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At least 1,099 records · Page 61

An overview of the endocrine and metabolic changes in manned space flight

Analyses of endocrinological and metabolic data from humans during spaceflight, particularly the Skylab crews, are summarized to define the levels of knowledge of these processes and the techniques for studying them. The glomerular filtration rate was tested by urine and blood samples, yielding indications of a creatinine clearance increase. The mechanisms for an increase of free water clearance, implying an increase of antidiuretic hormone, are uncertain, and tests are also under way to evaluate the role of prostaglandins in-flight, to account for decreases in catecholamine excretion. Bone mineral losses of 7.9% were observed at the end of 84 days, and processes are suggested for the calcium metabolism. Finally, the observation of almost universal weight loss among space crewmembers is examined, and a loss of muscle tone due to decreased metabolic efficiency is cited as a feature of long duration spaceflight.

Leach, C. S.↗

Impulsive phase of solar flares. I - Characteristics of high energy electrons

The models describing the operative physical processes occurring during the impulsive phase of a solar flare can be broadly classified as thermal or nonthermal models. The current investigation is part of a series of studies which analyze the general characteristics of the 'nonthermal' models. The results are presented of an analysis regarding the steady state distribution of energetic electrons within the flare plasma. The time independent Fokker-Planck equation is used to determine the steady state distribution of the electrons in the ambient plasma. The model investigated encompasses thick-target, thin-target, and trap aspects of nonthermal hard X-ray models. High energy electrons with some initial energy spectrum and pitch angle distribution are injected at a height above the photosphere either into a closed magnetic loop structure or into an open field structure. Some approximate analytic solutions are discussed and the results of a numerical analysis are presented.

Leach, J.↗

Computer simulations of postural change, water immersion and bedrest - An integrative approach for understanding the spaceflight response

Mathematical modeling techniques were used to simulate the fluid electrolyte (F-E) responses during gravity unloading. It is shown that the response to weightlessness can best be understood by separately examining the acute (hours to days) and chronic (days to weeks) phases, and assuming the presence of normal, although complex, feedback regulatory processes. Headward shifts of fluid are shown to be primarily responsible for acute body losses of extracellular F-E. Losses of body water are closely related to the volume of fluid shifts from the legs. A diuresis is predicted within the first several hours of hypogravity, and this may be obscured by a reduced F-E intake; on Skylab, early F-E losses occurred primarily by deficit intake.

Leonard, J. I.↗

Dynamics of weight loss during prolonged spaceflight

Data from three Skylab flights lasting 28, 59, and 84 days are used to study changes in body composition occurring during extended spaceflight. The analysis includes pre- and postflight measurements used to compute lean body mass and body fat losses for an entire mission using previously accepted methods based on total body water, potassium, and density, and also includes the daily metabolic balances in order to provide an estimate of the time course of the changes in water, protein, and fat. The analytical approach is explained and the results presented, including a summary of changes in lean body mass and changes in weight loss and tissue components. It is concluded that little more than half of the weight loss observed during the missions can be attributed to loss in lean body mass, the remainder being derived from fat stores.

Leach, C. S.↗

The interpretation of hard X-ray polarization measurements in solar flares

The significance of low hard X-ray polarization measurements for non-thermal models is discussed. Such a low polarization result, it is shown, can in fact occur in non-thermal models, and the ways in which the degree of X-ray polarization is correlated with the parameters of these models is discussed.

Leach, J.↗

Rate of wind abrasion on Mars

A brief description is given of the experiments performed to obtain data on windblown particles and abrasion of rocks in a simulated Martian environment. Preliminary results are presented and combined with Viking meteorological data in estimating rates of wind abrasion at the VL-1 site on Mars. Attention is also given to the implications that the results have for Martian surface history. Calculations of the present rates of abrasion by windblown particles on Mars yield values ranging from 0.021 cm/yr to nearly zero, depending on the target, the agent of abrasion, and the availability of windblown particles.

Greeley, R.↗

Fluid shifts and erythropoiesis - Relevance to the 'anemia' of space flight

To model the fluid shifts thought to occur in man during space flight, cephalic fluid shifts have been induced in man subjected to horizontal or headdown bedrest, in squirrel monkeys exposed to lower body positive pressure, and in rats subjected to antiorthostatic hypokinesia. The influence on erythropoiesis of such fluid redistribution has been studied. Only in man did a cephalic fluid shift consistently and significantly lead to a plasma volume reduction and an increased hematocrit. Although there was evidence for erythrosuppression and the subjects were 'anemic' at the end of the study, serum erythropoietin titers remained normal throughout bedrest. The erythrosuppression probably did not arise due to the increased hematocrit but may have been related to P50 shifts or the loss of body weight. Each model appeared to reproduce different parts of man's physiological response to weightlessness and promises to be useful in unraveling the etiology of the 'anemia' of space flight.

Dunn, C. D. R.↗

Effects of age and sex on hormonal responses to weightlessness simulation

The effects of horizontal bedrest on the excretion of catecholamines, aldosterone, and cortisol by human subjects grouped by age and sex are examined. The responses are assessed by assays of 24-hr urine samples collected throughout the studies. In 36-45-yr-olds, the excretion of epinephrine increases, whereas it decreases in the 46-55- and 56-65-yr-old groups. Norepinephrine excretion decreases (5-27%) in all groups during bedrest. Aldosterone excretion increases in the younger two groups of both males (19 and 6%) and females (47 and 9%). A slight decrease is observed in 56-65-yr-old males (6%), whereas excretion in females is unchanged. Cortisol excretion increases in the youngest groups of both men (12%) and women (13%) but decreases in the 56-65-yr-old groups (6 and 5%). For the two groups of intermediate age (46-55 yr), excretion in females decreases (15%), whereas in males it increases (19%). It is believed that hormone measurements may be of value in explaining variation in stress tolerance due to age and/or sex during space flight.

Larochelle, F.↗

Metabolic experiments on Spacelab-4

Studies of human metabolism are being considered in five experiments. These investigations address physiological effects of zero gravity which have become evident in previous manned space flights, namely, negative Na, Ca and N balances, the resorption of bone, loss of red cell mass, cephalad migration of body fluids, and a shift in water balance. Although these effects have been fairly well established by pre- and postflight measurements, details of the mechanism by which they occur remain largely unknown. Moreover, the data collected inflight, particularly during the first few hours of weightlessness, have been severely limited both in the amount of quantitative information obtained and with respect to the relative simplicity of the experimental techniques employed. During the Spacelab 4 mission, the acute stage of the response to zero gravity will be the main focus of attention of several experiments. Measurements conducted later in the mission will center on the adaptive phase of metabolic responses.

Leach, C. S.↗

Fluid and electrolyte homeostasis in space - A primate model to look at mechanisms

To elucidate the physiological mechanisms involved in the cardiovascular and renal responses to spaceflight, a ground-based primate model has been developed which uses lower body positive pressure (LBPP) to simulate the chronic central vascular expansion associated with weightlessnes. Four male squirrel monkeys with chronically implanted arterial and venous catheters and the capacity for continuous urine collection were subjected to LBPP for 4 days. Onset of LBPP resulted in an immediate diuresis, natriuresis and kaliuresis and a significant fall in plasma aldosterone and potassium levels. By day 2 the level of natriuresis had decreased by half, while potassium excretion and plasma aldosterone values had returned to control levels despite the persistence of a significantly reduced plasma potassium concentration. It is concluded that the low plasma potassium level appears not to stimulate a compensatory fall in plasma aldosterone because of the simultaneous presence of body volume contraction acting to raise aldosterone levels.

Moore-Ede, M. C.↗

The impulsive phase of solar flares. II - Characteristics of the hard X-rays

The results of an investigation into the electron distribution in the general non-thermal models of solar flares were used to calculate the characteristics of the impulsive hard X-rays. The height distribution, the spectrum, the polarization, and directivity of the X-rays were observed and how these X-ray characteristics are affected by the parameters defining the model was investigated. An expression is obtained for the X-ray intensity as a function of source height which is an excellent fit under certain constraints. Some available data with spatial resolution are examined and it is shown that it is possible to reproduce these data adequately with the non-thermal model and to determine the values of the parameters describing the flares. Previously announced in STAR as N82-34328

Leach, J.↗

Correlation of hard X-ray and type III bursts in solar flares

Correlations between X-ray and type 3 radio emission of solar bursts are described through a bivariate distribution function. Procedures for determining the form of this distribution are described. A model is constructed to explain the correlation between the X-ray spectral index and the ratio of X-ray to radio intensities. Implications of the model are discussed. Previously announced in STAR as N82-32243

Petrosian, V.↗

The interpretation of hard X-ray polarization measurements in solar flares

Observations of polarization of moderately hard X-rays in solar flares are reviewed and compared with the predictions of recent detailed modeling of hard X-ray bremsstrahlung production by non-thermal electrons. The recent advances in the complexity of the modeling lead to substantially lower predicted polarizations than in earlier models and more fully highlight how various parameters play a role in determining the polarization of the radiation field. The new predicted polarizations are comparable to those predicted by thermal modeling of solar flare hard X-ray production, and both are in agreement with the observations. In the light of these results, new polarization observations with current generation instruments are proposed which could be used to discriminate between non-thermal and thermal models of hard X-ray production in solar flares.

Leach, J.↗

The impulsive hard X-rays from solar flares

A technique for determining the physical arrangement of a solar flare during the impulsive phase was developed based upon a nonthermal model interpretation of the emitted hard X-rays. Accurate values are obtained for the flare parameters, including those which describe the magnetic field structure and the beaming of the energetic electrons, parameters which have hitherto been mostly inaccessible. The X-ray intensity height structure can be described readily with a single expression based upon a semi-empirical fit to the results from many models. Results show that the degree of linear polarization of the X-rays from a flaring loop does not exceed 25 percent and can easily and naturally be as low as the polarization expected from a thermal model. This is a highly significant result in that it supersedes those based upon less thorough calculations of the electron beam dynamics and requires that a reevaluation of hopes of using polarization measurements to discriminate between categories of flare models.

Leach, J.↗

Impact of IPAD on CAD/CAM database university research

IPAD program has provided direction, focus and software products which impacted on CAD/CAM data base research and follow-on research. The relationship of IPAD to the research projects which involve the storage of geometric data in common data ase facilities such as data base machines, the exchange of data between heterogeneous data bases, the development of IGES processors, the migration of lrge CAD/CAM data base management systems to noncompatible hosts, and the value of RIM as a research tool is described.

Leach, L. M.↗

Energy efficient engine: Turbine intermediate case and low-pressure turbine component test hardware detailed design report

A four stage, low pressure turbine component has been designed to power the fan and low pressure compressor system in the Energy Efficient Engine. Designs for a turbine intermediate case and an exit guide vane assembly also have been established. The components incorporate numerous technology features to enhance efficiency, durability, and performance retention. These designs reflect a positive step towards improving engine fuel efficiency on a component level. The aerodynamic and thermal/mechanical designs of the intermediate case and low pressure turbine components are presented and described. An overview of the predicted performance of the various component designs is given.

Leach, K.↗

Medical results from STS 1-4 - Analysis of body fluids

Venous blood was drawn from the eight crewmembers of Space Shuttle flights STS-1 through STS-4 three times before lift-off and twice after landing, and the characteristics of biochemical blood components were evaluated. Twenty-four-hour urine pools were collected 30 d before flight and on landing day or day 4 after landing, and electrolytes, selected hormones and other components were measured. The results indicated that, although fluid and electrolyte loss occur during space flight, conservation of these substances is begun almost immediately upon cessation of weightlessness. Enzyme and hormone measurements indicated that landing may have caused some stress on crewmembers.

Leach, C. S.↗

Concepts for NASA longitudinal health studies

Clinical data collected from a 15-year study of the homogenous group of pre-Shuttle astronauts have revealed no significant long-term effects from spaceflight. The current hypothesis suggests that repeated exposures to the space environment in the Shuttle era will similarly have no long-term health effects. However, a much more heterogenous group of astronauts and non-astronaut scientists will fly in Shuttle, and data on this group's adaptation to the space environment and readaptation to earth are currently sparse. In addition, very little information is available concerning the short- and long-term medical consequences of long duration exposure to space and subsequent readaptation to the earth environment. In this paper, retrospective clinical information on astronauts is reviewed and concepts for conducting epidemiological studies examining long-term health effects of spaceflight on humans, including associated occupational risks factors, are presented.

Nicogossian, A. E.↗