant interactions of overexpressed antiapoptotic family members such as Mcl-1 promote cell transformation, cancer survival, and resistance to chemotherapy. Discovering potent and selective Mcl-1 inhibitors that can relieve apoptotic blockades is thus a high priority for cancer research. An attractive strategy for disabling Mcl-1 involves using designer peptides to competitively engage its binding groove, mimicking the structural mechanism of action of native sensitizer BH3-only proteins. We transformed Mcl-1–binding peptides into α-helical, cell-penetrating constructs that are selectively cytotoxic to Mcl-1–dependent cancer cells. Critical to the design of effective inhibitors was our introduction of an all-hydrocarbon cross-link or “staple” that stabilizes α-helical structure, increases target binding affinity, and independently confers binding specificity for Mcl-1 over related Bcl-2 family paralogs. Two crystal structures of complexes at 1.4 Å and 1.9 Å resolution demonstrate how the hydrophobic staple induces an unanticipated structural rearrangement in Mcl-1 upon binding. Systematic sampling of staple location and iterative optimization of peptide sequence in accordance with established design principles provided peptides that target intracellular Mcl-1. Here, this work provides proof of concept for the development of potent, selective, and cell-permeable stapled peptides for therapeutic targeting of Mcl-1 in cancer, applying a design and validation workflow applicable to a host of challenging biomedical targets.

59 BASIC BIOLOGICAL SCIENCES↗

Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1

T cell-engaging bispecific antibodies (biAbs) present a promising strategy for cancer immunotherapy, and numerous bispecific formats have been developed for retargeting cytolytic T cells toward tumor cells. To explore the therapeutic utility of T cell-engaging biAbs targeting the receptor tyrosine kinase ROR1, which is expressed by tumor cells of various hematologic and solid malignancies, we used a bispecific ROR1 × CD3 scFv-Fc format based on a heterodimeric and aglycosylated Fc domain designed for extended circulatory t 1/2 and diminished systemic T cell activation. A diverse panel of ROR1-targeting scFv derived from immune and naïve rabbit antibody repertoires was compared in this bispecific format for target-dependent T cell recruitment and activation. An ROR1-targeting scFv with a membrane-proximal epitope, R11, revealed potent and selective antitumor activity in vitro, in vivo, and ex vivo and emerged as a prime candidate for further preclinical and clinical studies. Here, to elucidate the precise location and engagement of this membrane-proximal epitope, which is conserved between human and mouse ROR1, the 3D structure of scFv R11 in complex with the kringle domain of ROR1 was determined by X-ray crystallography at 1.6-Å resolution.

59 BASIC BIOLOGICAL SCIENCES↗

Measurements of the 27 Al(α,n) Thick Target Yield near Threshold

In this work, we present results from direct measurements of the 27 Al(α,n) thick-target yield from laboratory incident energies E α ≈ 3 to 5 MeV, performed with the 3 HeBF 3 Giant Barrel (HeBGB) neutron detector at the Edwards Accelerator Laboratory. Our measurements have a small energy cadence in order to address discrepancies and sparseness of thick-target-yield data sets existing for this energy region. We find general agreement with existing data sets, including yields derived from cross-section data, while resolving a discrepancy between existing thick-target-yield data sets for E α ≈ 4–5 MeV. However, for E α < 3.5 MeV, our results are substantially lower than previous thick-target-yield data and somewhat larger than yields calculated from existing cross-section data. Our data complete the energy range needed for estimates of the 27 Al(α,n) contribution to neutrino and dark matter detector backgrounds and result in increased viability of 27 Al(α,n) as a plasma diagnostic tool at fusion facilities such as the National Ignition Facility.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

High-Heat-Flux Target Design for the Material Plasma Exposure eXperiment

The Material Plasma Exposure eXperiment (MPEX) steady-state linear plasma facility is currently under design at Oak Ridge National Laboratory. The facility proposes to produce ITER divertor-relevant plasma conditions with steady-state heat fluxes up to 10 MW/m 2 with ion fluxes up to 10 24 /m 2 &middot;s. Plasmas will be produced from a helicon source with additional electron cyclotron and ion cyclotron heating, contained by superconducting magnets. MPEX will be capable of including targets that have been neutron irradiated from the High Flux Isotope Reactor (HFIR) in order to examine the effects of divertor-relevant plasma fluence on neutron-damaged materials. Targets can then be remotely transferred to an exchange chamber and moved into a handling station that is far from the MPEX magnets. Because of the high heat fluxes, the target must be actively cooled. Because the targets are activated, remote handling is required. The challenge of providing both active cooling and remote handling simultaneously has required a design and analysis effort that is the subject of this study.

Lumsdaine, Arnold↗

Thermohydraulic Design Analysis of the Target Assembly in the Material Plasma Exposure Experiment Facility

The Material Plasma Exposure eXperiment (MPEX) project seeks to design a steady-state linear plasma facility at Oak Ridge National Laboratory that will be used to study plasma-material interactions (PMIs) at fusion prototypic levels, supporting the evaluation and development of materials for the next generation of fusion devices. This study is focused on PMI exposure of small-size neutron-irradiated specimens, which are clamped onto an actively cooled component. A thermohydraulic evaluation of a new MPEX target assembly design to assess the appropriate operation during MPEX operation is presented. To further guide the design and assess the structural integrity of the components under expected loads, preliminary thermomechanical stress analyses were also conducted. To ensure good thermal contact between the components, thermal interface materials, such as silver flexible graphite, were used in the assembly. It was found that the maximum target temperatures of 1572, 1463, and 1315 K were obtained for Grafoil thicknesses of 0.61, 0.38, and 0.25 mm, respectively. The distribution of the axial deformation at high heat fluxes showed that there are no gaps between components, indicating good contact at material interfaces. Moreover, the contact pressure between the target and other components indicated that very good contact was established at these interfaces. Furthermore, the stress-strain conditions for the target will be further used to assess the appropriate operation during MPEX experiments and gain insight into materials science phenomena during PMI experiments.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

TARGET SELECTION FOR THE APACHE POINT OBSERVATORY GALACTIC EVOLUTION EXPERIMENT (APOGEE)

The Apache Point Observatory Galactic Evolution Experiment (APOGEE) is a high-resolution infrared spectroscopic survey spanning all Galactic environments (i.e., bulge, disk, and halo), with the principal goal of constraining dynamical and chemical evolution models of the Milky Way. APOGEE takes advantage of the reduced effects of extinction at infrared wavelengths to observe the inner Galaxy and bulge at an unprecedented level of detail. The survey's broad spatial and wavelength coverage enables users of APOGEE data to address numerous Galactic structure and stellar populations issues. In this paper we describe the APOGEE targeting scheme and document its various target classes to provide the necessary background and reference information to analyze samples of APOGEE data with awareness of the imposed selection criteria and resulting sample properties. APOGEE's primary sample consists of {approx}10{sup 5} red giant stars, selected to minimize observational biases in age and metallicity. We present the methodology and considerations that drive the selection of this sample and evaluate the accuracy, efficiency, and caveats of the selection and sampling algorithms. We also describe additional target classes that contribute to the APOGEE sample, including numerous ancillary science programs, and we outline the targeting data that will be included in the public data releases.

79 ASTRONOMY AND ASTROPHYSICS↗

Effect of dielectric target properties on plasma surface ionization wave propagation

Surface ionization waves (SIWs) propagating along dielectric covered, grounded surfaces have been studied for various dielectric bulk and surface conditions; a dependence on the propagation velocity with respect to dielectric electrical thickness and near surface permittivity profiles are observed. SIWs generated by an atmospheric pressure plasma source are imaged interacting with planar dielectric surface. Surface wave velocity is obtained by tracking emission intensity as a function of time. Target dielectric thickness is varied from $d = 0.15-10$ mm and dielectric constant is varied from $\epsilon_r = 6.21 - 9.4$. The propagation of SIWs can be generally predicted by relating their velocity to the RC time constant of the circuit generated between the plasma and the dielectric surface, but it is found that this approximation breaks down for dielectric substrates of sufficient thickness and wave velocity becomes constant. The results show that wave velocity is stable and predictable for target thicknesses beyond a certain point determined by the permittivity of the target material. It is also shown that SIW propagation is strongly driven by the dielectric material near to the surface of the target in addition to the bulk material. The possible mechanisms driving these thickness dependent behaviors is discussed.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Electron dynamics in radio frequency magnetron sputtering argon discharges with a dielectric target

Abstract We demonstrate a self-consistent and complete description of electron dynamics in a typical electropositive radio frequency magnetron sputtering (RFMS) argon discharge with a dielectric target. The electron dynamics, including the electron power absorption dynamics in one radio frequency (RF) period, is studied via a fully kinetic 2d3v particle-in-cell/Monte Carlo collision (PIC/MCC) electrostatic simulation. The interplay between the fundamental plasma parameters is analyzed through their spatiotemporal dynamics. Due to the influence of magnetic trap on the electron transport, a spatially dependent charging that perturbs the electric potential is observed on the dielectric target surface, resulting in a spatially dependent ion energy distribution along the target surface. The E × B drift-to-discharge current ratio is in approximate agreement with Bohm diffusion. The electron power absorption can be primarily decoupled into the positive Ohmic power absorption in the bulk plasma region and the negative pressure-induced power absorption near the target surface. Ohmic power absorption is the dominant electron power absorption mechanism, mostly contributed by the azimuthal electron current. The power absorption due to electron inertial effects is negligible on time-average. Both the maximum power absorption and dissipation of electrons appear in the bulk plasma region during the second half of the RF period, implying a strong electron trapping in magnetron discharges. The contribution of secondary electrons is negligible under typical RFMS discharge conditions.

Physics↗

Constraining primordial non-Gaussianity from DESI quasar targets and Planck CMB lensing

We detect the cross-correlation between 2.7 million DESI quasar targets across 14,700 deg 2 (180 quasars deg -2 ) and Planck 2018 CMB lensing at ~30σ. We use the cross-correlation on very large scales to constrain local primordial non-Gaussianity via the scale dependence of quasar bias. The DESI quasar targets lie at an effective redshift of 1.51 and are separated into four imaging regions of varying depth and image quality. We select quasar targets from Legacy Survey DR9 imaging, apply additional flux and photometric redshift cuts to improve the purity and reduce the fraction of unclassified redshifts, and use early DESI spectroscopy of 194,000 quasar targets to determine their redshift distribution and stellar contamination fraction (2.6%). Due to significant excess large-scale power in the quasar autocorrelation, we apply weights to mitigate contamination from imaging systematics such as depth, extinction, and stellar density. We use realistic contaminated mocks to determine the greatest number of systematic modes that we can fit, before we are biased by overfitting and spuriously remove real power. We find that linear regression with one to seven imaging templates removed per region accurately recovers the input cross-power, f NL and linear bias. As in previous analyses, our fNL constraint depends on the linear primordial non-Gaussianity bias parameter, b Φ = 2(b - p)δ c assuming universality of the halo mass function. We measure f NL = -26 +45 -40 with p = 1.6 (f NL = -18 +29 -27 with p = 1.0), and find that this result is robust under several systematics tests. Future spectroscopic quasar cross-correlations with Planck lensing can tighten the f NL constraints by a factor of 2 if they can remove the excess power on large scales in the quasar auto power spectrum.

79 ASTRONOMY AND ASTROPHYSICS↗

Soft pattern of gravitational Rutherford scattering from heavy target mass expansion

We investigate the soft behavior of the tree-level Rutherford scattering processes mediated via $t$-channel one-graviton exchange. We consider two types of Rutherford scattering processes, {\it e.g.}, a low-energy massless structureless projectile (up to spin-$1$) hits a static massive composite particle carrying various spins (up to spin-$2$), and a slowly-moving light projectile hits a heavy static composite target. The unpolarized cross sections in the first type are found to exhibit universal forms at the first two orders in $1/M$ expansion, yet differ at the next-to-next-to-leading order, though some terms at this order still remain universal or depend on the target spin in a definite manner. The unpolarized cross sections in the second type are universal at the lowest order in projectile velocity expansion and through all orders in $1/M$, independent of the spins of both projectile and target. The universality partially breaks down at relative order-$v^2/M^2$, albeit some terms at this order still depend on the target spin in a specific manner.

Rutherford scattering↗

Determination of the mean energy of fast electron losses and anisotropies through thick-target emission on WEST

Abstract A new method to obtain the mean energy of fast electron losses in fusion plasmas using a versatile multi-energy hard x-ray (HXR) detector is presented. The method is based on measuring the thick-target emission of tungsten in the divertor region produced by fast electron losses interacting with the target and modeling the tungsten spectra by a Monte Carlo code which simulates the interaction between a beam of electrons and a solid target. The mean energy of the fast electron losses is determined through the comparison between the experimental and synthetic emission. The results show that fast electron losses during lower hybrid current drive discharges at WEST have a mean energy of 90–140 keV and represent only 2% of the total heat flux at the target. Additionally, anisotropic HXR emission has been detected for the first time at the WEST core and edge plasma, with opposite directions. It is due to the forward-peak emission of two distinctive populations of fast electrons: co-current fast electrons in the core and counter-current fast electron losses at the inner strike point. In view of future experiments like ITER where electron cyclotron current drive will generate a fast electron population, this technique could serve as a real-time monitor of fast electron losses and eventually feed an actuator on the current drive generation.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

LnPO 4 Nanoparticles Doped with Ac-225 and Sequestered Daughters for Targeted Alpha Therapy

For targeted alpha therapy (TAT) with 225 Ac, daughter radioisotopes from the parent emissions should be controlled. We report on a second-generation layered nanoparticle (NP) with improved daughter retention that can mediate TAT of lung tumor colonies. NPs of La 3+ , Gd 3+ , and 225 Ac 3+ ions were coated with additional layers of GdPO 4 and then coated with gold via citrate reduction of NaAuCl 4 . MAb 201b, targeting thrombomodulin in lung endothelium, was added to a polyethylene glycol (dPEG)-COOH linker. Furthermore, we quantified the NPs:mAb ratio by labeling the mAb with 125 I. NPs showed 30% injected dose/organ antibody-mediated uptake in the lung, which increased to 47% in mice pretreated with clodronate liposomes to reduce phagocytosis. Retention of daughter 213 Bi in lung tissue was more than 70% at one hour and about 90% at 24 hours postinjection. Treatment of mice with lung-targeted 225 Ac NP reduced EMT-6 lung colonies relative to cold antibody competition for targeting or phosphate-buffered saline injected controls. Finally, we show that LnPO 4 NPs represent a viable solution to deliver the 225 Ac as an in vivo α generator. The NPs successfully retain a large percentage of the daughter products without compromising the tumoricidal properties of the α-radiation.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Box tomography: localized imaging of remote targets buried in an unknown medium, a step forward for understanding key structures in the deep Earth

We discuss an application of tomographic methods to the imaging of localized geological structures buried inside the Earth, where neither seismic sources nor receivers are necessarily present. We call this ‘box tomography’. The essential difference between box-tomography and standard tomographic methods is that the numerical modelling (i.e. the ray tracing in traveltime tomography and the wave propagation in waveform tomography or full waveform inversion) is completely confined within the small box-region imaged. Thus, box tomography is a lot more efficient than global tomography (i.e. where we invert for the velocity in the larger volume that encompasses all the sources and receivers), for imaging localized objects. The principal difficulty in the box tomography problem comes from the medium outside the box-region imaged, that masks the target structure. In the data recorded at the surface, the information carried by the waves about the target structure is mixed with that about the surrounding medium. The main focus of this paper is to evaluate how well box tomography can extract useful information to produce accurate images of remote buried objects, especially in the difficult situation where the velocity distribution above the target structure is not known a priori. We implemented traveltime box tomography, where first arrival times are inverted using ray theory, and, waveform box tomography or full waveform box inversion, where seismograms are inverted using either scattering integrals or adjoint methods. Whatever the method employed, we found that, in the simple situation where the velocity structure is known around the target region, box-tomography is faster and more accurate than global tomography. Most importantly, through examples and simple analysis, we show that box-tomography can produce accurate images of localized structures even though the velocity distribution is not a priori known around the box-region imaged. In the last section of this paper, we evaluate the usage of box-tomography for imaging geological structures in the deep Earth. We performed 2-D synthetic experiments in a fluid planet and we argue that box tomography can be employed for refining our current global tomographic models within arbitrary regions inside the Earth. This has important implications for understanding the composition and dynamics of the Earth’s interior.

Masson, Yder↗

Preliminary clustering properties of the DESI BGS bright targets using DR9 Legacy Imaging Surveys

ABSTRACT We characterize the selection cuts and clustering properties of a magnitude-limited sample of bright galaxies that is part of the Bright Galaxy Survey (BGS) of the Dark Energy Spectroscopic Instrument (DESI) using the ninth data release of the Legacy Imaging Surveys (DR9). We describe changes in the DR9 selection compared to the DR8 one and we also compare the DR9 selection in three distinct regions: BASS/MzLS in the north Galactic Cap (NGC), DECaLS in the NGC, and DECaLS in the south Galactic Cap (SGC). We investigate the systematics associated with the selection and assess its completeness by matching the BGS targets with the Galaxy and Mass Assembly (GAMA) survey. We measure the angular clustering for the overall bright sample (rmag ≤ 19.5) and as function of apparent magnitude and colour. This enables to determine the clustering strength r0 and slope γ by fitting a power-law model that can be used to generate accurate mock catalogues for this tracer. We use a counts-in-cells technique to explore higher order statistics and cross-correlations with external spectroscopic data sets in order to check the evolution of the clustering with redshift and the redshift distribution of the BGS targets using clustering redshifts. While this work validates the properties of the BGS bright targets, the final target selection pipeline and clustering properties of the entire DESI BGS will be fully characterized and validated with the spectroscopic data of Survey Validation.

79 ASTRONOMY AND ASTROPHYSICS↗

Characterizing the target selection pipeline for the Dark Energy Spectroscopic Instrument Bright Galaxy Survey

ABSTRACT We present the steps taken to produce a reliable and complete input galaxy catalogue for the Dark Energy Spectroscopic Instrument (DESI) Bright Galaxy Survey (BGS) using the photometric Legacy Survey DR8 DECam. We analyse some of the main issues faced in the selection of targets for the DESI BGS, such as star–galaxy separation, contamination by fragmented stars and bright galaxies. Our pipeline utilizes a new way to select BGS galaxies using Gaia photometry and we implement geometrical and photometric masks that reduce the number of spurious objects. The resulting catalogue is cross-matched with the Galaxy And Mass Assembly (GAMA) survey to assess the completeness of the galaxy catalogue and the performance of the target selection. We also validate the clustering of the sources in our BGS catalogue by comparing with mock catalogues and the Sloan Digital Sky Survey (SDSS) data. Finally, the robustness of the BGS selection criteria is assessed by quantifying the dependence of the target galaxy density on imaging and other properties. The largest systematic correlation we find is a 7 per cent suppression of the target density in regions of high stellar density.

79 ASTRONOMY AND ASTROPHYSICS↗

Angular clustering properties of the DESI QSO target selection using DR9 Legacy Imaging Surveys

ABSTRACT The quasar target selection for the upcoming survey of the Dark Energy Spectroscopic Instrument (DESI) will be fixed for the next 5 yr. The aim of this work is to validate the quasar selection by studying the impact of imaging systematics as well as stellar and galactic contaminants, and to develop a procedure to mitigate them. Density fluctuations of quasar targets are found to be related to photometric properties such as seeing and depth of the Data Release 9 of the DESI Legacy Imaging Surveys. To model this complex relation, we explore machine learning algorithms (random forest and multilayer perceptron) as an alternative to the standard linear regression. Splitting the footprint of the Legacy Imaging Surveys into three regions according to photometric properties, we perform an independent analysis in each region, validating our method using extended Baryon Oscillation Spectroscopic Survey (eBOSS) EZ-mocks. The mitigation procedure is tested by comparing the angular correlation of the corrected target selection on each photometric region to the angular correlation function obtained using quasars from the Sloan Digital Sky Survey (SDSS) Data Release 16. With our procedure, we recover a similar level of correlation between DESI quasar targets and SDSS quasars in two-thirds of the total footprint and we show that the excess of correlation in the remaining area is due to a stellar contamination that should be removed with DESI spectroscopic data. We derive the Limber parameters in our three imaging regions and compare them to previous measurements from SDSS and the 2dF QSO Redshift Survey.

79 ASTRONOMY AND ASTROPHYSICS↗