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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,081 records · Page 60
All sourcesNASA NTRSDOE OSTI
DOE OSTI2012

GAMMA-RAY ACTIVITY IN THE CRAB NEBULA: THE EXCEPTIONAL FLARE OF 2011 APRIL

The Large Area Telescope on board the Fermi satellite observed a gamma-ray flare in the Crab Nebula lasting for approximately nine days in April of 2011. The source, which at optical wavelengths has a size of Almost-Equal-To 11 lt-yr across, doubled its gamma-ray flux within eight hours. The peak photon flux was (186 {+-} 6) Multiplication-Sign 10{sup -7} cm{sup -2} s{sup -1} above 100 MeV, which corresponds to a 30-fold increase compared to the average value. During the flare, a new component emerged in the spectral energy distribution, which peaked at an energy of (375 {+-} 26) MeV at flare maximum. The observations imply that the emission region was likely relativistically beamed toward us and that variations in its motion are responsible for the observed spectral variability.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2015

Gamma-ray flare activity from PSR B1259-63 during 2014 Periastron Passage and comparison to its 2010 passage

PSR B1259–63/LS 2883 is a gamma-ray binary system containing a radio pulsar in a highly elliptical ~3.4-year orbit around a Be star. In its 2010 periastron passage, multiwavelength emission from radio to TeV was observed, as well as an unexpected GeV flare measured by the Fermi Large Area Telescope (LAT). We report the results of LAT monitoring of PSR B1259–63 during its most recent 2014 periastron passage. We also compare the gamma-ray behavior in this periastron with the former in 2010 and find that PSR B1259–63 shows a recurrent GeV flare. Furthermore, the similarities and differences in the phenomenology of both periastron passages are discussed.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2022

ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site

Abstract ADARs (adenosine deaminases acting on RNA) can be directed to sites in the transcriptome by complementary guide strands allowing for the correction of disease-causing mutations at the RNA level. However, ADARs show bias against editing adenosines with a guanosine 5′ nearest neighbor (5′-GA sites), limiting the scope of this approach. Earlier studies suggested this effect arises from a clash in the RNA minor groove involving the 2-amino group of the guanosine adjacent to an editing site. Here we show that nucleosides capable of pairing with guanosine in a syn conformation enhance editing for 5′-GA sites. We describe the crystal structure of a fragment of human ADAR2 bound to RNA bearing a G:G pair adjacent to an editing site. The two guanosines form a Gsyn:Ganti pair solving the steric problem by flipping the 2-amino group of the guanosine adjacent to the editing site into the major groove. Also, duplexes with 2′-deoxyadenosine and 3-deaza-2′-deoxyadenosine displayed increased editing efficiency, suggesting the formation of a Gsyn:AH+anti pair. This was supported by X-ray crystallography of an ADAR complex with RNA bearing a G:3-deaza dA pair. This study shows how non-Watson–Crick pairing in duplex RNA can facilitate ADAR editing enabling the design of next generation guide strands for therapeutic RNA editing.

Doherty, Erin E.↗