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At least 1,099 records · Page 61

Field application of pathogen detection technologies

Over the last 10 years there has been a significant increase in commercial products designed for field-based detection of microbial pathogens. This is due, in part, to the anthrax attacks in the United States in 2001, and the need for first responders to quickly identify the composition of suspected white powders and other potential biothreats. Demand for rapid detection is also driven by the need to ensure safe food, water, and environmental systems. From a technology perspective, rapid identification methods have largely capitalized on PCR and other molecular recognition techniques that can be deployed as robust field instrumentation. Examples of the relevant needs include the ability to: 1) declare a water distribution system free of microbial pathogens after a pipe/main break repair; 2) assess risks of contamination such as when produce production and processing plants are located near concentrated animal feeing operations; 3) evaluate the safety of ready-to-eat products; 4) determine the extent of potential serious disease outbreaks in remote and/or disaster stricken areas where access to clinical laboratories is not an immediate option; and 5) quickly assess credible biological terrorism events. Many of the principles underlying rapid detection methods are derived from methods for environmental microbiology, but there is a dearth of literature describing and evaluating field-based detection systems. Thus, the aims of this chapter are to: 1) summarize the different kinds of commercially available sampling kits and field-based biological detectors; 2) highlight some of the continued challenges of sample preparation to stimulate new research towards minimizing the impact of inhibitors on PCR-based detection systems; 3) describe our general rationale and statistically-based approach for instrument evaluation; 4) provide statistical and spatial guidelines for developing valid sampling plans; and 5) summarize some current needs and emerging technologies. This information is presented both to highlight the state of the field, and to also highlight major questions that students may wish to consider investigating further. Where possible we will cite studies that have been conducted and published either in traditional peer-reviewed or other literature (e.g., AOAC International Methods).

Straub, Tim M.↗

Use of Unlabeled Samples for Mitigating the Hughes Phenomenon

The use of unlabeled samples in improving the performance of classifiers is studied. When the number of training samples is fixed and small, additional feature measurements may reduce the performance of a statistical classifier. It is shown that by using unlabeled samples, estimates of the parameters can be improved and therefore this phenomenon may be mitigated. Various methods for using unlabeled samples are reviewed and experimental results are provided.

Landgrebe, David A.↗

The velocity distribution function of galaxy clusters as a cosmological probe

We present a new approach for quantifying the abundance of galaxy clusters and constraining cosmological parameters using dynamical measurements. In the standard method, galaxy line-of-sight velocities, v, or velocity dispersions are used to infer cluster masses, M, to quantify the halo mass function (HMF), dn(M)/dlog(M), which is strongly affected by mass measurement errors. In our new method, the probability distributions of velocities for each cluster in the sample are summed to create a new statistic called the velocity distribution function (VDF), dn(v)/dv. The VDF can be measured more directly and precisely than the HMF and can be robustly predicted with cosmological simulations that capture the dynamics of subhalos or galaxies. We apply these two methods to realistic (ideal) mock cluster catalogs with (without) interlopers and forecast the bias and constraints on the matter density parameter Ω{sub m} and the amplitude of matter fluctuations σ{sub 8} in flat ΛCDM cosmologies. For an example observation of 200 massive clusters, the VDF with (without) interloping galaxies constrains the parameter combination σ{sub 8} Ω{sub m}{sup 0.29(0.29)}=0.589±0.014 (0.584±0.011) and shows only minor bias. However, the HMF with interlopers is biased to low Ω{sub m} and high σ{sub 8} and the fiducial model lies well outside of the forecast constraints, prior to accounting for Eddington bias. When the VDF is combined with constraints from the cosmic microwave background, the degeneracy between cosmological parameters can be significantly reduced. Upcoming spectroscopic surveys that probe larger volumes and fainter magnitudes will provide clusters for applying the VDF as a cosmological probe.

79 ASTRONOMY AND ASTROPHYSICS↗

The Field Substellar Mass Function Based on the Full-sky 20 pc Census of 525 L, T, and Y Dwarfs

We present final Spitzer trigonometric parallaxes for 361 L, T, and Y dwarfs. We combine these with prior studies to build a list of 525 known L, T, and Y dwarfs within 20 pc of the Sun, 38 of which are presented here for the first time. Using published photometry and spectroscopy as well as our own follow-up, we present an array of color–magnitude and color–color diagrams to further characterize census members, and we provide polynomial fits to the bulk trends. Using these characterizations, we assign each object a T(eff) value and judge sample completeness over bins of T(eff) and spectral type. Except for types ≥T8 and T(eff) < 600 K, our census is statistically complete to the 20 pc limit. We compare our measured space densities to simulated density distributions and find that the best fit is a power law (dN/dM ∝ M^(-α) with α = 0.6 ± 0.1. We find that the evolutionary models of Saumon & Marley correctly predict the observed magnitude of the space density spike seen at 1200 K < T(eff) < 1350 K, believed to be caused by an increase in the cooling timescale across the L/T transition. Defining the low-mass terminus using this sample requires a more statistically robust and complete sample of dwarfs ≥Y0.5 and with T(eff) < 400 K. We conclude that such frigid objects must exist in substantial numbers, despite the fact that few have so far been identified, and we discuss possible reasons why they have largely eluded detection.

J. Davy Kirkpatrick↗

Global Sensitivity Analysis with Small Sample Sizes: Ordinary Least Squares Approach

A new version of global sensitivity analysis is developed in this paper. This new version coupled with tools from statistics, machine learning, and optimization can devise small sample sizes that allow for the accurate ordering of sensitivity coefficients for the first 10-30 most sensitive chemical reactions in complex chemical-kinetic mechanisms, and is particularly useful for studying the chemistry in realistic devices. A key part of the paper is calibration of these small samples. Because these small sample sizes are developed for use in realistic combustion devices, the calibration is done over the ranges of conditions in such devices, with a test case being the operating conditions of a compression ignition engine studied earlier. Compression ignition engines operate under low-temperature combustion conditions with quite complicated chemistry making this calibration difficult, leading to the possibility of false positives and false negatives in the ordering of the reactions. So an important aspect of the paper is showing how to handle the trade-off between false positives and false negatives using ideas from the multiobjective optimization literature. The combination of the new global sensitivity method and the calibration are sample sizes a factor of approximately 10 times smaller than were available with our previous algorithm.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Bayesian operator inference for data-driven reduced-order modeling

This work proposes a Bayesian inference method for the reduced-order modeling of time-dependent systems. Informed by the structure of the governing equations, the task of learning a reduced-order model from data is posed as a Bayesian inverse problem with Gaussian prior and likelihood. The resulting posterior distribution characterizes the operators defining the reduced-order model, hence the predictions subsequently issued by the reduced-order model are endowed with uncertainty. The statistical moments of these predictions are estimated via a Monte Carlo sampling of the posterior distribution. Since the reduced models are fast to solve, this sampling is computationally efficient. Furthermore, the proposed Bayesian framework provides a statistical interpretation of the regularization term that is present in the deterministic operator inference problem, and the empirical Bayes approach of maximum marginal likelihood suggests a selection algorithm for the regularization hyperparameters. The proposed method is demonstrated on two examples: the compressible Euler equations with noise-corrupted observations, and a single-injector combustion process.

97 MATHEMATICS AND COMPUTING↗

Sensitivity of neutron observables to the model input in simulations of 252 Cf ( sf )

Within the framework of $FREYA$ event-by-event fission simulations, we study the sensitivity of various neutron observables to the input yield function $Y$ ($A,Z,$TKE) on which the fission event sampling is based. We first perform a statistical analysis of the available fission data in order to determine the distribution of possible yield functions $Y$ ($A,Z$,TKE) and we then construct a sample of 15,000 such yield functions. For each of these, $FREYA$ is used to generate one million fission events, leading to a corresponding ensemble of fission observables, including the neutron multiplicity distribution and its factorial moments, the neutron energy spectrum, and the neutron-neutron angular correlation. This procedure allows us to study the sensitivity of those neutron observables to the uncertainty in the experimental data. Particular attention is given to the pronounced anticorrelation between the mean neutron multiplicity $\bar{v}$ and the mean total fragment kinetic energy TKE. Because the former observable is very well determined experimentally, it is possible to exploit that inherent anticorrelation to derive a significantly stricter tolerance on TKE. In addition, we study the sensitivity to the various $FREYA$ parameters and we introduce a method for determining a A-dependent x parameter, $x$($A$), based on the measured A-dependent neutron multiplicity, ($A$).

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Divide and conquer: using RhizoVision Explorer to aggregate data from multiple root scans using image concatenation and statistical methods

Roots are important in agricultural and natural systems for determining plant productivity and soil carbon inputs. Sometimes, the amount of roots in a sample is too much to fit into a single scanned image, so the sample is divided among several scans, and there is no standard method to aggregate the data. Here, we describe and validate two methods for standardizing measurements across multiple scans: image concatenation and statistical aggregation. We developed a Python script that identifies which images belong to the same sample and returns a single, larger concatenated image. These concatenated images and the original images were processed with RhizoVision Explorer, a free and open-source software. An R script was developed, which identifies rows of data belonging to the same sample and applies correct statistical methods to return a single data row for each sample. These two methods were compared using example images from switchgrass, poplar, and various tree and ericaceous shrub species from a northern peatland and the Arctic. Most root measurements were nearly identical between the two methods except median diameter, which cannot be accurately computed by statistical aggregation. We believe the availability of these methods will be useful to the root biology community.

59 BASIC BIOLOGICAL SCIENCES↗

Inferring subhalo effective density slopes from strong lensing observations with neural likelihood-ratio estimation

ABSTRACT Strong gravitational lensing has emerged as a promising approach for probing dark matter (DM) models on sub-galactic scales. Recent work has proposed the subhalo effective density slope as a more reliable observable than the commonly used subhalo mass function. The subhalo effective density slope is a measurement independent of assumptions about the underlying density profile and can be inferred for individual subhaloes through traditional sampling methods. To go beyond individual subhalo measurements, we leverage recent advances in machine learning and introduce a neural likelihood-ratio estimator to infer an effective density slope for populations of subhaloes. We demonstrate that our method is capable of harnessing the statistical power of multiple subhaloes (within and across multiple images) to distinguish between characteristics of different subhalo populations. The computational efficiency warranted by the neural likelihood-ratio estimator over traditional sampling enables statistical studies of DM perturbers and is particularly useful as we expect an influx of strong lensing systems from upcoming surveys.

Astronomy & Astrophysics↗

A comparison of compact, presumably young with extended, evolved radio active galactic nuclei

Context.The triggering and evolution of active galactic nuclei (AGNs) and the interaction of the AGN with its host galaxy is an important topic in extragalactic astrophysics. Radio sources with peaked spectra (peaked spectrum sources, PSS) and compact symmetric objects (CSO) are powerful, compact, and presumably young AGNs and therefore particularly suitable to study aspects of the AGN-host connection. Aims.We use a statistical approach to investigate properties of a PSS-CSO sample that are related to host galaxies and could potentially shed light on the link between host galaxies and AGNs. The main goal is to compare the PSS-CSO sample with a matching comparison sample of extended sources (ECS) to see if the two have significant differences. Methods.We analysed composite spectra, diagnostic line diagrams, multi-band spectral energy distributions (MBSEDs), star formation (SF) indicators, morphologies, and cluster environments for a sample of 121 PSSs and CSOs for which spectra are available from the Sloan Digital Sky Survey (SDSS). The statistical results were compared with those of the ECS sample, where we generally considered the two subsamples of quasi-stellar objects (QSOs) and radio galaxies separately. The analysis is based on a large set of archival data in the spectral range from the ultraviolet to mid-infrared. Results.We find significant differences between the PSS-CSO and the ECS sample. In particular, we find that the ECS sample has a higher proportion of passive galaxies with a lower star formation activity. This applies to both sub-samples (QSOs or radio galaxies) as well as to the entire sample. The star formation rates of the PSS-CSO host galaxies with available data are typically in the range ∼0 to 5 ℳ ⊙ yr −1 , and the stellar masses are in the range 3 × 10 11 to 10 12 ℳ ⊙ . Secondly, in agreement with previous results, we find a remarkably high proportion of PSS-CSO host galaxies with merger signatures. The merger fraction of the PSS-CSO sample is 0.61 ± 0.07, which is significantly higher than that of the comparison sample (0.15 ± 0.06). We suggest that this difference can be explained by assuming that the majority of the PSSs and CSOs cannot evolve to extended radio sources and are therefore not represented in our comparison sample.

Astronomy & Astrophysics↗

A METHOD TO SEARCH FOR CORRELATIONS OF ULTRA-HIGH ENERGY COSMIC-RAY MASSES WITH THE LARGE-SCALE STRUCTURES IN THE LOCAL GALAXY DENSITY FIELD

One of the main goals of investigations using present and future giant extensive air shower (EAS) arrays is the mass composition of ultra-high energy cosmic rays (UHECRs). A new approach to the problem is presented, combining the analysis of arrival directions with the statistical test of the paired EAS samples. One of the ideas of the method is to search for possible correlations between UHECR masses and their separate sources; for instance, if there are two sources in different areas of the celestial sphere injecting different nuclei, but the fluxes are comparable so that arrival directions are isotropic, then the aim is to reveal a difference in the mass composition of cosmic-ray fluxes. The method is based on a non-parametric statistical test-the Wilcoxon signed-rank routine-which does not depend on the populations fitting any parameterized distributions. Two particular algorithms are proposed: first, using measurements of the depth of the EAS maximum position in the atmosphere; and second, relying on the age variance of air showers initiated by different primary particles. The formulated method is applied to the Yakutsk array data, in order to demonstrate the possibility of searching for a difference in average mass composition between the two UHECR sets, arriving particularly from the supergalactic plane and a complementary region.

79 ASTRONOMY AND ASTROPHYSICS↗

Development of Ultra Small Scale Mechanical Testing and Localized He Implantation for Nuclear Applications

Mechanical properties degradation of components deployed in nuclear applications has been a concern since the deployment of first generation nuclear power plants. Radiation damage along with environmental degradation, elevated temperatures, and long term deployment of nuclear structures pose a challenging environment for all materials in these applications. Traditionally, the mechanical properties are assessed by standardized macroscopic testing methods. While those are providing engineering relevant data these techniques do have limitations, especially on reactor irradiated materials, due to the large size of the samples. Limitations on the amount of radioactivity of large samples must be applied for research applications as they are conducted at universities. In addition it can be difficult to retrieve sufficiently large amounts of material from an operating reactor component. Therefore smaller sample sizes are desirable and reduce the amount of radioactive material which needs to be handled or material which needs to be retrieved. In addition, the number of tests which can be performed on materials irradiated in a test reactor program is limited due to limited space in specific dose and temperature positions. Downsizing of the mechanical test can overcome this issue and perform more tests on the same amount of irradiated materials, reducing the statistical uncertainties. In addition, smaller scale samples allow access to specific regions of interest in a material or component, be it the zone in front of a crack tip or the sampling of very small components like springs or welded areas. In addition ion beam irradiation has become an integral part of nuclear materials research to enhance the understanding of radiation damage in materials in a time and cost effective fashion. The drawback of ion beam irradiation is the small penetration depth of the ions into the material making localized microstructural characterization as well as small scale mechanical testing necessary. Another more fundamental motivation is the fact that since the beginning of electron microscopy, one has been concerned about imaging and quantifying defects in materials. Multiscale tools to image a large range of radiation induced defects have been established starting from atom probe tomography to transmission electron microscopy, up to scattering techniques. Mechanical testing, however, has always been performed on a large scale, and an attempt to match the same scale where a defect is observed with the materials' mechanical property response has not yet been realized. However, the question of separate effects testing on specific radiation induced defects remains and is an additional driving force for small scale mechanical testing. In this work we present an approach for small scale mechanical testing in irradiated materials and the variety of possible test methods developed today. We also present recent efforts of performing localized ion beam implantation to achieve a number of different doses in the same region of interest enhancing comparability and quantification of observed phenomena. It is the intention to give the reader an overview of the different microscale mechanical testing techniques possible today as well as an introduction of a novel ion beam irradiation method using a newly established capability. In this paper we can't discuss all aspects of all small scale mechanical testing of irradiated materials However, It does give an overview over the techniques enabled due to recent effort and enhanced instrument capability. While indentation or micro compression testing has been performed previously tensile testing and ion beam irradiation using the He ion beam microscope are novel approaches not attempted previously. (authors)

36 MATERIALS SCIENCE↗

Dynamic analysis environment for nuclear forensic analyses

We report a Dynamic Analysis Environment (DAE) software package is introduced to facilitate group inclusion/exclusion method testing, evaluation and comparison for pre-detonation nuclear forensics applications. Employing DAE, the multivariate signatures of a questioned material can be compared to the signatures for different, known groups, enabling the linking of the questioned material to its potential process, location, or fabrication facility. Advantages of using DAE for group inclusion/exclusion include built-in query tools for retrieving data of interest from a database, the recording and documentation of all analysis steps, a clear visualization of the analysis steps intelligible to a non-expert, and the ability to integrate analysis tools developed in different programming languages. Two group inclusion/exclusion methods are implemented in DAE: principal component analysis, a parametric feature extraction method, and k nearest neighbors, a nonparametric pattern recognition method. Spent Fuel Isotopic Composition (SFCOMPO), an open source international database of isotopic compositions for spent nuclear fuels (SNF) from 14 reactors, is used to construct PCA and KNN models for known reactor groups, and 20 simulated SNF samples are utilized in evaluating the performance of these group inclusion/exclusion models. For all 20 simulated samples, PCA in conjunction with the Q statistic correctly excludes a large percentage of reactor groups and correctly includes the true reactor of origination. As a result, employing KNN, 14 of the 20 simulated samples are classified to their true reactor of origination.

97 MATHEMATICS AND COMPUTING↗

AN INFRARED EXCESS IDENTIFIED IN RADIO-LOUD BROAD ABSORPTION LINE QUASARS

If broad absorption line (BAL) quasars represent a high-covering-fraction evolutionary state (even if this is not the sole factor governing the presence of BALs), it is expected that they should show an excess of mid-infrared radiation compared to normal quasars. Some previous studies have suggested that this is not the case. We perform the first analysis of the IR properties of radio-loud BAL quasars, using IR data from WISE and optical (rest-frame ultraviolet) data from SDSS, and compare the BAL quasar sample with a well-matched sample of unabsorbed quasars. We find a statistically significant excess in the mid- to near-infrared luminosities of BAL quasars, particularly at rest-frame wavelengths of 1.5 and 4 {mu}m. Our sample was previously used to show that BALs are observed along many lines of sight toward quasars, but with an overabundance of more edge-on sources, suggesting that orientation factors into the appearance of BALs. The evidence here-of a difference in IR luminosities between BAL quasars and unabsorbed quasars-can be ascribed to evolution. This suggests that a merging of the current BAL paradigms is needed to fully describe the class.

79 ASTRONOMY AND ASTROPHYSICS↗

Magnetic Inflation and Stellar Mass. II. On the Radii of Single, Rapidly Rotating, Fully Convective M-Dwarf Stars

Main-sequence, fully convective M dwarfs in eclipsing binaries are observed to be larger than stellar evolutionary models predict by as much as 10%–15%. A proposed explanation for this discrepancy involves effects from strong magnetic fields, induced by rapid rotation via the dynamo process. Although, a handful of single, slowly rotating M dwarfs with radius measurements from interferometry also appear to be larger than models predict, suggesting that rotation or binarity specifically may not be the sole cause of the discrepancy. We test whether single, rapidly rotating, fully convective stars are also larger than expected by measuring their Rsin i distribution. We combine photometric rotation periods from the literature with rotational broadening (vsin i) measurements reported in this work for a sample of 88 rapidly rotating M dwarf stars. Using a Bayesian framework, we find that stellar evolutionary models underestimate the radii by 10%--15%{sub −2.5}{sup +3}, but that at higher masses (0.18 < M < 0.4 M {sub Sun}), the discrepancy is only about 6% and comparable to results from interferometry and eclipsing binaries. At the lowest masses (0.08 < M < 0.18 M {sub Sun}), we find that the discrepancy between observations and theory is 13%–18%, and we argue that the discrepancy is unlikely to be due to effects from age. Furthermore, we find no statistically significant radius discrepancy between our sample and the handful of M dwarfs with interferometric radii. We conclude that neither rotation nor binarity are responsible for the inflated radii of fully convective M dwarfs, and that all fully convective M dwarfs are larger than models predict.

79 ASTRONOMY AND ASTROPHYSICS↗

Chandrasekhar's relation and stellar rotation in the Kepler field

According to the statistical law of large numbers, the expected mean of identically distributed random variables of a sample tends toward the actual mean as the sample increases. Under this law, it is possible to test the Chandrasekhar's relation (CR), (V) = (π/4){sup –1}(Vsin i), using a large amount of Vsin i and V data from different samples of similar stars. In this context, we conducted a statistical test to check the consistency of the CR in the Kepler field. In order to achieve this, we use three large samples of V obtained from Kepler rotation periods and a homogeneous control sample of Vsin i to overcome the scarcity of Vsin i data for stars in the Kepler field. We used the bootstrap-resampling method to estimate the mean rotations ((V) and (Vsin i)) and their corresponding confidence intervals for the stars segregated by effective temperature. Then, we compared the estimated means to check the consistency of CR, and analyzed the influence of the uncertainties in radii measurements, and possible selection effects. We found that the CR with (sin i) = π/4 is consistent with the behavior of the (V) as a function of (Vsin i) for stars from the Kepler field as there is a very good agreement between such a relation and the data.

79 ASTRONOMY AND ASTROPHYSICS↗

Radio-Optical Alignments in a Low Radio Luminosity Sample

We present an optically-based study of the alignment between the radio axes and the optical major axes of eight z approximately 0.7 radio galaxies in a 7C sample. The radio galaxies in this sample are approximately 20-times less radio luminous than 3C galaxies at the same redshift, and are significantly less radio-luminous than any other well-defined samples studied to date. Using Nordic Optical Telescope images taken in good seeing conditions at rest-frame wavelengths just longward of the 4000A break, we find a statistically significant alignment effect in the 7C sample. Furthermore, in two cases where the aligned components are well separated from the host we have been able to confirm spectroscopically that they are indeed at the same redshift as the radio galaxy. However, a quantitative analysis of the alignment in this sample and in a corresponding 3C sample from HST (Hubble Space Telescope) archival data indicates that the percentage of aligned flux may be lower and of smaller spatial scale in the 7C sample. Our study suggests that alignments on the 50-kpc scale are probably closely related to the radio luminosity, whereas those on the 15 kpc scale are not. We discuss these results in the context of popular models for the alignment effect.

Lacy, Mark↗

An Overview of Particle Sampling Bias

The complex relation between particle arrival statistics and the interarrival statistics is explored. It is known that the mean interarrival time given an initial velocity is generally not the inverse of the mean rate corresponding to that velocity. Necessary conditions for the measurement of the conditional rate are given.

Meyers, James F.↗