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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,081 records · Page 60

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DOE OSTI2024

Structural basis of divergent substrate recognition and inhibition of human neurolysin

A zinc metallopeptidase neurolysin (Nln) processes diverse bioactive peptides to regulate signaling in the mammalian nervous system. To understand how Nln interacts with various peptides with dissimilar sequences, we determined crystal structures of Nln in complex with diverse peptides including dynorphins, angiotensin, neurotensin, and bradykinin. The structures show that Nln binds these peptides in a large dumbbell-shaped interior cavity constricted at the active site, making minimal structural changes to accommodate different peptide sequences. The structures also show that Nln readily binds similar peptides with distinct registers, which can determine whether the peptide serves as a substrate or a competitive inhibitor. We analyzed the activities and binding of Nln toward various forms of dynorphin A peptides, which highlights the promiscuous nature of peptide binding and shows how dynorphin A (1–13) potently inhibits the Nln activity while dynorphin A (1–8) is efficiently cleaved. Our work provides insights into the broad substrate specificity of Nln and may aid in the future design of small molecule modulators for Nln.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2020

Metabolic Feedback Inhibition Influences Metabolite Secretion by the Human Gut Symbiont Bacteroides thetaiotaomicron

ABSTRACT Microbial metabolism and trophic interactions between microbes give rise to complex multispecies communities in microbe-host systems. Bacteroides thetaiotaomicron ( B. theta ) is a human gut symbiont thought to play an important role in maintaining host health. Untargeted nuclear magnetic resonance metabolomics revealed B. theta secretes specific organic acids and amino acids in defined minimal medium. Physiological concentrations of acetate and formate found in the human intestinal tract were shown to cause dose-dependent changes in secretion of metabolites known to play roles in host nutrition and pathogenesis. While secretion fluxes varied, biomass yield was unchanged, suggesting feedback inhibition does not affect metabolic bioenergetics but instead redirects carbon and energy to CO 2 and H 2 . Flux balance analysis modeling showed increased flux through CO 2 -producing reactions under glucose-limiting growth conditions. The metabolic dynamics observed for B. theta , a keystone symbiont organism, underscores the need for metabolic modeling to complement genomic predictions of microbial metabolism to infer mechanisms of microbe-microbe and microbe-host interactions. IMPORTANCE Bacteroides is a highly abundant taxon in the human gut, and Bacteroides thetaiotaomicron ( B. theta ) is a ubiquitous human symbiont that colonizes the host early in development and persists throughout its life span. The phenotypic plasticity of keystone organisms such as B. theta is important to understand in order to predict phenotype(s) and metabolic interactions under changing nutrient conditions such as those that occur in complex gut communities. Our study shows B. theta prioritizes energy conservation and suppresses secretion of “overflow metabolites” such as organic acids and amino acids when concentrations of acetate are high. Secreted metabolites, especially amino acids, can be a source of nutrients or signals for the host or other microbes in the community. Our study suggests that when metabolically stressed by acetate, B. theta stops sharing with its ecological partners.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2025

Adoption of AI in the Utility T&D Sector: Use Cases, Consequence, Assessment and Benefits

Digital transformation and utilization of artificial intelligence (AI) in the electric grid are fundamentally changing the industry’s approach to common problems and enabling a broader paradigm shift in grid planning and operations. The change in approach is circularly both enabling and driving modernization, with load growth and reliable management of data center and AI infrastructure shifting away from planning approaches with relatively predictable behaviors and toward a mix of consumer and industrial choices that surpass human cognitive abilities to process. This movement has potential to condition humans to not understand the system on which the AI depends, while requiring it for development of the necessary infrastructure. Approaches which would address most likely grid conditions and events, such as faults, aging of equipment, and weather, now must also account for large loads which shift not based upon weather or time of day, but the computational load. Quantifying computational load is independent of the traditional grid forecasting variables, where a data center’s aggregate load is determined by user and AI system behavior and decoupled from normal grid planning and operations. AI is both the cause and solution for these challenges, with new grid planning tools integrating massive amounts of decisions into frameworks.

24 POWER TRANSMISSION AND DISTRIBUTION↗

NASA NTRS1991

Intelligent control based on fuzzy logic and neural net theory

In the conception and design of intelligent systems, one promising direction involves the use of fuzzy logic and neural network theory to enhance such systems' capability to learn from experience and adapt to changes in an environment of uncertainty and imprecision. Here, an intelligent control scheme is explored by integrating these multidisciplinary techniques. A self-learning system is proposed as an intelligent controller for dynamical processes, employing a control policy which evolves and improves automatically. One key component of the intelligent system is a fuzzy logic-based system which emulates human decision making behavior. It is shown that the system can solve a fairly difficult control learning problem. Simulation results demonstrate that improved learning performance can be achieved in relation to previously described systems employing bang-bang control. The proposed system is relatively insensitive to variations in the parameters of the system environment.

Lee, Chuen-Chien↗

NASA NTRS1992

Mission to Planet Earth

Mission to Planet Earth (MTPE) is NASA's concept for an international science program to produce the understanding needed to predict changes in the earth's environment. NASA and its interagency and international partners will place satellites carrying advanced sensors in strategic earth orbits to gather multidisciplinary data. A sophisticated data system will process and archive an unprecedented amount of information about the earth and how it works as a system. Increased understanding of the earth system is a basic human responsibility, a prerequisite to informed management of the planet's resources and to the preservation of the global environment.

Wilson, Gregory S.↗

NASA NTRS1992

Mission to Planet Earth

Mission to Planet Earth (MTPE) is NASA's concept for an international science program to produce the understanding needed to predict changes in the Earth's environment. NASA and its interagency and international partners will place satellites carrying advanced sensors in strategic Earth orbits to gather multidisciplinary data. A sophisticated data system will process and archive an unprecedented amount of information about the Earth and how it works as a system. Increased understanding of the Earth system is a basic human responsibility, a prerequisite to informed management of the planet's resources and to the preservation of the global environment. An overview of the MTPE, flight programs, data and information systems, interdisciplinary research efforts, and international coordination, is presented.

Wilson, Gregory S.↗

NASA NTRS1994

Mission to Planet Earth

Tilford, Shelby G.↗

NASA NTRS1992

Duration versus response to space-flight exposure

The duration of human expeditions into space has been as short as a few hours and as long as a year, and although we still need much more information, we can identify some trends indicating effects of flight duration on the physiologic response to space flight. Evidence suggests that after a period of dynamic change that varies for each physiologic system, some physiologic variable stabilize at levels that may differ from those at 1 G. Other variables appear to undergo change from time to time even after months in space, and others have not been observed to reach a plateau. Effects on the neurovestibular system begin very early and certain ones diminish rapidly. Effects of weightlessness on fluid and electrolyte physiology appear to reach a peak after that of neurophysiologic effects. It is possible that the initial responses of these two systems follow a more similar time course than is now apparent. Responses of the cardiovascular system reach a peak that approaches clinical significance after about 3 weeks. The mass of red blood cells is maximally altered after about a month. Bone mineral and lean body mass are lost gradually for at least 6 months, perhaps longer.

Leach, Carolyn S.↗

NASA NTRS2003

TRMM Fire Algorithm, Product and Applications

Land fires are frequent menaces to human lives and property. They also change the state of the vegetation and contribute to the climate forcing by releasing large amount of aerosols and greenhouse gases into the atmosphere. This paper summarizes methodologies of detecting global land fires from the Tropical Rainfall Measuring Mission (TRMM) Visible Infrared Scanner FIRS) measurements. The TRMM Science Data and Information System (TSDIS) fire products include global images of daily hot spots and monthly fire counts at 0.5 deg. x 0.5 deg. resolution, as well as text fiies that details necessary information of all fire pixels. The information includes date, orbit number, pixel number, local time, solar zenith angle, latitude, longitude, reflectance of visible/near infrared channels, brightness temperatures of infrared channels, as well as background brightness temperatures of infrared channels. These products have been archived since January 1998. The TSDIS fire products are compared with the coincidental European Commission (EC) Joint Research Center (JRC) 1 km AVHRR fire products. Analyses of the TSDIS monthly fire products during the period from 1998 to 2003 manifested seasonal cycles of biomass fires over Southeast Asia, Africa, North America and South America. The data also showed interannual variations associated with the 98/99 ENS0 cycle in Central America and the Indonesian region. In order to understand the variability of global land fires and their effects on the distribution of atmospheric aerosols, statistical methods were applied to the TSDIS fire products as well as to the Total Ozone Mapping Spectrometer (TOMS) aerosol index products for a period of five years from January 1998 to December 2002. The variability of global atmospheric aerosol is consistent with the fire variations over these regions during this period. The correlation between fire count and TOMS aerosol index is about 0.55 for fire pixels in Southeast Asia, Indonesia, and Africa. Parallel statistical analyses such as Empirical Orthogonal Function (EOF) analysis and Singular Spectrum Analysis (SSA) methods were applied to pentad TRMM fire data and TOMS aerosol data. The EOF analyses showed contrast between North and South hemispheres and also inter- continental transitions in Africa and America. EOF and SSA analyses also identified 25-60 day intra-seasonal oscillations that were superimposed on the annual cycles of both fire and aerosol data. The intra-seasonal variability of fires showed similarity of tropical rainfall oscillation modes. The TRMM fire products were also compared to the coincident TRMh4 rainfall and other rainfall products to investigate the interaction between rainfall and fire. The results indicate that the annual, interannual and intraseasonal variability of fire are dominated by global rainfall variations. However, the feedback of fire to the rainfall occurrence at regional scale for certain regions is also evident.

Ji, Yi-Min↗

NASA NTRS2002

The immune system in space and microgravity

Space flight and models that created conditions similar to those that occur during space flight have been shown to affect a variety of immunological responses. These have primarily been cell-mediated immune responses including leukocyte proliferation, cytokine production, and leukocyte subset distribution. The mechanisms and biomedical consequences of these changes remain to be established. Among the possible causes of space flight-induced alterations in immune responses are exposure to microgravity, exposure to stress, exposure to radiation, and many more as yet undetermined causes. This review chronicles the known effects of space flight on the immune system and explores the possible role of stress in contributing to these changes.

unmanned↗

NASA NTRS2006

Analysis of Aircraft Control Performance using a Fuzzy Rule Base Representation of the Cooper-Harper Aircraft Handling Quality Rating

The Cooper-Harper rating of Aircraft Handling Qualities has been adopted as a standard for measuring the performance of aircraft since it was introduced in 1966. Aircraft performance, ability to control the aircraft, and the degree of pilot compensation needed are three major key factors used in deciding the aircraft handling qualities in the Cooper- Harper rating. We formulate the Cooper-Harper rating scheme as a fuzzy rule-based system and use it to analyze the effectiveness of the aircraft controller. The automatic estimate of the system-level handling quality provides valuable up-to-date information for diagnostics and vehicle health management. Analyzing the performance of a controller requires a set of concise design requirements and performance criteria. Ir, the case of control systems fm a piloted aircraft, generally applicable quantitative design criteria are difficult to obtain. The reason for this is that the ultimate evaluation of a human-operated control system is necessarily subjective and, with aircraft, the pilot evaluates the aircraft in different ways depending on the type of the aircraft and the phase of flight. In most aerospace applications (e.g., for flight control systems), performance assessment is carried out in terms of handling qualities. Handling qualities may be defined as those dynamic and static properties of a vehicle that permit the pilot to fully exploit its performance in a variety of missions and roles. Traditionally, handling quality is measured using the Cooper-Harper rating and done subjectively by the human pilot. In this work, we have formulated the rules of the Cooper-Harper rating scheme as fuzzy rules with performance, control, and compensation as the antecedents, and pilot rating as the consequent. Appropriate direct measurements on the controller are related to the fuzzy Cooper-Harper rating system: a stability measurement like the rate of change of the cost function can be used as an indicator if the aircraft is under control; the tracking error is a good measurement for performance needed in the rating scheme. Finally, the change of the control amount or the output of a confidence tool, which has been developed by the authors, can be used as an indication of pilot compensation. We use a number of known aircraft flight scenarios with known pilot ratings to calibrate our fuzzy membership functions. These include normal flight conditions and situations in which partial or complete failure of tail, aileron, engine, or throttle occurs.

Tseng, Chris↗

NASA NTRS2008

The Interim: Until You Achieve an Operationally Responsive Ground System

Everyone wants to achieve a 'Responsive' Ground Data System (GDS), but that takes time. What do you do in the interim? Our group, called the Integration, Test and Deployment Team (ITD), is a group of responsive engineers whose primary focus is to assist JPL projects to successfully adapt, test, integrate and deploy their ground data system. The team configures and adapts the GDS for a project, so that analysts, engineers and scientist do not need to be experts in the GDS to operate it. The team has developed a human interface to accommodate all types of users. It provides Graphical User Interfaces (GUI's) for those that want GUI's, command line interfaces for those that want control, and selection button interfaces for other users. The cornerstone of a responsive Ground Data System is responsive people. Without individuals who can be aware of a project's changing needs and requirements, how can the GDS become responsive?.

Ground Data System (GDS)↗

NASA NTRS2008

The Interim : until you achieve an operationally responsive ground system

ground data system (GDS)↗

NASA NTRS2000

Critical Questions for Space Human Factors

Traditional human factors contributions to NASA's crewed space programs have been rooted in the classic approaches to quantifying human physical and cognitive capabilities and limitations in the environment of interest, and producing recommendations and standards for the selection or design of mission equipment. Crews then evaluate the interfaces, displays, or equipment, and with the assistance of human factors experts, improvements are made as funds, time, control documentation, and weight allow. We have come a long way from the early spaceflight days, where men with the ' right stuff were the solution to operating whatever equipment was given to them. The large and diverse Shuttle astronaut corps has impacted mission designs to accommodate a wide range of human capabilities and preferences. Yet with existing long duration experience, we have seen the need to address a different set of dynamics when designing for optimal crew performance: critical equipment and mission situations degrade, and human function changes with mission environment, situation, and duration. Strategies for quantifying the critical nature of human factors requirements are being worked by NASA. Any exploration-class mission will place new responsibilities on mission designers to provide the crew with the information and resources to accomplish the mission. The current duties of a Mission Control Center to monitor system status, detect degradation or malfunction, and provide a proven solution, will need to be incorporated into on-board systems to allow the crew autonomous decision-making. The current option to resupply and replace mission systems and resources, including both vehicle equipment and human operators, will be removed, so considerations of maintenance, onboard training, and proficiency assessment are critical to providing a self-sufficient crew. As we 'move in' to the International Space Station, there are tremendous opportunities to investigate our ability to design for autonomous crews. Yet prioritizing the research that can and should be done by NASA will be based on the critical nature of the issues, and the impact of the individual research questions on mission design. The risks to crew health and safety associated with answering critical human factors issues must be properly included and communicated in order to support the Agency's decisions regarding future space programs.

Woolford, Barbara↗

NASA NTRS2014

Wetware, Hardware, or Software Incapacitation: Observational Methods to Determine When Autonomy Should Assume Control

Control-theoretic modeling of human operator's dynamic behavior in manual control tasks has a long, rich history. There has been significant work on techniques used to identify the pilot model of a given structure. This research attempts to go beyond pilot identification based on experimental data to develop a predictor of pilot behavior. Two methods for pre-dicting pilot stick input during changing aircraft dynamics and deducing changes in pilot behavior are presented This approach may also have the capability to detect a change in a subject due to workload, engagement, etc., or the effects of changes in vehicle dynamics on the pilot. With this ability to detect changes in piloting behavior, the possibility now exists to mediate human adverse behaviors, hardware failures, and software anomalies with autono-my that may ameliorate these undesirable effects. However, appropriate timing of when au-tonomy should assume control is dependent on criticality of actions to safety, sensitivity of methods to accurately detect these adverse changes, and effects of changes in levels of auto-mation of the system as a whole.

Trujillo, Anna C.↗

NASA NTRS2018

Observaciones de la Tierra desde la Estación Espacial Internacional

The International Space Station is a "global observation and diagnosis station." It promotes international Earth observations aimed at understanding and resolving the environmental issues of our home planet. A wide variety of Earth observation payloads can be attached to the exposed facilities on the station's exterior as well as within the Destiny module. The presence of a human crew also provides a unique capability for real-time observation of the Earth, and "on the fly" data collection using hand-held digital cameras, and the astronauts may also provide input to ground personnel programming the station's automated Earth observation systems. Several instruments are currently collecting data from the International Space Station; in addition, some instruments have completed their data collection missions, with other remote sensing systems in development or proposed by researchers from the partner countries, NASA, academic institutions, and corporations. The existing international partnerships, fundamental to the International Space Station, facilitate data sharing that can benefit people around the world and promote international collaboration on other Earth observation activities. The station contributes to humanity by collecting data on global climate, environmental change, and natural hazards using its unique complement of crew-operated and automated Earth observation payloads.

Sotomayor, Jorge L.↗

NASA NTRSDate not supplied

GL4U: Training the next generation of bioinformaticians, one omics datatype at a time

Spaceflight modifies gene expression in every organism examined to date, including humans. Understanding how these gene expression changes affect physiology is crucial for the development of countermeasures to enable long-duration manned missions. NASA’s GeneLab project provides researchers open access to multi-omics data, including genetic and gene expression data, from spaceflight experiments that can be mined to understand the effects of spaceflight on biological systems. To ensure new knowledge generation through data re-use, it is important to maximize the number of scientists who utilize GeneLab data. Training students on the GeneLab platform is the best way to create long-term adopters of this NASA database and its tools. Turning students into future instructors and advocates will also accelerate the dissemination of these data and tools to the broader scientific community. Therefore, in collaboration with the GeneLab Educational Working Group (EWG), GeneLab has created GeneLab for Colleges and Universities (GL4U). GL4U provides space biology-relevant training in bioinformatics to the next generation of scientists through direct and indirect approaches. The GeneLab team plans to host two annual data processing bootcamps, one for college-level students (direct) and one for college educators (indirect – training of trainers), in which participants learn to analyze GeneLab’s space-relevant omics data. During the bootcamp, educators will receive materials and training to enable them to run the bootcamp at their home institutions or alternatively to adapt the content to implement within existing courses, thereby extending the reach of this initiative. The GL4U direct training pilot program was conducted in June 2021 in collaboration with USRA and San Jose State University (SJSU). During the pilot, SJSU students participated in a week-long bootcamp consisting of space biology-specific lectures and hands-on instruction using Jupyter Notebooks to analyze RNA sequence data. This pilot demonstrates the capacity of GL4U for training young scientists and encouraging data re-use.

Jonathan Matthew Galazka↗

NASA NTRSDate not supplied

Advanced Information Systems Technology for NASA Earth System Digital Twins (ESDT)

ESA and NASA have both started programs to design and develop Digital Twins of the Earth and/or Earth systems. Organized around interconnected, multi-domain, high-scale modeling capabilities, the three major components of an Earth System Digital Twin are a continuously updated Digital Replica of the Earth System of interest, dynamic Forecasting models, and Impact Assessment capabilities. Earth System Digital Twins integrate diverse Earth and human activity models, continuous observations, and information system capabilities to provide unified, comprehensive representations and predictions that can be utilized for monitoring the health of the Planet, as well as for developing actionable information to support decision making. More generally, Digital Twins will help researchers better understand the fundamental Earth systems that impact everything from wildfires to climate change. This Townhall will first provide a short description of ESA’s, NASA’s and CNES’s current efforts in Digital Twins: • Destination Earth (DestinE) is the first initiative of the European Union to create a Digital Twin of the Earth, particularly focused on weather and climate, and as a coordinated effort between the European Centre for Medium-Range Weather Forecasts (ECMWF), ESA and the European Organization for the Exploitation of Meteorological Satellites (EUMETSAT). • Additionally, ESA is developing several Digital Twin Earth Precursor Activities to study some of the key scientific and technical challenges associated with building a “Digital Twin Earth”. These include forests, hydrology, Antarctica, food systems, oceans, and climate hot spots Digital Twin prototypes. • NASA Earth Science Technology Office (ESTO)’s Advanced Information Systems Technology (AIST) Program has started an initiative in Earth System Digital Twins (ESDT), with 14 current projects in this area, developing various information systems technologies and prototypes that will help prepare the development of future NASA Digital Twins. • CNES is currently developing the concept of a Digital Twin Factory (DTF), which relies on a data lake, a high computing capability using clouds and/or HPC and has thematic algorithms and methodologies able to generate registered and coherent layers of information in order to enrich a datacube from which physical indicators can be computed spatially. NASA, ESA and CNES are also currently defining science use cases that will be presented during the townhall; those and a few short discussions of current projects will serve as a starting point to engage a dialogue about Digital Twins of the Earth with the IGARSS community.

earth science remote sensing; Information systems↗